AU2002220596A1 - Synthesis of r(+)alpha-lipoic acid - Google Patents
Synthesis of r(+)alpha-lipoic acidInfo
- Publication number
- AU2002220596A1 AU2002220596A1 AU2002220596A AU2059602A AU2002220596A1 AU 2002220596 A1 AU2002220596 A1 AU 2002220596A1 AU 2002220596 A AU2002220596 A AU 2002220596A AU 2059602 A AU2059602 A AU 2059602A AU 2002220596 A1 AU2002220596 A1 AU 2002220596A1
- Authority
- AU
- Australia
- Prior art keywords
- alpha
- halo
- octanoic acid
- methylbenzylamine
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Biological Depolymerization Polymers (AREA)
- General Preparation And Processing Of Foods (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI00A2188 | 2000-10-10 | ||
IT2000MI002188A IT1319196B1 (it) | 2000-10-10 | 2000-10-10 | Sintesi dell'acido r(+)alfa-lipoico. |
PCT/EP2001/011576 WO2002030919A1 (en) | 2000-10-10 | 2001-10-08 | SYNTHESIS OF R(+)α-LIPOIC ACID |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002220596A1 true AU2002220596A1 (en) | 2002-04-22 |
Family
ID=11445937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002220596A Abandoned AU2002220596A1 (en) | 2000-10-10 | 2001-10-08 | Synthesis of r(+)alpha-lipoic acid |
Country Status (11)
Country | Link |
---|---|
US (1) | US6864374B2 (ko) |
EP (1) | EP1335911B1 (ko) |
JP (1) | JP4257574B2 (ko) |
KR (1) | KR100822532B1 (ko) |
AT (1) | ATE266020T1 (ko) |
AU (1) | AU2002220596A1 (ko) |
CZ (1) | CZ301710B6 (ko) |
DE (1) | DE60103179T2 (ko) |
ES (1) | ES2219577T3 (ko) |
IT (1) | IT1319196B1 (ko) |
WO (1) | WO2002030919A1 (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10201464B4 (de) * | 2002-01-16 | 2005-06-16 | Viatris Gmbh & Co. Kg | Verfahren zur Herstellung reiner Thioctsäure |
ITMI20030831A1 (it) | 2003-04-22 | 2004-10-23 | Laboratorio Chimico Int Spa | Sale basico dell'acido tiottico con la l-carnitina. |
CN100387593C (zh) * | 2006-01-26 | 2008-05-14 | 南京师范大学 | 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法 |
ITMI20061024A1 (it) | 2006-05-25 | 2007-11-26 | Eurand Pharmaceuticals Ltd | Pellet a base di acido lipoico |
JP2012506429A (ja) * | 2008-10-24 | 2012-03-15 | バイオリンク ライフ サイエンシーズ,インコーポレイテッド | 真性糖尿病及びその共存症の処置に有用である、水に不溶な安定なR−(+)−α−リポ酸塩 |
AU2009322999A1 (en) * | 2008-12-01 | 2011-06-30 | Invasc Therapeutics, Inc. | Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders |
CN101880224B (zh) * | 2009-05-08 | 2013-02-20 | 上海医药工业研究院 | 一种6,8-二氯辛酸的拆分方法 |
US8080674B2 (en) * | 2009-06-12 | 2011-12-20 | Ampac Fine Chemicals Llc. | Preparation of polymer-free R-(+)-α-lipoic acid magnesium salt |
DE102012109704A1 (de) * | 2012-10-11 | 2014-04-17 | Epcos Ag | Keramisches Bauelement mit Schutzschicht und Verfahren zu dessen Herstellung |
CN109942426B (zh) * | 2019-04-02 | 2022-03-22 | 福建科宏生物工程股份有限公司 | 一种s-(-)-硫辛酸循环利用的处理方法 |
CN116496245A (zh) * | 2023-03-01 | 2023-07-28 | 杭州新曦科技有限公司 | 用于制备R-α-硫辛酸及其相关中间体的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
DE3814163A1 (de) * | 1988-04-27 | 1989-11-09 | Rhein Chemie Rheinau Gmbh | Verfahren zur herstellung von disulfiden |
DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
DE4342619A1 (de) * | 1993-12-14 | 1995-06-22 | Bayer Ag | Verbessertes Verfahren zur Herstellung von 2,2'-Dinitrodiphenyldisulfid |
DE19510130C1 (de) * | 1995-03-21 | 1996-11-21 | Asta Medica Ag | Verfahren zur Herstellung rieselfähiger R,S-Thioctsäure, R,S-Thioctsäure sowie deren Verwendung |
GB9510858D0 (en) * | 1995-05-30 | 1995-07-26 | Chiroscience Ltd | Process for preparing lipoic acid |
DE19533881A1 (de) * | 1995-09-13 | 1997-03-20 | Dresden Arzneimittel | Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester |
CZ96798A3 (cs) * | 1997-04-02 | 1998-10-14 | Sankyo Company Limited | Deriváty dithiolanu, jejich příprava a jejich terapeutické účinky |
ES2340488T3 (es) * | 1998-10-26 | 2010-06-04 | The Research Foundation Of State University Of New York | Sales derivadas del acido lipoico y su utilizacion para el tratamiento de las enfermedades. |
AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
DE19938621A1 (de) * | 1999-08-14 | 2001-02-22 | Sueddeutsche Kalkstickstoff | Verfahren zur Herstellung von lösemittelfreier alpha-Liponsäure |
IT1319195B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Processo per la produzione dell'acido r(+)alfa-lipoico. |
-
2000
- 2000-10-10 IT IT2000MI002188A patent/IT1319196B1/it active
-
2001
- 2001-10-08 DE DE60103179T patent/DE60103179T2/de not_active Expired - Lifetime
- 2001-10-08 CZ CZ20031007A patent/CZ301710B6/cs not_active IP Right Cessation
- 2001-10-08 WO PCT/EP2001/011576 patent/WO2002030919A1/en active IP Right Grant
- 2001-10-08 JP JP2002534305A patent/JP4257574B2/ja not_active Expired - Fee Related
- 2001-10-08 ES ES01986686T patent/ES2219577T3/es not_active Expired - Lifetime
- 2001-10-08 EP EP01986686A patent/EP1335911B1/en not_active Expired - Lifetime
- 2001-10-08 AT AT01986686T patent/ATE266020T1/de not_active IP Right Cessation
- 2001-10-08 AU AU2002220596A patent/AU2002220596A1/en not_active Abandoned
- 2001-10-08 KR KR1020037004734A patent/KR100822532B1/ko not_active IP Right Cessation
- 2001-10-08 US US10/398,890 patent/US6864374B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6864374B2 (en) | 2005-03-08 |
IT1319196B1 (it) | 2003-09-26 |
ITMI20002188A0 (it) | 2000-10-10 |
ES2219577T3 (es) | 2004-12-01 |
DE60103179T2 (de) | 2005-05-04 |
US20040002610A1 (en) | 2004-01-01 |
KR100822532B1 (ko) | 2008-04-16 |
JP4257574B2 (ja) | 2009-04-22 |
WO2002030919A1 (en) | 2002-04-18 |
CZ301710B6 (cs) | 2010-06-02 |
ATE266020T1 (de) | 2004-05-15 |
DE60103179D1 (en) | 2004-06-09 |
EP1335911B1 (en) | 2004-05-06 |
JP2004511477A (ja) | 2004-04-15 |
KR20030070001A (ko) | 2003-08-27 |
EP1335911A1 (en) | 2003-08-20 |
ITMI20002188A1 (it) | 2002-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA27706A1 (fr) | Procede de preparation de la duloxetine et intermediaires destines a etre utilises dans ledit procede | |
BG106786A (en) | Process for the preparation of amorphous atorvastatin | |
AU2002220596A1 (en) | Synthesis of r(+)alpha-lipoic acid | |
ES2195510T3 (es) | Derivados de imidazopiridina y procedimiento para prepararlos. | |
JP5972867B2 (ja) | プテリジン誘導体の調製方法 | |
WO2002030918A3 (en) | PROCESS FOR THE PRODUCTION OF R(+)α-LIPOIC ACID | |
EP1215206A4 (en) | METHOD FOR THE PRODUCTION OF 4 (5) -AMINO-5 (4) -CARBOXAMIDOIMIDAZOLES AND THEIR INTERMEDIATE PRODUCTS | |
BR0108489A (pt) | Processo para a produção de n-(fosfonometil) glicina | |
CA2164918A1 (en) | Thiol compounds | |
HU199113B (en) | Process for production of new derivatives of 2,3-diamin-acryl-acid-nitril | |
TR199800860T2 (xx) | Bir klavulanik asit tuzu �retimi. | |
ATE286048T1 (de) | Verfahren zur herstellung von carbostyril- derivaten | |
EP1661894A4 (en) | PROCESS FOR THE PRODUCTION OF 4-AMINOTETRAHYDROPYRANES AND SALTS THEREOF HAVING ACIDS, INTERMEDIATES THEREFOR, AND PROCESS FOR THE PRODUCTION THEREOF | |
JP2579532B2 (ja) | アミノアセトニトリル誘導体及びその製造方法 | |
JP2531708B2 (ja) | 3−(3,5−ジ第3級ブチル−4−ヒドロキシフェニル)プロピオン酸エステルの分離精製法 | |
ATE520679T1 (de) | Verfahren zur herstellung von (dioxolenon-4- yl)methylester-derivate | |
AU658662B2 (en) | Process for the preparation of a dextrogyral isomer of an isoindolinone derivative | |
HK1056870A1 (en) | Intermediate and process for producing fluorinatedcarboxylic acid derivative from the same. | |
NZ508179A (en) | Process for preparing crystalline salts of amoxycillin | |
GB2418916A (en) | Process for purifying citalopram using polybasic acids | |
EP1623975A4 (en) | PROCESS FOR PREPARING A PYRROLIDINE DERIVATIVE | |
SE8503811D0 (sv) | Novel process for the preparation of an aminolactone | |
EP1293495A4 (en) | PROCESS FOR THE PREPARATION OF BROMISOPHTHALIC ACID COMPOUNDS | |
TH39400A3 (th) | กรรมวิธีสำหรับการเตรียมอนุพันธ์ของโพรพิออนิค แอซิด | |
TH60894A (th) | วิธีการสำหรับการเตรียมแอสซิทาโลแพรม |