ATE277191T1 - Retrovirale vektoren für die transduktion des beta-globingens, sowie derivaten der beta-ort kontrollierten region des beta-orts - Google Patents
Retrovirale vektoren für die transduktion des beta-globingens, sowie derivaten der beta-ort kontrollierten region des beta-ortsInfo
- Publication number
- ATE277191T1 ATE277191T1 AT94920181T AT94920181T ATE277191T1 AT E277191 T1 ATE277191 T1 AT E277191T1 AT 94920181 T AT94920181 T AT 94920181T AT 94920181 T AT94920181 T AT 94920181T AT E277191 T1 ATE277191 T1 AT E277191T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- location
- retroviral vectors
- gene
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Road Signs Or Road Markings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/076,090 US5631162A (en) | 1993-06-11 | 1993-06-11 | Retroviral vectors for transducing β-globin gene and β-locus control region derivatives |
PCT/US1994/006661 WO1994029470A1 (en) | 1993-06-11 | 1994-06-10 | Retroviral vectors for transducing beta-globin gene and beta-locus control region derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE277191T1 true ATE277191T1 (de) | 2004-10-15 |
Family
ID=22129871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94920181T ATE277191T1 (de) | 1993-06-11 | 1994-06-10 | Retrovirale vektoren für die transduktion des beta-globingens, sowie derivaten der beta-ort kontrollierten region des beta-orts |
Country Status (8)
Country | Link |
---|---|
US (1) | US5631162A (de) |
EP (1) | EP0706575B1 (de) |
JP (1) | JPH09501046A (de) |
AT (1) | ATE277191T1 (de) |
CA (1) | CA2164953A1 (de) |
DE (1) | DE69434022T2 (de) |
ES (1) | ES2231774T3 (de) |
WO (1) | WO1994029470A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE181361T1 (de) * | 1994-09-19 | 1999-07-15 | Massachusetts Inst Technology | Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie |
EP0835320A1 (de) * | 1995-05-10 | 1998-04-15 | Introgene B.V. | Verbesserte retroviralen vektoren, besonders angepasst zur gen-therapie |
DK0918874T3 (da) * | 1996-08-16 | 2001-05-14 | Medical Res Council | Selvreplikerende episomale ekspressionsvektorer, som giver vævsspecifik genekspression |
GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
GB2344592B (en) * | 1997-09-25 | 2002-09-11 | Oxford Biomedica Ltd | Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site |
CA2246005A1 (en) * | 1998-10-01 | 2000-04-01 | Hsc Research And Development Limited Partnership | Hybrid genes for gene therapy in erythroid cells |
GB9906615D0 (en) * | 1999-03-22 | 1999-05-19 | Oxford Biomedica Ltd | Vector |
GB9910664D0 (en) * | 1999-05-07 | 1999-07-07 | Zeneca Ltd | Cells and assay |
EP1409025B1 (de) * | 2001-06-29 | 2011-11-30 | Sloan Kettering Institute For Cancer Research | Vektor kodierend humanes globin-gen und seine verwendung bei der behandlung von hämoglobinopathien |
CN103403151A (zh) * | 2011-01-03 | 2013-11-20 | 蓝鸟生物公司 | 提高基因转导的细胞的递送的方法 |
WO2014162318A2 (en) * | 2013-03-30 | 2014-10-09 | Usha Biotech Limited | Methods and constructs for expressing biologically active proteins in mammalian cells |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8718779D0 (en) * | 1987-08-07 | 1987-09-16 | Grosveld F G | Dna sequence & expression vector |
JP2779192B2 (ja) * | 1987-09-17 | 1998-07-23 | マサチユセツツ・インスチチユート・オブ・テクノロジー | ヒト赤血球特異的転写エンハンサー |
-
1993
- 1993-06-11 US US08/076,090 patent/US5631162A/en not_active Expired - Lifetime
-
1994
- 1994-06-10 EP EP94920181A patent/EP0706575B1/de not_active Expired - Lifetime
- 1994-06-10 CA CA002164953A patent/CA2164953A1/en not_active Abandoned
- 1994-06-10 ES ES94920181T patent/ES2231774T3/es not_active Expired - Lifetime
- 1994-06-10 AT AT94920181T patent/ATE277191T1/de not_active IP Right Cessation
- 1994-06-10 JP JP7502159A patent/JPH09501046A/ja active Pending
- 1994-06-10 WO PCT/US1994/006661 patent/WO1994029470A1/en active IP Right Grant
- 1994-06-10 DE DE69434022T patent/DE69434022T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2164953A1 (en) | 1994-12-22 |
EP0706575A1 (de) | 1996-04-17 |
ES2231774T3 (es) | 2005-05-16 |
EP0706575B1 (de) | 2004-09-22 |
DE69434022D1 (de) | 2004-10-28 |
WO1994029470A1 (en) | 1994-12-22 |
DE69434022T2 (de) | 2005-08-18 |
JPH09501046A (ja) | 1997-02-04 |
US5631162A (en) | 1997-05-20 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |