AT488231T - Quinazolinones as potassium channel modulators - Google Patents

Quinazolinones as potassium channel modulators

Info

Publication number
AT488231T
AT488231T AT03808616T AT03808616T AT488231T AT 488231 T AT488231 T AT 488231T AT 03808616 T AT03808616 T AT 03808616T AT 03808616 T AT03808616 T AT 03808616T AT 488231 T AT488231 T AT 488231T
Authority
AT
Austria
Prior art keywords
quinazolinones
potassium channel
channel modulators
modulators
potassium
Prior art date
Application number
AT03808616T
Other languages
German (de)
Inventor
Grant Mcnaughton-Smith
James Thomas
George Amato
Original Assignee
Icagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US43614502P priority Critical
Application filed by Icagen Inc filed Critical Icagen Inc
Priority to PCT/US2003/041657 priority patent/WO2004058704A2/en
Publication of AT488231T publication Critical patent/AT488231T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
AT03808616T 2002-12-23 2003-12-23 Quinazolinones as potassium channel modulators AT488231T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US43614502P true 2002-12-23 2002-12-23
PCT/US2003/041657 WO2004058704A2 (en) 2002-12-23 2003-12-23 Quinazolinones as potassium channel modulators

Publications (1)

Publication Number Publication Date
AT488231T true AT488231T (en) 2010-12-15

Family

ID=32682347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03808616T AT488231T (en) 2002-12-23 2003-12-23 Quinazolinones as potassium channel modulators

Country Status (8)

Country Link
US (2) US20040198724A1 (en)
EP (1) EP1585522B1 (en)
JP (1) JP4652816B2 (en)
AT (1) AT488231T (en)
AU (2) AU2003303484C1 (en)
CA (1) CA2505195C (en)
DE (1) DE60335028D1 (en)
WO (1) WO2004058704A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7799832B2 (en) * 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US20090291973A1 (en) * 2005-11-18 2009-11-26 Neurosearch A/S Novel Quinazoline Derivatives and Their Medical Use
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
AU2007288253B2 (en) * 2006-08-23 2013-05-02 Xenon Pharmaceuticals Inc. Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
ES2375417T3 (en) * 2006-11-28 2012-02-29 Valeant Pharmaceuticals International 1,4-diamino bicyclic analogs of retigabine as modulators of the potassium channels.
EP2152272A2 (en) * 2007-05-23 2010-02-17 NeuroSearch A/S Novel 2,3-diamino-quinazolinone derivatives and their medical use
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
EP2334380A1 (en) * 2008-05-30 2011-06-22 Mitologics Anti-ligands molecules and biological applications
WO2010039534A2 (en) * 2008-09-23 2010-04-08 Georgetown University Viral and fungal inhibitors
WO2010039538A2 (en) 2008-09-23 2010-04-08 Georgetown University Flavivirus inhibitors and methods for their use
TWI504395B (en) * 2009-03-10 2015-10-21
TW201038565A (en) * 2009-03-12 2010-11-01 Gruenenthal Gmbh Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
TWI461197B (en) 2009-03-12 2014-11-21
TWI475020B (en) 2009-03-12 2015-03-01
JP5837933B2 (en) 2010-08-27 2015-12-24 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング KCNQ2 / 3-substituted 2-oxy as a regulator - quinoline-3-carboxamide
BR112013004690A2 (en) 2010-08-27 2016-05-10 Grünenthal GmbH And 2-oxo-2-thioxo-dihydroquinoline-3-carboxamides as modulators of KCNQ2 / 3
WO2012025237A1 (en) 2010-08-27 2012-03-01 Grünenthal GmbH Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators
CA2807886A1 (en) 2010-09-01 2012-03-08 Gruenenthal Gmbh Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators
WO2012067824A1 (en) * 2010-11-16 2012-05-24 Abbott Laboratories Potassium channel modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3867384A (en) * 1972-09-01 1975-02-18 Greg A Bullock 2-Amino-4(3H)-quinazolinones
US4855289A (en) * 1984-06-04 1989-08-08 Wester Per O Combination of two active substances
FR2582514B1 (en) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medications-based amides, new amides and their preparation
US5276038A (en) * 1992-06-01 1994-01-04 American Cyanamid Company 1-aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)urea fungicidal agents
BR9406662A (en) * 1993-05-12 1996-02-06 Du Pont Compound disease control method and plant fungicidal composition mildew control method Wheat powder
US6255311B1 (en) * 1998-01-14 2001-07-03 E. I. Du Pont De Nemours And Company Fungicidal fused bicyclic pyrimidinones
US6667300B2 (en) * 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
JP4977837B2 (en) * 2003-09-10 2012-07-18 アイカジェン, インコーポレイテッド Fused heterocycle as potassium channel modulators

Also Published As

Publication number Publication date
EP1585522A2 (en) 2005-10-19
US20100190746A1 (en) 2010-07-29
AU2003303484C1 (en) 2012-06-14
DE60335028D1 (en) 2010-12-30
WO2004058704A2 (en) 2004-07-15
EP1585522B1 (en) 2010-11-17
WO2004058704A3 (en) 2005-07-07
AU2003303484B2 (en) 2009-09-17
CA2505195C (en) 2012-07-10
WO2004058704A8 (en) 2005-10-27
JP2006512379A (en) 2006-04-13
AU2009245837A1 (en) 2010-01-07
JP4652816B2 (en) 2011-03-16
US20040198724A1 (en) 2004-10-07
AU2003303484A1 (en) 2004-07-22
CA2505195A1 (en) 2004-07-15
EP1585522A4 (en) 2006-08-09
AU2009245837B2 (en) 2011-12-01

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Legal Events

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