ATE210431T1 - POLYURETHANE HYDROGEL DRUG RESERVOIRS FOR USE IN TRANSDERMAL DRUG DELIVERY SYSTEMS - Google Patents

POLYURETHANE HYDROGEL DRUG RESERVOIRS FOR USE IN TRANSDERMAL DRUG DELIVERY SYSTEMS

Info

Publication number
ATE210431T1
ATE210431T1 AT96932225T AT96932225T ATE210431T1 AT E210431 T1 ATE210431 T1 AT E210431T1 AT 96932225 T AT96932225 T AT 96932225T AT 96932225 T AT96932225 T AT 96932225T AT E210431 T1 ATE210431 T1 AT E210431T1
Authority
AT
Austria
Prior art keywords
reservoirs
drug
delivery systems
transdermal
drug delivery
Prior art date
Application number
AT96932225T
Other languages
German (de)
Inventor
Tung-Fen Chen
Chia-Ming Chiang
Janan Jona
Priti Joshi
Asha Ramdas
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE210431T1 publication Critical patent/ATE210431T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymerisation Methods In General (AREA)

Abstract

High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence of a photoinitiator. Drug loading as high as 65 to 70 wt.% or higher can be achieved by absorbing drug formulation into the reservoir after hydrogel synthesis. Methods for making and using transdermal systems containing such reservoirs are provided as well.
AT96932225T 1995-09-14 1996-09-13 POLYURETHANE HYDROGEL DRUG RESERVOIRS FOR USE IN TRANSDERMAL DRUG DELIVERY SYSTEMS ATE210431T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52810595A 1995-09-14 1995-09-14
US58112895A 1995-12-29 1995-12-29
US71371496A 1996-09-13 1996-09-13
PCT/US1996/014739 WO1997009970A1 (en) 1995-09-14 1996-09-13 Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems

Publications (1)

Publication Number Publication Date
ATE210431T1 true ATE210431T1 (en) 2001-12-15

Family

ID=27414986

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96932225T ATE210431T1 (en) 1995-09-14 1996-09-13 POLYURETHANE HYDROGEL DRUG RESERVOIRS FOR USE IN TRANSDERMAL DRUG DELIVERY SYSTEMS

Country Status (9)

Country Link
EP (1) EP0907359B1 (en)
AT (1) ATE210431T1 (en)
AU (1) AU7109796A (en)
CA (1) CA2231648C (en)
DE (1) DE69618021T2 (en)
DK (1) DK0907359T3 (en)
ES (1) ES2167602T3 (en)
PT (1) PT907359E (en)
WO (1) WO1997009970A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024148A1 (en) * 1995-12-29 1997-07-10 Cygnus, Inc. Systems and methods for the transdermal administration of androgenic agents
ATE237277T1 (en) 1998-09-04 2003-05-15 Powderject Res Ltd SECOND MEDICAL INDICATION OF A PARTICLE ADMINISTRATION METHOD
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
AU3932600A (en) * 1999-04-01 2000-10-23 Alza Corporation Transdermal drug delivery devices comprising a polyurethane drug reservoir
DE10128685A1 (en) * 2001-06-13 2002-12-19 Beiersdorf Ag Self-adhesive sticking plaster matrix material comprising active material and penetration enhancer, useful for skin care, especially controlled application of active material to skin
WO2007092350A1 (en) * 2006-02-02 2007-08-16 H.B. Fuller Licensing & Financing, Inc. Wound care articles, drug delivery systems and methods of using the same
WO2012142124A2 (en) * 2011-04-11 2012-10-18 Alliqua, Inc. Transdermal patches having ionized beam crosslinked polymers and improved release characteristics

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118779A (en) * 1989-10-10 1992-06-02 Polymedica Industries, Inc. Hydrophilic polyurethane elastomers
IL101828A0 (en) * 1991-05-24 1992-12-30 Gensia Pharma Polyurethane hydrogel compositions for iontophoretic drug delivery
DE69125484T2 (en) * 1991-08-07 1997-10-02 Hartmann Paul Ag Wound dressing on a roll
US5160328A (en) * 1991-08-07 1992-11-03 Ndm Acquisition Corp. Hydrogel bandage
US5423737A (en) * 1993-05-27 1995-06-13 New Dimensions In Medicine, Inc. Transparent hydrogel wound dressing with release tab

Also Published As

Publication number Publication date
EP0907359A1 (en) 1999-04-14
CA2231648C (en) 2003-01-28
DE69618021T2 (en) 2002-05-16
PT907359E (en) 2002-04-29
DE69618021D1 (en) 2002-01-24
WO1997009970A1 (en) 1997-03-20
EP0907359B1 (en) 2001-12-12
ES2167602T3 (en) 2002-05-16
CA2231648A1 (en) 1997-03-20
DK0907359T3 (en) 2002-03-25
AU7109796A (en) 1997-04-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee