AU2002357479A1 - Thrombin-cleavable chimeric proteins - Google Patents

Thrombin-cleavable chimeric proteins

Info

Publication number
AU2002357479A1
AU2002357479A1 AU2002357479A AU2002357479A AU2002357479A1 AU 2002357479 A1 AU2002357479 A1 AU 2002357479A1 AU 2002357479 A AU2002357479 A AU 2002357479A AU 2002357479 A AU2002357479 A AU 2002357479A AU 2002357479 A1 AU2002357479 A1 AU 2002357479A1
Authority
AU
Australia
Prior art keywords
thrombin
chimeric proteins
cleavable chimeric
cleavable
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2002357479A
Other versions
AU2002357479B2 (en
Inventor
Martine Aiach
Elsa Bianchini
Claire Calmel
Bernard Le Bonniec
Virginie Louvain
Pierre-Emmanuel Marque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National De La Sante Et De La Recherche Medicale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0113492A priority Critical patent/FR2831170B1/en
Priority to FR01/13492 priority
Application filed by Institut National De La Sante Et De La Recherche Medicale filed Critical Institut National De La Sante Et De La Recherche Medicale
Priority to PCT/EP2002/012191 priority patent/WO2003035861A2/en
Publication of AU2002357479A1 publication Critical patent/AU2002357479A1/en
Assigned to INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE reassignment INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Request for Assignment Assignors: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-INSERM
Publication of AU2002357479B2 publication Critical patent/AU2002357479B2/en
Application granted granted Critical
Application status is Ceased legal-status Critical
Anticipated expiration legal-status Critical

Links

AU2002357479A 2001-10-19 2002-10-18 Thrombin-cleavable chimeric proteins Ceased AU2002357479B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0113492A FR2831170B1 (en) 2001-10-19 2001-10-19 C MODIFIED proteins activatable by thrombin
FR01/13492 2001-10-19
PCT/EP2002/012191 WO2003035861A2 (en) 2001-10-19 2002-10-18 Thrombin-cleavable chimeric proteins

Publications (2)

Publication Number Publication Date
AU2002357479A1 true AU2002357479A1 (en) 2003-07-03
AU2002357479B2 AU2002357479B2 (en) 2008-03-06

Family

ID=8868473

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002357479A Ceased AU2002357479B2 (en) 2001-10-19 2002-10-18 Thrombin-cleavable chimeric proteins

Country Status (10)

Country Link
US (1) US7589178B2 (en)
EP (1) EP1436389B1 (en)
JP (1) JP4355924B2 (en)
AT (1) AT350470T (en)
AU (1) AU2002357479B2 (en)
CA (1) CA2463772C (en)
DE (1) DE60217377T2 (en)
ES (1) ES2279010T3 (en)
FR (1) FR2831170B1 (en)
WO (1) WO2003035861A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006100035A (en) * 2003-06-11 2006-08-27 Шеринг Акциенгезельшафт (De) New modified korinovye molecules having substituted activating sequences, and their use
WO2004113385A1 (en) * 2003-06-20 2004-12-29 Maxygen Holdings Ltd. Protein c propeptide variants
RU2396347C2 (en) 2004-08-17 2010-08-10 Ксл Бехринг Гмбх Modified vitamin k dependent polypeptides
WO2006126102A2 (en) * 2005-04-20 2006-11-30 Viromed Co., Ltd. Compositions and methods for fusion protein separation
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
WO2007015782A1 (en) * 2005-07-29 2007-02-08 Ecole Polytechnique Federale De Lausanne Molecular variant fibrinogen fusion proteins
MX2008006313A (en) * 2005-11-15 2008-11-06 Philadelphia Children Hospital Reactive dyestuffs, method for the production thereof, and use of the same.
EP1820508A1 (en) 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
EP2199387A1 (en) 2008-12-19 2010-06-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Serine protease derivatives and uses for the prevention and/or the treatment of blood coagulation disorders
EP2358874B1 (en) * 2008-12-19 2017-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Serine protease derivatives and uses in the prevention or the treatment of blood coagulation disorders
SG186875A1 (en) 2010-07-09 2013-02-28 Biogen Idec Hemophilia Inc Chimeric clotting factors
LT2717898T (en) 2011-06-10 2019-03-25 Bioverativ Therapeutics Inc. Pro-coagulant compounds and methods of use thereof
US8900822B2 (en) * 2011-11-21 2014-12-02 Ethicon, Inc. Fibrinogen assay
US20130309753A1 (en) * 2012-05-16 2013-11-21 Saint Louis University Recombinant auto-activating protease precursors
US10287564B2 (en) 2012-06-08 2019-05-14 Bioverativ Therapeutics Inc. Procoagulant compounds
CA2875247A1 (en) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Chimeric clotting factors
MX365612B (en) 2012-07-25 2019-06-07 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof.
FR3001729B1 (en) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Factor x mutants
US9789209B2 (en) 2013-03-14 2017-10-17 The Regents Of The University Of California, Berke Activatable membrane-interacting peptides and methods of use
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
RU2648144C2 (en) 2013-09-24 2018-03-22 Пфайзер Инк. COMPOSITIONS COMPRISING HETEROGENEOUS POPULATIONS OF RECOMBINANT HUMAN CLOTTING FACTOR Xa PROTEINS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
US5851983A (en) * 1987-12-28 1998-12-22 Teijin Limited Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
AT405516B (en) 1997-02-27 1999-09-27 Immuno Ag Factor X analog with a modified protease cleavage site
US6232456B1 (en) * 1997-10-06 2001-05-15 Abbott Laboratories Serine protease reagents and methods useful for detecting and treating diseases of the prostate
FR2841904B1 (en) 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Similar factors x cleavable by thrombin

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