ATE555078T1 - PROCESS AND INTERMEDIATE PRODUCTS - Google Patents
PROCESS AND INTERMEDIATE PRODUCTSInfo
- Publication number
- ATE555078T1 ATE555078T1 AT01975197T AT01975197T ATE555078T1 AT E555078 T1 ATE555078 T1 AT E555078T1 AT 01975197 T AT01975197 T AT 01975197T AT 01975197 T AT01975197 T AT 01975197T AT E555078 T1 ATE555078 T1 AT E555078T1
- Authority
- AT
- Austria
- Prior art keywords
- intermediate products
- products
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
- C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23178400P | 2000-09-12 | 2000-09-12 | |
| PCT/US2001/028443 WO2002022554A1 (en) | 2000-09-12 | 2001-09-12 | Process and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555078T1 true ATE555078T1 (en) | 2012-05-15 |
Family
ID=22870636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01975197T ATE555078T1 (en) | 2000-09-12 | 2001-09-12 | PROCESS AND INTERMEDIATE PRODUCTS |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6570024B2 (en) |
| EP (1) | EP1322597B1 (en) |
| JP (1) | JP4886961B2 (en) |
| AR (1) | AR030612A1 (en) |
| AT (1) | ATE555078T1 (en) |
| AU (1) | AU2001294549A1 (en) |
| CY (1) | CY1112871T1 (en) |
| DK (1) | DK1322597T3 (en) |
| ES (1) | ES2383792T3 (en) |
| PT (1) | PT1322597E (en) |
| WO (1) | WO2002022554A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| WO2002092771A2 (en) | 2001-05-11 | 2002-11-21 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| CA2567520A1 (en) * | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Maytansinoid-antibody conjugates |
| EP3088004B1 (en) | 2004-09-23 | 2018-03-28 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| BRPI0515745A (en) * | 2004-12-09 | 2008-08-05 | Centocor Inc | antiintegrin immunoconjugates, methods and uses |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| JP5618549B2 (en) | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Method of treatment using EGFR antibody and SRC inhibitor and related preparation |
| ES2609915T3 (en) | 2007-08-14 | 2017-04-25 | Ludwig Institute For Cancer Research Ltd. | Monoclonal antibody 175 addressed to the EGF receptor and derivatives and uses thereof |
| KR20180056805A (en) | 2009-06-04 | 2018-05-29 | 노파르티스 아게 | METHODS FOR IDENTIFICATION OF SITES FOR IgG CONJUGATION |
| SG176947A1 (en) | 2009-07-03 | 2012-01-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them |
| RU2580038C2 (en) | 2009-12-04 | 2016-04-10 | Дженентек, Инк. | Multispecific antibodies, thereof analogues, compositions and methods |
| JP2013514788A (en) | 2009-12-23 | 2013-05-02 | アビペップ ピーティーワイ リミテッド | Immunoconjugate and production method 2 |
| US9173961B2 (en) | 2010-02-10 | 2015-11-03 | Immunogen, Inc. | CD20 antibodies and uses thereof |
| WO2011156328A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CN106279418A (en) | 2011-05-27 | 2017-01-04 | 葛兰素集团有限公司 | BCMA(CD269/TNFRSF17) associated proteins |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| CA2910945A1 (en) | 2013-05-08 | 2014-11-13 | Zymeworks Inc. | Bispecific her2 and her3 antigen binding constructs |
| WO2015073721A1 (en) | 2013-11-13 | 2015-05-21 | Zymeworks Inc. | Monovalent antigen binding constructs targeting egfr and/or her2 and uses thereof |
| US10077318B2 (en) | 2014-09-12 | 2018-09-18 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| PT3956332T (en) * | 2019-04-18 | 2023-04-24 | Indena Spa | Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof |
| WO2022248870A1 (en) | 2021-05-28 | 2022-12-01 | Glaxosmithkline Intellectual Property Development Limited | Combination therapies for treating cancer |
| WO2023057893A1 (en) | 2021-10-05 | 2023-04-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapies for treating cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE430062B (en) * | 1977-03-04 | 1983-10-17 | Pharmacia Fine Chemicals Ab | COUPLING OR TIOLATION REAGENTS |
| JPS61112042A (en) * | 1985-07-31 | 1986-05-30 | Wakunaga Seiyaku Kk | Compound suitable as crosslinking reagent |
| CA2026147C (en) * | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| JP3408158B2 (en) * | 1998-07-17 | 2003-05-19 | 大日本製薬株式会社 | Sultopride derivatives and anti-sultopride antibodies |
| US6573074B2 (en) * | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
| US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
-
2001
- 2001-09-05 AR ARP010104219A patent/AR030612A1/en unknown
- 2001-09-12 PT PT01975197T patent/PT1322597E/en unknown
- 2001-09-12 AT AT01975197T patent/ATE555078T1/en active
- 2001-09-12 WO PCT/US2001/028443 patent/WO2002022554A1/en active Application Filing
- 2001-09-12 US US10/009,381 patent/US6570024B2/en not_active Expired - Lifetime
- 2001-09-12 DK DK01975197.3T patent/DK1322597T3/en active
- 2001-09-12 EP EP01975197A patent/EP1322597B1/en not_active Expired - Lifetime
- 2001-09-12 ES ES01975197T patent/ES2383792T3/en not_active Expired - Lifetime
- 2001-09-12 AU AU2001294549A patent/AU2001294549A1/en not_active Abandoned
- 2001-09-12 JP JP2002526755A patent/JP4886961B2/en not_active Expired - Fee Related
-
2003
- 2003-03-17 US US10/390,252 patent/US6884874B2/en not_active Expired - Lifetime
-
2012
- 2012-06-15 CY CY20121100548T patent/CY1112871T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001294549A1 (en) | 2002-03-26 |
| DK1322597T3 (en) | 2012-07-02 |
| CY1112871T1 (en) | 2016-04-13 |
| US20040014980A1 (en) | 2004-01-22 |
| EP1322597A1 (en) | 2003-07-02 |
| ES2383792T3 (en) | 2012-06-26 |
| US20020156318A1 (en) | 2002-10-24 |
| JP4886961B2 (en) | 2012-02-29 |
| JP2004509094A (en) | 2004-03-25 |
| PT1322597E (en) | 2012-06-01 |
| EP1322597A4 (en) | 2005-10-19 |
| WO2002022554A1 (en) | 2002-03-21 |
| EP1322597B1 (en) | 2012-04-25 |
| AR030612A1 (en) | 2003-08-27 |
| US6570024B2 (en) | 2003-05-27 |
| US6884874B2 (en) | 2005-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE283273T1 (en) | HEMISYNTHETIC PROCESS AND INTERMEDIATE PRODUCTS THEREOF | |
| ATE555078T1 (en) | PROCESS AND INTERMEDIATE PRODUCTS | |
| ATE452540T1 (en) | COMPOSITION AND METHOD | |
| CY2008006I1 (en) | TROPANIC PRODUCTS USEFUL IN THEPAPETIKI | |
| DE60139930D1 (en) | DISINFECTING AND DESODORING PROCESS | |
| DE60134496D1 (en) | POLYESTER PROCESS | |
| DE60115902D1 (en) | OSTEOIMPLANTAT AND METHOD FOR THE PRODUCTION THEREOF | |
| DE60138648D1 (en) | MODULAR ATOMS AND METHOD FOR CONVERTING THE SAME | |
| DE60112988D1 (en) | Harness and manufacturing process | |
| DE59913180D1 (en) | PRODUCT ORDERING PROCESS AND SYSTEM | |
| DE60018158T8 (en) | Side airbag system and its manufacturing process | |
| DE60100770D1 (en) | Double lane conveyor cleaning apparatus and method | |
| ATA10852001A (en) | COMPONENT AND METHOD FOR THE PRODUCTION THEREOF | |
| DE60229770D1 (en) | FRICTION-REDUCING COMPOSITION AND METHOD | |
| DE50103327D1 (en) | MICROMECHANICAL COMPONENT AND CORRESPONDING PRODUCTION METHOD | |
| DE60017012D1 (en) | Orginalitätsverschluss and production process | |
| ATE286658T1 (en) | DOUGH FORMING MACHINE AND METHOD | |
| DE60116486D1 (en) | GALLENGANGSTENT AND METHOD FOR THE PRODUCTION THEREOF | |
| DE60134540D1 (en) | TÖCHIOMETRIE IMPOSING ISOLIERSHAICH AND METHOD FOR THE PRODUCTION | |
| DE69904731D1 (en) | FEINZERKLEINERER AND FEINZERKLEINERUNGS PROCESS | |
| ATE322174T1 (en) | FROZEN CONFECTIONAL PRODUCTS AND PRODUCTION PROCESS | |
| DE60106372D1 (en) | Redox system and process | |
| ATE361663T1 (en) | STRIPPER AND GOODS CONVEYOR | |
| DE60134283D1 (en) | Document feeder and method | |
| FI20010075A (en) | Functional product and method |