AT528649T - A method for detecting misfolded proteins and prion - Google Patents

A method for detecting misfolded proteins and prion

Info

Publication number
AT528649T
AT528649T AT06720716T AT06720716T AT528649T AT 528649 T AT528649 T AT 528649T AT 06720716 T AT06720716 T AT 06720716T AT 06720716 T AT06720716 T AT 06720716T AT 528649 T AT528649 T AT 528649T
Authority
AT
Austria
Prior art keywords
prion
method
misfolded proteins
detecting misfolded
detecting
Prior art date
Application number
AT06720716T
Other languages
German (de)
Inventor
Cindy Orser
Tao Pan
Jasmeet Sethi
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US65273305P priority Critical
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Priority to PCT/US2006/005095 priority patent/WO2006088823A2/en
Publication of AT528649T publication Critical patent/AT528649T/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • G01N33/54333Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2828Prion diseases
AT06720716T 2005-02-15 2006-02-14 A method for detecting misfolded proteins and prion AT528649T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US65273305P true 2005-02-15 2005-02-15
PCT/US2006/005095 WO2006088823A2 (en) 2005-02-15 2006-02-14 Method for detecting misfolded proteins and prions

Publications (1)

Publication Number Publication Date
AT528649T true AT528649T (en) 2011-10-15

Family

ID=36916969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06720716T AT528649T (en) 2005-02-15 2006-02-14 A method for detecting misfolded proteins and prion

Country Status (11)

Country Link
US (1) US8372593B2 (en)
EP (1) EP1853915B1 (en)
JP (1) JP5048522B2 (en)
CN (1) CN101156068B (en)
AT (1) AT528649T (en)
AU (1) AU2006214463B2 (en)
BR (1) BRPI0607350A2 (en)
CA (1) CA2597912C (en)
HK (1) HK1110936A1 (en)
MX (1) MX2007009819A (en)
WO (1) WO2006088823A2 (en)

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CA2448981C (en) 2001-05-31 2014-03-18 Arete Associates Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
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AU2007277186B2 (en) * 2006-07-28 2014-01-30 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
CA2675039A1 (en) * 2007-01-12 2008-07-17 Alicon Ag Method for removing prion protein
JP2011517666A (en) * 2008-03-21 2011-06-16 エイディーライフ インコーポレイティッド The use of pyrene for transporting peptides across the blood-brain barrier
US9229009B2 (en) * 2008-10-31 2016-01-05 Yale University Methods and kits for detecting misfolded proteins
CN102365295A (en) * 2009-01-30 2012-02-29 阿德利夫股份有限公司 Conformationally dynamic peptides
WO2011149917A1 (en) 2010-05-25 2011-12-01 Adlyfe, Inc. STABILIZED AMYLOID- β OLIGOMERS AND USES THEREOF
EP2712425A2 (en) 2011-04-27 2014-04-02 Adlyfe, Inc. Ocular detection of amyloid proteins
CN102901825A (en) * 2011-07-29 2013-01-30 中国科学院生物物理研究所 Application of MDA modified protein as misfolded protein fluorescence probe
DE102012104504A1 (en) * 2012-05-24 2013-11-28 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung Marker substance for use in detection reagent of immunoassay for specific detection of biomaterial, has hetero element, subunit that is peptide, and reporter group that comprises chelating agent, complexing agent and ion exchanger
JP6178586B2 (en) * 2013-02-20 2017-08-09 サヴィッド・セラピューティックス株式会社 Biotin variants, streptavidin variants and their use
CN105092854A (en) * 2014-05-07 2015-11-25 湖州数问生物技术有限公司 In-vitro diagnostic device and kit

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FR2842303B1 (en) * 2002-07-09 2004-09-24 Commissariat Energie Atomique automated detection method of PrPres and its applications
WO2004018511A2 (en) * 2002-08-23 2004-03-04 Copenhagen Biotech Assets Aps Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
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US20060057671A1 (en) 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
AU2007277186B2 (en) * 2006-07-28 2014-01-30 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

Also Published As

Publication number Publication date
HK1110936A1 (en) 2012-08-10
MX2007009819A (en) 2007-11-07
WO2006088823A3 (en) 2007-03-29
JP5048522B2 (en) 2012-10-17
AU2006214463B2 (en) 2012-08-30
US8372593B2 (en) 2013-02-12
CN101156068A (en) 2008-04-02
BRPI0607350A2 (en) 2009-09-01
WO2006088823A2 (en) 2006-08-24
CN101156068B (en) 2015-03-18
CA2597912A1 (en) 2006-08-24
US20110081660A1 (en) 2011-04-07
CA2597912C (en) 2013-06-04
EP1853915A4 (en) 2008-09-03
EP1853915A2 (en) 2007-11-14
JP2008530565A (en) 2008-08-07
EP1853915B1 (en) 2011-10-12
AU2006214463A1 (en) 2006-08-24

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