AT92538T - Strengthening and detection of nucleic acid. - Google Patents

Strengthening and detection of nucleic acid.

Info

Publication number
AT92538T
AT92538T AT89902420T AT89902420T AT92538T AT 92538 T AT92538 T AT 92538T AT 89902420 T AT89902420 T AT 89902420T AT 89902420 T AT89902420 T AT 89902420T AT 92538 T AT92538 T AT 92538T
Authority
AT
Austria
Prior art keywords
strengthening
detection
nucleic acid
nucleic
acid
Prior art date
Application number
AT89902420T
Other languages
German (de)
Inventor
Harvey I Miller
Sean Johnston
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US14646288A priority Critical
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to EP89902420A priority patent/EP0359789B1/en
Priority to PCT/US1989/000120 priority patent/WO1989006700A1/en
Publication of AT92538T publication Critical patent/AT92538T/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22517472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT92538(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse Transcribing RNA Viruses
    • C12N2740/00011Reverse Transcribing RNA Viruses
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
AT89902420T 1988-01-21 1989-01-12 Strengthening and detection of nucleic acid. AT92538T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14646288A true 1988-01-21 1988-01-21
EP89902420A EP0359789B1 (en) 1988-01-21 1989-01-12 Amplification and detection of nucleic acid sequences
PCT/US1989/000120 WO1989006700A1 (en) 1988-01-21 1989-01-12 Amplification and detection of nucleic acid sequences

Publications (1)

Publication Number Publication Date
AT92538T true AT92538T (en) 1993-08-15

Family

ID=22517472

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89902420T AT92538T (en) 1988-01-21 1989-01-12 Strengthening and detection of nucleic acid.

Country Status (10)

Country Link
EP (1) EP0359789B1 (en)
JP (3) JP2846018B2 (en)
AT (1) AT92538T (en)
AU (1) AU624601B2 (en)
DE (2) DE68908054T2 (en)
DK (1) DK175944B1 (en)
ES (1) ES2010094A6 (en)
NO (1) NO300782B1 (en)
NZ (1) NZ227688A (en)
WO (1) WO1989006700A1 (en)

Families Citing this family (176)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
DE69033179D1 (en) * 1989-02-13 1999-07-29 Geneco Pty Ltd Detecting a nucleic acid sequence or a change therein
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
DE3929030A1 (en) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh A method for amplification of nucleic acids
US7049102B1 (en) * 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
PT96458B (en) * 1990-01-10 1998-06-30 Chiron Corp Use of dependent RNA polymerase transcripts as registers DNA molecules for signal amplification in assays hibridazacao nucleic acid
US7585512B1 (en) 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
US5169766A (en) * 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
EP0648281A4 (en) * 1991-09-10 1997-06-04 Jack D Love Dna/rna target and signal amplification.
DE4213029A1 (en) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh aeuresequenzen method for the specific amplification of nucleic
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5256555A (en) 1991-12-20 1993-10-26 Ambion, Inc. Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions
WO1993022461A1 (en) * 1992-05-06 1993-11-11 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5834202A (en) 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US5614389A (en) * 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
DE4238699A1 (en) * 1992-11-17 1994-05-19 Boehringer Mannheim Gmbh Simple nucleic acid amplification method
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
CA2270132A1 (en) * 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US5863724A (en) * 1994-04-13 1999-01-26 Baylor College Of Medicine Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
US6593086B2 (en) 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
FR2724934B1 (en) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimera and its use in obtaining transcripts of a nucleic acid
US5789169A (en) * 1994-11-03 1998-08-04 Regents Of The University Of California Methods for the diagnosis of glaucoma
US5606043A (en) * 1994-11-03 1997-02-25 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5849879A (en) * 1994-11-03 1998-12-15 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5654141A (en) * 1994-11-18 1997-08-05 Thomas Jefferson University Amplification based detection of bacterial infection
EP0754939B1 (en) * 1995-02-02 2004-03-31 Yokogawa Electric Corporation Optical fibre detecting device
US5753787A (en) * 1995-04-10 1998-05-19 Yale University Nucleic acids encoding ancylostoma secreted protein
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2369007B1 (en) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6132954A (en) * 1996-08-20 2000-10-17 Baylor College Of Medicine Methods of screening for agents that delay a cell cycle and compositions comprising era and an analogue of wild-type era
US6071493A (en) 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6475724B1 (en) 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
JP2005504513A (en) 2001-05-09 2005-02-17 コリクサ コーポレイション Compositions and methods for prostate cancer therapy and diagnosis
US6713300B1 (en) 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
US6117643A (en) 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
AU2001399A (en) 1997-12-18 1999-07-05 Ecogen Inc. Insect-resistant transgenic plants and methods for improving delta-endotoxin activity against target insects
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
JP2004513615A (en) 2000-06-28 2004-05-13 コリクサ コーポレイション Compositions and methods for the treatment and diagnosis of lung cancer
US7029861B1 (en) 1998-09-15 2006-04-18 Board Of Regents, The University Of Texas System LPS-response gene compositions and methods
US7037682B2 (en) 1999-03-13 2006-05-02 Government Of The Republic Of Singapore In vitro activity assay for human hepatitis B virus (HBV) DNA polymerase, and its use for screening for inhibitors of HBV DNA polymerase
AU2150900A (en) 1998-11-16 2000-06-05 Board Of Regents, The University Of Texas System Hiv-specific t-cell induction
US6156515A (en) 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
JP2002542805A (en) 1999-04-30 2002-12-17 ユニバーシティ オブ フロリダ Adeno-associated virus delivery ribozyme compositions and methods of use
EP2325198A1 (en) 1999-06-01 2011-05-25 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence
JP2003510017A (en) 1999-06-22 2003-03-18 インビトロジェン コーポレイション Improved primers and methods for the detection and identification of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
AT389020T (en) 2000-04-21 2008-03-15 Corixa Corp Compounds and methods for treatment and diagnosis of Chlamydia infections
JP4813746B2 (en) 2000-07-10 2011-11-09 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ,センターズ フォー Chromosome 3p21.3 gene is a tumor suppressor
AU2897402A (en) 2000-12-13 2002-06-24 Nugen Technologies Inc Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
JP3853161B2 (en) * 2001-02-19 2006-12-06 独立行政法人科学技術振興機構 The method for amplifying a trace amount of mRNA and cDNA
NZ523167A (en) 2001-03-09 2006-08-31 Nugen Technologies Inc Methods, compositions and kits for amplifying RNA sequences of interest which employ an RNA/DNA composite primer
JP4338402B2 (en) 2001-05-22 2009-10-07 ユニバーシティ オブ シカゴ N4 virus single-stranded dna-dependent rna polymerase
US8137911B2 (en) 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
AU2003303395A1 (en) 2003-12-23 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
JP2004536614A (en) 2001-08-01 2004-12-09 ユニバーシティ オブ ユタUniversity Of Utah Pde3 cyclic nucleotide phosphodiesterase isoform selective inhibitors and activators
EP2135960A1 (en) 2001-09-19 2009-12-23 Intergenetics Incorporated Genetic analysis for stratification of cancer risk by determining the allelic profile of the VDR-ApaI and CYP11B2 genes
EP1908851A3 (en) 2001-09-19 2008-06-25 Intergenetics Incorporated Genetic analysis for stratification of cancer risk
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US20050059006A1 (en) 2001-12-10 2005-03-17 Sridhar Kudaravalli Methods of treating psychosis and schizophrenia based on polymorphisms in the cntf gene
ES2405405T3 (en) 2001-12-17 2013-05-31 Corixa Corporation Compositions and methods for therapy and diagnosis of inflammatory bowel disease
US6916474B2 (en) 2002-07-15 2005-07-12 Board Of Regents, The University Of Texas System Antibodies with increased affinities for anthrax antigens
ES2444699T3 (en) 2002-08-12 2014-02-26 Jennerex, Inc. Vaccinia virus for use in treating cancer
AU2002951411A0 (en) 2002-09-16 2002-09-26 The University Of Sydney Genotype screen
AU2003294440A1 (en) 2002-11-21 2004-06-18 Epicentre Technologies Methods for using riboprimers for strand displacement replication of target sequences
KR101110889B1 (en) 2003-01-06 2012-02-20 코릭사 코포레이션 Certain aminoalkyl glucosaminide phosphate compounds and their use
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
DE602004036672C5 (en) 2003-01-29 2012-11-29 454 Life Sciences Corporation Nucleic acid amplification-based beads emulsion
WO2004081225A2 (en) 2003-03-07 2004-09-23 Rubicon Genomics, Inc. Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process
EP1606419A1 (en) 2003-03-18 2005-12-21 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
WO2004092418A2 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
AT554166T (en) 2003-07-25 2012-05-15 Life Technologies Corp Methods and compositions for producing RNA from a fixed sample
DE602004030271D1 (en) 2003-09-12 2011-01-05 Univ Cincinnati Procedures for risk assessment, survival prediction and treatment of heart failure and other suffering on the basis of polymorphisms of adrenergic receptors
AT510928T (en) 2004-02-19 2011-06-15 Univ Alberta Leptin promoter polymorphisms and uses thereof
WO2005118810A1 (en) 2004-06-03 2005-12-15 Athlomics Pty Ltd Agents and methods for diagnosing stress
JP4933435B2 (en) 2004-09-14 2012-05-16 ザ ユニバーシティー オブ シンシナティ Bucindolol treatment method based on gene targeting
US9127305B2 (en) 2005-02-28 2015-09-08 Bioquest, Inc. Methods for performing direct enzymatic reactions involving nucleic acid molecules
EP2365079A1 (en) 2005-03-05 2011-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
US20090264305A1 (en) 2005-07-07 2009-10-22 Athlomics Pty Ltd. Polynucleotide Marker Genes and their Expression, for Diagnosis of Endotoxemia
US7494788B2 (en) 2005-07-11 2009-02-24 Molecular Kinetics, Inc. Entropic bristle domain sequences and their use in recombinant protein production
US7838646B2 (en) 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
EP1929046B1 (en) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
AU2006304883A1 (en) 2005-10-21 2007-04-26 Genenews Inc. Method and apparatus for correlating levels of biomarker products with disease
WO2007053358A2 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Methods for identifying compounds of interest using encoded libraries
EP2299267A3 (en) 2005-11-16 2011-05-04 Novartis AG Biomarkers for anti-NogoA antibody treatment in spinal cord injury
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
CA2653248C (en) 2006-05-25 2017-09-26 Monsanto Technology Llc A method to identify disease resistant quantitative trait loci in soybean and compositions thereof
JP5606067B2 (en) 2006-09-15 2014-10-15 オタワ ホスピタル リサーチ インスティテュート Oncolytic rhabdovirus
KR100823642B1 (en) * 2006-09-26 2008-04-21 고려대학교 산학협력단 A strain having productivity for cutinase, a selection method for the strain, a cutinase produced by the strain and a composition comprising the cutinase
EP2102239B1 (en) 2006-11-30 2012-04-25 Research Development Foundation Improved immunoglobulin libraries
AU2007336839C1 (en) * 2006-12-21 2013-12-19 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US8445267B2 (en) 2007-04-09 2013-05-21 University Of Florida Research Foundation, Inc. Tyrosine-modified recombinant rAAV vector compositions and methods for use
WO2008137475A2 (en) 2007-05-01 2008-11-13 Research Development Foundation Immunoglobulin fc libraries
EP2173872B1 (en) 2007-06-29 2014-04-02 CellScript, Inc. Copy dna and sense rna
EP2335363B1 (en) * 2008-08-29 2018-05-30 Telefonaktiebolaget LM Ericsson (publ) Fibre monitoring in optical networks
EP2421552B8 (en) 2009-04-22 2017-01-25 Indiana University Research and Technology Corporation Collagen v for use in the treatment of asthma
EP2449104B1 (en) 2009-06-29 2014-06-04 Luminex Corporation Chimeric primers with hairpin conformations and methods of using same
WO2011003020A1 (en) 2009-07-01 2011-01-06 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
DK3042957T3 (en) 2009-07-17 2018-01-02 Bioatla Llc At the same time, integrated selection and development of human protein-performance and expression in production hosts
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
BR112012005774A2 (en) 2009-09-14 2017-07-04 Jennerex Inc anticancer combination therapy vaccinia virus oncolytic
KR20110050327A (en) 2009-11-07 2011-05-13 주식회사 씨젠 T h d primer target detection
BR112012013664A2 (en) 2009-12-10 2017-07-04 Childrens Hospital Of Eastern Ontario Res Institute Inc oncolytic rhabdovirus
CA2784344C (en) 2009-12-21 2018-01-02 Seegene, Inc. Tsg primer target detection
US20130131161A1 (en) 2009-12-23 2013-05-23 Michael R. Bristow Methods and compositions for cardiovascular diseases and conditions
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
US20130281324A1 (en) 2010-04-16 2013-10-24 Nuevolution A/S Bi-functinal complexes and methods for making and using such complexes
BR112012026730A8 (en) 2010-04-23 2018-07-03 Univ Florida viral vector recombinant adeno-associated, virion, plurality of infectious viral particles, mammalian host cell, kit, composition, use, methods for preventing, treating or ameliorating the disease, disorder, disorder, failure or abnormal condition in the mammal one or more symptoms thereof to provide therapeutically effective amounts of peptide, polypeptide or guanylate protein adenylate biologically active mammal in need thereof, to increase the level of biologically active retgc1 protein in one or more retinal cell mammal and to treat or ameliorate one or more symptoms of retinal dystrophy in mammalian
KR101223660B1 (en) 2010-05-20 2013-01-17 광주과학기술원 Pharmaceutical Compositions for Preventing or Treating Arthritis Comprising HIF-2α Inhibitor as an Active Ingredient
KR101176139B1 (en) 2010-05-20 2012-08-22 광주과학기술원 Transgenic Mice Overexpressing HIF-2α as an Animal Model of Arthritis and Uses Thereof
CN105924499A (en) 2010-07-16 2016-09-07 生物蛋白有限公司 Novel methods of protein evolution
US9663834B2 (en) 2010-07-16 2017-05-30 Tocagen Inc. Retrovirus detection
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2857413A1 (en) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
WO2012094386A1 (en) 2011-01-04 2012-07-12 Jennerex Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
WO2012109133A1 (en) 2011-02-07 2012-08-16 Research Development Foundation Engineered immunoglobulin fc polypeptides
CA2828532A1 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
US9057107B2 (en) 2011-03-08 2015-06-16 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US20140287931A1 (en) 2011-04-04 2014-09-25 Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis Methods and compositions for predicting resistance to anticancer treatment
KR101291668B1 (en) 2011-04-21 2013-08-01 서울대학교산학협력단 Shuttle Vectors for Mycobacteria-Escherichia coli and Uses Thereof
JP6407714B2 (en) 2011-04-25 2018-10-17 アドヴァンスド バイオサイエンス ラボラトリーズ インコーポレイテッド Truncated hiv envelope protein (env), the method associated with the and compositions
WO2012167382A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
EP2723365A1 (en) 2011-06-21 2014-04-30 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
US9428535B2 (en) 2011-10-03 2016-08-30 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
WO2013090648A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
NZ624231A (en) 2011-11-14 2016-10-28 Nestec Sa Assays and methods for selecting a treatment regimen for a subject with depression
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
EP2809783A2 (en) 2012-02-02 2014-12-10 Invenra, Inc. High throughput screen for biologically active polypeptides
US9795596B2 (en) 2012-03-29 2017-10-24 Novartis Ag Pharmaceutical diagnostic
US20150064235A1 (en) 2012-03-30 2015-03-05 Moderna Therapeutics, Inc. Modified polynucleotides
AU2013243954A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9597380B2 (en) 2012-11-26 2017-03-21 Modernatx, Inc. Terminally modified RNA
EP2740805B1 (en) 2012-12-07 2019-02-20 SuppreMol GmbH Stratification and treatment of patients suffering from idiopathic thrombocytopenic purpura
CN104919191A (en) 2012-12-21 2015-09-16 精密公司 Fluidic circuits and related manufacturing methods
US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
KR101403507B1 (en) 2013-03-21 2014-06-09 주식회사 현일바이오 Methods for Selectively Detecting Mycobacterium tuberculosis complex and Nontuberculous mycobacteria and Kits Using the Same
KR101507505B1 (en) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 A Method for Diagnosing Myotonic Dystrophy Type 1
AU2014262726A1 (en) 2013-05-07 2015-11-12 Micronics, Inc. Device for preparation and analysis of nucleic acids
US10190153B2 (en) 2013-05-07 2019-01-29 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
WO2014183023A1 (en) 2013-05-09 2014-11-13 Trustees Of Boston University Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease
CA2935577A1 (en) 2014-01-07 2015-07-16 Bioatla, Llc Proteins targeting orthologs
EP3154693A1 (en) 2014-06-11 2017-04-19 Micronics, Inc. Microfluidic cartridges and apparatus with integrated assay controls for analysis of nucleic acids
KR101718800B1 (en) 2015-01-21 2017-03-24 주식회사 디알나노 Nanocomplexs for Co-delivering a Drug and siRNA and Uses Thereof
JP2018505893A (en) 2015-02-09 2018-03-01 リサーチ ディベロップメント ファウンデーション Engineered immunoglobulin fc polypeptide shows improved complement activation
US9789087B2 (en) 2015-08-03 2017-10-17 Thomas Jefferson University PAR4 inhibitor therapy for patients with PAR4 polymorphism
WO2017040380A2 (en) 2015-08-28 2017-03-09 Research Development Foundation Engineered antibody fc variants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Method and kits for the amplification and detection of nucleic acid sequences
US4819269A (en) * 1987-07-21 1989-04-04 Hughes Aircraft Company Extended imaging split mode loudspeaker system
AU618965B2 (en) * 1987-07-31 1992-01-16 Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
IE72468B1 (en) * 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences

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