AT516288T - Pyrrolobenzodiazepine derivatives, compositions containing them, and associated methods therewith - Google Patents

Pyrrolobenzodiazepine derivatives, compositions containing them, and associated methods therewith

Info

Publication number
AT516288T
AT516288T AT04817338T AT04817338T AT516288T AT 516288 T AT516288 T AT 516288T AT 04817338 T AT04817338 T AT 04817338T AT 04817338 T AT04817338 T AT 04817338T AT 516288 T AT516288 T AT 516288T
Authority
AT
Austria
Prior art keywords
compositions containing
associated methods
methods therewith
pyrrolobenzodiazepine derivatives
pyrrolobenzodiazepine
Prior art date
Application number
AT04817338T
Other languages
German (de)
Inventor
Paul Liu
B Vishnuvaijala
Kenneth Snader
David Thurston
Philip Howard
Luke Hsiao
Gregory Turner
Original Assignee
Us Gov Health & Human Serv
Spirogen Ltd
Starks Ass
Midwest Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US51375103P priority Critical
Application filed by Us Gov Health & Human Serv, Spirogen Ltd, Starks Ass, Midwest Research Inst filed Critical Us Gov Health & Human Serv
Priority to PCT/US2004/035050 priority patent/WO2005040170A2/en
Publication of AT516288T publication Critical patent/AT516288T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
AT04817338T 2003-10-22 2004-10-22 Pyrrolobenzodiazepine derivatives, compositions containing them, and associated methods therewith AT516288T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US51375103P true 2003-10-22 2003-10-22
PCT/US2004/035050 WO2005040170A2 (en) 2003-10-22 2004-10-22 Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto

Publications (1)

Publication Number Publication Date
AT516288T true AT516288T (en) 2011-07-15

Family

ID=34520132

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04817338T AT516288T (en) 2003-10-22 2004-10-22 Pyrrolobenzodiazepine derivatives, compositions containing them, and associated methods therewith

Country Status (6)

Country Link
US (2) US7511032B2 (en)
EP (1) EP1675857B1 (en)
AT (1) AT516288T (en)
AU (1) AU2004284075A1 (en)
CA (1) CA2543318C (en)
WO (1) WO2005040170A2 (en)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69907977T2 (en) 1998-08-27 2004-07-22 Spirogen Ltd., Ryde Pyrrolobenzodiazepine
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
ES2376879T3 (en) * 2003-09-04 2012-03-20 Celgene Corporation Polymorphic forms of 3- (4- amino-1-oxo-1,3-dihydro-isoindol-2-yl) -piperidine-2,6-dione
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
JP4909258B2 (en) 2004-03-01 2012-04-04 スピロゲン リミティッド 11-Hydroxy-5H-pyrrolo [2,1-c] [1,4] benzodiazepin-5-one derivatives as key intermediates for preparing C2-substituted pyrrolobenzodiazepines
EP1723152B1 (en) 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
FR2869231B1 (en) * 2004-04-27 2008-03-14 Sod Conseils Rech Applic Therapeutic composition containing at least one pyrrolobenzodiazepine derivative and fludarabine
GB0410725D0 (en) * 2004-05-13 2004-06-16 Spirogen Ltd Pyrrolobenzodiazepine therapeutic agents
NZ563136A (en) * 2005-04-21 2009-11-27 Spirogen Ltd Pyrrolobenzodiazepines
EP1813614B1 (en) * 2006-01-25 2011-10-05 Sanofi Cytotoxic agents comprising new tomaymycin derivatives
CA2658276A1 (en) * 2006-07-18 2008-01-24 Sanofi-Aventis Antagonist antibody for the treatment of cancer
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
PT2019104E (en) 2007-07-19 2013-12-03 Sanofi Sa Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
GB0813432D0 (en) 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
EP3100745B1 (en) 2009-02-05 2018-04-18 Immunogen, Inc. Novel benzodiazepine derivatives
FR2949469A1 (en) 2009-08-25 2011-03-04 Sanofi Aventis Anticancer derivatives, their preparation and their therapeutic application
AR078470A1 (en) 2009-10-02 2011-11-09 Sanofi Aventis Antibodies that specifically bind EphA2 receptor
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
WO2011130616A1 (en) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines used to treat proliferative diseases
JP5870400B2 (en) 2010-04-15 2016-03-01 シアトル ジェネティクス,インコーポレーテッド Targeted pyrrolobenzodiazepine conjugates
FR2963007B1 (en) 2010-07-26 2013-04-05 Sanofi Aventis Anticancer derivatives, their preparation and their therapeutic application
PL2675480T3 (en) 2011-02-15 2019-07-31 Immunogen, Inc. Methods of preparation of conjugates
AU2012311505B2 (en) 2011-09-20 2016-09-29 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
NZ623216A (en) 2011-10-14 2016-05-27 Seattle Genetics Inc Pyrrolobenzodiazepines and targeted conjugates
US9399073B2 (en) 2011-10-14 2016-07-26 Seattle Genetics, Inc. Pyrrolobenzodiazepines
US9526798B2 (en) 2011-10-14 2016-12-27 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
AU2012322932B2 (en) 2011-10-14 2016-11-10 Medimmune Limited Pyrrolobenzodiazepines
WO2013053872A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
AR090549A1 (en) 2012-03-30 2014-11-19 Genentech Inc anti-antibodies and immunoconjugates LGR5
TW201402609A (en) 2012-05-01 2014-01-16 Genentech Inc Anti-PMEL17 antibodies and immunoconjugates
JP2015523380A (en) 2012-07-09 2015-08-13 ジェネンテック, インコーポレイテッド Immune complex comprising anti-CD79B antibody
US20140030279A1 (en) 2012-07-09 2014-01-30 Spirogen Sarl Anti-cd22 antibodies and immunoconjugates
DK2877493T3 (en) 2012-07-25 2018-06-14 Celldex Therapeutics Inc Anti-kit antibodies and applications thereof
EP2887965A1 (en) 2012-08-22 2015-07-01 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
BR112015008253A2 (en) 2012-10-12 2017-07-04 Spirogen Sarl PYRROLOBENZODIAZEPINES and CONJUGATES THEREOF
CA2887897A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd25 antibody conjugates
ES2713164T3 (en) 2012-10-12 2019-05-20 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP2906249B1 (en) 2012-10-12 2018-06-27 MedImmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
HUE035694T2 (en) 2012-10-12 2018-05-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
WO2014057117A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
CN103933575B (en) 2013-01-23 2017-09-29 上海新理念生物医药科技有限公司 A kind of three flute profile connexons and its application
KR20150127199A (en) 2013-03-14 2015-11-16 제넨테크, 인크. Anti-b7-h4 antibodies and immunoconjugates
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
EA201690195A1 (en) 2013-08-12 2016-05-31 Дженентек, Инк. Antibody conjugate connections on the basis of dimer 1- (hlormethyl) -2,3-digydro-1h-benzo [e] indol and methods of application and treatment
CA2929565A1 (en) 2013-12-16 2015-06-25 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
JP6332773B2 (en) * 2013-09-02 2018-05-30 ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. Novel cytotoxic molecules for conjugation of drugs and cell binding molecules
MX2016003248A (en) 2013-09-17 2016-06-07 Genentech Inc Methods of using anti-lgr5 antibodies.
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015089344A1 (en) 2013-12-13 2015-06-18 Genentech, Inc. Anti-cd33 antibodies and immunoconjugates
EP3129055A4 (en) 2014-04-11 2017-11-22 Medimmune, LLC Bispecific her2 antibodies
CN106414499A (en) 2014-05-22 2017-02-15 基因泰克公司 Anti-GPC3 antibodies and immunoconjugates
EP3189057A1 (en) 2014-09-03 2017-07-12 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
US10077318B2 (en) 2014-09-12 2018-09-18 Genentech, Inc. Cysteine engineered antibodies and conjugates
WO2016040724A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anti-b7-h4 antibodies and immunoconjugates
TW201625690A (en) 2014-09-12 2016-07-16 Genentech Inc Anti -cll-1 antibody and immune conjugate
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
BR112017004953A2 (en) 2014-09-17 2017-12-05 Genentech Inc immunoconjugate, pharmaceutical formulation, method of treatment and method of inhibiting cell proliferation
BR112017006602A2 (en) 2014-10-01 2017-12-19 Medimmune Llc conjugation method of a polypeptide
CN106279352A (en) 2015-05-29 2017-01-04 上海新理念生物医药科技有限公司 Derivatives of dolastatin 10 and application thereof
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
WO2017064675A1 (en) 2015-10-16 2017-04-20 Genentech, Inc. Hindered disulfide drug conjugates
CN106729743A (en) 2015-11-23 2017-05-31 四川科伦博泰生物医药股份有限公司 Anti-ErbB2 antibody-drug conjugate, composition, preparation method and application of anti-ErbB2 antibody-drug conjugate
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
WO2017196847A1 (en) 2016-05-10 2017-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Variable new antigen receptor (vnar) antibodies and antibody conjugates targeting tumor and viral antigens
TW201808336A (en) 2016-05-11 2018-03-16 賽諾菲公司 Treatment regimen using anti-MUC1 maytansinoid immunoconjugate antibody for the treatment of tumors
US20170370906A1 (en) 2016-05-27 2017-12-28 Genentech, Inc. Bioanalytical analysis of site-specific antibody drug conjugates
WO2017214182A1 (en) 2016-06-07 2017-12-14 The United States Of America. As Represented By The Secretary, Department Of Health & Human Services Fully human antibody targeting pdi for cancer immunotherapy
CA3031559A1 (en) 2016-08-02 2018-02-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies targeting glypican-2 (gpc2) and use thereof
WO2018027204A1 (en) 2016-08-05 2018-02-08 Genentech, Inc. Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
CN109689111A (en) 2016-08-11 2019-04-26 基因泰克公司 Pyrrolobenzodiazepines * prodrug and its antibody conjugates
EP3468991A1 (en) 2016-11-21 2019-04-17 cureab GmbH Anti-gp73 antibodies and immunoconjugates
EP3559038A1 (en) 2016-12-21 2019-10-30 The United States of America as represented by The Secretary Department of Health and Human Services Human monoclonal antibodies specific for flt3 and uses thereof
TW201839001A (en) 2017-04-20 2018-11-01 美商伊繆諾金公司 Cytotoxic benzodiazepine derivatives and conjugates thereof
WO2018213064A1 (en) 2017-05-19 2018-11-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibody targeting tnfer2 for cancer immunotherapy
WO2019005208A1 (en) 2017-06-30 2019-01-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human mesothelin antibodies and uses in cancer therapy
WO2019006280A1 (en) 2017-06-30 2019-01-03 Lentigen Technology, Inc. Human monoclonal antibodies specific for cd33 and methods of their use
WO2019065964A1 (en) * 2017-09-29 2019-04-04 第一三共株式会社 Antibody-pyrrolobenzodiazepine derivative conjugate
WO2019133652A1 (en) 2017-12-28 2019-07-04 Immunogen, Inc. Benzodiazepine derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
JPS58180487A (en) 1982-04-16 1983-10-21 Kyowa Hakko Kogyo Co Ltd Antibiotic dc-81 and its preparation
US4508647A (en) 1982-07-26 1985-04-02 Bristol-Myers Company Antitumor antibiotics BBM-2040A and BBM-2040B
US4464467A (en) 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
US4464497A (en) * 1982-12-15 1984-08-07 General Electric Company Carbon black filled flame retardant polycarbonate compositions
IN165717B (en) 1986-08-07 1989-12-23 Battelle Memorial Institute Method of preparing a therapeutic compound
GB9205051D0 (en) 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
DE69907977T2 (en) 1998-08-27 2004-07-22 Spirogen Ltd., Ryde Pyrrolobenzodiazepine

Also Published As

Publication number Publication date
WO2005040170A2 (en) 2005-05-06
US20070072846A1 (en) 2007-03-29
WO2005040170A8 (en) 2006-05-11
EP1675857B1 (en) 2011-07-13
US7834005B2 (en) 2010-11-16
WO2005040170A3 (en) 2005-06-30
CA2543318C (en) 2013-01-08
US20090149449A1 (en) 2009-06-11
AU2004284075A1 (en) 2005-05-06
CA2543318A1 (en) 2005-05-06
US7511032B2 (en) 2009-03-31
EP1675857A2 (en) 2006-07-05

Similar Documents

Publication Publication Date Title
DK1530574T3 (en) Macrocyclic pyrimidines, their method and use as drugs
DE60221900D1 (en) Film-composing compositions and their use
DE60326894D1 (en) 1,4-Diazabicycloalkane derivatives, their preparation and use
DE60330333D1 (en) Therapeutic compositions contain 1,2,3,6-tetrahydropyrimidin-2-one and corresponding methods
DE60325718D1 (en) Nystatin NANOPARTICLE COMPOSITIONS
DK1638551T3 (en) Immunosuppressive compounds and compositions
DK3384931T3 (en) Superfin formother formulation
DK1633699T3 (en) Aryl-carbaldehydroxime derivatives and their use as estrogenic agents
DE60318860D1 (en) Chinucledin derivatives and their use
DE50312295D1 (en) 8-ä3-amino-piperidin-1-ylü-xanthine, their preparation and their use as drug
DK1556385T3 (en) Heterocyclocarboxamid derivatives
DE60330372D1 (en) Indole-3-SULFUR DERIVATIVES
DE60319406D1 (en) Meso-substituted porphyrine
FR2861076B1 (en) N-heterocyclymethylbenzamide derivatives, their preparation and their therapeutic use
RU2414469C3 (en) New oxazolidinon derivatives
AP2089A (en) Compositions and methods for combination antiviraltherapy
DE60334015D1 (en) Pyridopyrrolizin and pyridoindolizin derivatives
DK1474408T3 (en) N-phenyl-2-pyrimidineamine derivatives
DK1611131T3 (en) Pyrazolopyridine derivatives
DE60326697D1 (en) Hair-resistant compositions, polymers and methods
DK1465615T3 (en) Tricyclic bisonone derivatives and methods for their use
DE60326060D1 (en) Non-Crosslinking PYRROLOA2,1-CÜ1,4ÜBENZODIAZEPINE AS POTENTIAL ANTITUMOR AGENTS AND THEIR PREPARATION
FR2854158B1 (en) 2-acylamino-4-phenylethiazole derivatives, their preparation and their therapeutic use
DE50312949D1 (en) Acyl-4-carboxy-phenyl-urea derivatives, process for their preparation and their use
DE50310516D1 (en) Fredericamycin DERIVATIVES

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties