AT519780T - An acylated insulin and zinc-containing compositions and methods for preparing these compositions - Google Patents

An acylated insulin and zinc-containing compositions and methods for preparing these compositions

Info

Publication number
AT519780T
AT519780T AT06841562T AT06841562T AT519780T AT 519780 T AT519780 T AT 519780T AT 06841562 T AT06841562 T AT 06841562T AT 06841562 T AT06841562 T AT 06841562T AT 519780 T AT519780 T AT 519780T
Authority
AT
Austria
Prior art keywords
compositions
zinc
preparing
methods
acylated insulin
Prior art date
Application number
AT06841562T
Other languages
German (de)
Inventor
Svend Havelund
Frantisek Hubalek
Helle Olsen
Ib Jonassen
Thomas Hoeg-Jensen
Anne Plum
Ulla Ribel-Madsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP05113021 priority Critical
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to PCT/EP2006/070104 priority patent/WO2007074133A2/en
Publication of AT519780T publication Critical patent/AT519780T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
AT06841562T 2005-12-28 2006-12-21 An acylated insulin and zinc-containing compositions and methods for preparing these compositions AT519780T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05113021 2005-12-28
PCT/EP2006/070104 WO2007074133A2 (en) 2005-12-28 2006-12-21 Compositions comprising an acylated insulin and zinc and method of making the said compositions

Publications (1)

Publication Number Publication Date
AT519780T true AT519780T (en) 2011-08-15

Family

ID=36888823

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06841562T AT519780T (en) 2005-12-28 2006-12-21 An acylated insulin and zinc-containing compositions and methods for preparing these compositions

Country Status (10)

Country Link
US (2) US20090074882A1 (en)
EP (2) EP1969004B1 (en)
JP (3) JP4808785B2 (en)
CN (1) CN101389650B (en)
AT (1) AT519780T (en)
DK (1) DK1969004T3 (en)
ES (1) ES2371361T3 (en)
PL (1) PL1969004T3 (en)
PT (1) PT1969004E (en)
WO (1) WO2007074133A2 (en)

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JP4463814B2 (en) 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブNovo Nordisk Aktie Selsxab New insulin derivative
US20090011976A1 (en) * 2004-11-12 2009-01-08 Novo Nordisk A/S Stable Formulations Of Peptides
JP5410020B2 (en) 2005-02-02 2014-02-05 ノヴォ ノルディスク アー/エス Insulin derivative
US8067362B2 (en) 2005-02-02 2011-11-29 Novo Nordisk As Insulin derivatives
PT1969004E (en) * 2005-12-28 2011-11-25 Novo Nordisk As Compositions comprising an acylated insulin and zinc and method of making the said compositions
AT482977T (en) * 2006-02-27 2010-10-15 Novo Nordisk As insulin derivatives
ES2548393T3 (en) 2006-05-09 2015-10-16 Novo Nordisk A/S Insulin derivative
EP2024390B1 (en) 2006-05-09 2015-08-19 Novo Nordisk A/S Insulin derivative
EP2074141B1 (en) 2006-09-22 2016-08-10 Novo Nordisk A/S Protease resistant insulin analogues
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
CN101677947B (en) 2007-06-13 2013-07-17 诺沃-诺迪斯克有限公司 Pharmaceutical formulation comprising an insulin derivative
WO2009060071A1 (en) * 2007-11-08 2009-05-14 Novo Nordisk A/S Insulin derivative
JP5241849B2 (en) 2007-11-16 2013-07-17 ノボ・ノルデイスク・エー/エス Pharmaceutical composition comprising insulin and insulinotropic peptide
JP5762001B2 (en) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー/エス Protease stabilized insulin analogue
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease stabilized, acylated insulin analogues
CN102202683A (en) 2008-10-30 2011-09-28 诺沃-诺迪斯克有限公司 Treating diabetes melitus using insulin injections with less than daily injection frequency
US9180261B2 (en) 2010-01-12 2015-11-10 Dance Biopharm Inc. Preservative free insulin formulations and systems and methods for aerosolizing
MX2012012943A (en) * 2010-05-10 2012-11-29 Novo Nordisk As Process for the preparation of insulin-zinc complexes.
KR20130139297A (en) 2010-10-27 2013-12-20 노보 노르디스크 에이/에스 Treating diabetes melitus using insulin injections administered with varying injection intervals
EP2651432A1 (en) 2010-12-14 2013-10-23 Novo Nordisk A/S Fast-acting insulin in combination with long-acting insulin
MX342922B (en) 2011-02-01 2016-10-19 Novo Nordisk As Purification of insulin.
CN102675452B (en) 2011-03-17 2015-09-16 重庆富进生物医药有限公司 Hypoglycemic and continued with high receptor binding and human insulin analogue conjugate
WO2013153000A2 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
US9884094B2 (en) 2012-05-01 2018-02-06 Novo Nordisk A/S Method of treating diabetes mellitus
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
US20160296602A1 (en) * 2013-03-20 2016-10-13 Novo Nordisk A/S Dosing Regimen
JP2016519127A (en) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー/エス New dosing regimen
DK3055325T3 (en) 2013-10-07 2018-04-16 Novo Nordisk As New derivative of an insulin analogue
AR099569A1 (en) 2014-02-28 2016-08-03 Novo Nordisk As Insulin derivatives and medical uses of these
BR112017018060A2 (en) * 2015-02-25 2018-04-10 Dance Biopharm Inc insulin formulation, unit dose, and method of treating an individual with diabetes mellitus.
EP3273981A1 (en) 2015-03-24 2018-01-31 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of diabetes
US20190169257A1 (en) * 2016-08-02 2019-06-06 Jiangsu Hengrui Medicine Co., Ltd. Acylated derivative of human insulin or analogue thereof
AU2017378102A1 (en) 2016-12-16 2019-05-30 Novo Nordisk A/S Insulin containing pharmaceutical compositions
WO2019149245A1 (en) * 2018-02-01 2019-08-08 江苏恒瑞医药股份有限公司 Pharmaceutical composition comprising acylated derivative of human insulin analog and preparation method thereof
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

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US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
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DE3827533A1 (en) * 1988-08-13 1990-02-15 Hoechst Ag A pharmaceutical preparation for the treatment of diabetes mellitus
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US5830999A (en) * 1995-01-26 1998-11-03 Regents Of The University Of California Stabilization of insulin through ligand binding interations
US6251856B1 (en) * 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US5866538A (en) * 1996-06-20 1999-02-02 Novo Nordisk A/S Insulin preparations containing NaCl
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
IL119029D0 (en) * 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
AU6611898A (en) * 1997-03-20 1998-10-20 Novo Nordisk A/S Method for preparation of a therapeutic powder through coprecipitation of insulin and absorption enhancer
UA69393C2 (en) 1997-10-24 2000-10-16 Novo Nordisk As Aggregates of derivatives of human insulin
US6451762B1 (en) * 1997-10-24 2002-09-17 Novo Nordisk A/S Aggregates of human insulin derivatives
US20020155994A1 (en) * 1997-10-24 2002-10-24 Svend Havelund Aggregates of human insulin derivatives
ZA9809744B (en) * 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
CO4970787A1 (en) * 1997-12-23 2000-11-07 Lilly Co Eli insoluble compositions of insulin and insulin derivatives which control blood glucose
WO1999034821A1 (en) * 1998-01-09 1999-07-15 Novo Nordisk A/S Stabilised insulin compositions
RU2218935C2 (en) * 1998-10-16 2003-12-20 Ново Нордиск А/С Stable concentrated preparative insulin forms for delivery by way of lung
US6211144B1 (en) * 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
DK1146896T3 (en) * 1999-01-26 2002-09-02 Lilly Co Eli Formulations containing monodisperse hexameric acylated insulin analogs
US6652886B2 (en) * 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
DE10114178A1 (en) * 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations having improved stability
AU2003208316A1 (en) * 2002-03-13 2003-09-22 Novo Nordisk A/S Minimising body weight gain in insulin treatment
EP1506230B1 (en) * 2002-05-07 2011-01-19 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
EP1506003A1 (en) 2002-05-07 2005-02-16 Novo Nordisk A/S Soluble formulations comprising insulin aspart and insulin detemir
US20040138099A1 (en) * 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes
CA2518143A1 (en) * 2003-03-04 2004-09-16 The Technology Development Company Ltd. Delivery system for drug and cell therapy
JP4463814B2 (en) * 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブNovo Nordisk Aktie Selsxab New insulin derivative
EP1687428A1 (en) * 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
JP5410020B2 (en) 2005-02-02 2014-02-05 ノヴォ ノルディスク アー/エス Insulin derivative
US8067362B2 (en) * 2005-02-02 2011-11-29 Novo Nordisk As Insulin derivatives
PT1969004E (en) * 2005-12-28 2011-11-25 Novo Nordisk As Compositions comprising an acylated insulin and zinc and method of making the said compositions
AT482977T (en) * 2006-02-27 2010-10-15 Novo Nordisk As insulin derivatives
ES2548393T3 (en) * 2006-05-09 2015-10-16 Novo Nordisk A/S Insulin derivative
CN101677947B (en) * 2007-06-13 2013-07-17 诺沃-诺迪斯克有限公司 Pharmaceutical formulation comprising an insulin derivative
JP5241849B2 (en) * 2007-11-16 2013-07-17 ノボ・ノルデイスク・エー/エス Pharmaceutical composition comprising insulin and insulinotropic peptide

Also Published As

Publication number Publication date
CN101389650A (en) 2009-03-18
US20140328943A1 (en) 2014-11-06
JP2009522231A (en) 2009-06-11
JP4808785B2 (en) 2011-11-02
EP2505593A1 (en) 2012-10-03
PT1969004E (en) 2011-11-25
ES2371361T3 (en) 2011-12-30
WO2007074133A2 (en) 2007-07-05
DK1969004T3 (en) 2011-11-28
EP1969004B1 (en) 2011-08-10
JP5026567B2 (en) 2012-09-12
JP2011006428A (en) 2011-01-13
PL1969004T3 (en) 2012-01-31
JP2011121963A (en) 2011-06-23
CN101389650B (en) 2012-10-10
WO2007074133A3 (en) 2007-10-11
EP1969004A2 (en) 2008-09-17
US20090074882A1 (en) 2009-03-19

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