AU2018361833B2 - Genetic regulation of immunoresponse by chromosome interactions - Google Patents

Genetic regulation of immunoresponse by chromosome interactions Download PDF

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Publication number
AU2018361833B2
AU2018361833B2 AU2018361833A AU2018361833A AU2018361833B2 AU 2018361833 B2 AU2018361833 B2 AU 2018361833B2 AU 2018361833 A AU2018361833 A AU 2018361833A AU 2018361833 A AU2018361833 A AU 2018361833A AU 2018361833 B2 AU2018361833 B2 AU 2018361833B2
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Australia
Prior art keywords
responder
chromosome
probe
interactions
nucleic acids
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AU2018361833A
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AU2018361833A1 (en
Inventor
Alexandre Akoulitchev
Ewan HUNTER
Aroul Selvam Ramadass
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Oxford Biodynamics PLC
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Oxford Biodynamics PLC
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Assigned to Oxford BioDynamics PLC reassignment Oxford BioDynamics PLC Amend patent request/document other than specification (104) Assignors: OXFORD BIODYNAMICS LIMITED
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018361833A 2017-11-03 2018-11-02 Genetic regulation of immunoresponse by chromosome interactions Active AU2018361833B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762581287P 2017-11-03 2017-11-03
US62/581,287 2017-11-03
GB2018052818 2018-10-03
GBPCT/GB2018/052818 2018-10-03
PCT/GB2018/053196 WO2019086898A2 (en) 2017-11-03 2018-11-02 Genetic regulation

Publications (2)

Publication Number Publication Date
AU2018361833A1 AU2018361833A1 (en) 2020-04-30
AU2018361833B2 true AU2018361833B2 (en) 2021-04-22

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Family Applications (1)

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AU2018361833A Active AU2018361833B2 (en) 2017-11-03 2018-11-02 Genetic regulation of immunoresponse by chromosome interactions

Country Status (13)

Country Link
US (1) US11840737B2 (https=)
EP (1) EP3704274B1 (https=)
JP (2) JP2021501592A (https=)
KR (1) KR102885025B1 (https=)
CN (1) CN111511930B (https=)
AU (1) AU2018361833B2 (https=)
CA (1) CA3078675A1 (https=)
ES (1) ES2987603T3 (https=)
HU (1) HUE066292T2 (https=)
MY (1) MY199800A (https=)
PL (1) PL3704274T3 (https=)
SG (1) SG11202003233YA (https=)
WO (1) WO2019086898A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220333199A1 (en) * 2019-09-11 2022-10-20 Oxford BioDynamics PLC Diagnostic Chromosome Marker
EP4121964A1 (en) * 2020-03-17 2023-01-25 Regeneron Pharmaceuticals, Inc. Methods and systems for determining responders to treatment
GB202008269D0 (en) * 2020-06-02 2020-07-15 Oxford Biodynamics Ltd Detecting a chromosome marker
GB202016176D0 (en) * 2020-10-12 2020-11-25 Oxford BioDynamics PLC Disease marker
TW202302862A (zh) * 2021-03-04 2023-01-16 英商牛津生物力學公眾有限公司 染色體交互作用標記物
WO2025215190A1 (en) * 2024-04-12 2025-10-16 Oxford BioDynamics PLC Method of typing chromosome markers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016207653A1 (en) * 2015-06-24 2016-12-29 Oxford Biodynamics Limited Detection of chromosome interactions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036993A1 (es) * 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
GB0603251D0 (en) 2006-02-17 2006-03-29 Isis Innovation DNA conformation
US8642295B2 (en) * 2007-01-11 2014-02-04 Erasmus University Medical Center Circular chromosome conformation capture (4C)
JP2011502108A (ja) * 2007-10-15 2011-01-20 武田薬品工業株式会社 癌の予防・治療剤
GB0810051D0 (en) 2008-06-02 2008-07-09 Oxford Biodynamics Ltd Method of diagnosis
ES2700877T3 (es) * 2009-05-12 2019-02-19 Koninklijke Philips Nv Fosfodiesterasa 4D7 como marcador de cáncer de próstata
EP3004877A4 (en) * 2013-06-06 2017-04-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment prevention, and treatment of cancer using pd-l1 isoforms
US20160299146A1 (en) 2013-11-20 2016-10-13 Dana-Farber Cancer Institute, Inc. Kynurenine Pathway Biomarkers Predictive of Anti-Immune Checkpoint Inhibitor Response

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016207653A1 (en) * 2015-06-24 2016-12-29 Oxford Biodynamics Limited Detection of chromosome interactions
WO2016207661A1 (en) * 2015-06-24 2016-12-29 Oxford Biodynamics Limited Detection processes using sites of chromosome interaction

Also Published As

Publication number Publication date
CN111511930B (zh) 2024-11-22
HUE066292T2 (hu) 2024-07-28
PL3704274T3 (pl) 2024-07-08
CN111511930A (zh) 2020-08-07
MY199800A (en) 2023-11-23
KR20200081380A (ko) 2020-07-07
US11840737B2 (en) 2023-12-12
JP2023082157A (ja) 2023-06-13
CA3078675A1 (en) 2019-05-09
JP2021501592A (ja) 2021-01-21
US20210230702A1 (en) 2021-07-29
EP3704274C0 (en) 2024-04-17
EP3704274A2 (en) 2020-09-09
SG11202003233YA (en) 2020-05-28
NZ763540A (en) 2025-03-28
JP7631400B2 (ja) 2025-02-18
KR102885025B1 (ko) 2025-11-11
WO2019086898A3 (en) 2019-06-13
EP3704274B1 (en) 2024-04-17
AU2018361833A1 (en) 2020-04-30
WO2019086898A2 (en) 2019-05-09
ES2987603T3 (es) 2024-11-15

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