AT486077T - Method for producing maytansinoidesters - Google Patents

Method for producing maytansinoidesters

Info

Publication number
AT486077T
AT486077T AT06718890T AT06718890T AT486077T AT 486077 T AT486077 T AT 486077T AT 06718890 T AT06718890 T AT 06718890T AT 06718890 T AT06718890 T AT 06718890T AT 486077 T AT486077 T AT 486077T
Authority
AT
Austria
Prior art keywords
maytansinoidesters
producing
method
Prior art date
Application number
AT06718890T
Other languages
German (de)
Inventor
Wayne Widdison
Ravi Chari
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US64498405P priority Critical
Application filed by Immunogen Inc filed Critical Immunogen Inc
Priority to PCT/US2006/001885 priority patent/WO2006078809A2/en
Publication of AT486077T publication Critical patent/AT486077T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
AT06718890T 2005-01-21 2006-01-20 Method for producing maytansinoidesters AT486077T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US64498405P true 2005-01-21 2005-01-21
PCT/US2006/001885 WO2006078809A2 (en) 2005-01-21 2006-01-20 Method for the preparation of maytansinoid esters

Publications (1)

Publication Number Publication Date
AT486077T true AT486077T (en) 2010-11-15

Family

ID=36692868

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06718890T AT486077T (en) 2005-01-21 2006-01-20 Method for producing maytansinoidesters

Country Status (14)

Country Link
US (1) US7301019B2 (en)
EP (1) EP1838715B1 (en)
JP (2) JP5425402B2 (en)
AT (1) AT486077T (en)
AU (1) AU2006206421B2 (en)
CA (1) CA2601670C (en)
CY (1) CY1111157T1 (en)
DE (1) DE602006017797D1 (en)
DK (1) DK1838715T3 (en)
ES (1) ES2355153T3 (en)
PL (1) PL1838715T3 (en)
PT (1) PT1838715E (en)
SI (1) SI1838715T1 (en)
WO (1) WO2006078809A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
DE60234094D1 (en) 2001-05-11 2009-12-03 Ludwig Inst For Cancer Res Ltd Specific tie proteins and its use
US7276497B2 (en) * 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
US7301019B2 (en) * 2005-01-21 2007-11-27 Immunogen, Inc. Method for the preparation of maytansinoid esters
JP5167130B2 (en) * 2005-08-09 2013-03-21 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. Method for acylating maytansinol with chiral amino acids
CN110613845A (en) 2007-01-25 2019-12-27 达娜-法勃肿瘤研究所公司 Use of anti-EGFR antibodies in the treatment of EGFR mutant-mediated diseases
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
ES2643239T3 (en) 2008-01-31 2017-11-21 Genentech, Inc. Anti-CD79b and immunoconjugate antibodies and methods of use
EP2641618A3 (en) 2007-07-16 2013-10-23 Genentech, Inc. Humanized anti-CD79B antibodies and immunoconjugates and methods of use
EP2502937B1 (en) 2007-07-16 2016-04-06 Genentech, Inc. Anti-CD 79b Antibodies And Immunoconjugates And Methods Of Use
JP5532486B2 (en) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Monoclonal antibody 175 targeting EGF receptor and derivatives and uses thereof
MX2011010264A (en) 2009-04-01 2011-10-11 Genentech Inc Anti-fcrh5 antibodies and immunoconjugates and methods of use.
CN102596922A (en) 2009-10-06 2012-07-18 免疫基因公司 Potent conjugates and hydrophilic linkers
RU2573994C2 (en) 2010-02-10 2016-01-27 Иммьюноджен, Инк Anti-cd20 antibodies and thereof application
CN103313990B (en) 2010-11-17 2016-07-20 基因泰克公司 Alanyl maytansinol antibody coupling matter
EA029797B1 (en) 2011-06-21 2018-05-31 Иммуноджен, Инк. Novel maytansinoid derivatives with peptide linker and conjugates thereof
AU2012312274B2 (en) 2011-09-22 2017-11-16 Amgen Inc. CD27L antigen binding proteins
CN102731526B (en) * 2012-05-14 2014-09-10 福建省微生物研究所 New ansamitocin compounds and preparation method thereof
US9012629B2 (en) * 2012-09-26 2015-04-21 Immunogen, Inc. Methods for the acylation of maytansinol
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
TW201425336A (en) 2012-12-07 2014-07-01 Amgen Inc BCMA antigen binding proteins
CN103333246B (en) 2012-12-21 2015-09-16 百奥泰生物科技(广州)有限公司 Tumor growth inhibitors of a kind of anti-EGFR acceptor and its production and use
CN104530235A (en) 2012-12-21 2015-04-22 百奥泰生物科技(广州)有限公司 Antibody drug derivative for inhibiting tumor growth as well as preparation method and use of antibody drug derivative
CN103254213B (en) 2012-12-21 2015-02-25 百奥泰生物科技(广州)有限公司 Preparation method of maytenin-like ester and composition used in method
CN103333179B (en) 2012-12-21 2017-06-16 百奥泰生物科技(广州)有限公司 Class maytansine derivative and its production and use
US9920121B2 (en) 2013-01-25 2018-03-20 Amgen Inc. Antibodies targeting CDH19 for melanoma
EP2961434A2 (en) 2013-02-28 2016-01-06 ImmunoGen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
PT3004167T (en) 2013-05-30 2018-11-13 Kiniksa Pharmaceuticals Ltd Oncostatin m receptor antigen binding proteins
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
TWI541022B (en) 2013-12-18 2016-07-11 應克隆公司 Compounds to fibroblast growth factor receptor-3 (fgfr3) and methods of treatment
JP6417421B2 (en) 2014-02-28 2018-11-07 ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. Charged conjugates and their use for conjugates
SG11201707585UA (en) * 2015-03-17 2017-10-30 Regeneron Pharma Amino acid acylation reagents and methods of using the same
TW201711702A (en) 2015-06-04 2017-04-01 應克隆公司 Therapies utilizing compounds to fibroblast growth factor receptor-3 (FGFR3)
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN107417701A (en) * 2016-03-03 2017-12-01 凯惠科技发展(上海)有限公司 A kind of Preparation Method And Their Intermediate of maytansine ester

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55164685A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164686A (en) * 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US6020507A (en) * 1998-03-02 2000-02-01 Bristol-Myers Squibb Company Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US7301019B2 (en) * 2005-01-21 2007-11-27 Immunogen, Inc. Method for the preparation of maytansinoid esters

Also Published As

Publication number Publication date
CA2601670C (en) 2013-04-02
WO2006078809A2 (en) 2006-07-27
EP1838715A4 (en) 2009-06-03
JP5425402B2 (en) 2014-02-26
CY1111157T1 (en) 2015-06-11
DK1838715T3 (en) 2011-02-14
US7301019B2 (en) 2007-11-27
PT1838715E (en) 2011-01-27
CA2601670A1 (en) 2006-07-27
US20060167245A1 (en) 2006-07-27
PL1838715T3 (en) 2011-04-29
JP2014012693A (en) 2014-01-23
ES2355153T3 (en) 2011-03-23
JP2008528493A (en) 2008-07-31
AU2006206421A1 (en) 2006-07-27
EP1838715A2 (en) 2007-10-03
SI1838715T1 (en) 2011-02-28
AU2006206421B2 (en) 2010-12-16
WO2006078809A3 (en) 2007-07-12
EP1838715B1 (en) 2010-10-27
DE602006017797D1 (en) 2010-12-09

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