AU2004216133B2 - Adenosine A1 receptor antagonist for the treatment of cardiac and renal diseases - Google Patents

Adenosine A1 receptor antagonist for the treatment of cardiac and renal diseases Download PDF

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Publication number
AU2004216133B2
AU2004216133B2 AU2004216133A AU2004216133A AU2004216133B2 AU 2004216133 B2 AU2004216133 B2 AU 2004216133B2 AU 2004216133 A AU2004216133 A AU 2004216133A AU 2004216133 A AU2004216133 A AU 2004216133A AU 2004216133 B2 AU2004216133 B2 AU 2004216133B2
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tricyclo
nonyl
hydroxy
patient
trans
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AU2004216133A
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AU2004216133A1 (en
Inventor
Roland Blantz
Howard C. Dittrich
Lauren Otsuki
Scott Thomson
Kenneth J. Widder
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NovaCardia Inc
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NovaCardia Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2004216133A 2003-02-24 2004-02-24 Adenosine A1 receptor antagonist for the treatment of cardiac and renal diseases Ceased AU2004216133B2 (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US44995303P 2003-02-24 2003-02-24
US60/449,953 2003-02-24
US45049903P 2003-02-25 2003-02-25
US45050003P 2003-02-25 2003-02-25
US60/450,499 2003-02-25
US60/450,500 2003-02-25
US45132603P 2003-02-28 2003-02-28
US60/451,326 2003-02-28
US46481203P 2003-04-21 2003-04-21
US46481503P 2003-04-21 2003-04-21
US46481103P 2003-04-21 2003-04-21
US46481303P 2003-04-21 2003-04-21
US60/464,812 2003-04-21
US60/464,815 2003-04-21
US60/464,811 2003-04-21
US60/464,813 2003-04-21
PCT/US2004/005755 WO2004075856A2 (en) 2003-02-24 2004-02-24 Adenosine a1 receptor antagonist for the treatment of cardiac and renal diseases

Publications (2)

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AU2004216133A1 AU2004216133A1 (en) 2004-09-10
AU2004216133B2 true AU2004216133B2 (en) 2008-12-04

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AU2004216133A Ceased AU2004216133B2 (en) 2003-02-24 2004-02-24 Adenosine A1 receptor antagonist for the treatment of cardiac and renal diseases

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US (1) US20040229901A1 (US06894165-20050517-C00155.png)
EP (2) EP1603545A2 (US06894165-20050517-C00155.png)
JP (1) JP2006518765A (US06894165-20050517-C00155.png)
KR (1) KR20050106038A (US06894165-20050517-C00155.png)
AU (1) AU2004216133B2 (US06894165-20050517-C00155.png)
BR (1) BRPI0407494A (US06894165-20050517-C00155.png)
CA (1) CA2516730A1 (US06894165-20050517-C00155.png)
MX (1) MXPA05008805A (US06894165-20050517-C00155.png)
WO (1) WO2004075856A2 (US06894165-20050517-C00155.png)

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JP2007532671A (ja) * 2004-04-16 2007-11-15 ノヴァカーディア，インク． アデノシンａ１受容体アンタゴニストおよびアルドステロン阻害剤を含む併用療法
CA2622911C (en) * 2005-09-16 2016-12-06 Cornell Research Foundation, Inc. Methods for reducing cd36 expression
CA2648281A1 (en) * 2006-04-06 2007-10-18 Novacardia, Inc. Co-administration of adenosine a1 receptor antagonists and anticonvulsants
JP2009540003A (ja) * 2006-06-16 2009-11-19 ノヴァカーディア，インク． Ａａ１ｒａの低頻度投与を含む腎機能の長期間にわたる改善
TW200808819A (en) * 2006-06-19 2008-02-16 Solvay Pharm Gmbh Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty
WO2008121893A1 (en) * 2007-03-29 2008-10-09 Novacardia, Inc. Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
US20080242684A1 (en) * 2007-03-29 2008-10-02 Howard Dittrich Methods of administration of adenosine a1 receptor antagonists
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
CN101909612A (zh) * 2007-12-27 2010-12-08 拜尔动物保健有限责任公司 使用β-受体阻滞剂治疗心脏病
CN109890364B (zh) * 2016-10-03 2023-10-17 儿童医疗中心公司 糖尿病肾病的预防和治疗

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