AT528008T - Rnai-modulation of aha and their therapeutic use - Google Patents

Rnai-modulation of aha and their therapeutic use


Publication number
AT528008T AT07797577T AT07797577T AT528008T AT 528008 T AT528008 T AT 528008T AT 07797577 T AT07797577 T AT 07797577T AT 07797577 T AT07797577 T AT 07797577T AT 528008 T AT528008 T AT 528008T
Prior art keywords
therapeutic use
Prior art date
Application number
Other languages
German (de)
Rainer Constien
Birgit Bramlage
Pamela Tan
Hans-Peter Vornlocher
William Balch
Original Assignee
Alnylam Pharmaceuticals Inc
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US80184006P priority Critical
Application filed by Alnylam Pharmaceuticals Inc, Scripps Research Inst filed Critical Alnylam Pharmaceuticals Inc
Priority to PCT/US2007/069229 priority patent/WO2007137156A2/en
Publication of AT528008T publication Critical patent/AT528008T/en



    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3515Lipophilic moiety, e.g. cholesterol
AT07797577T 2006-05-19 2007-05-18 Rnai-modulation of aha and their therapeutic use AT528008T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US80184006P true 2006-05-19 2006-05-19
PCT/US2007/069229 WO2007137156A2 (en) 2006-05-19 2007-05-18 Rnai modulation of aha and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
AT528008T true AT528008T (en) 2011-10-15



Family Applications (1)

Application Number Title Priority Date Filing Date
AT07797577T AT528008T (en) 2006-05-19 2007-05-18 Rnai-modulation of aha and their therapeutic use

Country Status (9)

Country Link
US (3) US7812150B2 (en)
EP (2) EP2023937B1 (en)
JP (1) JP2009537153A (en)
CN (2) CN101489566B (en)
AT (1) AT528008T (en)
AU (1) AU2007253803B2 (en)
BR (1) BRPI0712034A2 (en)
CA (1) CA2652770A1 (en)
WO (1) WO2007137156A2 (en)

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US8229398B2 (en) * 2006-01-30 2012-07-24 Qualcomm Incorporated GSM authentication in a CDMA network
AT528008T (en) * 2006-05-19 2011-10-15 Alnylam Pharmaceuticals Inc Rnai-modulation of aha and their therapeutic use
US7910722B2 (en) 2007-07-05 2011-03-22 Florida State University Research Foundation RNAi therapeutic for treatment of hepatitis C infection
CN102575252B (en) 2009-06-01 2016-04-20 光环生物干扰疗法公司 A polynucleotide polyvalent rna interference, compositions and methods of use
US20110152343A1 (en) * 2009-12-22 2011-06-23 Functional Genetics, Inc. Protease inhibitors and broad-spectrum antiviral
CN103902847B (en) * 2012-12-26 2016-12-28 中国科学院深圳先进技术研究院 Analysis of polyglutamine pathogenesis
CN105018484B (en) * 2015-07-31 2017-10-13 北京泱深生物信息技术有限公司 Crtap gene and its expression product as a target for diagnosis and treatment of Alzheimer's disease
WO2017147420A1 (en) * 2016-02-25 2017-08-31 The University Of Florida Research Foundation, Inc. Methods and compositions with vitamin d compounds for treatment of cystic fibrosis and respiratory disorders

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EP2023937A4 (en) 2009-10-28
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US7812150B2 (en) 2010-10-12
AU2007253803B2 (en) 2012-05-24
CN101489566B (en) 2012-04-18
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EP2023937A2 (en) 2009-02-18
US20110003882A1 (en) 2011-01-06
JP2009537153A (en) 2009-10-29
AU2007253803A1 (en) 2007-11-29
US8114984B2 (en) 2012-02-14
WO2007137156A8 (en) 2009-12-17
CA2652770A1 (en) 2007-11-29
EP2392583A1 (en) 2011-12-07
US20120142757A1 (en) 2012-06-07
US20080113931A1 (en) 2008-05-15
CN101489566A (en) 2009-07-22
CN101454335A (en) 2009-06-10
WO2007137156A3 (en) 2008-10-23

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