AT493386T - TRANS-3-azabicyclo-Ä3.1.0Ü-HEXANE DERIVATIVES - Google Patents

TRANS-3-azabicyclo-Ä3.1.0Ü-HEXANE DERIVATIVES

Info

Publication number
AT493386T
AT493386T AT08789439T AT08789439T AT493386T AT 493386 T AT493386 T AT 493386T AT 08789439 T AT08789439 T AT 08789439T AT 08789439 T AT08789439 T AT 08789439T AT 493386 T AT493386 T AT 493386T
Authority
AT
Austria
Prior art keywords
azabicyclo
trans
hexane derivatives
hexane
derivatives
Prior art date
Application number
AT08789439T
Other languages
German (de)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
David Lehmann
Thierry Sifferlen
Daniel Trachsel
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IB2007052987 priority Critical
Priority to IB2008051167 priority
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Priority to PCT/IB2008/052985 priority patent/WO2009016560A2/en
Publication of AT493386T publication Critical patent/AT493386T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
AT08789439T 2007-07-27 2008-07-25 TRANS-3-azabicyclo-Ä3.1.0Ü-HEXANE DERIVATIVES AT493386T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IB2007052987 2007-07-27
IB2008051167 2008-03-28
PCT/IB2008/052985 WO2009016560A2 (en) 2007-07-27 2008-07-25 Trans-3-aza-bicyclo[3.1.0]hexane derivatives

Publications (1)

Publication Number Publication Date
AT493386T true AT493386T (en) 2011-01-15

Family

ID=40130778

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08789439T AT493386T (en) 2007-07-27 2008-07-25 TRANS-3-azabicyclo-Ä3.1.0Ü-HEXANE DERIVATIVES

Country Status (8)

Country Link
EP (1) EP2185512B1 (en)
JP (1) JP2010534646A (en)
CN (1) CN101790515A (en)
AT (1) AT493386T (en)
CA (1) CA2693817A1 (en)
DE (1) DE602008004265D1 (en)
TW (1) TW200904799A (en)
WO (1) WO2009016560A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2350460T3 (en) * 2006-09-29 2011-01-24 Actelion Pharmaceuticals Ltd. Derivatives of 3-aza-biciclo [3.1.0] hexano.
WO2008150364A1 (en) 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
EP2275421A1 (en) 2009-07-15 2011-01-19 Rottapharm S.p.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
WO2011051342A1 (en) 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
CN102822169A (en) 2009-12-30 2012-12-12 艾科尔公司 Substituted naphthalenyl-pyrimidine compounds
AR080754A1 (en) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Imidazo (1,2-a) pyrazine and their use as inhibitors of PDE10
ES2541531T3 (en) 2011-02-18 2015-07-21 Actelion Pharmaceuticals Ltd. New pyrazole and imidazole derivatives useful as orexin antagonists
WO2013010947A2 (en) 2011-07-15 2013-01-24 Basf Se Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests ii
ES2672732T3 (en) 2012-02-07 2018-06-15 Eolas Therapeutics Inc. Prolines / substituted piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
ITMI20120322A1 (en) 2012-03-01 2013-09-02 Rottapharm Spa Compounds of 4,4-Difluoro piperidine
BR112014030173A2 (en) 2012-06-04 2017-06-27 Actelion Pharmaceuticals Ltd benzimidazole proline derivatives
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
US9550784B2 (en) 2012-07-09 2017-01-24 Beerse Pharmaceutica NV Inhibitors of phosphodiesterase 10 enzyme
CN104718213B (en) * 2012-07-18 2018-02-27 圣母大学 5,5 heteroaromatic anti-infective compounds
MX2015004638A (en) 2012-10-10 2015-07-14 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives.
JP2016510810A (en) 2013-03-12 2016-04-11 アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
CA2929720C (en) 2013-12-03 2019-06-18 Actelion Pharmaceuticals Ltd Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist
EA030137B1 (en) 2013-12-03 2018-06-29 Идорсиа Фармасьютиклз Лтд CRYSTALLINE FORM OF (S)-(2-(6-CHLORO-7-METHYL-1H-BENZO[d]IMIDAZOL-2-YL)-2-METHYLPYRROLIDIN-1-YL)(5-METHOXY-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)METHANONE AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS
TR201815342T4 (en) 2013-12-04 2018-11-21 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives.
WO2016025669A1 (en) 2014-08-13 2016-02-18 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130335D0 (en) * 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
AT344261T (en) * 2002-09-18 2006-11-15 Glaxo Group Ltd Cyclic n-aroylamines as orexine receptor antagonists
ES2350460T3 (en) * 2006-09-29 2011-01-24 Actelion Pharmaceuticals Ltd. Derivatives of 3-aza-biciclo [3.1.0] hexano.

Also Published As

Publication number Publication date
WO2009016560A3 (en) 2009-03-26
DE602008004265D1 (en) 2011-02-10
EP2185512B1 (en) 2010-12-29
CA2693817A1 (en) 2009-02-05
EP2185512A2 (en) 2010-05-19
JP2010534646A (en) 2010-11-11
TW200904799A (en) 2009-02-01
CN101790515A (en) 2010-07-28
WO2009016560A2 (en) 2009-02-05

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Legal Events

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