AT557105T - Strategies for high passage identification and detection of polymorphisms - Google Patents

Strategies for high passage identification and detection of polymorphisms

Info

Publication number
AT557105T
AT557105T AT10184351T AT10184351T AT557105T AT 557105 T AT557105 T AT 557105T AT 10184351 T AT10184351 T AT 10184351T AT 10184351 T AT10184351 T AT 10184351T AT 557105 T AT557105 T AT 557105T
Authority
AT
Austria
Prior art keywords
polymorphisms
strategies
detection
high passage
passage identification
Prior art date
Application number
AT10184351T
Other languages
German (de)
Inventor
Eijk Michael Josephus Theresia Van
Der Poel Henricus Johannes Adam Van
Original Assignee
Keygene Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US69305305P priority Critical
Priority to EP06075104 priority
Priority to US75903406P priority
Application filed by Keygene Nv filed Critical Keygene Nv
Publication of AT557105T publication Critical patent/AT557105T/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/10—Methods of screening libraries by measuring physical properties, e.g. mass
AT10184351T 2005-06-23 2006-06-23 Strategies for high passage identification and detection of polymorphisms AT557105T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US69305305P true 2005-06-23 2005-06-23
EP06075104 2006-01-16
US75903406P true 2006-01-17 2006-01-17

Publications (1)

Publication Number Publication Date
AT557105T true AT557105T (en) 2012-05-15

Family

ID=36940150

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06757808T AT491045T (en) 2005-06-23 2006-06-23 Strategies with high throughput to identify and detect polymorphisms
AT10184351T AT557105T (en) 2005-06-23 2006-06-23 Strategies for high passage identification and detection of polymorphisms

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06757808T AT491045T (en) 2005-06-23 2006-06-23 Strategies with high throughput to identify and detect polymorphisms

Country Status (9)

Country Link
US (13) US8785353B2 (en)
EP (3) EP2302070B1 (en)
JP (2) JP5220597B2 (en)
CN (3) CN101641449B (en)
AT (2) AT491045T (en)
DE (1) DE602006018744D1 (en)
DK (2) DK2302070T3 (en)
ES (2) ES2393318T3 (en)
WO (1) WO2006137733A1 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006019855D1 (en) 2005-05-10 2011-03-10 Oregon State Method of mapping polymorphisms and polymorphism microarrays
JP5220597B2 (en) 2005-06-23 2013-06-26 キージーン ナムローゼ フェンノートシャップ Method for identifying one or more polymorphisms and methods of use thereof
CA2623539C (en) 2005-09-29 2015-12-15 Keygene N.V. High throughput screening of mutagenized populations
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
EP2363504A1 (en) 2005-12-22 2011-09-07 Keygene N.V. Method for high-throughtput AFLP-based polymorphism detection
US20090247415A1 (en) * 2005-12-22 2009-10-01 Keygene N.V. Strategies for trranscript profiling using high throughput sequencing technologies
US7932029B1 (en) * 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
WO2007114693A2 (en) 2006-04-04 2007-10-11 Keygene N.V. High throughput detection of molecular markers based on aflp and high throughput sequencing
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
AR066922A1 (en) 2007-06-08 2009-09-23 Monsanto Technology Llc Molecular breeding methods of plant germplasm directed by sequencing
WO2009040682A2 (en) * 2007-09-26 2009-04-02 Population Genetics Technologies Ltd. Methods and compositions for reducing the complexity of a nucleic acid sample
JP2012510810A (en) * 2008-12-04 2012-05-17 キージーン・エン・フェー Method for reducing repetitive sequences in adapter-linked restriction fragments
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
JP5799484B2 (en) 2009-12-14 2015-10-28 トヨタ自動車株式会社 Probe design method in DNA microarray, DNA microarray having probe designed by the method
ES2555106T3 (en) 2010-04-05 2015-12-29 Prognosys Biosciences, Inc. Spatially coded biological assays
CN102933721B (en) 2010-06-09 2015-12-02 凯津公司 For high throughput screening of combinatorial sequences barcode
CN103180459B (en) * 2010-07-09 2016-10-19 赛尔冉迪思股份有限公司 The sequencing strategy in 3-D genes of interest group region
CN102409046B (en) * 2010-09-21 2013-09-18 深圳华大基因科技服务有限公司 Small RNA (ribonucleic acid) tags
CN102409048B (en) * 2010-09-21 2013-10-23 深圳华大基因科技服务有限公司 DNA index library building method based on high throughput sequencing
GB201016484D0 (en) 2010-09-30 2010-11-17 Geneseque As Method
US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
CA2823815A1 (en) * 2011-01-14 2012-07-19 Keygene N.V. Paired end random sequence based genotyping
CA2840493A1 (en) 2011-06-27 2013-01-03 University Of Florida Research Foundation, Inc. Method for genome complexity reduction and polymorphism detection
CN102567652A (en) * 2011-12-13 2012-07-11 上海大学 SNP (single nucleotide polymorphism) data filtering method
CN108611398A (en) 2012-01-13 2018-10-02 Data生物有限公司 Genotyping is carried out by new-generation sequencing
PL2814959T3 (en) 2012-02-17 2018-07-31 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US20130281308A1 (en) * 2012-04-24 2013-10-24 Gen9, Inc. Methods for sorting nucleic acids and preparative in vitro cloning
WO2013163263A2 (en) * 2012-04-24 2013-10-31 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
KR101890140B1 (en) 2012-05-07 2018-09-28 삼성전자주식회사 A method for controlling a display apparatus using a camera device and mobile device, display apparatus, and system thereof
US9968901B2 (en) 2012-05-21 2018-05-15 The Scripps Research Institute Methods of sample preparation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
WO2015044412A1 (en) * 2013-09-30 2015-04-02 Qiagen Gmbh Dna-adapter-molecules for the preparation of dna-libraries and method for producing them and use
GB201319779D0 (en) * 2013-11-08 2013-12-25 Cartagenia N V Genetic analysis method
AU2015315103A1 (en) * 2014-09-09 2017-04-27 Igenomx International Genomics Corporation Methods and compositions for rapid nucleic acid library preparation
CN104450697B (en) * 2014-12-02 2017-01-11 中国科学院海洋研究所 SNP marker associated with oyster antiviral properties and application thereof
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
CN105420363A (en) * 2015-12-15 2016-03-23 江苏省中国科学院植物研究所 CDNA-AFLP method suitable for gene difference expression researches of wire grass
EP3433378A1 (en) 2016-03-22 2019-01-30 Vib Vzw Means and methods for amplifying nucleotide sequences
CN106480191A (en) * 2016-10-20 2017-03-08 南昌大学 A kind of method of river razor clam freshwater mussel F type mitochondrial genome complete sequence amplification
JP2018191598A (en) * 2017-05-19 2018-12-06 トヨタ自動車株式会社 Random primer sets and methods for preparing dna libraries using the same
CN107589193A (en) * 2017-10-25 2018-01-16 南京工业大学 A kind of method that protein inhibitor is screened using micro-reaction device
WO2019121603A1 (en) 2017-12-18 2019-06-27 Keygene N.V. Chemical mutagenesis of cassava

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04504356A (en) 1989-01-31 1992-08-06
US20100267023A1 (en) 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
HU223760B1 (en) 1991-09-24 2005-01-28 Keygene N.V. Selective restriction fragmentumsokszorosítás general method of DNA fingerprinting analysis
WO1995019697A1 (en) 1994-01-21 1995-07-27 North Carolina State University Methods for within family selection in woody perennials using genetic markers
EG23907A (en) * 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
EP0804618B1 (en) 1994-11-28 1999-01-27 E.I. Du Pont De Nemours And Company Compound microsatellite primers for the detection of genetic polymorphisms
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
AU6024598A (en) 1997-01-10 1998-08-03 Pioneer Hi-Bred International, Inc. Hybridization-based genetic amplification and analysis
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
ES2163271T3 (en) 1997-05-13 2002-01-16 Azign Bioscience As Procedure to clone differentially expressed mRNAs and display transcriptionists (dodets).
DE69838210T2 (en) 1997-12-15 2008-05-15 Csl Behring Gmbh Labeled primer, suitable for the detection of nucleic acids
CA2273616A1 (en) 1998-06-08 1999-12-08 The Board Of Trustees Of The Leland Stanford Junior University Method for parallel screening of allelic variation
DE69813203T2 (en) 1998-07-21 2004-02-12 Keygene N.V. Improved primer for AFLP amplification
DE69816286T2 (en) 1998-07-29 2004-05-27 Keygene N.V. A method for the detection of nucleic acid methylation by AFLP
US6232067B1 (en) 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US6361947B1 (en) 1998-10-27 2002-03-26 Affymetrix, Inc. Complexity management and analysis of genomic DNA
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
WO2000040755A2 (en) 1999-01-06 2000-07-13 Cornell Research Foundation, Inc. Method for accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US20040029155A1 (en) 1999-01-08 2004-02-12 Curagen Corporation Method for identifying a biomolecule
DE19911130A1 (en) 1999-03-12 2000-09-21 Hager Joerg A method for identifying chromosomal regions and genes
EP1190092A2 (en) 1999-04-06 2002-03-27 Yale University Fixed address analysis of sequence tags
US7169552B1 (en) 1999-04-09 2007-01-30 Keygene N.V. Detection of polymorphisms in AFLP fragments using primer extension techniques
US20020119448A1 (en) 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US20030204075A9 (en) 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
AU7712400A (en) 1999-09-23 2001-04-24 Gene Logic, Inc. Indexing populations
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
AU1413601A (en) 1999-11-19 2001-06-04 Takara Bio Inc. Method of amplifying nucleic acids
WO2001075167A1 (en) 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
US20040053236A1 (en) 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
EP1282729A2 (en) 2000-05-15 2003-02-12 Keygene N.V. Microsatellite-aflp
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
GB0016742D0 (en) 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
DE60131903T2 (en) 2000-10-24 2008-11-27 The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto Direct multiplex characterization of genomic dna
EA005141B1 (en) * 2001-02-15 2004-12-30 Такара Био Инк. Method of detecting nucleotide polymorphism
US7141364B1 (en) 2001-03-29 2006-11-28 Council Of Scientific And Industrial Research Universal primers for wildlife identification
EP1386005A1 (en) 2001-04-20 2004-02-04 Karolinska Innovations AB Methods for high throughput genome analysis using restriction site tagged microarrays
EP1417475A4 (en) 2001-07-06 2006-06-28 454 Corp Method for isolation of independent, parallel chemical micro-reactions using a porous filter
EP1362929A3 (en) 2002-05-17 2004-05-19 Affymetrix, Inc. Methods for genotyping
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7504222B2 (en) * 2001-10-31 2009-03-17 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
WO2004001074A1 (en) 2002-06-21 2003-12-31 Lynx Therapeutics, Inc. Method for detecting foreign dna in a host genome
AT358182T (en) * 2002-09-05 2007-04-15 Plant Bioscience Ltd Genome division
US20040157238A1 (en) 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
CA2510381C (en) 2002-12-18 2014-07-08 Third Wave Technologies, Inc. Detection of small nucleic acids
JP2004208586A (en) 2002-12-27 2004-07-29 Wakunaga Pharmaceut Co Ltd Detection of hla(human leukocyte antigen)
US7970548B2 (en) 2003-01-10 2011-06-28 Keygene N.V. AFLP-based method for integrating physical and genetic maps
EP2145955B1 (en) 2003-01-29 2012-02-22 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
JP4691014B2 (en) 2003-02-26 2011-06-01 カリダ ゲノミクス，インコーポレーテッド Random array DNA analysis by hybridization
JP4888876B2 (en) 2003-06-13 2012-02-29 英 夫 原 Recombinant adeno-associated virus vector for the treatment of Alzheimer's disease
US7365179B2 (en) 2003-09-09 2008-04-29 Compass Genetics, Llc Multiplexed analytical platform
US20050153317A1 (en) 2003-10-24 2005-07-14 Metamorphix, Inc. Methods and systems for inferring traits to breed and manage non-beef livestock
WO2005065814A1 (en) 2004-01-07 2005-07-21 Solexa Limited Modified molecular arrays
US20050233354A1 (en) 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
DE602005018166D1 (en) 2004-02-12 2010-01-21 Population Genetics Technologi Genetic analysis by sequence-specific sorting
US7709262B2 (en) 2004-02-18 2010-05-04 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
EP1574585A1 (en) * 2004-03-12 2005-09-14 Plant Research International B.V. Method for selective amplification of DNA fragments for genetic fingerprinting
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
DE602006019855D1 (en) 2005-05-10 2011-03-10 Oregon State Method of mapping polymorphisms and polymorphism microarrays
CN101278058A (en) 2005-06-23 2008-10-01 科因股份有限公司 Improved strategies for sequencing complex genomes using high throughput sequencing technologies
JP5220597B2 (en) 2005-06-23 2013-06-26 キージーン ナムローゼ フェンノートシャップ Method for identifying one or more polymorphisms and methods of use thereof
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
CA2623539C (en) 2005-09-29 2015-12-15 Keygene N.V. High throughput screening of mutagenized populations
CN101310024B (en) 2005-11-14 2012-10-03 科因股份有限公司 Method for high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites
EP2363504A1 (en) 2005-12-22 2011-09-07 Keygene N.V. Method for high-throughtput AFLP-based polymorphism detection
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
WO2007114693A2 (en) 2006-04-04 2007-10-11 Keygene N.V. High throughput detection of molecular markers based on aflp and high throughput sequencing
US20140051585A1 (en) * 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination

Also Published As

Publication number Publication date
EP1910562A1 (en) 2008-04-16
WO2006137733A1 (en) 2006-12-28
JP2008546404A (en) 2008-12-25
US20090036323A1 (en) 2009-02-05
US8785353B2 (en) 2014-07-22
US9898576B2 (en) 2018-02-20
US20170137872A1 (en) 2017-05-18
US20120316073A1 (en) 2012-12-13
US9023768B2 (en) 2015-05-05
JP5220597B2 (en) 2013-06-26
US20160145689A1 (en) 2016-05-26
US20180025111A1 (en) 2018-01-25
US9493820B2 (en) 2016-11-15
ES2393318T3 (en) 2012-12-20
US20170206314A1 (en) 2017-07-20
ES2387878T3 (en) 2012-10-03
US9376716B2 (en) 2016-06-28
US9898577B2 (en) 2018-02-20
US8685889B2 (en) 2014-04-01
EP1910562B1 (en) 2010-12-08
CN101641449B (en) 2014-01-29
US10235494B2 (en) 2019-03-19
EP2292788A1 (en) 2011-03-09
DK2302070T3 (en) 2012-11-26
DE602006018744D1 (en) 2011-01-20
EP2302070A2 (en) 2011-03-30
EP2292788B1 (en) 2012-05-09
US20140213462A1 (en) 2014-07-31
DK2292788T3 (en) 2012-07-23
US20180137241A1 (en) 2018-05-17
US10095832B2 (en) 2018-10-09
US20180247017A1 (en) 2018-08-30
US9896721B2 (en) 2018-02-20
CN105039313A (en) 2015-11-11
EP2302070B1 (en) 2012-08-22
EP2302070A3 (en) 2011-06-22
CN102925561B (en) 2015-09-09
US20150232924A1 (en) 2015-08-20
AT491045T (en) 2010-12-15
JP2013063095A (en) 2013-04-11
JP5823994B2 (en) 2015-11-25
US20140274744A1 (en) 2014-09-18
US9447459B2 (en) 2016-09-20
CN102925561A (en) 2013-02-13
US20190147977A1 (en) 2019-05-16
CN101641449A (en) 2010-02-03
US9453256B2 (en) 2016-09-27
US20160060686A1 (en) 2016-03-03
CN105039313B (en) 2018-10-23

Similar Documents

Publication Publication Date Title
DK1934179T3 (en) Methods and intermediates
DK1763584T3 (en) Compositions and Methods for the Extraction and Detection of Microbial ATP
FR2886532B1 (en) Method and system for detecting the fall of a person
DK1954274T3 (en) Substituted quinolones and methods of use
GB2429707B (en) Enzyme inhibitors
DK3457307T3 (en) Device for identification and authentication
DK2099447T3 (en) Imidazotriazines and imidazopyrimidines as kinase inhibitors
DK1940839T3 (en) Pyridopyrimidione Inhibitors of P13Ka
DK1997291T3 (en) Method and device for secure approval
AT545456T (en) Carbon dioxide detection and associated procedures
AT471311T (en) Inhibitors of 11-beta-hydroxysteroiddehydrogenase 1
EP1812049A4 (en) Kallikrein inhibitors and uses thereof
RU2007123360A (en) Pyrrolopyrazines and pyrazolopyrazines USEFUL AS PROTEINKINASE INHIBITORS
DK2402758T3 (en) Methods and uses for identifying the origin of a carcinoma of unknown primary origin
RU2007133111A (en) Compounds inhibiting raf and methods
GB0916071D0 (en) Assessment and analysis of software security flaws
AT429269T (en) Detector for atriates flimmenn and flatters
AT511128T (en) Statistical processing for the detection of anomalous situations
EP1893077A4 (en) System and method of computer-aided detection
EP2030011A4 (en) Systems and methods for analyzing nanoreporters
IL198487D0 (en) 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors
IL186045D0 (en) Human detection and tracking for security applications
EP2082382A4 (en) Multi-mode tags and methods of making and using the same
AT514939T (en) Method and system for the detection, classification and identification of particles
AT516661T (en) Method and system for customs monitoring