AU2019282231B2 - EAAT2 activators and methods of using thereof - Google Patents
EAAT2 activators and methods of using thereof Download PDFInfo
- Publication number
- AU2019282231B2 AU2019282231B2 AU2019282231A AU2019282231A AU2019282231B2 AU 2019282231 B2 AU2019282231 B2 AU 2019282231B2 AU 2019282231 A AU2019282231 A AU 2019282231A AU 2019282231 A AU2019282231 A AU 2019282231A AU 2019282231 B2 AU2019282231 B2 AU 2019282231B2
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- rtg4510
- vehicle
- alkyl
- compound
- control
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862680423P | 2018-06-04 | 2018-06-04 | |
| US201862680418P | 2018-06-04 | 2018-06-04 | |
| US62/680,423 | 2018-06-04 | ||
| US62/680,418 | 2018-06-04 | ||
| PCT/US2019/035452 WO2019236625A1 (en) | 2018-06-04 | 2019-06-04 | Eaat2 activators and methods of using thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2019282231A1 AU2019282231A1 (en) | 2021-01-14 |
| AU2019282231B2 true AU2019282231B2 (en) | 2025-04-17 |
Family
ID=68771005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019282231A Active AU2019282231B2 (en) | 2018-06-04 | 2019-06-04 | EAAT2 activators and methods of using thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11702403B2 (https=) |
| EP (2) | EP4685140A1 (https=) |
| JP (2) | JP2021527636A (https=) |
| CN (1) | CN112533601B (https=) |
| AU (1) | AU2019282231B2 (https=) |
| CA (1) | CA3102762A1 (https=) |
| ES (1) | ES3041367T3 (https=) |
| IL (1) | IL279199B1 (https=) |
| WO (1) | WO2019236625A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3877376T3 (da) | 2018-11-06 | 2023-10-02 | Edgewise Therapeutics Inc | Pyridazinonforbindelser og anvendelser deraf |
| CA3118908A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| AU2019374812B2 (en) | 2018-11-06 | 2025-03-06 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| CN113939295B (zh) * | 2019-03-20 | 2025-05-16 | 金翅雀生物公司 | 哒嗪酮及其使用方法 |
| EP4149621B1 (en) * | 2020-05-13 | 2024-10-30 | Edgewise Therapeutics, Inc. | Pyridazinone compounds for the treatment of neuromuscular diseases |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4397854A (en) * | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| WO2008103277A2 (en) * | 2007-02-16 | 2008-08-28 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors |
| EP2196465A1 (en) * | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors |
| WO2014032398A1 (zh) * | 2012-08-28 | 2014-03-06 | 中国科学院上海药物研究所 | 哒嗪酮类化合物、其制备方法、药物组合物及其用途 |
| US20140303174A1 (en) * | 2011-08-02 | 2014-10-09 | The Brigham And Women S Hospital, Inc. | Pyridazine derivatives as EAAT2 Activators |
| WO2018081378A1 (en) * | 2016-10-26 | 2018-05-03 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating cftr |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260756A (en) * | 1979-11-15 | 1981-04-07 | American Cyanamid Company | 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines |
| US4404203A (en) * | 1981-05-14 | 1983-09-13 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| AU691673B2 (en) * | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
| CA2742411A1 (en) * | 2000-09-18 | 2002-03-21 | Eisai R&D Management Co., Ltd. | Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations |
| AUPR606401A0 (en) * | 2001-07-02 | 2001-07-26 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
| JP2003313169A (ja) * | 2002-04-19 | 2003-11-06 | Otsuka Chemical Holdings Co Ltd | ４，４−ジフルオロ−３−ブテニル化合物及び農園芸用殺虫・殺ダニ剤 |
| ES2232306B1 (es) * | 2003-11-10 | 2006-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| JP4890439B2 (ja) * | 2005-03-07 | 2012-03-07 | 杏林製薬株式会社 | ピラゾロピリジン−４−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤 |
| US8426412B2 (en) | 2008-04-08 | 2013-04-23 | Dow Agrosciences, Llc. | 2-alkynyl-6-pyridin-2-yl-pyridazinones, 2-alkynyl-6-pyridin-2-yl-dihydropyridazinones, 2-alkynyl-6-pyrimidin-2-yl-pyridazinones and 2-alkynyl-6-pyrimidin-2-yl-dihydropyridazinones and their use as fungicides |
| AU2013365926B9 (en) * | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| EP2953944B1 (en) * | 2013-02-07 | 2017-04-26 | Merck Patent GmbH | Pyridazinone-amides derivatives |
| LT2953952T (lt) * | 2013-02-07 | 2017-08-25 | Merck Patent Gmbh | Makrocikliniai piridazinono dariniai |
| KR102420322B1 (ko) * | 2014-06-17 | 2022-07-13 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포이노시타이드 3-키나아제 억제제로서 인돌리진 유도체 |
| CN106467495A (zh) * | 2015-08-19 | 2017-03-01 | 中国科学院上海药物研究所 | 哒嗪酮类化合物、其制备方法、药物组合物及用途 |
| WO2017123991A1 (en) | 2016-01-15 | 2017-07-20 | The Brigham And Women's Hospital, Inc. | Pyridazine derivatives as eaat2 activators |
-
2019
- 2019-06-04 EP EP25194190.2A patent/EP4685140A1/en active Pending
- 2019-06-04 CN CN201980052147.6A patent/CN112533601B/zh active Active
- 2019-06-04 JP JP2020567510A patent/JP2021527636A/ja active Pending
- 2019-06-04 IL IL279199A patent/IL279199B1/en unknown
- 2019-06-04 EP EP19815032.8A patent/EP3801528B1/en active Active
- 2019-06-04 AU AU2019282231A patent/AU2019282231B2/en active Active
- 2019-06-04 US US16/972,311 patent/US11702403B2/en active Active
- 2019-06-04 WO PCT/US2019/035452 patent/WO2019236625A1/en not_active Ceased
- 2019-06-04 ES ES19815032T patent/ES3041367T3/es active Active
- 2019-06-04 CA CA3102762A patent/CA3102762A1/en active Pending
-
2022
- 2022-10-04 US US17/959,654 patent/US12286420B2/en active Active
-
2023
- 2023-07-18 US US18/354,330 patent/US20240208936A1/en active Pending
-
2024
- 2024-08-09 JP JP2024133796A patent/JP7794910B2/ja active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4397854A (en) * | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| WO2008103277A2 (en) * | 2007-02-16 | 2008-08-28 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors |
| EP2196465A1 (en) * | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors |
| US20140303174A1 (en) * | 2011-08-02 | 2014-10-09 | The Brigham And Women S Hospital, Inc. | Pyridazine derivatives as EAAT2 Activators |
| WO2014032398A1 (zh) * | 2012-08-28 | 2014-03-06 | 中国科学院上海药物研究所 | 哒嗪酮类化合物、其制备方法、药物组合物及其用途 |
| WO2018081378A1 (en) * | 2016-10-26 | 2018-05-03 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating cftr |
Non-Patent Citations (7)
| Title |
|---|
| DATABASE PUBCHEM 30 November 2012 (2012-11-30), XP055660680, Database accession no. 68896020 * |
| DATABASE PUBCHEM 5 December 2007 (2007-12-05), XP055660676, Database accession no. 20492827 * |
| HARDING RACHEL J. ET AL: "Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 21, 27 October 2017 (2017-10-27), pages 9090 - 9096 * |
| IBRAHIM TAMER H. ET AL: "Synthesis of Some Novel 2,6-Disubstituted Pyridazin-3(2 H )-one Derivatives as Analgesic, Anti-Inflammatory, and Non-Ulcerogenic Agents", ARCHIV DER PHARMAZIE, vol. 350, no. 9, 9 August 2017, pages 1700093 * |
| MASAHISA YAMAGUSHI: "Novel antiasthmatic agents with dual activities of thromboxane", CHEM. PHARM. BULL., 1 January 1994 (1994-01-01), pages 1850 - 1853, XP055879960, Retrieved from the Internet [retrieved on 20220117] * |
| MATYUS P ET AL: "Synthesis, antihypertensive and @a-adrenoceptor activity of novel 2-aminoalkyl-3(2H)-pyridazinones", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 2, 1 March 1992, pages 107 - 114 * |
| STRAPPAGHETTI G ET AL: "Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 18, 15 September 2008, pages 5140 - 5145 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024160326A (ja) | 2024-11-13 |
| US12286420B2 (en) | 2025-04-29 |
| US20210171497A1 (en) | 2021-06-10 |
| US20230138663A1 (en) | 2023-05-04 |
| ES3041367T3 (en) | 2025-11-11 |
| WO2019236625A1 (en) | 2019-12-12 |
| IL279199A (en) | 2021-01-31 |
| IL279199B1 (en) | 2026-04-01 |
| JP7794910B2 (ja) | 2026-01-06 |
| CN112533601A (zh) | 2021-03-19 |
| EP4685140A1 (en) | 2026-01-28 |
| AU2019282231A1 (en) | 2021-01-14 |
| US20240208936A1 (en) | 2024-06-27 |
| US11702403B2 (en) | 2023-07-18 |
| CN112533601B (zh) | 2024-08-16 |
| JP2021527636A (ja) | 2021-10-14 |
| EP3801528A1 (en) | 2021-04-14 |
| EP3801528A4 (en) | 2022-03-09 |
| EP3801528B1 (en) | 2025-08-06 |
| CA3102762A1 (en) | 2019-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |