ATE130370T1 - Verfahren zur expression von, als fusionsproteine produzierten, heterologen proteinen in e. coli, deren verwendungen, expressionsvektoren und rekombinante stämme. - Google Patents
Verfahren zur expression von, als fusionsproteine produzierten, heterologen proteinen in e. coli, deren verwendungen, expressionsvektoren und rekombinante stämme.Info
- Publication number
- ATE130370T1 ATE130370T1 AT90202108T AT90202108T ATE130370T1 AT E130370 T1 ATE130370 T1 AT E130370T1 AT 90202108 T AT90202108 T AT 90202108T AT 90202108 T AT90202108 T AT 90202108T AT E130370 T1 ATE130370 T1 AT E130370T1
- Authority
- AT
- Austria
- Prior art keywords
- proteins
- coli
- expression
- heterologous
- heterologue
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 241000588724 Escherichia coli Species 0.000 abstract 4
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 241000701533 Escherichia virus T4 Species 0.000 abstract 1
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 210000000805 cytoplasm Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU89149A CU22222A1 (es) | 1989-08-03 | 1989-08-03 | Procedimiento para la expresion de proteinas heterologicas producidas de forma fusionada en escherichia coli, su uso, vectores de expresion y cepas recombinantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE130370T1 true ATE130370T1 (de) | 1995-12-15 |
Family
ID=5459457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90202108T ATE130370T1 (de) | 1989-08-03 | 1990-08-02 | Verfahren zur expression von, als fusionsproteine produzierten, heterologen proteinen in e. coli, deren verwendungen, expressionsvektoren und rekombinante stämme. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0416673B1 (de) |
| JP (1) | JPH04158797A (de) |
| AT (1) | ATE130370T1 (de) |
| CU (1) | CU22222A1 (de) |
| DE (1) | DE69023580T2 (de) |
| ES (1) | ES2081913T3 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4002636A1 (de) * | 1990-01-30 | 1991-08-01 | Boehringer Mannheim Gmbh | Expression von hiv1- und 2-polypeptiden und deren verwendung |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US6168785B1 (en) * | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
| US6929791B2 (en) | 1998-07-16 | 2005-08-16 | Institut Pasteur | Peptides of IL-2 and derivatives thereof |
| NZ511488A (en) * | 1998-10-16 | 2003-10-31 | Immunex Corp | Inhibitors of platelet activation and recruitment comprising an Ala residue and heterologous peptides capable of forming a stable secondary structure attached to a CD39 polypeptide |
| US7264809B1 (en) | 1998-10-16 | 2007-09-04 | Immunex Corporation | Methods of inhibiting platelet activation and recruitment |
| AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2002314111A1 (en) * | 2001-06-15 | 2003-01-02 | F. Hoffmann-La Roche Ag | Method for the recombinant production of peptidic antiviral fusion inhibitors, and acetylation of gb41 fragments |
| CA2471363C (en) | 2001-12-21 | 2014-02-11 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1594530A4 (de) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albuminfusionsproteine |
| WO2007141650A2 (en) * | 2006-01-17 | 2007-12-13 | Instituto De Medicina Molecular | Compositions and methods for diagnosing hiv-2 infection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3541856A1 (de) * | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
| DE3636903A1 (de) * | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
| ATE87103T1 (de) * | 1985-12-17 | 1993-04-15 | Akzo Nv | Immunochemisches reagenz. |
| EP0345792A3 (de) * | 1988-06-10 | 1991-05-02 | F. Hoffmann-La Roche Ag | HTLV-1/HIV-1-Fusionsproteine |
-
1989
- 1989-08-03 CU CU89149A patent/CU22222A1/es unknown
-
1990
- 1990-08-02 AT AT90202108T patent/ATE130370T1/de not_active IP Right Cessation
- 1990-08-02 EP EP90202108A patent/EP0416673B1/de not_active Expired - Lifetime
- 1990-08-02 ES ES90202108T patent/ES2081913T3/es not_active Expired - Lifetime
- 1990-08-02 DE DE69023580T patent/DE69023580T2/de not_active Expired - Fee Related
- 1990-08-03 JP JP2205268A patent/JPH04158797A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CU22222A1 (es) | 1995-01-31 |
| EP0416673A1 (de) | 1991-03-13 |
| ES2081913T3 (es) | 1996-03-16 |
| DE69023580T2 (de) | 1996-04-11 |
| JPH04158797A (ja) | 1992-06-01 |
| EP0416673B1 (de) | 1995-11-15 |
| DE69023580D1 (de) | 1995-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |