AT495741T - Aminoindazone derivatives with kinaseinhibiering effect, method for the production thereof and pharmaceutical compositions containing thereof - Google Patents

Aminoindazone derivatives with kinaseinhibiering effect, method for the production thereof and pharmaceutical compositions containing thereof

Info

Publication number
AT495741T
AT495741T AT02774629T AT02774629T AT495741T AT 495741 T AT495741 T AT 495741T AT 02774629 T AT02774629 T AT 02774629T AT 02774629 T AT02774629 T AT 02774629T AT 495741 T AT495741 T AT 495741T
Authority
AT
Austria
Prior art keywords
aminoindazone
kinaseinhibiering
derivatives
production
effect
Prior art date
Application number
AT02774629T
Other languages
German (de)
Inventor
Raffaella Amici
Anello Matteo D
Katia Martina
Barbara Salom
Anna Vulpetti
Original Assignee
Pfizer Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US96216201A priority Critical
Application filed by Pfizer Italia Srl filed Critical Pfizer Italia Srl
Priority to PCT/EP2002/010534 priority patent/WO2003028720A1/en
Publication of AT495741T publication Critical patent/AT495741T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring-systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
AT02774629T 2001-09-26 2002-09-19 Aminoindazone derivatives with kinaseinhibiering effect, method for the production thereof and pharmaceutical compositions containing thereof AT495741T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US96216201A true 2001-09-26 2001-09-26
PCT/EP2002/010534 WO2003028720A1 (en) 2001-09-26 2002-09-19 Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AT495741T true AT495741T (en) 2011-02-15

Family

ID=25505498

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02774629T AT495741T (en) 2001-09-26 2002-09-19 Aminoindazone derivatives with kinaseinhibiering effect, method for the production thereof and pharmaceutical compositions containing thereof

Country Status (19)

Country Link
US (1) US7511136B2 (en)
EP (2) EP1820503B1 (en)
JP (1) JP4542338B2 (en)
KR (1) KR20040047869A (en)
CN (1) CN1556702A (en)
AT (1) AT495741T (en)
BR (1) BR0212841A (en)
CA (1) CA2460145C (en)
CZ (1) CZ2004359A3 (en)
DE (1) DE60238999D1 (en)
EA (1) EA007430B1 (en)
ES (2) ES2380054T3 (en)
IL (1) IL160744D0 (en)
MX (1) MXPA04001114A (en)
NO (1) NO20041086L (en)
NZ (1) NZ531765A (en)
PL (1) PL368347A1 (en)
WO (1) WO2003028720A1 (en)
ZA (1) ZA200401848B (en)

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EP1572200B1 (en) 2002-12-12 2011-08-17 Aventis Pharma S.A. Aminoindazole derivatives and use thereof as kinase inhibitors
GEP20084435B (en) 2002-12-19 2008-07-25 Pharmacia Italia Spa Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
WO2004104007A1 (en) 2003-05-22 2004-12-02 Pharmacia Italia S.P.A. Pyrazolo-quinazoline derivatives,process for their preparation and their use as kinase inhibitors
US7141568B2 (en) 2003-07-09 2006-11-28 Pfizer Italia S.R.L. Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US20050107386A1 (en) * 2003-11-19 2005-05-19 Rama Krishna Narla Methods of treating diseases and disorders by targeting multiple kinases
TW200526204A (en) 2004-02-03 2005-08-16 Pharmacia Italia Spa 1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors
WO2005077912A1 (en) * 2004-02-12 2005-08-25 Mitsubishi Pharma Corporation Indazole compound and pharmaceutical use thereof
JP2007523937A (en) * 2004-02-27 2007-08-23 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Indazole derivative and pharmaceutical composition containing the same
EP1647549A1 (en) * 2004-10-14 2006-04-19 Laboratoire Theramex Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents
AT479687T (en) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinase inhibitors
EP1904503B1 (en) 2005-07-19 2013-11-06 Nerviano Medical Sciences S.R.L. 1h-thieno[2,3-c]-pyrazole compounds useful as kinase inhibitors
CN101243090A (en) 2005-08-25 2008-08-13 霍夫曼-拉罗奇有限公司 P38 MAP kinase inhibitors and methods for using the same
MX2009003793A (en) 2006-10-09 2009-12-14 Takeda Pharmaceutical Kinase inhibitors.
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7618982B2 (en) 2005-12-19 2009-11-17 Nerviano Medical Sciences S.R.L. Heteroarylpyrrolopyridinones active as kinase inhibitors
RS52298B (en) * 2006-01-31 2012-12-31 Array Biopharma Inc. Kinase inhibitors and methods of use thereof
US9012487B2 (en) 2006-03-03 2015-04-21 Nerviano Medical Sciences S.R.L. Bicyclo-pyrazoles active as kinase inhibitors
JPWO2008001886A1 (en) * 2006-06-30 2009-11-26 協和発酵キリン株式会社 Aurora inhibitor
DE102006030479A1 (en) * 2006-07-01 2008-03-20 Merck Patent Gmbh indazole
WO2008070994A1 (en) 2006-12-14 2008-06-19 Nps Pharmaceuticals, Inc. Use of d-serine derivatives for the treatment of anxiety disorders
US20080146549A1 (en) * 2006-12-18 2008-06-19 Coleman Peter R Accelerated opiate dependence detoxification process
JP2010513370A (en) * 2006-12-19 2010-04-30 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Pyrazolo [3,4-d] pyrimidine p38 MAP kinase inhibitor
MX2009006401A (en) * 2006-12-20 2009-06-23 Nerviano Medical Sciences Srl Indazole derivatives as kinase inhibitors for the treatment of cancer.
JP5337717B2 (en) 2007-02-27 2013-11-06 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Isoquinolinopyrrolopyridinone active as a kinase inhibitor
EP2003129B1 (en) 2007-06-11 2017-08-09 Nerviano Medical Sciences S.r.l. 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives
JP2011502958A (en) * 2007-06-19 2011-01-27 タケダ サン ディエゴ インコーポレイテッド Glucokinase activated indazole compound
KR101653548B1 (en) * 2008-01-08 2016-09-02 머크 샤프 앤드 돔 리미티드 2-4-3--3--2--7- Pharmaceutically acceptable salts of 2-4-3-piperidin-3-ylphenyl-2H-indazole-7-carboxamide
JP5683462B2 (en) 2008-07-24 2015-03-11 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Therapeutic combination comprising an aurora kinase inhibitor and an antiproliferative agent
ES2630026T3 (en) * 2008-12-18 2017-08-17 Nerviano Medical Sciences S.R.L. Active substituted indazole derivatives as kinase inhibitors
RU2652638C2 (en) 2010-12-17 2018-04-28 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Substituted pyrazolo-quinazoline derivatives as kinase inhibitors
WO2012152763A1 (en) 2011-05-12 2012-11-15 Nerviano Medical Sciences S.R.L. Substituted indazole derivatives active as kinase inhibitors
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
EP3307725A1 (en) 2015-06-11 2018-04-18 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
DE102015012050A1 (en) * 2015-09-15 2017-03-16 Merck Patent Gmbh Compounds as ASIC inhibitors and their uses

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Also Published As

Publication number Publication date
DE60238999D1 (en) 2011-03-03
BR0212841A (en) 2004-08-03
EP1820503A2 (en) 2007-08-22
CZ2004359A3 (en) 2004-09-15
ZA200401848B (en) 2005-03-07
JP2005512967A (en) 2005-05-12
WO2003028720A1 (en) 2003-04-10
NO20041086L (en) 2004-03-15
CA2460145C (en) 2011-04-26
ES2357502T3 (en) 2011-04-27
EA200400476A1 (en) 2004-08-26
EP1820503A3 (en) 2008-05-21
US7511136B2 (en) 2009-03-31
IL160744D0 (en) 2004-08-31
CN1556702A (en) 2004-12-22
EA007430B1 (en) 2006-10-27
EP1820503B1 (en) 2012-02-22
JP4542338B2 (en) 2010-09-15
US20040254177A1 (en) 2004-12-16
ES2380054T3 (en) 2012-05-08
CA2460145A1 (en) 2003-04-10
EP1432416B1 (en) 2011-01-19
NZ531765A (en) 2006-02-24
EP1432416A1 (en) 2004-06-30
KR20040047869A (en) 2004-06-05
MXPA04001114A (en) 2004-05-20
PL368347A1 (en) 2005-03-21

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties