AU2021212559B2 - Benzoselenophene-based compound, pharmaceutical composition containing same, and antibody-drug conjugate - Google Patents

Benzoselenophene-based compound, pharmaceutical composition containing same, and antibody-drug conjugate Download PDF

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Publication number
AU2021212559B2
AU2021212559B2 AU2021212559A AU2021212559A AU2021212559B2 AU 2021212559 B2 AU2021212559 B2 AU 2021212559B2 AU 2021212559 A AU2021212559 A AU 2021212559A AU 2021212559 A AU2021212559 A AU 2021212559A AU 2021212559 B2 AU2021212559 B2 AU 2021212559B2
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cancer
antibody
substituted
compound
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AU2021212559A1 (en
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Min Cheol Kim
Dongyeol LIM
Amol MHETRE
Do-Hyun Nam
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Aimed Bio Inc
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Aimed Bio Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
    • C07D421/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61P35/00—Antineoplastic agents
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    • A61K31/28—Compounds containing heavy metals
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2021212559A 2020-01-30 2021-01-27 Benzoselenophene-based compound, pharmaceutical composition containing same, and antibody-drug conjugate Active AU2021212559B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20200011222 2020-01-30
KR10-2020-0011222 2020-01-30
PCT/KR2021/001082 WO2021153984A1 (ko) 2020-01-30 2021-01-27 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체

Publications (2)

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AU2021212559A1 AU2021212559A1 (en) 2022-08-11
AU2021212559B2 true AU2021212559B2 (en) 2023-11-23

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087684A1 (en) * 2006-02-03 2007-08-09 Bionomics Limited Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
KR20130034638A (ko) * 2011-09-28 2013-04-05 사회복지법인 삼성생명공익재단 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법
KR20170041562A (ko) * 2015-10-07 2017-04-17 세종대학교산학협력단 벤조셀레노펜계 화합물 및 이를 포함하는 항체-약물 결합체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
ES2244991T3 (es) 1996-03-08 2005-12-16 The Scripps Research Institute Analogosmcbi de cc-1065 y las duocarmicinas.
BRPI0617546A2 (pt) * 2005-09-26 2011-07-26 Medarex Inc conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
EP1994000B1 (en) * 2006-02-02 2017-08-23 Syntarga B.V. Water-soluble cc-1065 analogs and their conjugates
TWI412367B (zh) * 2006-12-28 2013-10-21 梅達雷克斯有限責任公司 化學鏈接劑與可裂解基質以及其之綴合物
WO2013048177A2 (ko) * 2011-09-28 2013-04-04 세종대학교산학협력단 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법
KR101460207B1 (ko) * 2011-12-07 2014-11-11 세종대학교산학협력단 셀레노펜-접합 방향족 화합물을 포함하는 항암제
US9819889B2 (en) * 2015-08-07 2017-11-14 Omnivision Technologies, Inc. Method and system to implement a stacked chip high dynamic range image sensor
KR102894542B1 (ko) * 2020-01-30 2025-12-03 (주)에임드바이오 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087684A1 (en) * 2006-02-03 2007-08-09 Bionomics Limited Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
KR20130034638A (ko) * 2011-09-28 2013-04-05 사회복지법인 삼성생명공익재단 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법
KR20170041562A (ko) * 2015-10-07 2017-04-17 세종대학교산학협력단 벤조셀레노펜계 화합물 및 이를 포함하는 항체-약물 결합체

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MHETRE A. B., et al., 2019, 'Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI)', RSC Advances, 9(50), pages 29023-36 *
MHETRE. A. B., et al., 2017, 'Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)', Organic & Biomolecular Chemistry, 15(5), pages 1198-1208 *

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JP7726628B2 (ja) 2025-08-20
CN115038699B (zh) 2024-12-03
US11576896B2 (en) 2023-02-14
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US20220380360A1 (en) 2022-12-01
EP4083041A1 (en) 2022-11-02
US20210236464A1 (en) 2021-08-05
CA3165524A1 (en) 2021-08-05
KR102596247B1 (ko) 2023-11-01
CN115038699A (zh) 2022-09-09
CA3165524C (en) 2025-05-13
KR20210097601A (ko) 2021-08-09
AU2021212559A1 (en) 2022-08-11
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US11938115B2 (en) 2024-03-26

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