ATE140035T1 - Verfahren zur charakterisierung von hla dp - Google Patents

Verfahren zur charakterisierung von hla dp

Info

Publication number
ATE140035T1
ATE140035T1 AT89906241T AT89906241T ATE140035T1 AT E140035 T1 ATE140035 T1 AT E140035T1 AT 89906241 T AT89906241 T AT 89906241T AT 89906241 T AT89906241 T AT 89906241T AT E140035 T1 ATE140035 T1 AT E140035T1
Authority
AT
Austria
Prior art keywords
dpbeta
individual
alleles
hla
dpalpha
Prior art date
Application number
AT89906241T
Other languages
English (en)
Inventor
Henry A Erlich
Glenn T Horn
Teodorica L Bugawan
Ann B Begovich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE140035T1 publication Critical patent/ATE140035T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dot-Matrix Printers And Others (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)
  • Coloring (AREA)
AT89906241T 1988-05-20 1989-05-18 Verfahren zur charakterisierung von hla dp ATE140035T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19666088A 1988-05-20 1988-05-20
US25821288A 1988-10-14 1988-10-14
US07/347,506 US5310893A (en) 1986-03-31 1989-05-04 Method for HLA DP typing

Publications (1)

Publication Number Publication Date
ATE140035T1 true ATE140035T1 (de) 1996-07-15

Family

ID=27393631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89906241T ATE140035T1 (de) 1988-05-20 1989-05-18 Verfahren zur charakterisierung von hla dp

Country Status (9)

Country Link
US (2) US5310893A (de)
EP (1) EP0417160B1 (de)
JP (1) JP3117083B2 (de)
AT (1) ATE140035T1 (de)
AU (1) AU633830B2 (de)
DE (1) DE68926784T2 (de)
IE (1) IE74898B1 (de)
IL (1) IL90357A (de)
WO (1) WO1989011547A1 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818393B1 (en) 1982-07-30 2004-11-16 Biomirieux Sa DNA sequences coding for the DR beta-chain locus of the human lymphocyte antigen complex and polypeptides, diagnostic typing processes and products related thereto
US5567809A (en) * 1986-03-13 1996-10-22 Hoffmann-La Roche Inc. Methods and reagents for HLA DRbeta DNA typing
US5693517A (en) * 1987-06-17 1997-12-02 Roche Molecular Systems, Inc. Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions
US5561058A (en) * 1986-08-22 1996-10-01 Hoffmann-La Roche Inc. Methods for coupled high temperatures reverse transcription and polymerase chain reactions
US6270961B1 (en) * 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6919211B1 (en) * 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5192659A (en) * 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US20040197775A1 (en) * 1989-08-25 2004-10-07 Genetype A.G. Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
CA2025179A1 (en) * 1989-10-12 1991-04-13 William G. Weisburg Nucleic acid probes and methods for detecting cryptococcus neoformans
CA2032331A1 (en) * 1990-01-22 1991-07-23 Annie L. Wu Method and kits for detecting human leukocyte antigen dna
GB9002625D0 (en) * 1990-02-06 1990-04-04 Univ Singapore Human leukocyte antigen typing
US6013431A (en) * 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
US5645994A (en) * 1990-07-05 1997-07-08 University Of Utah Research Foundation Method and compositions for identification of species in a sample using type II topoisomerase sequences
DK0570371T3 (da) * 1990-07-11 2000-04-17 Genetype Ag Genomisk kortlægningmetode ved direkte haplotypebestemmelse ved anvendelse af intron sekvensanalyse
US5851762A (en) * 1990-07-11 1998-12-22 Gene Type Ag Genomic mapping method by direct haplotyping using intron sequence analysis
GB9020621D0 (en) * 1990-09-21 1990-10-31 Imp Cancer Res Tech Identification of organisms
GB2262987A (en) * 1990-09-21 1993-07-07 Imp Cancer Res Tech Identification of organisms
NL9002259A (nl) * 1990-10-17 1992-05-18 Eurodiagnostics B V Werkwijze voor het bepalen van een genotype door het vergelijken van de nucleotidensequentie van leden van een genfamilie, alsmede kit voor het opsporen van genetische variaties.
AU656161B2 (en) * 1990-12-06 1995-01-27 F. Hoffmann-La Roche Ag Methods and reagents for HLA DRbeta DNA typing
EP0834575B1 (de) 1990-12-06 2001-11-28 Affymetrix, Inc. (a Delaware Corporation) Identifizierung von Nukleinsäuren in Proben
DE69125368T2 (de) * 1990-12-21 1997-10-09 Hoffmann La Roche Karakterisierung von hla-dqbeta-dns
US5888819A (en) * 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US5578443A (en) * 1991-03-06 1996-11-26 Regents Of The University Of Minnesota DNA sequence-based HLA typing method
EP0577708A4 (en) * 1991-03-06 1998-02-04 Univ Minnesota Dna sequence-based hla typing method
GB9108354D0 (en) * 1991-04-18 1991-06-05 Solicitor For The Affairs Of H Nucleotide probes
US5424184A (en) * 1991-05-08 1995-06-13 Regents Of The University Of Minnesota DNA sequence-based HLA class I typing method
US6190864B1 (en) * 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
FR2679252B1 (fr) * 1991-07-17 1993-12-10 Bio Merieux Systeme de sondes permettant d'effectuer le typage hla dr, et procede de typage utilisant lesdites sondes.
US5976789A (en) * 1991-07-17 1999-11-02 Bio Merieux System of probes enabling HLA-DR typing to be performed, and typing method using said probes
NZ243802A (en) * 1991-07-31 1994-12-22 Hoffmann La Roche Polynucleotide probes and methods for their use for identifying and detecting bacteria capable of causing meningitis
WO1993009249A1 (en) * 1991-11-01 1993-05-13 Immunogenetics Research Foundation Genetic analysis
US6383747B1 (en) 1991-11-01 2002-05-07 The Immunogenetics Research Foundation Incorporated Method for determining ancestral haplotypes using haplospecific geometric elements within the major histocompatibility complex multigene cluster
CA2081582A1 (en) * 1991-11-05 1993-05-06 Teodorica Bugawan Methods and reagents for hla class i dna typing
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
FR2684688B1 (fr) * 1991-12-04 1994-03-18 Bertin Et Cie Procede de selection d'au moins un crible de mutations, son application a un procede d'identification rapide d'alleles de systemes polymorphes et dispositif pour sa mise en óoeuvre.
US5589333A (en) * 1992-02-03 1996-12-31 Thomas Jefferson University In situ polymerase chain reaction
EP0575845A3 (de) * 1992-06-23 1998-01-07 F. Hoffmann-La Roche Ag Verfahren für Charakterisierung von HLA-DP
US5512430A (en) * 1993-07-13 1996-04-30 Hri Research, Inc. Diagnostic array for virus infection
EP0787183A4 (de) * 1993-07-23 1998-05-27 Hyseq Inc Methode zum "screenen" von unbekannten organismen
US5674487A (en) * 1994-09-28 1997-10-07 Univ Jefferson Method for treating autoimmune diseases
US6033661A (en) 1995-06-07 2000-03-07 Thomas Jefferson University Composition and method for allogenetic mononuclear cell immunotherapy
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5908749A (en) * 1995-02-17 1999-06-01 Tge Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for high resolution HLA typing
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5780231A (en) * 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
GB9524381D0 (en) * 1995-11-29 1996-01-31 Anthony Nolan Bone Marrow Trus Method for identifying an unknown allele
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US5763184A (en) 1996-01-30 1998-06-09 Roche Molecular Systems, Inc. Nucleotide sequence variation in the ABO glycosyltransferase gene
US5763591A (en) * 1996-03-25 1998-06-09 Cedars-Sinai Medical Center Polynucleic acid sequences that are functionally associated with the development of autoimmune disease
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
US6309824B1 (en) 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
US20020042048A1 (en) 1997-01-16 2002-04-11 Radoje Drmanac Methods and compositions for detection or quantification of nucleic acid species
EP0972078B1 (de) * 1997-03-20 2005-06-01 Affymetrix, Inc. (a California Corporation) Iterative resequenzierung
US20040248176A1 (en) * 1997-03-20 2004-12-09 Affymetrix, Inc. Iterative resequencing
US6544730B1 (en) 1997-10-27 2003-04-08 Prescott Deininger High density polymorphic genetic locus
EP0953650A1 (de) * 1998-04-20 1999-11-03 Innogenetics N.V. Verfahren für die HLA Typisierung
US6355419B1 (en) 1998-04-27 2002-03-12 Hyseq, Inc. Preparation of pools of nucleic acids based on representation in a sample
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6528260B1 (en) * 1999-03-25 2003-03-04 Genset, S.A. Biallelic markers related to genes involved in drug metabolism
AU5495600A (en) * 1999-06-17 2001-01-09 Fred Hutchinson Cancer Research Center Oligonucleotide arrays for high resolution hla typing
US7112566B1 (en) * 1999-09-17 2006-09-26 The Regents Of The University Of California Systemic administration of Hypocretin-1
US20100268658A1 (en) * 2001-05-14 2010-10-21 Prolacta Bioscience Method for collecting, testing and distributing milk
US20020182243A1 (en) * 2001-05-14 2002-12-05 Medo Elena Maria Method of producing nutritional products from human milk tissue and compositions thereof
US7820030B2 (en) * 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
EP1536021A1 (de) * 2003-11-27 2005-06-01 Consortium National de Recherche en Genomique (CNRG) Methode zur Typisierung von HLA
BRPI0616323A2 (pt) 2005-09-20 2011-06-14 Prolacta Bioscience Inc mÉtodo para determinar se um fluido mamÁrio doado foi obtido a partir de um indivÍduo especÍfico
ES2577535T3 (es) 2005-10-21 2016-07-15 Regents Of The University Of California Mutaciones del oncogén de C-kit en melanomas
CN101432440B (zh) 2006-04-24 2013-08-21 西格马食品可变资本有限公司 通过实时聚合酶链反应检测和多重、同时量化病原体的方法
WO2008049021A2 (en) * 2006-10-17 2008-04-24 Life Technologies Corporation Methods of allele typing
ES2894973T3 (es) * 2006-11-29 2022-02-16 Prolacta Bioscience Inc Composiciones de leche materna y métodos de preparación y uso de las mismas
EP2101597B1 (de) * 2006-12-08 2012-10-17 Prolacta Bioscience, Inc. Zusammensetzungen menschlicher fette sowie verfahren zu ihrer herstellung und verwendung
CA2694832A1 (en) 2007-08-06 2009-02-12 Orion Genomics Llc Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the igf2 gene
JP2009077712A (ja) 2007-09-11 2009-04-16 F Hoffmann La Roche Ag B−Rafキナーゼ阻害剤に対する感受性についての診断試験
US20100086914A1 (en) * 2008-10-03 2010-04-08 Roche Molecular Systems, Inc. High resolution, high throughput hla genotyping by clonal sequencing
WO2009059321A2 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Rca locus analysis to assess susceptibility to amd and mpgnii
CA2718986A1 (en) * 2008-04-09 2009-10-15 Pacific Northwest Research Institute Methods for screening for genetic predisposition to type i diabetes
US20100261189A1 (en) * 2008-10-03 2010-10-14 Roche Molecular Systems, Inc. System and method for detection of HLA Variants
WO2010065652A1 (en) 2008-12-02 2010-06-10 Prolacta Bioscience, Inc. Human milk permeate compositions and methods of making and using same
ES2544265T3 (es) 2009-02-11 2015-08-28 Orion Genomics, Llc Combinaciones de polimorfismos para determinar la expresión específica de alelo de IGF2
GB0903343D0 (en) 2009-02-27 2009-04-22 Element Six Holding Gmbh Hard-metal body with graded microstructure
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US20140004510A1 (en) 2010-09-24 2014-01-02 Massachusetts Eye And Ear Infirmary Methods and compositions for prognosing and/or detecting age-related macular degeneration
JP6062433B2 (ja) 2011-08-03 2017-01-18 プロラクタ バイオサイエンス,インコーポレイテッド 細菌汚染を低減するためのヒト乳の精密濾過
CN104024431A (zh) 2011-08-31 2014-09-03 霍夫曼-拉罗奇有限公司 对血管发生抑制剂的响应
SG2014008585A (en) 2011-08-31 2014-04-28 Hoffmann La Roche Method for predicting risk of hypertension associated with anti-angiogenesis therapy
EP2758055A1 (de) 2011-09-19 2014-07-30 F.Hoffmann-La Roche Ag Kombinationsbehandlungen mit c-met antagonisten und b-raf antagonisten
JP2014533956A (ja) 2011-11-23 2014-12-18 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 血管新生阻害剤に対する応答性
EP2827701B1 (de) 2012-03-19 2020-11-18 Malaysian Palm Oil Board Gen zur kontrolle des schalenphänotyps bei palmen
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
CA2902990C (en) 2013-03-13 2021-11-16 Prolacta Bioscience, Inc. High fat human milk products
CA2902167A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits
WO2014172434A1 (en) 2013-04-16 2014-10-23 The Johns Hopkins University Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)
EP3125936B1 (de) 2014-03-31 2019-05-08 Debiopharm International SA Fgfr-fusionen
JP2017522015A (ja) 2014-06-24 2017-08-10 アボツト・モレキユラー・インコーポレイテツド ヒトkras中における1塩基多型の検出
US20160017421A1 (en) * 2014-07-16 2016-01-21 Roche Molecular Systems Non-invasive early detection of solid organ transplant rejection by quantitative analysis of hla gene amplicons
JP7231326B2 (ja) 2014-11-10 2023-03-01 ジェネンテック, インコーポレイテッド Il-33媒介性障害のための治療及び診断方法
SG11201805635RA (en) 2015-12-30 2018-07-30 Prolacta Bioscience Inc Human milk products useful in pre- and post-operative care
EP3279337A1 (de) 2016-08-04 2018-02-07 Servizo Galego de Saúde (SERGAS) Verwendung kurzer sonden zwischen 8 und 9 nukleotiden in multiplextests
US20180327817A1 (en) * 2017-05-15 2018-11-15 Rheonix, Inc. Strain Typing Assay and Method Without Need for Isolation in Pure Form and Subsequent Longitudinal Strain Tracking
EP3749362A1 (de) 2018-02-09 2020-12-16 F. Hoffmann-La Roche AG Therapeutische und diagnostische verfahren für mastzellvermittelte entzündliche erkrankungen
MX2018008742A (es) 2018-07-16 2020-01-17 Sigma Alimentos Sa De Cv Metodo y kit de diagnostico para detectar multiple y simultaneamente una combinacion de bacterias gram positivas y/o bacterias gram negativas.
JP2023516497A (ja) 2020-03-13 2023-04-19 メドイミューン・リミテッド Il33にリスクアレルを有する対象を治療するための治療方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683202A (en) * 1953-04-02 1954-07-06 Genisco Inc Variable resistance device
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US5110920A (en) * 1982-01-22 1992-05-05 Cetus Corporation HLA typing method and DNA probes used therein
US4582788A (en) * 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US6194561B1 (en) * 1986-03-13 2001-02-27 Roche Molecular Systems, Inc. Characterization and detection of sequences associated with autoimmune diseases
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme

Also Published As

Publication number Publication date
IL90357A (en) 1993-08-18
JP3117083B2 (ja) 2000-12-11
DE68926784T2 (de) 1997-02-27
EP0417160A1 (de) 1991-03-20
US5541065A (en) 1996-07-30
AU3690889A (en) 1989-12-12
AU633830B2 (en) 1993-02-11
IL90357A0 (en) 1989-12-15
US5310893A (en) 1994-05-10
IE891642L (en) 1989-11-20
IE74898B1 (en) 1997-08-13
WO1989011547A1 (en) 1989-11-30
DE68926784D1 (de) 1996-08-08
JPH03504325A (ja) 1991-09-26
EP0417160B1 (de) 1996-07-03

Similar Documents

Publication Publication Date Title
ATE140035T1 (de) Verfahren zur charakterisierung von hla dp
Ota et al. Modified PCR‐RFLP method for HLA‐DPB1 and‐DQA1 genotyping
Sullivan et al. Automated DNA profiling by fluorescent labeling of PCR products.
US6004783A (en) Cleaved amplified RFLP detection methods
US20020182609A1 (en) Microsphere based oligonucleotide ligation assays, kits, and methods of use, including high-throughput genotyping
KR930010192A (ko) 에이치엘에이(hla) 제i형 디엠에이(dna) 타이핑 방법 및 시약
CA2528577A1 (en) Methods and compositions for whole genome amplification and genotyping
ATE73502T1 (de) Verfahren und ausstattung zur bestimmung von spezifischen nukleotid-variationen und genetischen polymorphismen in nukleinsaeuren.
BR9507960A (pt) Sondas processos e kits para detenção de acidos nucleicos mycobacteriais em amostras biologicas
EP1173612A2 (de) Verfahren zur erkennung und/oder analyse, unter verwendung von primertechniken, von einfachen nukleotidpolymorphismen in restriktionsfragmenten speziell aus amplifizierten restriktionsfragmenten generiert durch aflp
ATE164630T1 (de) Verfahren und reagenzien für die karakterisierung von hla-drbeta-dns
CN111893192B (zh) 混合检材分析微单倍型复合扩增体系及构建及单倍型频率
CN111549107B (zh) 一种利用高通量测序进行基因分型的方法、试剂盒及应用
JPWO2005118791A1 (ja) 微量試料を用いる網羅的遺伝子発現プロフィール解析法
US20070231803A1 (en) Multiplex pcr mixtures and kits containing the same
Steube et al. A simple method using β-globin polymerase chain reaction for the species identification of animal cell lines—a progress report
EP0226288A3 (de) Mittel und Verfahren zur Bestimmung von Cystic Fibrosis beruhend auf genetischer Kopplung
Hue-Roye et al. Principles of PCR-based assays
ATE144557T1 (de) Nucleinsäure-proben und verfahren zum nachweis von giardia lamblia
Tsongalis et al. READIT: a novel technology used in the interrogation of nucleic acid sequences for single-nucleotide polymorphisms
CN112522381A (zh) 一种同时检测基因突变与拷贝数变化的高通量方法
CN109280663B (zh) 一种全自动核酸单链制备方法
CN107400722B (zh) 一种检测人基因组的竞争性实时荧光pcr snp探针
WO2005059505A3 (es) Método y kit para genotipificación de hla-b27 basados en la pcr en tiempo real
JPH11216000A (ja) Hla−a対立遺伝子型の判別方法

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time