AU2001263411A1 - Gene recombination and hybrid protein development - Google Patents

Gene recombination and hybrid protein development

Info

Publication number
AU2001263411A1
AU2001263411A1 AU2001263411A AU6341101A AU2001263411A1 AU 2001263411 A1 AU2001263411 A1 AU 2001263411A1 AU 2001263411 A AU2001263411 A AU 2001263411A AU 6341101 A AU6341101 A AU 6341101A AU 2001263411 A1 AU2001263411 A1 AU 2001263411A1
Authority
AU
Australia
Prior art keywords
crossover
parent
polymer
polymers
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001263411A
Other languages
English (en)
Inventor
Frances H Arnold
Stephen L. Mayo
Christopher A. Voigt
Zhen-Gang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of AU2001263411A1 publication Critical patent/AU2001263411A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2001263411A 2000-05-23 2001-05-23 Gene recombination and hybrid protein development Abandoned AU2001263411A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US20704800P 2000-05-23 2000-05-23
US60/207,048 2000-05-23
US23596000P 2000-09-27 2000-09-27
US60/235,960 2000-09-27
US28356701P 2001-04-13 2001-04-13
US60/283,567 2001-04-13
PCT/US2001/016831 WO2001090346A2 (en) 2000-05-23 2001-05-23 Gene recombination and hybrid protein development

Publications (1)

Publication Number Publication Date
AU2001263411A1 true AU2001263411A1 (en) 2001-12-03

Family

ID=27395018

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001263411A Abandoned AU2001263411A1 (en) 2000-05-23 2001-05-23 Gene recombination and hybrid protein development

Country Status (5)

Country Link
US (1) US20020045175A1 (US20020045175A1-20020418-M00007.png)
EP (1) EP1283877A2 (US20020045175A1-20020418-M00007.png)
AU (1) AU2001263411A1 (US20020045175A1-20020418-M00007.png)
CA (1) CA2405520A1 (US20020045175A1-20020418-M00007.png)
WO (1) WO2001090346A2 (US20020045175A1-20020418-M00007.png)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
US6951719B1 (en) 1999-08-11 2005-10-04 Proteus S.A. Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained
US6991922B2 (en) 1998-08-12 2006-01-31 Proteus S.A. Process for in vitro creation of recombinant polynucleotide sequences by oriented ligation
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US7024312B1 (en) * 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
WO2001075767A2 (en) * 2000-03-30 2001-10-11 Maxygen, Inc. In silico cross-over site selection
AU2002251710A1 (en) * 2000-11-10 2002-07-30 The Penn State Research Foundation A modeling framework for predicting the number, type, and distribution of crossovers in directed evolution experiments
US7711490B2 (en) 2001-01-10 2010-05-04 The Penn State Research Foundation Method and system for modeling cellular metabolism
US20040142433A1 (en) * 2001-02-02 2004-07-22 Padgett Hal S. Polynucleotide sequence variants
US7838219B2 (en) * 2001-02-02 2010-11-23 Novici Biotech Llc Method of increasing complementarity in a heteroduplex
US7582423B2 (en) * 2001-02-02 2009-09-01 Novici Biotech Llc Population of polynucleotide sequence variants
WO2002079468A2 (en) * 2001-02-02 2002-10-10 Large Scale Biology Corporation A method of increasing complementarity in a heteroduplex polynucleotide
EP1470219A4 (en) * 2001-04-16 2005-10-05 California Inst Of Techn PEROXIDE MOLDED CYTOCHROME OXYGENASE P450 OXYGENASE VARIANTS
WO2002090496A2 (en) * 2001-05-03 2002-11-14 Rensselaer Polytechnic Institute Novel methods of directed evolution
US7078211B2 (en) 2002-02-01 2006-07-18 Large Scale Biology Corporation Nucleic acid molecules encoding endonucleases and methods of use thereof
US20030157495A1 (en) * 2002-02-01 2003-08-21 Padgett Hal S. Nucleic acid molecules encoding CEL I endonuclease and methods of use thereof
US7747391B2 (en) * 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US7783428B2 (en) * 2002-03-01 2010-08-24 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20050084907A1 (en) * 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
AU2003213846A1 (en) * 2002-03-09 2003-09-29 Maxygen, Inc. Optimization of crossover points for directed evolution
US20030211484A1 (en) * 2002-05-13 2003-11-13 Keith Ball Sequence lineage evaluation interface
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
EP1532516A4 (en) 2002-07-10 2007-05-23 Penn State Res Found METHOD FOR DETERMINING GENE KNOCKOUT STRATEGIES
WO2005007806A2 (en) * 2003-05-07 2005-01-27 Duke University Protein design for receptor-ligand recognition and binding
US7524664B2 (en) 2003-06-17 2009-04-28 California Institute Of Technology Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
EP1700119B1 (en) * 2003-12-18 2010-02-10 Genencor International, Inc. Beta-lactamase cd4+ t-cell epitopes
US8715988B2 (en) * 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
US8026085B2 (en) * 2006-08-04 2011-09-27 California Institute Of Technology Methods and systems for selective fluorination of organic molecules
US8252559B2 (en) * 2006-08-04 2012-08-28 The California Institute Of Technology Methods and systems for selective fluorination of organic molecules
EP2099904A4 (en) * 2007-01-05 2010-04-07 California Inst Of Techn PROCESS FOR GENERATING NOVEL STABILIZED PROTEINS
WO2008121435A2 (en) * 2007-02-02 2008-10-09 The California Institute Of Technology Methods for generating novel stabilized proteins
US20080268517A1 (en) * 2007-02-08 2008-10-30 The California Institute Of Technology Stable, functional chimeric cytochrome p450 holoenzymes
US8802401B2 (en) * 2007-06-18 2014-08-12 The California Institute Of Technology Methods and compositions for preparation of selectively protected carbohydrates
US20110160071A1 (en) * 2008-06-03 2011-06-30 Baynes Brian M Novel Proteins and Methods for Designing the Same
WO2013016207A2 (en) 2011-07-22 2013-01-31 California Institute Of Technology Stable fungal cel6 enzyme variants
EP2951579B1 (en) 2013-01-31 2024-04-24 Codexis, Inc. Methods, systems, and software for identifying bio-molecules using models of multiplicative form
USD815146S1 (en) * 2016-03-25 2018-04-10 Illimina, Inc. Display screen with application icon
USD815145S1 (en) * 2016-03-25 2018-04-10 Illumina, Inc. Display screen with application icon

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6395547B1 (en) * 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
IL131986A0 (en) * 1997-03-18 2001-03-19 Novo Nordisk As Shuffling of heterologous dna sequences
US6365408B1 (en) * 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
AU772879B2 (en) * 1998-08-12 2004-05-13 Napro Biotherapeutics, Inc. Domain specific gene evolution
IL140441A0 (en) * 1998-09-29 2002-02-10 Maxygen Inc Shuffling of codon altered genes
US20020072864A1 (en) * 1999-08-31 2002-06-13 Emmanuel Lacroix Computer-based method for macromolecular engineering and design
AU2001238397A1 (en) * 2000-02-17 2001-08-27 California Institute Of Technology Computationally targeted evolutionary design

Also Published As

Publication number Publication date
CA2405520A1 (en) 2001-11-29
WO2001090346A3 (en) 2002-10-10
WO2001090346A2 (en) 2001-11-29
EP1283877A2 (en) 2003-02-19
US20020045175A1 (en) 2002-04-18

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application