ATE204180T1 - Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten - Google Patents

Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten

Info

Publication number
ATE204180T1
ATE204180T1 AT96915718T AT96915718T ATE204180T1 AT E204180 T1 ATE204180 T1 AT E204180T1 AT 96915718 T AT96915718 T AT 96915718T AT 96915718 T AT96915718 T AT 96915718T AT E204180 T1 ATE204180 T1 AT E204180T1
Authority
AT
Austria
Prior art keywords
calichamicine
derivatives
carrier conjugates
producing monomeric
monomeric
Prior art date
Application number
AT96915718T
Other languages
German (de)
English (en)
Inventor
Martin Paul Kunstmann
Irwin Jack Hollander
Philip Hamann
Arthur Kunz
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE204180T1 publication Critical patent/ATE204180T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96915718T 1995-06-07 1996-05-10 Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten ATE204180T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/475,005 US5712374A (en) 1995-06-07 1995-06-07 Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
PCT/US1996/006738 WO1996040261A1 (en) 1995-06-07 1996-05-10 Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates

Publications (1)

Publication Number Publication Date
ATE204180T1 true ATE204180T1 (de) 2001-09-15

Family

ID=23885856

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96915718T ATE204180T1 (de) 1995-06-07 1996-05-10 Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten

Country Status (28)

Country Link
US (1) US5712374A (ko)
EP (1) EP0837698B1 (ko)
JP (2) JPH11508232A (ko)
KR (1) KR100499648B1 (ko)
CN (1) CN1094063C (ko)
AR (1) AR002360A1 (ko)
AT (1) ATE204180T1 (ko)
AU (1) AU703862B2 (ko)
BG (1) BG63492B1 (ko)
BR (1) BR9608564A (ko)
CA (1) CA2223329A1 (ko)
CY (1) CY2355B1 (ko)
CZ (1) CZ298024B6 (ko)
DE (1) DE69614551T2 (ko)
DK (1) DK0837698T3 (ko)
ES (1) ES2160818T3 (ko)
GR (1) GR3036930T3 (ko)
HK (1) HK1016871A1 (ko)
HU (1) HU221246B1 (ko)
IL (1) IL118565A (ko)
IN (1) IN182139B (ko)
MX (1) MX9709316A (ko)
NO (1) NO324609B1 (ko)
NZ (1) NZ307926A (ko)
PT (1) PT837698E (ko)
TW (1) TW419377B (ko)
WO (1) WO1996040261A1 (ko)
ZA (1) ZA964614B (ko)

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AU5742396A (en) 1996-12-30
CZ298024B6 (cs) 2007-05-30
EP0837698B1 (en) 2001-08-16
BG63492B1 (bg) 2002-03-29
WO1996040261A1 (en) 1996-12-19
CN1186442A (zh) 1998-07-01
BG102100A (en) 1998-08-31
DK0837698T3 (da) 2001-11-12
IN182139B (ko) 1999-01-09
US5712374A (en) 1998-01-27
NO975706D0 (no) 1997-12-05
MX9709316A (es) 1998-02-28
NO975706L (no) 1997-12-05
HUP9901351A3 (en) 2000-02-28
CA2223329A1 (en) 1996-12-19
EP0837698A1 (en) 1998-04-29
KR100499648B1 (ko) 2006-04-21
TW419377B (en) 2001-01-21
CZ393997A3 (cs) 1998-03-18
IL118565A0 (en) 1996-10-16
NZ307926A (en) 1999-09-29
HUP9901351A2 (hu) 1999-08-30
JPH11508232A (ja) 1999-07-21
KR19990022453A (ko) 1999-03-25
DE69614551D1 (de) 2001-09-20
ZA964614B (en) 1997-12-04
HU221246B1 (en) 2002-09-28
PT837698E (pt) 2001-12-28
CN1094063C (zh) 2002-11-13
ES2160818T3 (es) 2001-11-16
JP2009073832A (ja) 2009-04-09
CY2355B1 (en) 2004-06-04
AU703862B2 (en) 1999-04-01
DE69614551T2 (de) 2002-04-11
GR3036930T3 (en) 2002-01-31
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BR9608564A (pt) 1999-07-06
IL118565A (en) 2004-06-20

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