ATE462417T1 - Microemulsionen als feste dosisformen zur oralen verabreichung - Google Patents

Microemulsionen als feste dosisformen zur oralen verabreichung

Info

Publication number
ATE462417T1
ATE462417T1 AT99941159T AT99941159T ATE462417T1 AT E462417 T1 ATE462417 T1 AT E462417T1 AT 99941159 T AT99941159 T AT 99941159T AT 99941159 T AT99941159 T AT 99941159T AT E462417 T1 ATE462417 T1 AT E462417T1
Authority
AT
Austria
Prior art keywords
drug
microemulsion
microemulsions
oral administration
dose forms
Prior art date
Application number
AT99941159T
Other languages
German (de)
English (en)
Inventor
S Pather
Sangeeta Gupte
Rajendra Khankari
John Hontz
Ramya Kumbale
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Application granted granted Critical
Publication of ATE462417T1 publication Critical patent/ATE462417T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99941159T 1998-08-13 1999-08-13 Microemulsionen als feste dosisformen zur oralen verabreichung ATE462417T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9634798P 1998-08-13 1998-08-13
PCT/US1999/018552 WO2000009093A1 (en) 1998-08-13 1999-08-13 Microemulsions as solid dosage forms for oral administration

Publications (1)

Publication Number Publication Date
ATE462417T1 true ATE462417T1 (de) 2010-04-15

Family

ID=22256941

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99941159T ATE462417T1 (de) 1998-08-13 1999-08-13 Microemulsionen als feste dosisformen zur oralen verabreichung

Country Status (9)

Country Link
US (1) US6280770B1 (https=)
EP (2) EP2127642A3 (https=)
JP (1) JP4815053B2 (https=)
AT (1) ATE462417T1 (https=)
AU (1) AU5486899A (https=)
CA (1) CA2339991C (https=)
DE (1) DE69942205D1 (https=)
ES (1) ES2341510T3 (https=)
WO (1) WO2000009093A1 (https=)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
US6793934B1 (en) 1999-12-08 2004-09-21 Shire Laboratories, Inc. Solid oral dosage form
AUPQ573300A0 (en) 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
EP1318790A4 (en) * 2000-09-19 2006-02-01 Cima Labs Inc PHARMACEUTICAL COMPOSITIONS FOR RECTAL AND VAGINAL ADMINISTRATION
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
WO2002083102A1 (en) * 2001-02-23 2002-10-24 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
US6692771B2 (en) 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
EE200400034A (et) * 2001-06-22 2004-06-15 Pfizer Products Inc. Amorfse ravimaine adsorbaatide farmatseutilised kompositsioonid
US20030068356A1 (en) 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
ITMI20011756A1 (it) * 2001-08-09 2003-02-09 Remedia S R L Composizione farmaceutica comprendente una microemulsione doppia acqua/olio/acqua incorporata in un supporto solido
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
BR0214679A (pt) * 2001-12-03 2004-12-14 Novacea Inc Composições farmacêuticas compreendendo compostos a base de vitamina d ativa
ITMI20012694A1 (it) * 2001-12-19 2003-06-19 Remedia S R L Composizione farmaceutica comprendente una microemulsione doppia olio/acqua/olio incorporata in un supporto solido
ATE395044T1 (de) 2002-02-01 2008-05-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
ITMI20021392A1 (it) * 2002-06-25 2003-12-29 Nicox Sa Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita'
WO2004002443A1 (en) * 2002-06-26 2004-01-08 Tuo Jin Solid dosage forms for rapid dissolution of poorly soluble drugs
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
FR2851918B1 (fr) * 2003-03-06 2006-06-16 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
JP2007501218A (ja) * 2003-08-04 2007-01-25 ファイザー・プロダクツ・インク 非晶質薬物の吸着物および親油性ミクロ相形成物質の医薬組成物
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ， インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
US20050220866A1 (en) * 2004-04-02 2005-10-06 Dr. Reddy's Laboratories Limited Novel capsule formulations of etoposide for oral use
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
ATE533473T1 (de) 2004-09-24 2011-12-15 Boehringer Ingelheim Pharma Neue klasse von surfuctantähnlichen materialien mit vitamin-e-tpgs und wasserlöslichem polymer
WO2006085217A2 (en) * 2005-02-08 2006-08-17 Pfizer Products Inc. Solid adsorbates of hydrophobic drugs
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
CA2604943C (en) 2005-04-15 2013-09-17 Clarus Therapeutics, Inc. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
EP1883408A4 (en) * 2005-05-25 2009-11-11 Transcept Pharmaceuticals Inc SOLID COMPOSITIONS AND METHODS FOR TREATMENT OF INSOMNIA IN THE NIGHT
JP5050322B2 (ja) * 2005-06-21 2012-10-17 三菱化学株式会社 含油固形物およびその製造方法
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
JP2010509363A (ja) * 2006-11-08 2010-03-25 ノババックス，インコーポレイテッド 固体剤形の多相医薬組成物の製造方法
WO2008091592A1 (en) 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
EP2162120B1 (en) 2007-06-04 2016-05-04 Bend Research, Inc Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US20090060993A1 (en) * 2007-09-04 2009-03-05 Joseph Schwarz Solid pharmaceutical composition for enhanced delivery of coenzyme q-10 and ubiquinones
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
EP2111854A1 (en) 2008-04-22 2009-10-28 Lek Pharmaceuticals D.D. Self-microemulsifying systems incorporated into liquid core microcapsules
CA2735660C (en) * 2008-09-09 2017-05-30 Cima Labs Inc. Dosage forms for weakly ionizable compounds
EP2385769A4 (en) * 2008-12-15 2014-08-20 Valeant Pharmaceuticals Luxembourg S R L QUICKLY SOLUBLE VITAMIN FORMULATION AND METHOD FOR THEIR USE
KR101004205B1 (ko) * 2008-12-17 2010-12-24 동아제약주식회사 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물
JP2012529451A (ja) * 2009-06-11 2012-11-22 フォトキュア エイエスエイ ５−アミノレブリン酸を含む固体組成物
ES2385240B1 (es) 2010-07-26 2013-09-23 Gp-Pharm, S.A. Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata.
US20120213855A1 (en) * 2011-02-17 2012-08-23 Cima Labs Inc. Dosage forms for weakly ionizable compounds
US20170325481A1 (en) * 2011-06-28 2017-11-16 Kemin Industries, Inc. Method of forming encapsulated compositions with enhanced solubility and stability
US20130004619A1 (en) * 2011-06-28 2013-01-03 Kemin Industries, Inc. Method of Forming Encapsulated Compositions with Enhanced Solubility and Stability
LT2914599T (lt) 2012-10-30 2018-02-12 Nektar Therapeutics Alfa-6-mpeg6-hidroksikodono, kaip opioidų agonistų, kieta druskos forma ir jos panaudojimas
ES2821528T3 (es) 2012-11-14 2021-04-26 Grace W R & Co Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado
WO2014096139A1 (en) * 2012-12-20 2014-06-26 Solural Pharma ApS Solid oral dosage form of testosterone derivative
US20160000799A1 (en) 2013-02-21 2016-01-07 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions of cetp inhibitors
US10245273B2 (en) 2013-12-26 2019-04-02 Clarus Therapeutics, Inc. Oral pharmaceutical products and methods of use combining testosterone esters with hypolipidemic agents
SG11201609352TA (en) 2014-06-19 2017-01-27 Solural Pharma ApS Solid oral dosage form of lipophilic compounds
KR102514657B1 (ko) * 2014-08-28 2023-03-29 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 테스토스테론의 제형 및 이를 이용한 치료 방법
AU2016267685A1 (en) 2015-05-28 2017-12-07 Dr. Reddy's Laboratories Ltd. Oral composition of celecoxib for treatment of pain
ITUA20164228A1 (it) * 2016-06-09 2017-12-09 Labomar S R L Formulazione a matrice grassa auto-emulsionante e gastro-resistente e relativo metodo di preparazione
US9950353B2 (en) * 2016-08-22 2018-04-24 Remediation Products, Inc. Bioremediation composition with time-release materials for removing energetic compounds from contaminated environments
US10869838B2 (en) 2017-10-10 2020-12-22 Douglas Pharmaceuticals, Ltd. Extended release pharmaceutical formulation
US10441544B2 (en) 2017-10-10 2019-10-15 Douglas Pharmaceuticals, Ltd. Extended release pharmaceutical formulation
US12090123B2 (en) 2017-10-10 2024-09-17 Douglas Pharmaceuticals Ltd. Extended release pharmaceutical formulation
US11471415B2 (en) 2017-10-10 2022-10-18 Douglas Pharmaceuticals, Ltd. Extended release pharmaceutical formulation and methods of treatment
MX2020003546A (es) 2017-10-10 2020-08-03 Douglas Pharmaceuticals Ltd Formulacion farmaceutica de liberacion prolongada y metodos de tratamiento.
US11564933B2 (en) 2019-04-12 2023-01-31 Tolmar, Inc. Methods of treating testosterone deficiency
CA3155176A1 (en) 2019-10-11 2021-04-15 Pike Therapeutics, Inc., 1219014 B.C. Ltd. Transdermal compositions comprising cannabidiol (cbd) for use in the treatment of seizure disorders
CA3144079A1 (en) 2020-12-28 2022-06-28 Biodelivery Sciences International, Inc. Methods of treating pain
JP2024505623A (ja) 2020-12-31 2024-02-07 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント 水難溶性極性溶質用の完全に希釈可能な自己マイクロ乳化デリバリーシステム（ｓｍｅｄｄｓ）

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH586568A5 (https=) * 1972-04-10 1977-04-15 Hoffmann La Roche
US3962384A (en) * 1972-04-10 1976-06-08 Hoffmann-La Roche Inc. Spray-drying technique for preparing agglomerated powders
JPS5157813A (en) * 1974-11-14 1976-05-20 Sankyo Co Ll dooba mataha sonojudotaiseizaino seiho
SE421042B (sv) * 1976-06-29 1981-11-23 Kockums Chem Sett att minska den for en viss biologisk effekt erforderliga mengden biologiskt aktiv substans
US4353806A (en) 1980-04-03 1982-10-12 Exxon Research And Engineering Company Polymer-microemulsion complexes for the enhanced recovery of oil
US4360061A (en) 1980-04-03 1982-11-23 Exxon Research And Engineering Co. Oil recovery process using polymer microemulsion complexes
DE3224619A1 (de) 1981-07-14 1983-05-19 Freund Industrial Co., Ltd., Tokyo Orale pharmazeutische zusammensetzung
FR2594693B1 (fr) * 1986-02-24 1990-01-05 Farah Nabil Nouveaux procedes de preparation a partir d'emulsions seches de formes orales solides a liberation modifiee et retardee de leur principes actifs
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5688761A (en) 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
AU668509B2 (en) 1991-04-19 1996-05-09 Affinity Biotech, Inc. Convertible microemulsion formulations
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
US5393527A (en) 1993-01-04 1995-02-28 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
US5435936A (en) 1993-09-01 1995-07-25 Colgate Palmolive Co. Nonaqueous liquid microemulsion compositions
ES2094688B1 (es) * 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
SE9503143D0 (sv) * 1995-09-12 1995-09-12 Astra Ab New preparation
US5800834A (en) 1996-06-10 1998-09-01 Spireas; Spiridon Liquisolid systems and methods of preparing same

Also Published As

Publication number Publication date
CA2339991A1 (en) 2000-02-24
EP1104290B1 (en) 2010-03-31
JP4815053B2 (ja) 2011-11-16
EP1104290A1 (en) 2001-06-06
WO2000009093A1 (en) 2000-02-24
US6280770B1 (en) 2001-08-28
EP2127642A3 (en) 2010-02-24
AU5486899A (en) 2000-03-06
JP2002522473A (ja) 2002-07-23
DE69942205D1 (de) 2010-05-12
CA2339991C (en) 2007-01-02
EP1104290A4 (en) 2006-01-18
ES2341510T3 (es) 2010-06-21
EP2127642A2 (en) 2009-12-02

Similar Documents

Publication Publication Date Title
ATE462417T1 (de) Microemulsionen als feste dosisformen zur oralen verabreichung
WO2005065069A3 (en) Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
ATE356612T1 (de) Orale, pharmazeutische darreichungsformen von flüssigen medikamenten mitverbesserter bioverfügbarkeit
UA41346C2 (uk) Фармацевтична композиція, яка містить флуоксетин або його сіль, таблетка на її основі, спосіб виробництва таблетки, яка диспергується
EP1685839B8 (en) Pharmaceutical oral dosage form comprising a combination of an opioid agonist and opioid antagonist
SE9301171D0 (sv) Pharmaceutical composition containing lipophilic drugs
MXPA03011538A (es) Composicion medicinal que sustancialmente no causaria dano a la mucosa intestinal.
CY1109861T1 (el) Διαδερμικο θεραπευτικο συστημα για την ασθενεια του παρκινσον που προκαλει υψηλα επιπεδα πλασματος της ροτιγοτινης
IL114596A (en) Pharmaceutical compositions containing an active substance blended with a carrier process for preparation thereof and their use for preparation of inhalated drugs
EP2269613A3 (en) Solid orald dosage form comprising a combination of metformin and glibenclamide
FR11C0017I2 (fr) Utilisation de spinosad ou d'une formulation comprennant spinosad
ATE293995T1 (de) Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten
WO1997015269A3 (en) Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
EP1649857A3 (en) New use of glutamate antagonists for the treatment of cancer
HK48392A (en) Drug particles having constant release and immediate release
DE69940557D1 (de) Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung
ATE292453T1 (de) Antivirale arznei
CA2353693A1 (en) Pharmaceutical composition containing citalopram
WO2003020214A3 (en) Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
NL193820B (nl) Vaste farmaceutische doseringsvorm voor orale toediening van Ibuprofen.
JP2002542281A5 (https=)
BG106234A (bg) Терапевтична употреба на мелатонин
CA2385755A1 (en) Prevention of colorectal cancer
EA200500387A1 (ru) Композиции для ингаляции с высоким содержанием лекарственных веществ
OA07029A (fr) Le chlorure de gallium, nouveau médicament anti-cancéreux.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties