ATE371661T1 - Tumorhemmende derivate von et-743 - Google Patents

Tumorhemmende derivate von et-743

Info

Publication number
ATE371661T1
ATE371661T1 AT02747577T AT02747577T ATE371661T1 AT E371661 T1 ATE371661 T1 AT E371661T1 AT 02747577 T AT02747577 T AT 02747577T AT 02747577 T AT02747577 T AT 02747577T AT E371661 T1 ATE371661 T1 AT E371661T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
alkenyl
alkyl
alkynyl
Prior art date
Application number
AT02747577T
Other languages
English (en)
Inventor
Valentin Martinez
Maria Flores
Pilar Gallego
Carmen Cuevas
Simon Munt
Ignacio Manzanares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE371661T1 publication Critical patent/ATE371661T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02747577T 2001-07-17 2002-07-17 Tumorhemmende derivate von et-743 ATE371661T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0117402.8A GB0117402D0 (en) 2001-07-17 2001-07-17 New antitumoral derivatives of et-743

Publications (1)

Publication Number Publication Date
ATE371661T1 true ATE371661T1 (de) 2007-09-15

Family

ID=9918658

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02747577T ATE371661T1 (de) 2001-07-17 2002-07-17 Tumorhemmende derivate von et-743

Country Status (16)

Country Link
US (2) US7759345B2 (de)
EP (3) EP2298780B1 (de)
JP (1) JP4653950B2 (de)
AT (1) ATE371661T1 (de)
AU (2) AU2002317967C1 (de)
CA (1) CA2453991C (de)
CY (2) CY1107809T1 (de)
DE (1) DE60222135T2 (de)
DK (3) DK2298780T3 (de)
ES (3) ES2394772T3 (de)
GB (1) GB0117402D0 (de)
MX (1) MXPA04000506A (de)
NO (2) NO335262B1 (de)
PT (3) PT2298780E (de)
SI (2) SI1854800T1 (de)
WO (1) WO2003008423A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
GB0521536D0 (en) * 2005-10-22 2005-11-30 Invibio Ltd Fiducial marker
JP6037337B2 (ja) 2010-05-25 2016-12-07 ファルマ、マール、ソシエダード、アノニマＰｈａｒｍａ Ｍｒｓ，Ｓ．Ａ． エクチナサイジン化合物の製造のための合成方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
ATE69234T1 (de) * 1986-06-09 1991-11-15 Univ Illinois Ekteinascidine 729, 743, 745, 759a, 759b and 770.
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
NZ507350A (en) 1998-04-06 2003-03-28 Univ Illinois Semi-synthetic ecteinascidins and use in treatment of tumors
DK1076486T3 (da) 1998-05-05 2006-01-09 Pharma Mar Sa Dyrkning af sessile marine dyr
HUP0101960A3 (en) 1998-05-11 2003-03-28 Pharma Mar Sa Metabolites of ecteinascidin 743, their use and pharmaceutical compositions containing them
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
WO2001053299A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
ES2244598T3 (es) 2000-04-12 2005-12-16 Pharma Mar, S.A. Derivados antitumorales de ecteinascidina.
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
EA005564B1 (ru) 2000-11-06 2005-04-28 Фарма Мар, С.А. Эффективные противоопухолевые лекарственные средства
BR0213424A (pt) 2001-10-19 2004-12-14 Pharma Mar Sa Uso aperfeiçoado de composto antitumoral na terapia contra câncer
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) 2002-08-13 2002-09-18 Pharma Mar Sa DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
JP2007511499A (ja) 2003-11-13 2007-05-10 ファーマ・マール・エス・アー・ウー コンビネーション
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2005049030A1 (en) 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
JP2008505862A (ja) 2004-07-09 2008-02-28 ファルマ、マール、ソシエダード、アノニマ 予後分子マーカー
AU2005288696A1 (en) 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
ES2326825T3 (es) 2004-10-26 2009-10-20 Pharma Mar S.A., Sociedad Unipersonal Doxorubicina liposomal pegilada en combinacion con ecteinascidina 743.
ATE368461T1 (de) 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
EP1962843B1 (de) 2005-11-25 2011-02-23 Pharma Mar S.A., Sociedad Unipersonal Verwendung von parp-1-hemmern
JP2009536956A (ja) 2006-05-12 2009-10-22 ファルマ・マール・ソシエダード・アノニマ 抗癌治療法
US20100267732A1 (en) 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
CN102099025A (zh) 2008-05-16 2011-06-15 马尔药品公司 Pm00104与另一抗肿瘤剂的联合疗法
WO2009138509A1 (en) 2008-05-16 2009-11-19 Pharma Mar, S.A. Multiple myeloma treatments

Also Published As

Publication number Publication date
NO20040189L (no) 2004-03-16
SI1854800T1 (sl) 2012-11-30
AU2002317967C1 (en) 2009-01-22
JP4653950B2 (ja) 2011-03-16
CA2453991A1 (en) 2003-01-30
US20060106021A1 (en) 2006-05-18
EP1406907A1 (de) 2004-04-14
EP1406907B1 (de) 2007-08-29
CY1107809T1 (el) 2013-06-19
NO20140711L (no) 2004-03-16
DE60222135D1 (de) 2007-10-11
JP2004536132A (ja) 2004-12-02
DK2298780T3 (da) 2013-01-07
CA2453991C (en) 2011-12-20
PT2298780E (pt) 2012-12-17
PT1406907E (pt) 2007-12-10
PT1854800E (pt) 2012-09-25
SI2298780T1 (sl) 2013-01-31
DE60222135T2 (de) 2008-05-21
GB0117402D0 (en) 2001-09-05
ES2389671T3 (es) 2012-10-30
DK1854800T3 (da) 2012-10-01
US7759345B2 (en) 2010-07-20
AU2008207381A1 (en) 2008-09-11
DK1406907T3 (da) 2008-02-04
EP1854800B1 (de) 2012-06-27
NO335262B1 (no) 2014-10-27
AU2008207381B2 (en) 2011-07-14
EP1854800A1 (de) 2007-11-14
EP2298780A1 (de) 2011-03-23
WO2003008423A1 (en) 2003-01-30
ES2291479T3 (es) 2008-03-01
EP2298780B1 (de) 2012-09-12
US20100197695A1 (en) 2010-08-05
NO340213B1 (no) 2017-03-20
US8076337B2 (en) 2011-12-13
MXPA04000506A (es) 2004-07-23
ES2394772T3 (es) 2013-02-05
CY1113359T1 (el) 2016-06-22
AU2002317967B2 (en) 2008-06-05

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