AT554785T - Modified fgf-21 polypeptides and their use - Google Patents

Modified fgf-21 polypeptides and their use

Info

Publication number
AT554785T
AT554785T AT08732507T AT08732507T AT554785T AT 554785 T AT554785 T AT 554785T AT 08732507 T AT08732507 T AT 08732507T AT 08732507 T AT08732507 T AT 08732507T AT 554785 T AT554785 T AT 554785T
Authority
AT
Austria
Prior art keywords
polypeptides
use
modified fgf
fgf
modified
Prior art date
Application number
AT08732507T
Other languages
German (de)
Inventor
Thomas Cujec
Roberto Mariani
Putnam Anna-Maria Hays
William Keefe
Nick Knudsen
Lillian Ho
Jason Pinkstaff
Vadim Kraynov
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US92129707P priority Critical
Priority to US98806007P priority
Application filed by Ambrx Inc filed Critical Ambrx Inc
Priority to PCT/US2008/057563 priority patent/WO2008121563A2/en
Publication of AT554785T publication Critical patent/AT554785T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factors [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y02A50/46Medical treatment of waterborne diseases characterized by the agent
    • Y02A50/468The waterborne disease being caused by a bacteria
    • Y02A50/473The waterborne disease being caused by a bacteria the bacteria being Escherichia coli, i.e. E. coli Infection
AT08732507T 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their use AT554785T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US92129707P true 2007-03-30 2007-03-30
US98806007P true 2007-11-14 2007-11-14
PCT/US2008/057563 WO2008121563A2 (en) 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their uses

Publications (1)

Publication Number Publication Date
AT554785T true AT554785T (en) 2012-05-15

Family

ID=39808850

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08732507T AT554785T (en) 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their use

Country Status (18)

Country Link
US (6) US8012931B2 (en)
EP (1) EP2068909B1 (en)
JP (3) JP2010523084A (en)
KR (4) KR101476472B1 (en)
CN (1) CN104163864B (en)
AT (1) AT554785T (en)
AU (1) AU2008232937B2 (en)
BR (1) BRPI0809583A2 (en)
CA (1) CA2682147C (en)
CY (1) CY1113188T1 (en)
DK (1) DK2068909T3 (en)
ES (1) ES2385114T3 (en)
HK (2) HK1134239A1 (en)
HR (1) HRP20120522T1 (en)
IL (2) IL200749A (en)
MX (1) MX2009010531A (en)
PT (1) PT2068909E (en)
WO (1) WO2008121563A2 (en)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
DE10163106A1 (en) * 2001-12-24 2003-07-10 Univ Hannover Medical implants, prostheses, prosthesis parts, medical instruments, equipment and aids from a halide-modified magnesium substance
US8013116B2 (en) 2004-11-29 2011-09-06 Universite Henri-Poincare-Nancy I Therapeutic peptides and method
EP2068909B1 (en) * 2007-03-30 2012-04-25 Ambrx, Inc. Modified fgf-21 polypeptides and their uses
ES2646614T3 (en) * 2007-08-03 2017-12-14 Eli Lilly And Company Use of a compound of FGF 21 and a compound of GLP 1 for the treatment of obesity
MX2010005317A (en) 2007-11-20 2010-06-02 Ambrx Inc Modified insulin polypeptides and their uses.
EA017690B1 (en) 2008-06-04 2013-02-28 Амген Инк. Fgf21 mutants and their use
AU2013211503C1 (en) * 2008-10-10 2016-09-29 Amgen Inc. FGF21 mutants and uses thereof
EA032727B1 (en) * 2008-10-10 2019-07-31 Амген Инк. Fgf21 mutant proteolysis-resistant polypeptide and use thereof
WO2010065439A1 (en) * 2008-12-05 2010-06-10 Eli Lilly And Company Variants of fibroblast growth factor 21
JP5599822B2 (en) 2009-01-23 2014-10-01 ノヴォ ノルディスク アー/エス FGF21 derivatives having albumin binder ABCDE and their use
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
AU2010246038A1 (en) 2009-05-05 2011-12-01 Amgen Inc. FGF21 mutants and uses thereof
TWI560197B (en) 2009-05-05 2016-12-01 Amgen Inc Fgf21 mutants and uses thereof
JP2013533227A (en) 2010-06-08 2013-08-22 ノヴォ ノルディスク アー/エス FGF21 analogs and derivatives
WO2010148142A1 (en) * 2009-06-17 2010-12-23 Amgen Inc. Chimeric fgf19 polypeptides and uses thereof
CN101993485B (en) 2009-08-20 2013-04-17 重庆富进生物医药有限公司 Peptide analog homologous dimer capable of accelerating insulin secretion and application thereof
WO2011058193A1 (en) 2009-11-16 2011-05-19 Mellitech [1,5]-diazocin derivatives
EP2506861A1 (en) * 2009-12-02 2012-10-10 Amgen Inc. Binding proteins that bind to human fgfr1c, human b-klotho and both human fgfr1c and human b-klotho
UA109888C2 (en) * 2009-12-07 2015-10-26 Isolated antibody or fragment thereof that binds to β-Klotho, FGF receptors and their complexes
EP2359843A1 (en) 2010-01-21 2011-08-24 Sanofi Pharmaceutical composition for treating a metabolic syndrome
WO2011130417A2 (en) 2010-04-15 2011-10-20 Amgen Inc. HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS
US20130116171A1 (en) 2010-04-16 2013-05-09 Salk Institute For Biological Studies Methods for treating metabolic disorders using fgf
WO2012010553A1 (en) 2010-07-20 2012-01-26 Novo Nordisk A/S N-terminal modified fgf21 compounds
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
NZ607069A (en) 2010-08-17 2014-10-31 Ambrx Inc Modified relaxin polypeptides and their uses
CN101935346B (en) * 2010-08-24 2012-08-08 哈尔滨博翱生物医药技术开发有限公司 Mutated human-source fibroblast growth factor and application in treating endocrine diseases
MX2013005075A (en) 2010-11-05 2013-05-28 Pfizer Anti-diabetic compounds.
US9023791B2 (en) 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
JP6162606B2 (en) 2011-01-14 2017-07-12 レッドウッド バイオサイエンス, インコーポレイテッド Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
JP2014512814A (en) * 2011-04-08 2014-05-29 アンセム・バイオサイエンシズ・プライベート・リミテッド A novel expression and secretion vector system for heterologous protein production in E. coli
WO2012140650A2 (en) * 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
WO2012151349A1 (en) 2011-05-03 2012-11-08 Liu Shu Q Neuroprotection by hepatic cells and hepatocyte secretory factors
TWI527590B (en) 2011-06-17 2016-04-01 Ares Trading Sa Lyophilized formulations of Fgf-18
WO2013006486A2 (en) 2011-07-01 2013-01-10 Ngm Biopharmaceuticals, Inc. Compositions, uses and methods for treatment of metabolic disorders and diseases
EP2548570A1 (en) 2011-07-19 2013-01-23 Sanofi Pharmaceutical composition for treating a metabolic syndrome
EP2750695A2 (en) * 2011-08-31 2014-07-09 Amgen Inc. Method of treating or ameliorating type 1 diabetes using fgf21
TW201315742A (en) 2011-09-26 2013-04-16 Novartis Ag Dual fuction proteins for treating metabolic disorders
AR087973A1 (en) 2011-10-04 2014-04-30 Lilly Co Eli Variants of factor fibroblast growth 21
NZ623185A (en) 2011-10-07 2016-01-29 Takeda Pharmaceutical 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
ES2623786T3 (en) 2011-12-22 2017-07-12 Pfizer Inc. Purification procedure of an H38C2 antibody sample
ES2640268T3 (en) 2012-02-15 2017-11-02 Novo Nordisk A/S Antibodies that bind to and block a trigger receptor expressed in myeloid cells 1 (TREM-1)
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
LT2814842T (en) 2012-02-15 2018-11-12 Novo Nordisk A/S Antibodies that bind peptidoglycan recognition protein 1
WO2013131091A1 (en) 2012-03-02 2013-09-06 New York University Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders
MX2014013913A (en) * 2012-05-15 2015-02-17 Lilly Co Eli Therapeutic uses of fibroblast growth factor 21 proteins.
US9474785B2 (en) * 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
US9464126B2 (en) * 2012-06-07 2016-10-11 New York University Chimeric fibroblast growth factor 21 proteins and methods of use
ES2632078T3 (en) 2012-06-11 2017-09-08 Eli Lilly And Company Fibroblast growth factor variants 21
TWI513705B (en) * 2012-06-11 2015-12-21 Lilly Co Eli Fibroblast growth factor 21 proteins
US8955588B2 (en) * 2012-09-10 2015-02-17 Halliburton Energy Services, Inc. Electron-poor orthoester for generating acid in a well fluid
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
CA2892152A1 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
KR20150104579A (en) 2012-12-27 2015-09-15 엔지엠 바이오파마슈티컬스, 아이엔씨. Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US9550820B2 (en) 2013-02-22 2017-01-24 New York University Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use
US20160235810A1 (en) 2013-10-18 2016-08-18 Novartis Ag Methods of treating diabetes and related disorders
WO2015061331A1 (en) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
SG11201603134XA (en) 2013-10-21 2016-05-30 Salk Inst For Biological Studi Mutated fibroblast growth factor (fgf) 1 and methods of use
AU2014342630A1 (en) 2013-10-28 2016-05-05 Ngm Biopharmaceuticals, Inc. Cancer models and associated methods
EP3097122A4 (en) 2014-01-24 2017-09-20 NGM Biopharmaceuticals, Inc. Binding proteins and methods of use thereof
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
CN106536559A (en) 2014-07-17 2017-03-22 诺和诺德股份有限公司 Site directed mutagenesis of TREM-1 antibodies for decreasing viscosity
KR20170070227A (en) 2014-10-24 2017-06-21 브리스톨-마이어스 스큅 컴퍼니 Modified fgf-21 polypeptides and uses thereof
WO2016073855A1 (en) 2014-11-07 2016-05-12 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
BR112017011552A2 (en) 2014-12-23 2018-02-14 Novo Nordisk As fgf21 derivatives and their use
KR20160088656A (en) 2015-01-16 2016-07-26 주식회사유한양행 Long-acting fgf21 fusion proteins and pharmaceutical composition comprising the same
CN105018482B (en) * 2015-07-21 2017-10-24 吉林大学 A kind of heterozygosis tRNA and its application in glutathione peroxidase is prepared
TW201731867A (en) 2015-12-02 2017-09-16 賽諾菲公司 FGF21 variants
US20190201491A1 (en) * 2016-08-22 2019-07-04 Elanco Us Inc. Bovine fibroblast growth factor 21 and ketosis in dairy cattle
TW201837051A (en) 2017-02-08 2018-10-16 美商必治妥美雅史谷比公司 Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
WO2019043457A2 (en) * 2017-09-04 2019-03-07 89Bio Ltd. Mutant fgf-21 peptide conjugates and uses thereof
WO2019051073A1 (en) 2017-09-08 2019-03-14 Bristol-Myers Squibb Company Modified fibroblast growth factor 21 (fgf-21) for use in methods for treating nonalcoholic steatohepatitis (nash)

Family Cites Families (305)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2968158A (en) 1955-08-08 1961-01-17 Upjohn Co New benzene sulfonyl ureas; composition and process for lowering blood sugar therewith
US3097242A (en) 1960-06-29 1963-07-09 Olin Mathieson Hydrindene sulfonylureas
US3454635A (en) 1965-07-27 1969-07-08 Hoechst Ag Benzenesulfonyl-ureas and process for their manufacture
NL132376C (en) 1966-02-10
DE1670952B2 (en) 1967-11-25 1975-05-28 Bayer Ag, 5090 Leverkusen
CH505071A (en) 1968-04-26 1971-03-31 Hoffmann La Roche Sulphonylurea derivs hypoglycaemic
NL138933B (en) 1969-03-26 1973-05-15 Erba Carlo Spa A process for the preparation of benzeensulfonylureumderivaten with blood sugar-lowering action.
US3708486A (en) 1969-04-17 1973-01-02 Boehringer Sohn Ingelheim 2-(p-(n'-cycloalkyl-carbamido-n-sulfonyl)-phenethyl)-1,2,3,4-tetrahydro-1,3-dioxo-4,4-dimethyl-isoquinolines and alkali metal salts thereof
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
JPS6242903B2 (en) 1978-08-04 1987-09-10 Takeda Chemical Industries Ltd
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
ZA8101368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
EP0052322B1 (en) 1980-11-10 1985-03-27 Gersonde, Klaus, Prof. Dr. Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
FR2504010B1 (en) 1981-04-15 1985-10-25 Sanofi Sa Anticancer drugs containing the A chain of ricin has an associated anti-melanoma antibody, and process for their preparation
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
JPH026337B2 (en) 1981-06-10 1990-02-08 Ajinomoto Kk
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
DE3218121A1 (en) 1982-05-14 1983-11-17 Leskovar Peter Dr Ing Pharmaceutical compositions for tumour treatment
EP0102324A3 (en) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipids and surfactants in an aqueous medium
US4512922A (en) 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4820352A (en) 1983-01-10 1989-04-11 Bausch & Lomb Incorporated Cleaning and conditioning solutions for contact lenses and methods of use
CA1341116C (en) 1983-02-22 2000-10-17 Rae Lyn Burke Yeast expression systems with vectors having gapdh or pyk promoters and synthesis or foreign protein
US4876197A (en) 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
US4880734A (en) 1984-05-11 1989-11-14 Chiron Corporation Eukaryotic regulatable transcription
US5089398A (en) 1983-02-22 1992-02-18 Chiron Corporation Enhanced yeast transcription employing hybrid GAPDH promoter region constructs
JPS6240999B2 (en) 1983-03-09 1987-09-01 Teruhiko Betsupu
US4859600A (en) 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
US4755465A (en) 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
DE3485810D1 (en) 1983-05-27 1992-08-20 Texas A & M Univ Sys A method for producing a recombinant baculovirus expression vector.
DE3320583A1 (en) 1983-06-08 1984-12-13 Thomae Gmbh Dr K Novel pharmaceutical preparation forms of oral antidiabetic and process for their manufacture
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
JPH0428412B2 (en) 1983-06-29 1992-05-14 Daiichi Seiyaku Co
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US4689406A (en) 1983-08-10 1987-08-25 Amgen Enhancement of microbial expression of polypeptides
JPH0231079B2 (en) 1983-08-30 1990-07-11 Sankyo Co Chiazorijinjudotaioyobisonoseizoho
AT59966T (en) 1983-09-26 1991-02-15 Ehrenfeld Udo Agents and produce for the diagnosis and therapy of tumors and for the treatment of weaknesses of the cellular and humoral immune defense.
DE3474511D1 (en) 1983-11-01 1988-11-17 Terumo Corp Pharmaceutical composition containing urokinase
ZA8408495B (en) 1984-01-31 1985-09-25 Idaho Res Found Production of polypeptides in insect cells
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
EP0164556B1 (en) 1984-05-11 1994-03-02 Chiron Corporation Enhanced yeast transcription employing hybrid promoter region constructs
US4542225A (en) 1984-08-29 1985-09-17 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
US4738921A (en) 1984-09-27 1988-04-19 Eli Lilly And Company Derivative of the tryptophan operon for expression of fused gene products
US4659839A (en) 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US4837148A (en) 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
GB8430252D0 (en) 1984-11-30 1985-01-09 Beecham Group Plc Compounds
EP0188256B1 (en) 1985-01-14 1991-08-21 NeoRx Metal radionuclide labeled proteins for diagnosis and therapy
AR240698A1 (en) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Process for the preparation of 5-(4-(2-(5-ethyl-2-pyridil)-ethoxy)benzyl)-2,4-thiazolodinedione and their salts
DE3675588D1 (en) 1985-06-19 1990-12-20 Ajinomoto Kk Hemoglobin, which is bound to a poly (alkenylenoxid).
EP0229108B1 (en) 1985-06-26 1990-12-27 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4680338A (en) 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
WO1990010277A1 (en) 1989-02-24 1990-09-07 Cell Analysis Systems, Inc. Method and apparatus for determining a proliferation index of a cell sample
US4699784A (en) 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
JPS63123383A (en) 1986-11-11 1988-05-27 Mitsubishi Kasei Corp Hybrid promoter, manifestation regulating dna sequence and manifestation vector
US5186933A (en) 1986-12-30 1993-02-16 Baylor College Of Medicine Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system
US4873255A (en) 1987-02-04 1989-10-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
WO1988007082A1 (en) 1987-03-16 1988-09-22 American Biogenetic Sciences, Inc. Recombinant baculovirus occlusion bodies in vaccines and biological insecticides
CA1304020C (en) 1987-03-23 1992-06-23 Meher H. Irani High level expression in yeast
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
AU2251488A (en) 1987-07-24 1989-03-01 Cetus Corporation Production of biologically active forms of csf using a baculovirus (acnpv)-insect cell expression system
AU2136788A (en) 1987-07-24 1989-03-01 Cetus Corporation Production of ricin toxins in a baculovirus-insect cell expression system
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
SG59988A1 (en) 1987-09-04 1999-02-22 Beecham Group Plc Substituted thiazolidinedione derivatives
US4929555A (en) 1987-10-19 1990-05-29 Phillips Petroleum Company Pichia transformation
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
CA1340772C (en) 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
US4847325A (en) 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5120754A (en) 1988-03-08 1992-06-09 Pfizer Inc. Thiazolidinedione hypoglycemic agents
US5223522A (en) 1988-03-08 1993-06-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
WO1989008650A1 (en) 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
US5674706A (en) 1988-05-06 1997-10-07 Chiron Corporation High level expression of proteins in yeast
CA1324969C (en) 1988-05-06 1993-12-07 Jeffrey R. Shuster High level expression of proteins in yeast
FR2631974B1 (en) 1988-05-31 1992-12-11 Agronomique Inst Nat Rech Baculovirus changes, process for its preparation and its application as a gene expression vector
WO1990001556A1 (en) 1988-08-05 1990-02-22 Mount Sinai School Of Medicine Of The City University Of New York In vivo infection of live insects with a recombinant baculovirus
GB8819453D0 (en) 1988-08-16 1988-09-21 Roy P Production of bluetongue virus non-structural proteins using baculovirus expression vector
NZ230425A (en) 1988-09-02 1992-07-28 Molecular Eng Ass Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector
US5218092A (en) 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
GB8824591D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Fractionation process
AT189526T (en) 1988-10-28 2000-02-15 Genentech Inc A method for detecting active domains and amino acid residues in polypeptides and hormone variant
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
JPH04504651A (en) 1988-11-18 1992-08-20
AT135370T (en) 1988-12-22 1996-03-15 Kirin Amgen Inc Chemically modified granulocyte colony-causing factor
US4902502A (en) 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
AU5187190A (en) 1989-02-23 1990-09-26 University Of Ottawa Improved baculovirus expression system capable of producing foreign gene proteins at high levels
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
ES2247656T3 (en) 1989-04-19 2006-03-01 Enzon, Inc. A process for forming a modified polypeptide comprising a polypeptide and polyalkylene oxide.
US4897405A (en) 1989-04-21 1990-01-30 American Home Products Corporation Novel naphthalenylalkyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
US5766883A (en) 1989-04-29 1998-06-16 Delta Biotechnology Limited Polypeptides
WO1990014428A1 (en) 1989-05-17 1990-11-29 University Of Georgia Research Foundation, Inc. Improved baculovirus expression vectors
DK0400472T3 (en) 1989-05-27 1996-05-13 Sumitomo Pharma A process for preparing polyethylene glycol derivatives and modified protein
FR2649120B1 (en) 1989-06-30 1994-01-28 Cayla New strain and mutants of filamentous fungi, recombinant protein production process using said strain, and strains and proteins obtained according to such process
US5258185A (en) 1989-08-23 1993-11-02 Bauer Kurt H Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use
GB8919434D0 (en) 1989-08-25 1989-10-11 Beecham Group Plc Novel compounds
US5162601A (en) 1989-11-22 1992-11-10 The Upjohn Company Plant potyvirus expression vector with a gene for protease
US5312808A (en) 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
FR2664905B1 (en) 1990-07-18 1994-08-12 Agronomique Inst Nat Rech Baculovirus change, its process of preparation and expression vectors obtained from said baculovirus.
WO1992001800A1 (en) 1990-07-20 1992-02-06 Chiron Corporation Method for integrative transformation of yeast using dispersed repetitive elements
WO1992002628A1 (en) 1990-08-02 1992-02-20 Chiron Corporation Expression of human cmv glycoprotein-h using the baculovirus-insect cell expression system
CA2090969C (en) 1990-09-04 2001-08-21 Russell Arthur Brierley Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5492821A (en) 1990-11-14 1996-02-20 Cargill, Inc. Stabilized polyacrylic saccharide protein conjugates
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
DK0564531T3 (en) 1990-12-03 1998-09-28 Genentech Inc Enrichment process of variant proteins with altered binding properties
US5231178A (en) 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
WO1992016555A1 (en) 1991-03-18 1992-10-01 Enzon, Inc. Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
AU1651992A (en) 1991-03-19 1992-10-21 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Expression of influenza nucleoprotein antigens in baculovirus
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US6126944A (en) 1991-04-26 2000-10-03 The United States Of America As Represented By The Department Of Health And Human Services Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus
US5281698A (en) 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5290686A (en) 1991-07-31 1994-03-01 The United States Of America As Represented By The Department Of Health And Human Services Expression of influenza a M2 protein in baculovirus
IT1260468B (en) 1992-01-29 1996-04-09 A method for maintaining the activity 'of proteolytic enzymes modified with polyethylene glycol
FR2686899B1 (en) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa New biologically active polypeptides, their preparation and pharmaceutical compositions containing them.
EP0636156B1 (en) 1992-04-14 1997-07-30 Cornell Research Foundation, Inc. Dendritic based macromolecules and method of production
US5516657A (en) 1992-05-11 1996-05-14 Cambridge Biotech Corporation Baculovirus vectors for expression of secretory and membrane-bound proteins
ZA9303926B (en) 1992-06-17 1994-01-03 Amgen Inc Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
AU5006993A (en) 1992-08-21 1994-03-15 Enzon, Inc. Novel attachment of polyalkylene oxides to bio-effecting substances
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
NZ250375A (en) 1992-12-09 1995-07-26 Ortho Pharma Corp Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
AU6029594A (en) 1993-01-15 1994-08-15 Enzon, Inc. Factor viii - polymeric conjugates
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5532142A (en) 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides
IL104734D0 (en) 1993-02-15 1993-06-10 Univ Bar Ilan Bioactive conjugates of cellulose with amino compounds
WO1994028024A1 (en) 1993-06-01 1994-12-08 Enzon, Inc. Carbohydrate-modified polymer conjugates with erythropoietic activity
WO1995000162A1 (en) 1993-06-21 1995-01-05 Enzon, Inc. Site specific synthesis of conjugated peptides
GB9317618D0 (en) 1993-08-24 1993-10-06 Royal Free Hosp School Med Polymer modifications
US5762939A (en) 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
US5874454A (en) 1993-09-15 1999-02-23 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5491076A (en) 1993-11-01 1996-02-13 The Texas A&M University System Expression of foreign genes using a replicating polyprotein producing virus vector
US5605792A (en) 1993-11-04 1997-02-25 The Ohio State University Research Foundation Infectious bursal disease virus VP2 fusion protein expressed by baculovirus, use as diagnostic
US5951974A (en) 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
KR960705579A (en) 1993-11-10 1996-11-08 에릭에스. 딕커 An improved interferon-polymer conjugate (Improved interferon polymer conjugates)
US5738846A (en) 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
FR2715664B1 (en) 1994-01-31 1996-04-12 Proteine Performance Sa Recombinant baculovirus and its use for the production of monoclonal antibodies.
JP3090586B2 (en) 1994-03-15 2000-09-25 片倉工業株式会社 Cysteine ​​protease gene defective baculovirus and their preparation as well as preparation of useful proteins using this
US5473034A (en) 1994-03-18 1995-12-05 Hyogo Prefectural Government Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
US5629384A (en) 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
AU2826495A (en) 1994-06-02 1996-01-04 Enzon, Inc. Method of solubilizing substantially water insoluble materials
US5730990A (en) 1994-06-24 1998-03-24 Enzon, Inc. Non-antigenic amine derived polymers and polymer conjugates
US6403375B1 (en) 1994-08-24 2002-06-11 Boyce Thompson Institute For Plant Research, Inc. Establishment of Trichoplusia ni cell lines in serum-free medium for recombinant protein and baculovirus production
US5650234A (en) 1994-09-09 1997-07-22 Surface Engineering Technologies, Division Of Innerdyne, Inc. Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
US5871986A (en) 1994-09-23 1999-02-16 The General Hospital Corporation Use of a baculovirus to express and exogenous gene in a mammalian cell
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
WO1996041813A2 (en) 1994-11-09 1996-12-27 Offord Robin E Functionalized polymers for site-specific attachment
IL116085A (en) 1994-12-16 1999-12-31 Ortho Pharma Corp Spray dried erythropoietin
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
EP0842275A1 (en) 1995-02-17 1998-05-20 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) PRODUCTION OF BIOLOGICALLY ACTIVE RECOMBINANT BOVINE FOLLICLE STIMULATING HORMONE (REC bFSH) IN THE BACULOVIRUS EXPRESSION SYSTEM
FR2732035B1 (en) 1995-03-23 1997-05-30 Agronomique Inst Nat Rech A method of regulating expression of a gene in a baculovirus by a binding site of a retinoic acid receptor, and vector for the implementation of said METHOD
US6184344B1 (en) 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
NZ308772A (en) 1995-05-17 1999-04-29 Du Pont Recombinant baculovirus insecticides
US6852502B1 (en) 1995-06-06 2005-02-08 Bioveris Corporation Electrochemiluminescent enzyme biosensors
WO1996040662A2 (en) * 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
AU5893696A (en) 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US5861279A (en) 1996-01-17 1999-01-19 Schering Corporation Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
AU1690697A (en) 1996-01-17 1997-08-11 Schering Corporation Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin antagonists
US5747639A (en) 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
EP0964702B1 (en) 1996-08-02 2006-10-04 Ortho-McNeil Pharmaceutical, Inc. Polypeptides having a single covalently bound n-terminal water-soluble polymer
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
WO1998026080A1 (en) 1996-12-13 1998-06-18 Chiron Corporation Method for expression of heterologous proteins in yeast
JP2001508783A (en) 1997-01-29 2001-07-03 ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー Peg Act
GB9703406D0 (en) 1997-02-19 1997-04-09 Chiron Spa Expression of heterologous proteins
US5859037A (en) 1997-02-19 1999-01-12 Warner-Lambert Company Sulfonylurea-glitazone combinations for diabetes
US6057338A (en) 1997-04-04 2000-05-02 Merck & Co., Inc. Somatostatin agonists
US6025372A (en) 1997-04-04 2000-02-15 Merck & Co., Inc. Somatostatin agonists
AU7266898A (en) 1997-04-30 1998-11-24 Enzon, Inc. Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
JP4011124B2 (en) 1997-06-06 2007-11-21 協和醗酵工業株式会社 Chemically modified polypeptide
US5965393A (en) 1997-07-01 1999-10-12 National Institute Of Immunology Method for enhancing foreign gene expression in baculovirus expression vector system
IL133974D0 (en) 1997-07-14 2001-04-30 Bolder Biotechnology Inc Derivatives of growth hormone and related proteins
GB9715660D0 (en) 1997-07-25 1997-10-01 Zeneca Ltd Proteins
EP1003889A1 (en) 1997-08-05 2000-05-31 Chiron Corporation NOVEL $i(PICHIA PASTORIS) GENE SEQUENCES AND METHODS FOR THEIR USE
DE19735593C2 (en) 1997-08-15 1999-08-26 Hepavec Ag Fuer Gentherapie Coat protein modified baculovirus vector for gene therapy
US6090584A (en) 1997-08-21 2000-07-18 University Technologies International Inc. Baculovirus artificial chromosomes and methods of use
US5989868A (en) 1997-09-12 1999-11-23 The Board Of Regents Of The University Of Oklahoma Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
EP1538206B1 (en) 1997-09-16 2010-03-24 Centocor, Inc. Method for the complete chemical synthesis and assembly of genes and genomes
WO1999016318A1 (en) 1997-09-26 1999-04-08 Uab Research Foundation Reduced antigenic cells and uses therefor
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6004573A (en) 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
AU1285499A (en) 1997-10-30 1999-05-24 Merck & Co., Inc. Somatostatin agonists
DE19748489A1 (en) 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylene glycol derivatized biomolecules and their use in heterogeneous detection methods
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
EP0924298A1 (en) 1997-12-18 1999-06-23 Bayer Ag Protein expression in baculovirus vector expression systems
US5981709A (en) 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
AU2898299A (en) 1998-03-04 1999-09-20 Onyx Pharmaceuticals, Inc. Baculovirus expression system and method for high throughput expression of genetic material
AT279430T (en) 1998-03-05 2004-10-15 Chiron Corp Process for improving the serum half-life of biologically active molecules
PT1061954E (en) 1998-03-12 2004-10-29 Nektar Therapeutics Al Corp Poly (ethylene glycol) derivatives with next reactive groups
KR100264953B1 (en) 1998-04-03 2000-06-08 박현우 Recombinant baculovirus, process for preparing thereof and microbial insecticides containing same
US6451986B1 (en) 1998-06-22 2002-09-17 Immunex Corporation Site specific protein modification
US6168932B1 (en) 1998-07-13 2001-01-02 Parker Hughes Institute Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system
US6245528B1 (en) 1998-07-28 2001-06-12 Academia Sinica Latent baculovirus expression system
US6368825B1 (en) 1998-08-10 2002-04-09 Academia Sinica Baculovirus containing minimal CMV promoter
DE69936322T2 (en) 1998-08-28 2008-02-21 Amylin Pharmaceuticals, Inc., San Diego Polyamide chains of exact length and their conjugates with proteins
WO2000020032A1 (en) 1998-10-06 2000-04-13 Trustees Of Dartmouth College RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
ES2289824T3 (en) 1998-10-30 2008-02-01 Novozymes A/S Glycosilated proteins with reduced allergenicity.
US6451346B1 (en) 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US6342216B1 (en) 1999-03-17 2002-01-29 The Board Of Regents, The University Of Texas System Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
US6994986B2 (en) 1999-03-17 2006-02-07 The Board Of Trustees Of The Leland Stanford University In vitro synthesis of polypeptides by optimizing amino acid metabolism
AU4325900A (en) 1999-03-17 2000-10-04 Board Of Trustees Of The Leland Stanford Junior University In vitro macromolecule biosynthesis methods using exogenous amino acids and a novel atp regeneration system
US6337191B1 (en) 1999-03-22 2002-01-08 The Board Of Trustees Of The Leland Stanford Junior University Vitro protein synthesis using glycolytic intermediates as an energy source
US6423790B1 (en) 1999-04-16 2002-07-23 William Marsh Rice University Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers
US6261805B1 (en) 1999-07-15 2001-07-17 Boyce Thompson Institute For Plant Research, Inc. Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US7408047B1 (en) * 1999-09-07 2008-08-05 Amgen Inc. Fibroblast growth factor-like polypeptides
CA2386517A1 (en) 1999-10-07 2001-04-12 Takeda Chemical Industries, Ltd. Amine derivatives
AU2039501A (en) 1999-10-15 2001-04-23 Rockefeller University, The System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae
WO2001032678A1 (en) 1999-11-05 2001-05-10 Smithkline Beecham Corporation sbgFGF-19a
ES2225252T3 (en) 1999-11-10 2005-03-16 Takeda Chemical Industries, Ltd. N-heterocyclic compounds with 5-membered hypoglycaemic and hypolipidaemic activity.
US6716626B1 (en) 1999-11-18 2004-04-06 Chiron Corporation Human FGF-21 nucleic acids
EP2163626A1 (en) * 1999-11-18 2010-03-17 Novartis Vaccines and Diagnostics, Inc. Human FGF-21 gene and gene expression products
US6348558B1 (en) 1999-12-10 2002-02-19 Shearwater Corporation Hydrolytically degradable polymers and hydrogels made therefrom
DE60026073T2 (en) 1999-12-22 2006-09-28 Nektar Therapeutics Al, Corp., Huntsville Sterically hindered derivatives of water-soluble polymeric
AT424431T (en) 1999-12-22 2009-03-15 Nektar Therapeutics Al Corp Process for preparing 1-benzotriazolcarbonate starter of water-soluble polymers
US6413507B1 (en) 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US6646110B2 (en) 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
WO2001062827A2 (en) 2000-02-22 2001-08-30 Shearwater Corporation N-maleimidyl polymer derivatives
AU5757701A (en) 2000-02-28 2001-09-03 Shearwater Corp Water-soluble polymer conjugates of artelinic acid
WO2001068854A2 (en) * 2000-03-13 2001-09-20 Amgen, Inc. Fibroblast growth factor-like molecules and uses thereof
GB0012997D0 (en) 2000-05-26 2000-07-19 Eurogene Limited Gene delivery
US6586207B2 (en) 2000-05-26 2003-07-01 California Institute Of Technology Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
JP2002030098A (en) 2000-07-17 2002-01-29 Institute Of Immunology Co Ltd Method for recovering virion envelope from budded virus of baculovirus
US7030218B2 (en) 2000-09-08 2006-04-18 Gryphon Therapeutics Pseudo native chemical ligation
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US20040138412A1 (en) 2001-09-07 2004-07-15 Paolo Botti Extended native chemical ligation
US6436386B1 (en) 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
TW593427B (en) 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7083970B2 (en) 2001-04-19 2006-08-01 The Scripps Research Institute Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
GB0113657D0 (en) 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components
AU2002322394A1 (en) 2001-07-30 2003-02-17 Eli Lilly And Company Method for treating diabetes and obesity
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
WO2003042204A1 (en) 2001-10-19 2003-05-22 Takeda Chemical Industries, Ltd. Amine derivative
MXPA04004336A (en) 2001-11-07 2005-05-16 Nektar Therapeutics Al Corp Branched polymers and their conjugates.
JP4399627B2 (en) 2001-11-14 2010-01-20 ジェネプロット インコーポレーティッド Chemical peptide ligation with three or more components
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
CA2468610A1 (en) 2002-01-15 2003-07-24 Eli Lilly And Company Method for reducing morbidity and mortality in critically ill patients
CA2476425C (en) 2002-02-15 2012-04-17 The Research Foundation Of State University Of New York At Buffalo Ribozymes with broad trna aminoacylation activity
DE60332725D1 (en) 2002-05-30 2010-07-08 Scripps Research Inst Copper-catalyzed leading of azides and acetylenes
WO2004035605A2 (en) 2002-10-16 2004-04-29 The Scripps Research Institute Glycoprotein synthesis
EP1578949B1 (en) 2002-10-16 2009-04-22 The Scripps Research Institute Site specific incorporation of keto amino acids into proteins
JP4486893B2 (en) 2002-12-22 2010-06-23 ザ スクリップス リサーチ インスティテュート Protein array
CA2520750A1 (en) 2003-04-17 2004-11-04 The Scripps Research Institute Orthogonal aminoacyl-trna synthetase
ES2298785T3 (en) 2003-06-12 2008-05-16 Eli Lilly And Company Fusion proteins.
DE602004011789T2 (en) 2003-07-07 2009-02-12 The Scripps Research Institute, La Jolla Compositions of orthogonal lysyl tRNA and aminoacyl-tRNA synthetase pairs and their uses
US7527943B2 (en) 2003-07-07 2009-05-05 The Scripps Research Institute Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
WO2005007870A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF
SG143252A1 (en) 2003-10-09 2008-06-27 Ambrx Inc Polymer derivatives
BRPI0416683A (en) 2003-12-10 2007-01-30 Lilly Co Eli human 21 fibroblast growth factor mutant (fgf-21), or a biologically active peptide thereof, polynucleotide, expression vector, host cell, process for producing a polypeptide, pharmaceutical composition, method for treating a patient, and, use da muteìna fgf-21
EP1727559A1 (en) 2004-01-26 2006-12-06 Eli Lilly And Company Use of fgf-21 and a thiazolidinedione for treating type 2 diabetes
US7896406B2 (en) 2004-01-30 2011-03-01 Certainteed Corporation Hose connector
NZ586034A (en) 2004-02-02 2011-10-28 Ambrx Inc Modified human growth hormone polypeptides and their uses
CN1914223B (en) * 2004-02-02 2012-02-29 Ambrx公司 Modified human interferon polypeptides and their uses
CA2557782A1 (en) * 2004-03-17 2005-10-06 Eli Lilly And Company Glycol linked fgf-21 compounds
ES2332100T3 (en) 2004-05-13 2010-01-26 Eli Lilly And Company Fgf-21 fusion proteins.
AU2005283025B2 (en) * 2004-09-02 2011-06-30 Eli Lilly And Company Muteins of fibroblast growth factor 21
WO2006028714A1 (en) 2004-09-02 2006-03-16 Eli Lilly And Company Muteins of fibroblast growth factor 21
EP2586456B1 (en) * 2004-10-29 2016-01-20 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (FGF)
US7655627B2 (en) * 2004-12-14 2010-02-02 Eli Lilly And Company Muteins of fibroblast growth factor 21
MX2007007590A (en) 2004-12-22 2007-12-10 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides.
BRPI0519568A2 (en) 2004-12-22 2009-01-27 Ambrx Inc aminoacyl trna synthetase compositions and their uses
CA2594561C (en) 2004-12-22 2014-12-23 Ambrx, Inc. Formulations of human growth hormone comprising a non-naturally encoded amino acid
EP1846019A2 (en) 2005-01-21 2007-10-24 Eli Lilly And Company Method for treating cardiovascular disease
AU2005335491B2 (en) 2005-08-18 2010-11-25 Ambrx, Inc. Compositions of tRNA and uses thereof
US7846445B2 (en) 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
NZ595303A (en) 2005-12-14 2013-03-28 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
KR20080081013A (en) 2005-12-30 2008-09-05 암브룩스, 인코포레이티드 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
EP2076500A4 (en) 2006-12-28 2009-12-09 Ambrx Inc Phenazine and quinoxaline substituted amino acids and polypeptides
EP2068909B1 (en) 2007-03-30 2012-04-25 Ambrx, Inc. Modified fgf-21 polypeptides and their uses
US8563521B2 (en) 2007-06-21 2013-10-22 Technische Universitat Munchen Biological active proteins having increased in vivo and/or in vitro stability
EA017690B1 (en) 2008-06-04 2013-02-28 Амген Инк. Fgf21 mutants and their use
EA032727B1 (en) 2008-10-10 2019-07-31 Амген Инк. Fgf21 mutant proteolysis-resistant polypeptide and use thereof
JP5599822B2 (en) 2009-01-23 2014-10-01 ノヴォ ノルディスク アー/エス FGF21 derivatives having albumin binder ABCDE and their use
AU2010246038A1 (en) 2009-05-05 2011-12-01 Amgen Inc. FGF21 mutants and uses thereof
WO2010142665A1 (en) 2009-06-11 2010-12-16 Novo Nordisk A/S Glp-1 and fgf21 combinations for treatment of diabetes type 2
JP2013533227A (en) 2010-06-08 2013-08-22 ノヴォ ノルディスク アー/エス FGF21 analogs and derivatives
TW201138808A (en) 2010-05-03 2011-11-16 Squibb Bristol Myers Co Serum albumin binding molecules
US9023791B2 (en) 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
MX2013013802A (en) 2011-05-25 2014-04-25 Amylin Pharmaceuticals Llc Amylin peptides and derivatives and uses thereof.
TWI593708B (en) 2011-09-26 2017-08-01 諾華公司 Fusion proteins for treating metabolic disorders
AR087973A1 (en) 2011-10-04 2014-04-30 Lilly Co Eli Variants of factor fibroblast growth 21
TWI513705B (en) 2012-06-11 2015-12-21 Lilly Co Eli Fibroblast growth factor 21 proteins
MA37963A1 (en) 2012-09-07 2018-06-29 Sanofi Sa fusion proteins for treating a metabolic syndrome
CN103923207B (en) 2014-04-08 2016-03-09 东北农业大学 Preparing a fgf-21 mutant proteins and their use in treating nonalcoholic fatty liver
KR20170070227A (en) 2014-10-24 2017-06-21 브리스톨-마이어스 스큅 컴퍼니 Modified fgf-21 polypeptides and uses thereof

Also Published As

Publication number Publication date
JP2010523084A (en) 2010-07-15
WO2008121563A3 (en) 2008-11-20
HRP20120522T1 (en) 2012-08-31
US9079971B2 (en) 2015-07-14
BRPI0809583A2 (en) 2019-09-03
US10377805B2 (en) 2019-08-13
CA2682147A1 (en) 2008-10-09
IL200749D0 (en) 2010-05-17
KR20100016014A (en) 2010-02-12
US20180298073A1 (en) 2018-10-18
US8383365B2 (en) 2013-02-26
KR20160121601A (en) 2016-10-19
AU2008232937A1 (en) 2008-10-09
US20130150564A1 (en) 2013-06-13
DK2068909T3 (en) 2012-08-06
HK1134239A1 (en) 2012-12-21
US20110172401A1 (en) 2011-07-14
US9517273B2 (en) 2016-12-13
KR101808787B1 (en) 2017-12-13
MX2009010531A (en) 2009-11-26
WO2008121563A2 (en) 2008-10-09
EP2068909A2 (en) 2009-06-17
KR101476472B1 (en) 2015-01-05
AU2008232937B2 (en) 2012-09-27
US20150273075A1 (en) 2015-10-01
CN104163864A (en) 2014-11-26
PT2068909E (en) 2012-07-04
CY1113188T1 (en) 2016-04-13
CN104163864B (en) 2017-08-01
US8012931B2 (en) 2011-09-06
ES2385114T3 (en) 2012-07-18
JP2015057404A (en) 2015-03-26
KR20150064249A (en) 2015-06-10
JP2017212986A (en) 2017-12-07
CA2682147C (en) 2017-08-08
US20170096463A1 (en) 2017-04-06
JP6158158B2 (en) 2017-07-05
US9975936B2 (en) 2018-05-22
IL258724D0 (en) 2018-06-28
EP2068909B1 (en) 2012-04-25
IL200749A (en) 2019-06-30
EP2068909A4 (en) 2010-02-24
HK1204331A1 (en) 2015-11-13
US20080255045A1 (en) 2008-10-16
KR20140012199A (en) 2014-01-29

Similar Documents

Publication Publication Date Title
DK2215224T3 (en) Polypeptides with alfa-glucuronidase activity and polynucleotides coding them
DK1983913T3 (en) Vertebral bars and their use
DK2224822T3 (en) Polypeptides with acetylxylanesterase activity and polynucleotides coding these
DK2171053T3 (en) natriuretic polypeptides
DK1954140T3 (en) Glycerollevulinetketals and their use
DK3178835T3 (en) Extended recombinant polypeptides and compositions including the same
DK2001903T3 (en) Long-term effective polypeptides and procedures for producing and administrating thereof
BRPI0809583A2 (en) modified fgf-21 polypeptides and their uses
IL205571D0 (en) 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin
DK1989249T3 (en) Composite material
GB0701426D0 (en) Compounds and their use
IL248322D0 (en) Variant activin receptor polypeptides and uses thereof
AT530210T (en) endoprostheses
AT542453T (en) Coffee and teepad
DK3037529T3 (en) Extended soluble ph20 polypeptides and use thereof
IL201227A (en) Stitched polypeptides
AT492561T (en) Improved protefibrilselective antibodies and their use
DE602007007095D1 (en) Artificial joint
DK2190473T3 (en) Peptid with reduced dimering
BRPI0907231A2 (en) pyrrolpyrimidines and pyrrolpyridines
TWI455715B (en) 4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use
AT513832T (en) 8-anilinoimidazopyridines and their use as anticrobraids and / or anti-inflammatory agents
BRPI0906722A2 (en) Methods and compositions using klotho-fgf fusion polypeptides
DK2222675T3 (en) 5-anilinoimidazopyridines and procedures for their use
DK2139490T3 (en) Diazo-bicyclic smac-mimetic substances and applications thereof