ATE256198T1 - ENZIMATIC SYNTHESIS OF PEPTIDOMIMETICS - Google Patents

ENZIMATIC SYNTHESIS OF PEPTIDOMIMETICS

Info

Publication number
ATE256198T1
ATE256198T1 AT99950932T AT99950932T ATE256198T1 AT E256198 T1 ATE256198 T1 AT E256198T1 AT 99950932 T AT99950932 T AT 99950932T AT 99950932 T AT99950932 T AT 99950932T AT E256198 T1 ATE256198 T1 AT E256198T1
Authority
AT
Austria
Prior art keywords
enzimatic
peptidomimetics
synthesis
group
formulae
Prior art date
Application number
AT99950932T
Other languages
German (de)
Inventor
Karen Holt
Stephen J C Taylor
Peter David Tiffin
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ATE256198T1 publication Critical patent/ATE256198T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the preparation of a compound of formula (1)comprises reacting compounds of formulae (2) and (3)in the presence of an enzyme, wherein A is a thiol-protecting group, B, C and D are each the same or different organic groups of up to 30 C atoms, optionally functionalized at any position, provided that neither a primary amine nor a primary amide is present, and X is a group that can be displaced by NH2.
AT99950932T 1998-10-23 1999-10-20 ENZIMATIC SYNTHESIS OF PEPTIDOMIMETICS ATE256198T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9823334.9A GB9823334D0 (en) 1998-10-23 1998-10-23 Enzyme coupling
PCT/GB1999/003466 WO2000024923A1 (en) 1998-10-23 1999-10-20 The enzyme-mediated synthesis of peptidomimetics

Publications (1)

Publication Number Publication Date
ATE256198T1 true ATE256198T1 (en) 2003-12-15

Family

ID=10841245

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99950932T ATE256198T1 (en) 1998-10-23 1999-10-20 ENZIMATIC SYNTHESIS OF PEPTIDOMIMETICS

Country Status (8)

Country Link
US (1) US6436697B1 (en)
EP (1) EP1123410B1 (en)
JP (1) JP2002528091A (en)
AT (1) ATE256198T1 (en)
AU (1) AU6352299A (en)
DE (1) DE69913557T2 (en)
GB (1) GB9823334D0 (en)
WO (1) WO2000024923A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7388098B2 (en) 2000-09-29 2008-06-17 Bristol-Myers Squibb Company Dynamic resolution of isomers and resolved isomers
WO2013026015A1 (en) 2011-08-18 2013-02-21 Dana-Farber Cancer Institute, Inc. Muc1 ligand traps for use in treating cancers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1009252A (en) * 1972-10-03 1977-04-26 Santen Pharmaceutical Co. N-(mercaptoacyl) aminoacids
EP0550450B1 (en) 1990-08-03 2003-05-14 Vertex Pharmaceuticals Incorporated Use of crosslinked crystals as a novel form of enzyme immobilization
DE4332738A1 (en) * 1993-09-25 1995-03-30 Basf Ag Racemate resolution of primary and secondary amines by enzyme-catalyzed acylation
CA2217857A1 (en) * 1995-05-10 1996-11-14 Darwin Discovery Limited Peptide compounds which inhibit metalloproteinase and tnf liberation and their therapeutic uses
GB9514867D0 (en) * 1995-07-20 1995-09-20 British Biotech Pharm Metalloproteinase inhibitors

Also Published As

Publication number Publication date
DE69913557D1 (en) 2004-01-22
US6436697B1 (en) 2002-08-20
EP1123410B1 (en) 2003-12-10
JP2002528091A (en) 2002-09-03
EP1123410A1 (en) 2001-08-16
AU6352299A (en) 2000-05-15
WO2000024923A1 (en) 2000-05-04
DE69913557T2 (en) 2004-09-16
GB9823334D0 (en) 1998-12-23

Similar Documents

Publication Publication Date Title
PT1299409E (en) ORGANIC COMPOUNDS
NO20004090L (en) Chemical connections
MXPA02004182A (en) 8 (anilino) 1 naphthalenesulfonate analogs and their use in analyte detection assays.
BR9713351A (en) N- (aryl / heteroaryl / alkylacetyl) amino acid amides, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by the use of such compounds
DE69927039D1 (en) SYNTHETIC ANALOGUE OF ECTEINASCIDINE-743
ATE316967T1 (en) CYCLIC AMIDE DERIVATIVES THAT INHIBIT CATHEPSIN K
NZ514662A (en) Amine derivatives
KR920700202A (en) Acryloyl substituted pyrrole derivatives
ATE122041T1 (en) PYRIMIDINE NUCLEOSIDE DERIVATIVE.
MY138051A (en) Compounds and processes
SE8904306D0 (en) CAPSAICIN DERIVATIVES
BG104617A (en) Novel naphthyl-substituted and anilide-substituted sulfonamides
ATE372320T1 (en) CYCLIC AMIDE DERIVATIVES
YU65899A (en) Stabilized carbapenem intermediates and synthetic use
SE8700328D0 (en) AMINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE
ATE256198T1 (en) ENZIMATIC SYNTHESIS OF PEPTIDOMIMETICS
DE69901627D1 (en) Process for the preparation of 3-amino-pyrrolidine derivatives
AU1930497A (en) Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof
PE20000734A1 (en) HETEROCICLIC COMPOUNDS DERIVED FROM FUROPYRIDINE AND THEIR THERAPEUTIC USE
DK0601191T3 (en) Hitherto unknown tetracyclic compound
ATE245147T1 (en) SUBSTITUTED AMINOQUINAZOLINONE (THION) DERIVATIVES
RS49954B (en) Process for the synthesis of hiv protease inhibitors
TR200002485T2 (en) N-Sulfonyl and N-Sulfinyl Phenylglycinamide
ATE322470T1 (en) FUNCTIONALIZED HIGHER DIAMONTOIDS
BR9808047B1 (en) process for the preparation of 1,3-disubstituted 2-nitroguanidines.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties