ATE220931T1 - Intradermale arzneimittelabgabevorrichtung - Google Patents

Intradermale arzneimittelabgabevorrichtung

Info

Publication number
ATE220931T1
ATE220931T1 AT95901584T AT95901584T ATE220931T1 AT E220931 T1 ATE220931 T1 AT E220931T1 AT 95901584 T AT95901584 T AT 95901584T AT 95901584 T AT95901584 T AT 95901584T AT E220931 T1 ATE220931 T1 AT E220931T1
Authority
AT
Austria
Prior art keywords
subject
housing
drug
skin
reservoir
Prior art date
Application number
AT95901584T
Other languages
English (en)
Inventor
Joseph Gross
John Gerard Kelly
Original Assignee
Elan Corp Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp Plc filed Critical Elan Corp Plc
Application granted granted Critical
Publication of ATE220931T1 publication Critical patent/ATE220931T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/14586Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
    • A61M5/14593Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm the diaphragm being actuated by fluid pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AT95901584T 1993-11-18 1994-11-17 Intradermale arzneimittelabgabevorrichtung ATE220931T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE930882 1993-11-18
US08/183,482 US5527288A (en) 1990-12-13 1994-01-18 Intradermal drug delivery device and method for intradermal delivery of drugs
PCT/IE1994/000055 WO1995013838A1 (en) 1993-11-18 1994-11-17 Intradermal drug delivery device

Publications (1)

Publication Number Publication Date
ATE220931T1 true ATE220931T1 (de) 2002-08-15

Family

ID=26319658

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95901584T ATE220931T1 (de) 1993-11-18 1994-11-17 Intradermale arzneimittelabgabevorrichtung

Country Status (11)

Country Link
US (1) US5527288A (de)
EP (1) EP0729366B9 (de)
JP (1) JPH09504974A (de)
AT (1) ATE220931T1 (de)
AU (1) AU693136B2 (de)
CA (1) CA2176342A1 (de)
DE (1) DE69431066T2 (de)
ES (1) ES2176310T4 (de)
IL (1) IL111685A (de)
NZ (1) NZ276485A (de)
WO (1) WO1995013838A1 (de)

Families Citing this family (760)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656032A (en) * 1989-06-16 1997-08-12 Science Incorporated Fluid delivery apparatus and method of making same
IE72524B1 (en) * 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
CA2151407A1 (en) * 1995-06-09 1996-12-10 Duncan Newman Injection device
IE77523B1 (en) * 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
KR19990044546A (ko) * 1995-09-11 1999-06-25 리암 다니엘 약물 투여 장치
US5693018A (en) * 1995-10-11 1997-12-02 Science Incorporated Subdermal delivery device
US5735818A (en) * 1995-10-11 1998-04-07 Science Incorporated Fluid delivery device with conformable ullage
DE19538879C1 (de) * 1995-10-19 1996-07-18 Tricumed Gmbh Infusionspumpe
US6068751A (en) * 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
WO1998033452A1 (en) 1997-02-03 1998-08-06 Dec International Nz Limited Active delivery device and related procedures
US5860957A (en) * 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US6010492A (en) * 1997-02-07 2000-01-04 Sarcos, Lc Apparatus for automatic administration of multiple doses of drugs
US6186982B1 (en) 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
US6530900B1 (en) 1997-05-06 2003-03-11 Elan Pharma International Limited Drug delivery device
US6129710A (en) * 1997-05-12 2000-10-10 Spectrum Biotech Inc. Needle cannula attachment device for a disposable syringe
EP0989871B1 (de) 1997-06-16 2004-09-01 ELAN CORPORATION, Plc Vorgefüllte medikamentenabgabevorrichtung
EP0990151A2 (de) 1997-06-16 2000-04-05 ELAN CORPORATION, Plc Verfahren zum kalibrieren und testen eines sensors für in vivo messung eines analytes, und vorrichtungen zum gebrauch dergleichen verfahren
DE69822823T2 (de) 1997-06-16 2005-01-13 Elan Corp. P.L.C., Athlone Kit zum verabreichen von arzneien und methode zu seiner verpackung
US6500150B1 (en) 1997-06-16 2002-12-31 Elan Pharma International Limited Pre-filled drug-delivery device and method of manufacture and assembly of same
US5858005A (en) 1997-08-27 1999-01-12 Science Incorporated Subcutaneous infusion set with dynamic needle
US5971722A (en) * 1997-09-05 1999-10-26 Baxter International Inc Electrochemical syringe pump having a sealed storage reservoir for a charge transfer medium
US6147970A (en) * 1997-09-30 2000-11-14 Gte Internetworking Incorporated Quality of service management for aggregated flows in a network system
US6045534A (en) * 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
US6086562A (en) * 1997-10-27 2000-07-11 Sarcos, Inc. Disposable automatic injection device
WO1999029259A1 (en) 1997-12-05 1999-06-17 Dec Research Improvements in and/or relating to delivery devices and their use
US5980496A (en) * 1997-12-11 1999-11-09 Sarcos L.C. Topical drug dispersing apparatus
WO1999032174A1 (de) 1997-12-19 1999-07-01 Arithmed Gmbh Tragbarer medikamentspender zur zeitversetzten verabreichung von injektions- oder infusionspräparaten
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US7335186B2 (en) * 1998-03-13 2008-02-26 Alexander George Brian O'Neil Patient controlled drug delivery device
EP1064035B1 (de) 1998-03-23 2003-11-26 ELAN CORPORATION, Plc Vorrichtung zur arzneimittelverarbreichung
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
AU7785998A (en) 1998-06-04 1999-12-20 Elan Corporation, Plc Gas driven drug delivery device
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
ATE280615T1 (de) 1998-08-31 2004-11-15 Johnson & Johnson Consumer Elektrotransportvorrichtung mit klingen
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
ATE290902T1 (de) 1999-04-16 2005-04-15 Johnson & Johnson Consumer Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US6461331B1 (en) 1999-05-21 2002-10-08 Minimed Inc. Device and method for infusion of small molecule insulin mimetic materials
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
CN1390148A (zh) * 1999-11-15 2003-01-08 维尔克鲁工业公司 皮肤附着件
WO2001051109A1 (en) * 2000-01-07 2001-07-19 Biovalve Technologies, Inc. Injection device
US20010041869A1 (en) * 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
US6572740B2 (en) * 2000-04-13 2003-06-03 Elan Pharma International Limited Electrolytic cell
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
ES2237592T3 (es) * 2000-08-18 2005-08-01 Becton Dickinson And Company Dispositivo de entrega de fluido a caudal constante con caudal seleccionable y boton de bolus regulable.
EP1341442B1 (de) 2000-10-13 2005-06-29 Alza Corporation Mikroklingeanordungsaufprallapplikator
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
WO2002051470A2 (en) * 2000-11-30 2002-07-04 Biovalve Technologies, Inc. Injection systems
WO2002055128A2 (en) * 2000-11-30 2002-07-18 Biovalve Technologies Inc Fluid delivery and measurement systems and methods
EP1345646A2 (de) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Mikronadel-vorrichtungen und deren herstellung
US7027478B2 (en) * 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
EP1361890B1 (de) 2001-02-23 2011-03-30 GlaxoSmithKline Biologicals s.a. Influenza vakzinzusammensetzungen zur intradermaler verabreichung
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
EP1381423A1 (de) * 2001-04-13 2004-01-21 Becton, Dickinson and Company Verfahren und vorrichtung zur intradermale abgabe von substanzen für systemischer absorption
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
JP2004531578A (ja) * 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
US6943267B1 (en) 2001-08-24 2005-09-13 Utah State University Thiophosphonate inhibitors of phosphatase enzymes and metallophosphatases
US8152789B2 (en) 2001-10-23 2012-04-10 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) * 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CA2499838C (en) * 2001-09-21 2012-12-18 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20060122577A1 (en) * 2001-09-26 2006-06-08 Poulsen Jens U Modular drug delivery system
US20030088238A1 (en) * 2001-09-26 2003-05-08 Poulsen Jens Ulrik Modular drug delivery system
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
AU2002337788A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US7311693B2 (en) * 2001-11-26 2007-12-25 Nilimedix Ltd. Drug delivery device and method
US6736796B2 (en) * 2001-11-26 2004-05-18 Nili-Med Ltd. Fluid drug delivery device
US7291126B2 (en) * 2001-11-26 2007-11-06 Nilimedix Ltd. Drug delivery device and method
JP2005510305A (ja) * 2001-11-29 2005-04-21 ノボ・ノルデイスク・エー/エス 汲み出された液体により加圧された、携帯型投与装置及びそのための使い捨てカートリッジ
US7407490B2 (en) * 2001-11-29 2008-08-05 Novo Nordisk A/S Delivery device and cartridge therefore
US6872275B2 (en) 2001-12-14 2005-03-29 Kimberly-Clark Worldwide, Inc. Process for adding superabsorbent to a pre-formed fibrous web via in situ polymerization
ATE525108T1 (de) * 2002-02-04 2011-10-15 Becton Dickinson Co Vorrichtung und verfahren zur versorgung oder entziehung einer substanz durch die haut
EP2578253B1 (de) 2002-03-26 2018-03-14 Becton, Dickinson and Company Vorrichtung und Verfahren zur mehrstufigen Flüssigkeitsausgabe
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
AU2003230256B2 (en) * 2002-05-06 2009-06-04 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US6801041B2 (en) * 2002-05-14 2004-10-05 Abbott Laboratories Sensor having electrode for determining the rate of flow of a fluid
US20050005710A1 (en) * 2002-05-15 2005-01-13 Therafuse, Inc. Liquid metering system
US6932796B2 (en) * 2002-05-15 2005-08-23 Tearafuse, Inc. Liquid metering system
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US7008403B1 (en) * 2002-07-19 2006-03-07 Cognitive Ventures Corporation Infusion pump and method for use
US7250037B2 (en) 2002-07-22 2007-07-31 Becton, Dickinson And Company Patch-like infusion device
US20040059316A1 (en) * 2002-07-31 2004-03-25 Smedegaard Jorgen K. Medical delivery device
EP1386626A1 (de) 2002-07-31 2004-02-04 Novo Nordisk A/S Abgabevorrichtung zur Behandlung von Diabetes mellitus
JP2005537054A (ja) * 2002-08-30 2005-12-08 ベクトン・ディキンソン・アンド・カンパニー 免疫調節化合物の薬物動態を制御する方法
US20040116905A1 (en) * 2002-09-09 2004-06-17 Pedersen Per Elgard Flow restrictor with safety feature
CA2498722A1 (en) * 2002-09-12 2004-03-25 Children's Hospital Medical Center Method and device for painless injection of medication
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US7014625B2 (en) * 2002-10-07 2006-03-21 Novo Nordick A/S Needle insertion device
US20050075670A1 (en) * 2002-10-07 2005-04-07 Henrik Bengtsson Signal device with electro-muscle stimulation feature
WO2004030726A1 (en) * 2002-10-07 2004-04-15 Novo Nordisk A/S Needle device comprising a plurality of needles
US7399401B2 (en) * 2002-10-09 2008-07-15 Abbott Diabetes Care, Inc. Methods for use in assessing a flow condition of a fluid
US7388079B2 (en) * 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
US7252651B2 (en) 2003-01-07 2007-08-07 Becton, Dickinson And Company Disposable injection device
US8641987B2 (en) * 2003-01-24 2014-02-04 Applied Biosystems, Llc Sample chamber array and method for processing a biological sample
IL154243A0 (en) * 2003-02-02 2003-09-17 Silex Projectors Ltd Stable infusion device
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
WO2004089448A1 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Delivery device
US20060069382A1 (en) * 2003-04-11 2006-03-30 Novo Nordisk A/S Delivery device
EP1617888B1 (de) 2003-04-23 2019-06-12 Valeritas, Inc. Hydraulisch aktivierte pumpe für langzeitabgabe von medikamenten
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
DE602004028231D1 (de) 2003-05-08 2010-09-02 Novo Nordisk As Eine auf die haut aufbringbare injektionsvorrichtung mit abtrennbarem betätigungsteil zum einführen der nadel
CN100574819C (zh) 2003-05-08 2009-12-30 诺沃挪第克公司 可枢转注射针头单元
DE602004013140T2 (de) 2003-05-08 2009-07-02 Novo Nordisk A/S Interne nadeleinführvorrichtung
EP1475113A1 (de) * 2003-05-08 2004-11-10 Novo Nordisk A/S Externer Nadeleinsetzer
CN1833030B (zh) 2003-05-22 2014-07-23 美国弗劳恩霍夫股份有限公司 用于表达、传递及纯化目标多肽的重组载体分子
JP2007500251A (ja) * 2003-06-13 2007-01-11 ベクトン・ディキンソン・アンド・カンパニー 生物学的に活性な作用物質の改良型皮内送達
WO2005002649A1 (en) 2003-07-08 2005-01-13 Novo Nordisk A/S Portable drug delivery device having an encapsulated needle
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
EP1502613A1 (de) 2003-08-01 2005-02-02 Novo Nordisk A/S Gerät mit Rückziehvorrichting für eine Nadel
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
MXPA06001370A (es) 2003-08-12 2006-05-15 Becton Dickinson Co Dispositivo de infusion similar a un parche.
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005023328A2 (en) * 2003-08-26 2005-03-17 Becton Dickinson And Company Methods for intradermal delivery of therapeutics agents
US20070185460A1 (en) 2003-08-28 2007-08-09 Lionel Vedrine Intradermal injection device
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US7361155B2 (en) * 2003-09-16 2008-04-22 Therafuse, Inc. Compensating liquid delivery system and method
JP2005087520A (ja) * 2003-09-18 2005-04-07 Terumo Corp 薬液注入装置
DE602004023756D1 (de) 2003-10-21 2009-12-03 Novo Nordisk As Innerer flüssigkeitskonnektor zur herstellung einer flüssigkeitsverbindung
KR20060099520A (ko) * 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 의료용 피부 장착 장치
ATE446111T1 (de) 2003-10-21 2009-11-15 Novo Nordisk As Innerer flüssigkeitskonnektor zur herstellung einer flüssigkeitsverbindung
EP1527792A1 (de) * 2003-10-27 2005-05-04 Novo Nordisk A/S Eine auf die Haut anbringbare medizinische Injektionsvorrichtung
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
EP2329763B1 (de) 2003-12-09 2017-06-21 DexCom, Inc. Signalverarbeitung in einem durchgehenden Analytsensor
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US7896841B2 (en) * 2004-02-17 2011-03-01 Children's Hospital Medical Center Injection device for administering a vaccine
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
US7108679B2 (en) * 2004-03-11 2006-09-19 Becton, Dickinson And Company Intradermal syringe and needle assembly
AU2005228145B2 (en) 2004-03-24 2011-03-03 Corium Pharma Solutions, Inc. Transdermal delivery device
ZA200608085B (en) 2004-03-30 2008-06-25 Novo Nordisk As Actuator system comprising detection means
CN100586495C (zh) * 2004-03-30 2010-02-03 诺和诺德公司 包括杠杆机构的致动器系统
ATE468142T1 (de) 2004-03-31 2010-06-15 Lilly Co Eli Injektionsgerät mit einer nadelkassette zur abgabe einer pharmazeutischen flüssigkeit
JP4981660B2 (ja) * 2004-04-12 2012-07-25 アラーガン、インコーポレイテッド マルチサイト注射システム
US20070135697A1 (en) * 2004-04-19 2007-06-14 Therasense, Inc. Method and apparatus for providing sensor guard for data monitoring and detection systems
EP1744784A2 (de) * 2004-05-11 2007-01-24 Becton, Dickinson and Company Schmerzmittelformulierungen und verfahren zu deren anwendung
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
US9044199B2 (en) 2004-07-13 2015-06-02 Dexcom, Inc. Transcutaneous analyte sensor
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
US20090216194A1 (en) * 2004-09-02 2009-08-27 Elgaard Pedersen Per Erik Medical Device Adapted for Detection of Drug Condition
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
EP1804859A1 (de) 2004-09-22 2007-07-11 Novo Nordisk A/S Medizinische vorrichtung mit kanüleneinführer
CN101027095B (zh) * 2004-09-22 2010-09-29 诺和诺德公司 带插管插入器的医疗器械
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
ES2391776T3 (es) 2004-11-22 2012-11-29 Novo Nordisk A/S Formulaciones solubles, estables conteniendo insulina con una sal de protamina
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
WO2006057636A1 (en) 2004-11-22 2006-06-01 Intelliject, Llc Devices, systems, and methods for medicament delivery
WO2006061354A1 (en) 2004-12-06 2006-06-15 Novo Nordisk A/S Ventilated skin mountable device
CN101107025A (zh) * 2005-01-17 2008-01-16 诺和诺德公司 附有生理特征综合监测的流体输送装置
CN101107028B (zh) 2005-01-24 2013-04-10 诺和诺德公司 经皮设备组件
CN101111281B (zh) 2005-02-01 2013-02-06 因特利杰克特有限公司 用于药物递送的设备、系统和方法
US20080188810A1 (en) * 2005-02-25 2008-08-07 Novo Nordisk A/S Pump Assembly With Safety Valve
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US20070060904A1 (en) * 2005-03-14 2007-03-15 Becton, Dickinson And Company Filling system and method for syringes with short needles
DK1861120T3 (en) 2005-03-23 2016-07-25 Glaxosmithkline Biologicals Sa Use of an influenza virus and an oil-in-water emulsion adjuvant to induce CD 4 T cell and / or enhanced B memory cell response
TR201910900T4 (tr) 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
EP1877116A1 (de) 2005-04-13 2008-01-16 Novo Nordisk A/S Medizinische auf der haut befestigbare vorrichtung und system
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US8137314B2 (en) * 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US7641649B2 (en) 2005-05-06 2010-01-05 Medtronic Minimed, Inc. Reservoir support and method for infusion device
US8277415B2 (en) * 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7905868B2 (en) * 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8840586B2 (en) 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8512288B2 (en) * 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
CN101175516B (zh) * 2005-05-13 2011-02-16 诺和诺德公司 适于检测经皮装置脱离的医疗装置
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
IL169807A (en) * 2005-07-21 2015-03-31 Steadymed Ltd Device for administering a drug
IL175460A (en) 2006-05-07 2011-05-31 Doron Aurbach Drug delivery device
US9687186B2 (en) 2005-07-21 2017-06-27 Steadymed Ltd. Drug delivery device
CA2616859C (en) 2005-08-03 2015-04-14 Fraunhofer Usa, Inc. Compositions and methods for production of immunoglobulins
US20090035446A1 (en) * 2005-09-06 2009-02-05 Theraject, Inc. Solid Solution Perforator Containing Drug Particle and/or Drug-Adsorbed Particles
US8105279B2 (en) 2005-09-26 2012-01-31 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US8053569B2 (en) * 2005-10-07 2011-11-08 Armagen Technologies, Inc. Nucleic acids encoding and methods of producing fusion proteins
US8741260B2 (en) * 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
US8124095B2 (en) 2005-10-07 2012-02-28 Armagen Technologies, Inc. Fusion proteins for delivery of erythropoietin to the CNS
WO2007045644A1 (en) * 2005-10-17 2007-04-26 Novo Nordisk A/S Vented drug reservoir unit
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
WO2007065944A1 (en) * 2005-12-08 2007-06-14 Novo Nordisk A/S Medical system comprising a sensor device
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
EP2311511B1 (de) 2006-02-09 2013-05-29 DEKA Products Limited Partnership Flüssigkeitsabgabesystem
CA2642056A1 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Hpv antigens, vaccine compositions, and related methods
WO2008048344A2 (en) * 2006-02-13 2008-04-24 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
KR20080106433A (ko) * 2006-02-13 2008-12-05 프라운호퍼 유에스에이, 인코포레이티드 인플루엔자 항원, 백신 조성물 및 관련 방법
CA2536845C (en) 2006-02-16 2009-10-27 Pka Softtouch Corp. Drug delivery device
CA2644694C (en) * 2006-03-10 2014-05-13 Sangeeta N. Bhatia Triggered self-assembly conjugates and nanosystems
US9173992B2 (en) * 2006-03-13 2015-11-03 Novo Nordisk A/S Secure pairing of electronic devices using dual means of communication
WO2007104756A1 (en) * 2006-03-13 2007-09-20 Novo Nordisk A/S Medical system comprising dual purpose communication means
CA2833354C (en) 2006-03-14 2015-12-15 University Of Southern California Mems device and method for delivery of therapeutic agents
US7666912B2 (en) 2006-03-23 2010-02-23 Massachusetts Eye And Ear Infirmary Compositions and methods for reducing body fat
SG173319A1 (en) 2006-03-30 2011-08-29 Valeritas Inc Multi-cartridge fluid delivery device
ES2776100T3 (es) 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
WO2007120638A2 (en) * 2006-04-12 2007-10-25 President And Fellows Of Harvard College Methods and compositions for modulating glycosylation
WO2007122207A1 (en) 2006-04-26 2007-11-01 Novo Nordisk A/S Skin-mountable device in packaging comprising coated seal member
US8367113B2 (en) 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
US9150626B2 (en) * 2006-06-02 2015-10-06 President And Fellows Of Harvard College Protein surface remodeling
WO2007141210A1 (en) * 2006-06-06 2007-12-13 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス, インコーポレイテッド スマートな非経口送達システム
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
WO2008021367A2 (en) * 2006-08-11 2008-02-21 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
US20100061990A1 (en) * 2006-08-14 2010-03-11 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
EP2051734B1 (de) 2006-08-18 2016-10-05 Armagen Technologies, Inc. Mittel zur verabreichung in die blut-hirn-schranke
US7794434B2 (en) * 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US20080051765A1 (en) * 2006-08-23 2008-02-28 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7828764B2 (en) * 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7811262B2 (en) * 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7682338B2 (en) * 2006-08-23 2010-03-23 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US20090263422A1 (en) 2006-09-15 2009-10-22 Emmanuel Jules Hanon Influenza vaccine
DE102006047613A1 (de) * 2006-10-07 2008-04-10 Sanofi-Aventis Deutschland Gmbh Peristaltische Mikropumpe mit wechselbarem Pumpenkopf
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
CN101541359B (zh) * 2006-11-21 2012-11-28 皇家飞利浦电子股份有限公司 药剂输送装置、胶囊和体内药物输送或诊断系统
EP2494958A1 (de) 2006-12-01 2012-09-05 Anterios, Inc. Nanopartikel aus amphiphilen Einheiten
CA2671850A1 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
BRPI0722082A8 (pt) 2006-12-26 2018-03-13 Lantheus Medical Imaging Inc ligantes para imagiologia da inervação cardíaca
JP5553612B2 (ja) 2007-01-22 2014-07-16 コリウム インターナショナル, インコーポレイテッド マイクロニードルアレイ用アプリケータ
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
CN101641123A (zh) * 2007-03-06 2010-02-03 诺沃-诺迪斯克有限公司 包括操作机构系统的泵组件
WO2008115433A1 (en) 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
JP2010523595A (ja) 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー ポリ(アミノ酸)ターゲッティング部分
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
CN101687024A (zh) * 2007-04-28 2010-03-31 美国弗劳恩霍夫股份有限公司 锥虫抗原、疫苗组合物和相关方法
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
DK2146760T3 (en) 2007-04-30 2019-01-28 Medtronic Minimed Inc FILLING OF RESERVOIR, BUBBLE MANAGEMENT AND DELIVERY SYSTEMS FOR INFUSION MEDIA AND PROCEDURES
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
WO2008137066A1 (en) * 2007-05-02 2008-11-13 The Board Of Regents Of The University Of Oklahoma Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
EP2164458A1 (de) 2007-06-01 2010-03-24 Novo Nordisk A/S Stabile nichtwässrige pharmazeutische zusammensetzungen
US20080306444A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
CA2684699C (en) * 2007-06-14 2017-03-21 Berna Biotech Ag Intradermal influenza vaccine
WO2008156676A1 (en) 2007-06-15 2008-12-24 President And Fellows Of Harvard College Methods and compositions for detecting and modulating o-glycosylation
US8002752B2 (en) 2007-06-25 2011-08-23 Medingo, Ltd. Protector apparatus
CA2692933C (en) * 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
CA3184105A1 (en) 2007-07-27 2009-02-05 Armagen Inc. Methods and compositions for increasing alpha-l-iduronidase activity in the cns
CN101801452B (zh) * 2007-08-06 2014-10-22 阿勒根公司 用于去氨加压素药物给送的设备
BRPI0815662A2 (pt) * 2007-08-20 2016-09-27 Fraunhofer Usa Inc vacinas, antígenos, composições, e métodos profilácticos e terapêuticos para gripe
US7771391B2 (en) * 2007-09-28 2010-08-10 Calibra Medical, Inc. Disposable infusion device with snap action actuation
US10420880B2 (en) 2007-10-02 2019-09-24 West Pharma. Services IL, Ltd. Key for securing components of a drug delivery system during assembly and/or transport and methods of using same
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
US9173997B2 (en) 2007-10-02 2015-11-03 Medimop Medical Projects Ltd. External drug pump
EP2205074A4 (de) * 2007-10-04 2013-07-31 Harvard College Moenomycin-analoga, syntheseverfahren und verwendung
EP4159114B1 (de) 2007-10-09 2024-04-10 DexCom, Inc. Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
EP2630966B1 (de) 2007-10-12 2017-04-19 Massachusetts Institute of Technology Impfstoffnanotechnologie
US8858787B2 (en) * 2007-10-22 2014-10-14 Baxter International Inc. Dialysis system having non-invasive fluid velocity sensing
WO2009055733A1 (en) 2007-10-25 2009-04-30 Proteus Biomedical, Inc. Fluid transfer port information system
US8557179B2 (en) * 2007-10-31 2013-10-15 Novo Nordisk A/S Non-porous material as sterilization barrier
US8419638B2 (en) 2007-11-19 2013-04-16 Proteus Digital Health, Inc. Body-associated fluid transport structure evaluation devices
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
WO2009086112A2 (en) 2007-12-20 2009-07-09 University Of Southern California Apparatus and methods for delivering therapeutic agents
EP2231257A4 (de) 2007-12-24 2013-11-06 Univ Queensland Beschichtungsverfahren
EP2237787A4 (de) * 2008-01-03 2012-03-21 Massachusetts Inst Technology Decoy-influenzatherapien
EP2727616B1 (de) 2008-01-03 2017-04-26 University Of Southern California Implantierbare Wirkstofffreisetzungsvorrichtungen sowie Geräte und Verfahren zum Auffüllen der Vorrichtungen
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US20090191067A1 (en) * 2008-01-25 2009-07-30 Phluid,Inc. Two chamber pumps and related methods
EP2247527A4 (de) 2008-02-07 2014-10-29 Univ Queensland Patch-herstellung
US8229535B2 (en) 2008-02-21 2012-07-24 Dexcom, Inc. Systems and methods for blood glucose monitoring and alert delivery
JP5149049B2 (ja) * 2008-03-17 2013-02-20 テルモ株式会社 薬剤注入装置
US8396528B2 (en) 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
WO2009126691A1 (en) * 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
WO2009134808A2 (en) * 2008-04-28 2009-11-05 President And Fellows Of Harvard College Supercharged proteins for cell penetration
ES2534864T3 (es) 2008-05-08 2015-04-29 Minipumps, Llc Bombas implantables y cánulas para las mismas
CN102202706A (zh) 2008-05-08 2011-09-28 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
US8486278B2 (en) 2008-05-08 2013-07-16 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
KR101383285B1 (ko) * 2008-05-21 2014-04-08 테라젝트, 인코포레이티드 고용체 퍼포레이터 패치의 제조 방법 및 그 사용
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
SI3225249T1 (sl) * 2008-05-21 2019-02-28 Ferring B.V. Orodisperzibilen dezmopresin za povečanje začetnega obdobja spanja, ki ga ne moti nokturija
CA2760680A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents
EP2433664B1 (de) 2008-06-06 2016-08-10 Wockhardt Limited Vorrichtung zur Freisetzung von biologischem Material
WO2009158687A1 (en) 2008-06-26 2009-12-30 Anterios, Inc. Dermal delivery
ES2801898T3 (es) * 2008-06-26 2021-01-14 Calibra Medical Llc Dispositivo de infusión desechable con detector de oclusión
EP2318832B1 (de) 2008-07-15 2013-10-09 Academia Sinica Glycan-arrays auf objektträgern mit ptfe-aluminiumbeschichtung und entsprechende verfahren
WO2010011313A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides
KR20110033304A (ko) * 2008-07-23 2011-03-30 메사추세츠 인스티튜트 오브 테크놀로지 Dna 손상에 대해 보호하고 신경세포 생존을 증가시키는 히스톤 디아세틸라제 1 (hdac1)의 활성화
US8056582B2 (en) * 2008-08-08 2011-11-15 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
US9393369B2 (en) 2008-09-15 2016-07-19 Medimop Medical Projects Ltd. Stabilized pen injector
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
WO2010077806A1 (en) 2008-12-15 2010-07-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
CN102333878B (zh) * 2008-12-22 2015-08-26 绿光生物科学公司 用于制造化合物的组合物和方法
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
CA2753214C (en) 2009-02-27 2017-07-25 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
WO2010108048A2 (en) 2009-03-18 2010-09-23 Armagen Technologies, Inc. Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins
EP2416660B1 (de) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Fettsäureamidhydrolase-hemmer
CA2757622A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010129023A2 (en) 2009-04-28 2010-11-11 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
EP2438046A4 (de) 2009-06-01 2013-04-17 Harvard College O-glcnac-transferasehemmer und verwendungen davon
US20120209249A1 (en) 2009-06-19 2012-08-16 Sanofi-Aventis Deutschland Gmbh Injection Arrangement for a Flowable Drug
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
US20110152770A1 (en) 2009-07-30 2011-06-23 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CA2771584A1 (en) 2009-08-18 2011-02-24 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
US20110060280A1 (en) * 2009-09-04 2011-03-10 Sean Caffey Adhesive skin patch with pump for subcutaneous drug delivery
US10071196B2 (en) * 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
WO2011034516A1 (en) * 2009-09-15 2011-03-24 Becton, Dickinson And Company Self-injection device
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
USD810279S1 (en) 2009-09-15 2018-02-13 Medimop Medical Projects Ltd. Injector device
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor
WO2011044542A1 (en) * 2009-10-09 2011-04-14 Armagen Technologies, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
KR20170098985A (ko) 2009-11-19 2017-08-30 솔리스 바이오다인 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US9555187B2 (en) 2009-12-16 2017-01-31 Becton, Dickinson And Company Self-injection device
US20130012865A1 (en) 2009-12-16 2013-01-10 Chrontech Pharma Ab Codon-optimzed hepatitis b virus core antigen (hbcag)
JP5650243B2 (ja) 2009-12-16 2015-01-07 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 自己注射装置
ES2929490T3 (es) 2009-12-16 2022-11-29 Becton Dickinson Co Dispositivo de autoinyección
DK2512552T3 (en) 2009-12-16 2015-06-08 Becton Dickinson Co Self Injection Device
JP5894082B2 (ja) 2009-12-16 2016-03-23 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 自己注射装置
DK2512559T3 (en) 2009-12-16 2019-03-25 Becton Dickinson Co SELF-INJECTIVE DEVICE
AU2010343102B2 (en) 2009-12-29 2016-03-24 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
CA2787940C (en) 2010-01-27 2020-01-07 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
WO2011094606A2 (en) 2010-02-01 2011-08-04 Proteus Biomedical, Inc. Data gathering system
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
SG189763A1 (en) 2010-02-01 2013-05-31 Proteus Digital Health Inc Two-wrist data gathering system
MX336742B (es) 2010-02-03 2016-01-29 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso.
EP3338770B1 (de) 2010-03-08 2023-06-07 Sloan-Kettering Institute For Cancer Research Cdc7-kinasehemmer und verwendungen davon
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
LT3766408T (lt) 2010-03-24 2022-07-11 Abbott Diabetes Care, Inc. Medicinos prietaiso įvedikliai
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
WO2011133724A2 (en) 2010-04-20 2011-10-27 Minipumps, Llc Electrolytically driven drug pump devices
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2011140190A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Tetrazolones as inhibitors of fatty acid synthase
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
KR20130071433A (ko) 2010-05-07 2013-06-28 그린라이트 바이오사이언시스, 아이엔씨. 효소의 재배치를 통한 대사 경로에서의 흐름의 제어 방법
EP2569031B1 (de) 2010-05-10 2017-10-11 Medimop Medical Projects Ltd. Genauer injektor für geringe volumen
BR122020018191B1 (pt) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc. Uso de agentes de imagiologia na preparação de uma composição para imagiologia e método para imagiologia
ES2545411T5 (es) 2010-06-07 2024-04-05 Amgen Inc Dispositivo de administración de fármaco
US9193989B2 (en) 2010-06-18 2015-11-24 Taiho Pharmaceutical Co., Ltd. PRPK-TPRKB modulators and uses thereof
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
DE102010038733A1 (de) * 2010-07-30 2012-02-02 Robert Bosch Gmbh Modulare Mikronadel-Transportvorrichtung
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
KR20180058866A (ko) 2010-08-13 2018-06-01 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
CA2809284C (en) 2010-08-31 2021-02-23 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
EP2611478B1 (de) 2010-09-02 2022-08-17 Becton, Dickinson and Company Selbstinjektionsvorrichtung mit nadelschutz mit aktivierungsverhinderung
US8585677B2 (en) 2010-09-21 2013-11-19 Brigham Young University Laminar injection apparatus and method
US8802110B2 (en) 2010-09-21 2014-08-12 Massachusetts Institute Of Technology Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
JP2013541976A (ja) * 2010-09-27 2013-11-21 ステディメッド, エルティーディー. サイズ効率的な薬物送達デバイス
CN104531671A (zh) 2010-10-01 2015-04-22 现代治疗公司 设计核酸及其使用方法
BR112013007946B1 (pt) 2010-10-04 2022-07-12 Massachusetts Institute Of Technology Composições farmacêuticas e imunogênicas compreendendo polipeptídeos de hemaglutinina
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
AU2011326427B2 (en) 2010-11-10 2016-01-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
UA115767C2 (uk) 2011-01-10 2017-12-26 Інфініті Фармасьютікалз, Інк. Способи отримання ізохінолінонів і тверді форми ізохінолінонів
ES2687494T3 (es) 2011-01-19 2018-10-25 Topokine Therapeutics, Inc. Métodos y composiciones para reducir la grasa corporal
CN103596559A (zh) 2011-01-24 2014-02-19 安特里奥公司 纳米颗粒组合物、其制剂和它们的用途
US20120328549A1 (en) 2011-01-24 2012-12-27 Anterios, Inc. Oil compositions
EP2667854B1 (de) 2011-01-24 2019-01-16 Anterios, Inc. Nanopartikelzusammensetzungen
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9173999B2 (en) 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
WO2012108954A2 (en) 2011-02-09 2012-08-16 Becton, Dickinson And Company Nighttime basal dosing device
MX2013010076A (es) 2011-03-03 2014-04-07 Tersus Pharmaceuticals Llc Composiciones y metodos que comprenden c16:1n7 palmitoleato.
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
WO2012135615A2 (en) 2011-03-30 2012-10-04 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
EP2691101A2 (de) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
EP2720740A1 (de) 2011-06-15 2014-04-23 ChronTech Pharma AB Injektionsnadel und vorrichtung
CA2840224C (en) 2011-06-22 2019-08-13 The General Hospital Corporation Treatment of proteinopathies
AU2012284088B2 (en) 2011-07-19 2015-10-08 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
RS58438B1 (sr) 2011-07-22 2019-04-30 Massachusetts Inst Technology Aktivatori klase i histonskih deacetilaza (hdacs) i njihova primena
EP2750737A1 (de) 2011-08-29 2014-07-09 Sid Technologies LLC Subkutane und intradermale pflasterinfusoren
CA2846431A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CN104159890B (zh) 2011-09-09 2018-04-10 蓝瑟斯医学影像公司 用于合成和使用显像剂的组合物、方法和系统
KR20150010932A (ko) 2011-09-09 2015-01-29 그린라이트 바이오사이언시스, 아이엔씨. 카바페넴의 무세포 제조법
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3384938A1 (de) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Manipulierte nukleinsäuren und verfahren zur verwendung davon
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
EP3492109B1 (de) 2011-10-03 2020-03-04 ModernaTX, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
US20130090633A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Osmotic patch pump
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
US8753284B2 (en) 2011-11-08 2014-06-17 Elwha, Llc Blood pressure cuff
US8702614B2 (en) * 2011-11-08 2014-04-22 Elwha Llc Inflatable cuff with built-in drug delivery device for dynamic drug therapy response to blood pressure incidents
WO2013074986A1 (en) 2011-11-17 2013-05-23 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
AT512226B1 (de) * 2011-11-22 2013-09-15 Toeth Ewald Aderlassnadel
AU2012346448B2 (en) 2011-12-02 2017-09-14 Armagen, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
CA3182961A1 (en) 2011-12-11 2013-06-20 Abbott Diabetes Care Inc Analyte sensor devices, connections, and methods
WO2013090648A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
EP2790697B1 (de) 2011-12-16 2019-10-23 University of Florida Research Foundation, Inc. Verwendung von 4'-desferrithiocin-analoga
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
CN104245014B (zh) * 2012-01-31 2017-05-24 麦迪麦珀医疗项目有限公司 时间依赖性的药物输送装置
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス,インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
CN107216380A (zh) 2012-02-15 2017-09-29 爱勒让治疗公司 拟肽大环化合物
EP2825225B1 (de) 2012-03-15 2018-05-09 Steadymed Ltd. Verbesserte schmerzreduzierung an einer infusionsstelle für arzneimittelabgabevorrichtungen
WO2013140395A1 (en) 2012-03-19 2013-09-26 Steadymed Ltd. Fluid-connection mechanism for patch-pumps
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US8999380B2 (en) 2012-04-02 2015-04-07 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
EP2833957A4 (de) * 2012-04-02 2016-03-09 Capricor Therapeutics Inc Therapie für nierenerkrankungen und/oder herzinsuffizienz durch intradermale infusion
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
EP2834254A2 (de) 2012-04-06 2015-02-11 President and Fellows of Harvard College Moenomycin-analoga, syntheseverfahren und verwendung
WO2013151697A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
WO2013152279A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
EP3492101A3 (de) 2012-05-10 2019-10-23 Massachusetts Institute Of Technology Mittel zur influenzaneutralisierung
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
KR101494616B1 (ko) * 2012-06-12 2015-03-04 (주)제이엠바이오텍 피부용 자가 주입기구
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてrsv及び百日咳菌に対する免疫応答を惹起するための方法
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
JP6302909B2 (ja) 2012-08-18 2018-03-28 アカデミア シニカAcademia Sinica シアリダーゼの同定および画像化のための細胞透過性プローブ
WO2014046950A1 (en) * 2012-09-24 2014-03-27 Enable Injections, Llc Medication vial and injector assemblies and methods of use
HUE054444T2 (hu) 2012-09-26 2021-09-28 Harvard College Prolinnal lezárt kapcsos peptidek és felhasználásuk
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
LT2909204T (lt) 2012-10-12 2019-05-10 The Broad Institute, Inc. Gsk3 inhibitoriai ir jų panaudojimo būdai
US20140107450A1 (en) 2012-10-12 2014-04-17 Dexcom, Inc. Sensors for continuous analyte monitoring, and related methods
US20140213866A1 (en) 2012-10-12 2014-07-31 Dexcom, Inc. Sensors for continuous analyte monitoring, and related methods
JP2014079325A (ja) * 2012-10-15 2014-05-08 Seiko Epson Corp 流体注入装置
EP2909194A1 (de) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Hemmer der cyclinabhängigen kinase 7 (cdk7)
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
CN104812384B (zh) 2012-11-01 2020-09-18 爱勒让治疗公司 二取代的氨基酸及其制备和使用方法
MX2015005536A (es) 2012-11-01 2015-10-29 Infinity Pharmaceuticals Inc Tratamiento de canceres utilizando moduladores de las isoformas de pi3 cinasa.
WO2014071247A1 (en) 2012-11-02 2014-05-08 Dana-Farber Cancer Institute, Inc. Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors
CN104936595A (zh) 2012-11-21 2015-09-23 托普凯恩制药公司 局部增加体脂肪的方法和组合物
US9597380B2 (en) 2012-11-26 2017-03-21 Modernatx, Inc. Terminally modified RNA
EP2922575B1 (de) 2012-11-26 2019-06-26 President and Fellows of Harvard College Trioxacarcine, trioxacarcin-antikörper-konjugate und verwendungen davon
JP2016505001A (ja) 2012-12-21 2016-02-18 エピザイム,インコーポレイティド Prmt5阻害剤およびその使用
KR102265808B1 (ko) 2012-12-21 2021-06-16 코리움, 인크. 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법
KR102173874B1 (ko) 2012-12-21 2020-11-05 에피자임, 인코포레이티드 테트라하이드로- 및 디하이드로-이소퀴놀린 prmt5 억제제 및 이의 용도
EP2935240A1 (de) 2012-12-21 2015-10-28 Epizyme, Inc. Prmt5-inhibitor und verwendungen davon
JP2016505002A (ja) 2012-12-21 2016-02-18 エピザイム,インコーポレイティド ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するprmt5阻害剤およびその使用
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
EP3434774A1 (de) 2013-01-17 2019-01-30 ModernaTX, Inc. Signal-sensor-polynukleotide zur veränderung zellulärer phänotypen
CA2898633C (en) 2013-02-07 2021-07-13 Massachusetts Institute Of Technology Human adaptation of h5 influenza
EP4272750A3 (de) 2013-02-07 2024-01-24 Children's Medical Center, Corp. Proteinantigene zum schutz gegen pneumokokkenkolonisation und/oder -befall
US10183156B2 (en) * 2013-02-28 2019-01-22 Sorrento Therapeutics, Inc. Transdermal drug delivery device
US9861801B2 (en) 2013-02-28 2018-01-09 Kimberly-Clark Worldwide, Inc. Drug delivery device
EP2968887B1 (de) 2013-03-12 2022-05-04 Corium, Inc. Mikroprojektionsapplikatoren
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN105307667B (zh) 2013-03-13 2019-04-19 哈佛大学的校长及成员们 钉合且缝合的多肽及其用途
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
EP2968116A1 (de) 2013-03-15 2016-01-20 Corium International, Inc. Mikroarray mit polymerfreien mikrostrukturen, verfahren zur herstellung und verfahren zur verwendung
ES2939317T3 (es) 2013-03-15 2023-04-20 Corium Pharma Solutions Inc Aplicadores de microproyección de impacto múltiple
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP2968119B1 (de) 2013-03-15 2019-09-18 Corium International, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe, verfahren zur verwendung und verfahren zur herstellung
EP2970194A1 (de) 2013-03-15 2016-01-20 Infinity Pharmaceuticals, Inc. Salze und feste formen von isochinolinonen und zusammensetzung damit sowie verfahren zur verwendung davon
CN105246458B (zh) 2013-03-15 2020-09-15 考里安公司 用于治疗剂递送的微阵列及其使用方法
MX2015013894A (es) 2013-04-03 2015-12-11 Allertein Therapeutics Llc Composiciones de nanoparticulas novedosas.
MX2020011518A (es) 2013-04-04 2022-10-17 Harvard College Macrólidos y métodos para su preparación y uso.
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
WO2014179464A1 (en) 2013-04-30 2014-11-06 Massachusetts Institute Of Technology Human adaptation of h3 influenza
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (de) 2013-05-10 2018-06-16
BR112015027608A2 (pt) 2013-05-23 2017-07-25 Kimberly Clark Co microagulhas com geometrias transversais de canal aberto melhoradas
KR20160013204A (ko) 2013-05-30 2016-02-03 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절제를 사용하는 암의 치료
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
WO2014197723A2 (en) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Human adaptation of h7 ha
EP3030239A4 (de) 2013-06-11 2017-03-08 Kala Pharmaceuticals, Inc. Harnstoffderivate und verwendungen davon
MX2015017274A (es) 2013-06-14 2016-08-04 Harvard College Moduladores del receptor del polipéptido insulina estabilizados.
EP3013365B1 (de) 2013-06-26 2019-06-05 Academia Sinica Rm2-antigene und verwendung davon
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
WO2015012944A1 (en) 2013-07-22 2015-01-29 Armagen Technologies, Inc Methods and compositions for increasing enzyme activity in the cns
RU2016105108A (ru) 2013-07-25 2017-08-30 Дана-Фарбер Кэнсер Инститьют, Инк. Ингибиторы факторов транскрипции и их применение
US9688977B2 (en) 2013-08-05 2017-06-27 Greenlight Biosciences, Inc. Engineered phosphoglucose isomerase proteins with a protease cleavage site
JP6564367B2 (ja) 2013-08-05 2019-08-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 併用免疫原性組成物
DK3030286T3 (da) 2013-08-05 2019-11-11 Cam Med Llc Komfortabel patch-pumpe
EP2839853A1 (de) * 2013-08-23 2015-02-25 LTS LOHMANN Therapie-Systeme AG Transdermales therapeutisches System mit Druckerzeugungsvorrichtung
AU2014317889B2 (en) 2013-09-06 2020-03-05 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
WO2015048121A1 (en) 2013-09-25 2015-04-02 University Of Florida Research Foundation, Inc. Vitamin c prodrugs and uses thereof
JP5550775B1 (ja) * 2013-10-01 2014-07-16 合同会社Syndeo 封入剤送出装置
BR112016007255A2 (pt) 2013-10-03 2017-09-12 Moderna Therapeutics Inc polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
CN105793255B (zh) 2013-10-04 2018-11-16 无限药品股份有限公司 杂环化合物及其用途
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9982009B2 (en) 2013-10-15 2018-05-29 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
US9902986B2 (en) 2013-10-16 2018-02-27 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
US20160264551A1 (en) 2013-10-18 2016-09-15 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド サイクリン依存性キナーゼ7(cdk7)の多環阻害剤
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX355330B (es) 2013-11-01 2018-04-16 Kala Pharmaceuticals Inc Formas cristalinas de compuestos terapeuticos y sus usos.
US10569015B2 (en) 2013-12-02 2020-02-25 Bigfoot Biomedical, Inc. Infusion pump system and method
MY180383A (en) 2013-12-24 2020-11-28 Harvard College Cortistatin analogues and syntheses and uses thereof
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2015109180A2 (en) 2014-01-16 2015-07-23 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド ジアゼパン誘導体の使用
MX2016011517A (es) 2014-03-07 2017-04-13 Univ Arizona Peptidos de crmp2 no narcoticos que seleccionan como diana canales de sodio para el dolor cronico.
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
WO2015148915A1 (en) 2014-03-27 2015-10-01 Academia Sinica Reactive labelling compounds and uses thereof
DK3122375T3 (da) 2014-03-28 2021-05-25 Univ Washington Through Its Center For Commercialization Vacciner mod bryst- og ovariecancer
US20150289788A1 (en) 2014-04-10 2015-10-15 Dexcom, Inc. Sensors for continuous analyte monitoring, and related methods
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164650A1 (en) * 2014-04-24 2015-10-29 Becton, Dickinson And Company Catheter insertion device
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
WO2015168380A1 (en) 2014-04-30 2015-11-05 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
CN106232171B (zh) 2014-04-30 2019-01-18 金伯利-克拉克环球有限公司 透皮药物递送设备的储盒部分和方法
US10350349B2 (en) 2014-05-20 2019-07-16 Cequr Sa Medicine delivery device with restricted access filling port
WO2015179635A2 (en) 2014-05-21 2015-11-26 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
JP6894239B2 (ja) 2014-05-27 2021-06-30 アカデミア シニカAcademia Sinica 増強された抗体の有効性のための普遍的グリコフォームに関する組成物および方法
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
EP3149037A4 (de) 2014-05-27 2018-01-10 Academia Sinica Anti-her2-glykoantikörper und verwendungen davon
CA2950415A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
EP3154582A4 (de) 2014-05-28 2018-01-10 Academia Sinica Anti-tnf-alpha-glycoantikörper und verwendungen davon
EP3888676A1 (de) 2014-06-13 2021-10-06 GlaxoSmithKline Biologicals S.A. Immunogene kombinationen
ES2715500T3 (es) 2014-06-19 2019-06-04 Ariad Pharma Inc Compuestos de heteroarilo para la inhibición de la quinasa
WO2015200425A1 (en) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Topical dosage regimen
EP3164379A1 (de) 2014-07-02 2017-05-10 Massachusetts Institute of Technology Lipidoide aus polyaminfettsäure und verwendungen davon
JP6820830B2 (ja) 2014-07-18 2021-01-27 ユニヴァーシティ オブ ワシントン がんワクチン組成物およびその使用方法
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US10137246B2 (en) 2014-08-06 2018-11-27 Bigfoot Biomedical, Inc. Infusion pump assembly and method
US10736966B2 (en) 2014-08-12 2020-08-11 Massachusetts Institute Of Technology Brush-poly (glycoamidoamine)-lipids and uses thereof
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
WO2016040369A2 (en) 2014-09-08 2016-03-17 Academia Sinica HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
KR102570210B1 (ko) 2014-09-24 2023-08-23 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 제제
EP3197478A4 (de) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen und verwendungen davon
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SI3209647T1 (sl) 2014-10-21 2021-01-29 Ariad Pharmaceuticals, Inc. Kristalinične oblike 5-kloro-N4-(-2-(dimetilfosforoil)fenil)-N2-(2-metoksi-4-(4-(4-metilpi- perazin-1-il) piperidin-1-il)pirimidin-2,4-diamina
US20180015101A1 (en) 2014-10-28 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for antigen-specific tolerance
EP3461904A1 (de) 2014-11-10 2019-04-03 ModernaTX, Inc. Alternative nukleinsäuremoleküle mit reduziertem uracilgehalt und verwendungen davon
WO2016086026A1 (en) 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
AU2015360438C1 (en) 2014-12-10 2019-02-07 Kala Pharmaceuticals, Inc. 1 -amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof
WO2016100949A2 (en) 2014-12-18 2016-06-23 Windgap Medical, Inc. Method and compositions for dissolving or solubilizing therapeutic agents
JP7358029B2 (ja) 2014-12-23 2023-10-10 スローン - ケタリング・インスティテュート・フォー・キャンサー・リサーチ グラナチシンbの多形体
US10870651B2 (en) 2014-12-23 2020-12-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
EP3240591A4 (de) * 2014-12-30 2018-09-05 MiniPumps, LLC Implantierbare elektrolytische membranpumpen
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3248005B1 (de) 2015-01-24 2020-12-09 Academia Sinica Neuartige glycankonjugate und verfahren zur verwendung davon
AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
AU2016235054B2 (en) 2015-03-24 2020-07-16 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
AU2016243529B2 (en) 2015-03-27 2021-03-25 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
MX2017012665A (es) 2015-03-30 2018-04-24 Greenlight Biosciences Inc Produccion de acido ribonucleico libre de celulas.
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication
CN107708693A (zh) 2015-04-27 2018-02-16 佛罗里达大学研究基金会 代谢程序化的金属螯合剂及其用途
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
JP6784352B2 (ja) * 2015-05-11 2020-11-11 国立大学法人 東京医科歯科大学 インスリン送達用デバイス
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
CA2984939A1 (en) 2015-05-14 2016-11-17 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
WO2016196934A1 (en) 2015-06-04 2016-12-08 Medimop Medical Projects Ltd. Cartridge insertion for drug delivery device
US10463847B2 (en) 2015-06-11 2019-11-05 Steadymed Ltd. Infusion set
US10702527B2 (en) 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
ES2949540T3 (es) 2015-06-19 2023-09-29 Massachusetts Inst Technology 2,5-piperazinadionas sustituidas con alquenilo y su uso en composiciones para suministrar un agente a un sujeto o una célula
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017004345A1 (en) 2015-06-30 2017-01-05 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US11142507B2 (en) 2015-09-09 2021-10-12 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. Mcl−1のモジュレーターとしてのペプチド模倣大環状分子
ES2908449T3 (es) 2015-09-17 2022-04-29 Modernatx Inc Polinucleótidos que contienen una región de cola estabilizadora
EP4286012A3 (de) 2015-09-17 2024-05-29 ModernaTX, Inc. Verbindungen und zusammensetzungen zur intrazellulären verabreichung von therapeutischen wirkstoffen
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
US9987432B2 (en) 2015-09-22 2018-06-05 West Pharma. Services IL, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
EP3355882A1 (de) 2015-10-01 2018-08-08 Kythera Biopharmaceuticals, Inc. Zusammensetzungen mit einem statin zur verwendung in verfahren zur adipolyse
CN113648488B (zh) 2015-10-09 2024-03-29 西医药服务以色列分公司 至预填充的流体储存器的弯曲流体路径附加装置
US9867932B2 (en) 2015-10-30 2018-01-16 International Business Machines Corporation Drug delivery device having a cavity sealed by a pressurized membrane
WO2017112865A1 (en) 2015-12-22 2017-06-29 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
EP4378388A3 (de) 2015-12-30 2024-08-14 DexCom, Inc. Systeme und verfahren für transkutane analytsensoren
WO2017120026A1 (en) 2016-01-05 2017-07-13 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
JP6885960B2 (ja) 2016-01-21 2021-06-16 ウェスト ファーマ サービシーズ イスラエル リミテッド 視覚的インジケータを有する薬剤デリバリデバイス
WO2017127215A1 (en) 2016-01-21 2017-07-27 Medimop Medical Projects Ltd. Needle insertion and retraction mechanism
JP6513297B2 (ja) 2016-01-21 2019-05-22 ウェスト ファーマ サービシーズ イスラエル リミテッド 自動注射器、受け入れフレーム及び自動注射器におけるカートリッジの接続方法
EP3411110B1 (de) * 2016-02-05 2020-08-05 PassPort Technologies, Inc. Durchdringende transdermale anwendungsvorrichtung
TW201808978A (zh) 2016-03-08 2018-03-16 中央研究院 N-聚醣及其陣列之模組化合成方法
US11389597B2 (en) 2016-03-16 2022-07-19 West Pharma. Services IL, Ltd. Staged telescopic screw assembly having different visual indicators
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
WO2017176963A1 (en) 2016-04-06 2017-10-12 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
KR101879934B1 (ko) * 2016-05-31 2018-07-19 중앙대학교 산학협력단 혈관 탐지 장치
WO2017210448A1 (en) 2016-06-02 2017-12-07 Medimop Medical Projects Ltd. Three position needle retraction
BR112018075078A2 (pt) 2016-06-03 2019-03-06 Sanofi Pasteur Inc. modificação de polipeptídeos da hemaglutinina do influenza manipulados
US10105449B2 (en) 2016-06-07 2018-10-23 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2017286606A1 (en) 2016-06-14 2018-12-13 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
EP3490635B1 (de) 2016-08-01 2021-11-17 West Pharma. Services Il, Ltd. Feder zur verhinderung eines unvollständigen verschliessen der tür
JP6869327B2 (ja) 2016-08-01 2021-05-12 ウェスト ファーマ サービシーズ イスラエル リミテッド 回転防止カートリッジ
KR102437120B1 (ko) 2016-08-05 2022-08-25 사노피 파스퇴르 인코포레이티드 다가 폐렴구균 다당류-단백질 접합체 조성물
BR112019001995A2 (pt) 2016-08-05 2019-05-07 Sanofi Pasteur, Inc. composição de conjugado de polissacarídeo pneumocócico multivalente ? proteína
WO2018039274A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
EP3538067A1 (de) 2016-11-08 2019-09-18 Modernatx, Inc. Stabilisierte formulierungen von lipidnanopartikeln
BR112019010131A2 (pt) 2016-11-21 2019-10-08 Eirion Therapeutics Inc entrega transdérmica de agentes grandes
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
AU2017373857A1 (en) * 2016-12-05 2019-06-13 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
WO2018107270A1 (en) 2016-12-15 2018-06-21 Pka Softtouch Corp. Intradermal drug delivery device having a locked post-dispensing configuration
US10688244B2 (en) 2016-12-23 2020-06-23 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
JP2020503950A (ja) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. 経皮薬剤送達の装置及び方法
EP3570735A4 (de) 2017-01-23 2020-10-21 Abbott Diabetes Care Inc. Systeme, vorrichtungen und verfahren für analytsensoreinsatz
EP4186888A1 (de) 2017-03-15 2023-05-31 ModernaTX, Inc. Verbindung und zusammensetzungen zur intrazellulären verabreichung von therapeutischen wirkstoffen
US11969506B2 (en) 2017-03-15 2024-04-30 Modernatx, Inc. Lipid nanoparticle formulation
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
JP7152787B2 (ja) 2017-03-31 2022-10-13 ヴァクザス ピーティーワイ リミテッド 表面をコーティングするための装置および方法
BR112019020810A2 (pt) 2017-04-05 2020-04-28 Biogen Ma Inc compostos tricíclicos como inibidores de glicogênio sintase cinase 3 (gsk3) e usos dos mesmos
JP6921997B2 (ja) 2017-05-30 2021-08-18 ウェスト ファーマ サービシーズ イスラエル リミテッド ウェアラブル注射器のモジュラ駆動トレイン
AU2018285954A1 (en) 2017-06-13 2019-12-19 Vaxxas Pty Limited Quality control of substrate coatings
EP3638678A1 (de) 2017-06-14 2020-04-22 Modernatx, Inc. Verbindungen und zusammensetzungen zur intrazellulären verabreichung von wirkstoffen
ES2963745T3 (es) 2017-06-23 2024-04-01 Dexcom Inc Sensores de analito transcutáneo, aplicadores de los mismos y cono de aguja que comprenden función anti-giro
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS AND USES THEREOF
GB201712184D0 (en) * 2017-07-28 2017-09-13 Owen Mumford Ltd Medicament delivery device
EP3661587A4 (de) 2017-08-04 2021-06-09 Vaxxas Pty Limited Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map)
CN111315359A (zh) 2017-08-31 2020-06-19 摩登纳特斯有限公司 制备脂质纳米颗粒的方法
KR102571743B1 (ko) 2017-10-11 2023-08-29 그린라이트 바이오사이언시스, 아이엔씨. 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
CN212438615U (zh) 2017-10-24 2021-02-02 德克斯康公司 可穿戴设备
US11786477B2 (en) 2017-12-01 2023-10-17 North Carolina State University Fibrin particles and methods of making the same
WO2019126421A1 (en) 2017-12-22 2019-06-27 West Pharma. Services Il., Ltd. Injector usable with different dimension cartridges
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
EP3801732A4 (de) 2018-05-29 2022-04-27 Morningside Venture Investments Limited Verfahren und systeme zur wirkstofffreisetzung
USD926325S1 (en) 2018-06-22 2021-07-27 Dexcom, Inc. Wearable medical monitoring device
WO2020056191A1 (en) 2018-09-13 2020-03-19 Eirion Therapeutics, Inc. Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors
AU2019338459A1 (en) 2018-09-13 2021-04-08 Eirion Therapeutics, Inc. Plasminogen activator inhibitor 1 (PAI-1) inhibitors and uses therefor
WO2020061367A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
JP2022501367A (ja) 2018-09-20 2022-01-06 モデルナティエックス インコーポレイテッドModernaTX, Inc. 脂質ナノ粒子の調製及びその投与方法
MX2021006102A (es) 2018-12-03 2021-09-21 Eirion Therapeutics Inc Suministro mejorado de agentes grandes.
EP3911644A1 (de) 2019-01-16 2021-11-24 Curza Global LLC Antimikrobielle verbindungen und verfahren
AU2020209167A1 (en) 2019-01-16 2021-08-12 Curza Global, Llc Antimicrobial compounds and methods
JP2022519557A (ja) 2019-01-31 2022-03-24 モデルナティエックス インコーポレイテッド 脂質ナノ粒子の調製方法
US11464908B2 (en) 2019-02-18 2022-10-11 Tandem Diabetes Care, Inc. Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
EP3969038A1 (de) 2019-05-14 2022-03-23 Eirion Therapeutics, Inc. Verzögerung der spitzenwirkung und/oder verlängerung der dauer der reaktion
US11587839B2 (en) 2019-06-27 2023-02-21 Analog Devices, Inc. Device with chemical reaction chamber
AU2020319876A1 (en) 2019-07-31 2022-02-24 Modernatx, Inc. Compositions and methods for delivery of RNA interference agents to immune cells
WO2021021729A1 (en) 2019-07-31 2021-02-04 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
WO2021030210A1 (en) 2019-08-09 2021-02-18 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
AU2020384885A1 (en) 2019-11-13 2022-06-09 Curza Global, Llc Antimicrobial compounds and methods
AU2021212262A1 (en) 2020-01-31 2022-09-22 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
US11712516B2 (en) 2020-04-17 2023-08-01 Analog Devices, Inc. Fluid delivery device
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
US20230174576A1 (en) 2020-10-30 2023-06-08 Xeno-Interface Inc. Beta-strand bridge peptide
WO2022092294A1 (ja) 2020-10-30 2022-05-05 学校法人慶應義塾 サルコペニア関連疾患等の新規治療および予防
TW202237068A (zh) 2020-12-09 2022-10-01 美商建南德克公司 製備脂質奈米顆粒的高通量方法及其用途
EP4305088A1 (de) 2021-03-09 2024-01-17 Massachusetts Institute of Technology Verzweigte poly(aminoester) zur verabreichung von nukleinsäuren
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US11510602B1 (en) 2021-11-08 2022-11-29 Satio, Inc. Dermal patch for collecting a physiological sample
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12029562B2 (en) 2021-04-14 2024-07-09 Satio, Inc. Dermal patch system
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11604084B2 (en) 2021-04-15 2023-03-14 Analog Devices, Inc. Sensor package
US11796367B2 (en) 2021-05-07 2023-10-24 Analog Devices, Inc. Fluid control system
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
EP4384534A1 (de) 2021-08-11 2024-06-19 Sanofi Pasteur, Inc. Verkürzte influenza-neuraminidase und verfahren zur verwendung davon
KR102664919B1 (ko) * 2021-09-13 2024-05-09 (주)비올 고주파 인가 장치
WO2023059857A1 (en) 2021-10-08 2023-04-13 Sanofi Pasteur Inc. Multivalent influenza vaccines
KR20240105412A (ko) 2021-11-05 2024-07-05 사노피 파스퇴르 인크 재조합 헤마글루티닌과 뉴라미니다제를 포함하는 다가 인플루엔자 백신 및 이의 사용 방법
CA3237139A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
WO2023114889A1 (en) 2021-12-16 2023-06-22 Modernatx, Inc. Processes for preparing lipid nanoparticles
CN114305868A (zh) * 2021-12-30 2022-04-12 康宇辰 一种环氧杀菌创伤敷贴
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023177579A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide
WO2024091918A2 (en) 2022-10-25 2024-05-02 Modernatx, Inc. Methods of lipid nanoparticle production in cross-mixers
WO2024121380A1 (en) 2022-12-08 2024-06-13 Pierre Fabre Medicament Vaccinal composition and adjuvant

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH60868A (de) * 1912-05-20 1913-08-16 Leo Meyhoefer Gasbeleuchtungsanlage
US3923060A (en) * 1974-04-23 1975-12-02 Jr Everett H Ellinwood Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means
US4140117A (en) * 1975-05-12 1979-02-20 Alza Corporation Cartridge for liquid infusion apparatus
US4753651A (en) * 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4522622A (en) * 1982-12-23 1985-06-11 Alza Corporation Multiple fluid pulse dispenser
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
CA1283827C (en) * 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US4734092A (en) * 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
FR2649617A1 (fr) * 1989-07-12 1991-01-18 Veprol Dispositif de delivrance d'un principe actif pharmacologique par pompage electrolytique
US5090963A (en) * 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser
US5156591A (en) * 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
SE9101022D0 (sv) * 1991-01-09 1991-04-08 Paal Svedman Medicinsk suganordning
ATE192936T1 (de) * 1991-10-24 2000-06-15 Insutech Inc Durch mittels elektrolyse in hydrogel erzeugten gasdruck angetriebenes infusionssystem
US5318557A (en) * 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device

Also Published As

Publication number Publication date
CA2176342A1 (en) 1995-05-26
AU1076395A (en) 1995-06-06
ES2176310T3 (es) 2002-12-01
IL111685A (en) 1998-09-24
EP0729366B9 (de) 2002-12-11
WO1995013838A1 (en) 1995-05-26
JPH09504974A (ja) 1997-05-20
IL111685A0 (en) 1995-01-24
DE69431066T2 (de) 2003-02-27
EP0729366B1 (de) 2002-07-24
US5527288A (en) 1996-06-18
AU693136B2 (en) 1998-06-25
NZ276485A (en) 1997-11-24
ES2176310T4 (es) 2003-03-16
EP0729366A1 (de) 1996-09-04
DE69431066D1 (de) 2002-08-29

Similar Documents

Publication Publication Date Title
ATE220931T1 (de) Intradermale arzneimittelabgabevorrichtung
DE69826003D1 (de) Vorgefüllte medikamentenabgabevorrichtung
US4421508A (en) Vacuum-compression injector
DE69620257D1 (de) Medikamentenverabreichungsvorrichtung mit kartusche
US8784380B2 (en) Method and device for painless injection of medication
US5041094A (en) Device for administering fluid drugs, in particular for infusion
WO2003022330A3 (en) Microneedle-based pen device for drug delivery and method for using same
US4403609A (en) Vacuum-compression injector
PT1092444E (pt) Dispositivo de administracao intradermica incluindo um conjunto de agulha
US20030229308A1 (en) Injector adapter and combination thereof
WO2003068290A3 (en) Intradermal injector
CA2148173A1 (en) Delivery Device for Injectable Materials
WO2002074361A3 (en) Retractable needle medical device for injecting fluid from a pre-filled cartridge
NO980963D0 (no) Anordning for legemiddellevering
AU8970698A (en) Device for implanting filamentous materials
BR0116974B1 (pt) dispositivo de injeção intradérmica com enchimento prévio.
AU6008596A (en) Prefilled safety syringe
US20070118093A1 (en) High-speed jet devices for drug delivery
ES2004405A6 (es) Adaptador a jeringuilla para el marcado de animales
EP0317298A3 (de) Vorrichtung für die hypodermische Injektion von Flüssigkeiten
RU2056867C1 (ru) Одноразовый шприц
GB2263871A (en) Hypodermic syringe with eccentrically positioned retractable nozzle

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties