AT483707T - 2-cyclopropylthiazolderivate - Google Patents

2-cyclopropylthiazolderivate

Info

Publication number
AT483707T
AT483707T AT08738121T AT08738121T AT483707T AT 483707 T AT483707 T AT 483707T AT 08738121 T AT08738121 T AT 08738121T AT 08738121 T AT08738121 T AT 08738121T AT 483707 T AT483707 T AT 483707T
Authority
AT
Austria
Prior art keywords
cyclopropylthiazolderivate
Prior art date
Application number
AT08738121T
Other languages
German (de)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IB2007051808 priority Critical
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Priority to PCT/IB2008/051883 priority patent/WO2008139416A1/en
Publication of AT483707T publication Critical patent/AT483707T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AT08738121T 2007-05-14 2008-05-13 2-cyclopropylthiazolderivate AT483707T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IB2007051808 2007-05-14
PCT/IB2008/051883 WO2008139416A1 (en) 2007-05-14 2008-05-13 2-cyclopropyl-thiazole derivatives

Publications (1)

Publication Number Publication Date
AT483707T true AT483707T (en) 2010-10-15

Family

ID=39673407

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08738121T AT483707T (en) 2007-05-14 2008-05-13 2-cyclopropylthiazolderivate

Country Status (9)

Country Link
US (1) US20100222328A1 (en)
EP (1) EP2155739B1 (en)
JP (1) JP2010526869A (en)
CN (1) CN101711247A (en)
AT (1) AT483707T (en)
CA (1) CA2685743A1 (en)
DE (1) DE602008002934D1 (en)
ES (1) ES2351079T3 (en)
WO (1) WO2008139416A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101522618A (en) * 2006-09-29 2009-09-02 埃科特莱茵药品有限公司 3-aza-bicyclo[3.1.0]hexane derivatives
AT496043T (en) 2006-12-01 2011-02-15 Actelion Pharmaceuticals Ltd 3-heteroaryl (amino and amido) -1- (biphenyl or phenylthiazolyl) carbonylpiperdinderivate as orexin receptor inhibitors
TW200833328A (en) * 2006-12-28 2008-08-16 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.1.0]hexane derivatives
CL2008000836A1 (en) * 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd derivatives of thiazolidine compounds, orexin receptor antagonists; pharmaceutical composition that comprises; and their use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's disease, Parkinson's disease, pain, among others.
US8288429B2 (en) * 2007-07-27 2012-10-16 Actelion Pharmaceuticals Ltd. 2-aza-bicyclo[3.3.0]octane derivatives
CA2699328A1 (en) * 2007-09-24 2009-04-02 Actelion Pharmaceuticals Ltd Pyrrolidines and piperidines as orexin receptor antagonists
US8236801B2 (en) * 2008-02-21 2012-08-07 Actelion Pharmaceuticals Ltd. 2-aza-bicyclo[2.2.1]heptane derivatives
WO2009133522A1 (en) * 2008-04-30 2009-11-05 Actelion Pharmaceuticals Ltd Piperidine and pyrrolidine compounds
JP2012505263A (en) * 2008-10-14 2012-03-01 アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd Phenethylamide derivatives and their heterocyclyl analogs
EP2275421A1 (en) 2009-07-15 2011-01-19 Rottapharm S.p.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
ITMI20120424A1 (en) 2012-03-19 2013-09-20 Rottapharm Spa Chemical compounds
CN104334544B (en) 2012-06-04 2016-10-19 埃科特莱茵药品有限公司 Benzimidazole-proline derivative
BR112015007516A2 (en) 2012-10-10 2017-07-04 Actelion Pharmaceuticals Ltd orexin receptor antagonists that are derivatives of [ortho bi (hetero) aryl] - [2- (meta bi (hetero) aryl) - pyrrolidin-1-yl] -methanone
CN105051040A (en) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 Azetidine amide derivatives as orexin receptor antagonists
JP6091716B2 (en) 2013-12-03 2017-03-08 アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd Orexin receptor antagonists as the (s) - (2-(6- chloro-7-methyl--1h- benzo [d] imidazol-2-yl) -2-methylpyrrolidin-1-yl) (5-methoxy-2 - (2h-1,2,3-triazol-2-yl) phenyl) methanone salt crystal form
LT3077389T (en) 2013-12-03 2017-12-11 Idorsia Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
MX2016007313A (en) 2013-12-04 2016-09-07 Actelion Pharmaceuticals Ltd Use of benzimidazole-proline derivatives.
WO2016025669A1 (en) 2014-08-13 2016-02-18 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
WO2016065587A1 (en) 2014-10-30 2016-05-06 Merck Sharp & Dohme Corp. Pyrazole orexin receptor antagonists
CN106588900A (en) * 2015-10-20 2017-04-26 北京康辰医药科技有限公司 Benzo-bicyclic compound or its pharmaceutically acceptable salt, pharmaceutical composition and their application
TW201843144A (en) 2017-05-03 2018-12-16 瑞士商愛杜西亞製藥有限公司 2 - ([1,2,3] triazol-2-yl) - benzoic acid derivative of

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1289955E (en) * 2000-06-16 2005-08-31 Smithkline Beecham Plc Piperidines for use as antagonists of orexine receptors
GB0130335D0 (en) * 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
EP1871752A4 (en) * 2005-04-12 2009-09-30 Merck & Co Inc Amidopropoxyphenyl orexin receptor antagonists

Also Published As

Publication number Publication date
CA2685743A1 (en) 2008-11-20
CN101711247A (en) 2010-05-19
ES2351079T3 (en) 2011-01-31
WO2008139416A1 (en) 2008-11-20
DE602008002934D1 (en) 2010-11-18
US20100222328A1 (en) 2010-09-02
JP2010526869A (en) 2010-08-05
EP2155739B1 (en) 2010-10-06
EP2155739A1 (en) 2010-02-24

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties