AT482934T - Biphenyl derivatives with beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity - Google Patents

Biphenyl derivatives with beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity

Info

Publication number
AT482934T
AT482934T AT04711253T AT04711253T AT482934T AT 482934 T AT482934 T AT 482934T AT 04711253 T AT04711253 T AT 04711253T AT 04711253 T AT04711253 T AT 04711253T AT 482934 T AT482934 T AT 482934T
Authority
AT
Austria
Prior art keywords
antagonist activity
biphenyl derivatives
beta2 adrenergic
receptor antagonist
receptor agonist
Prior art date
Application number
AT04711253T
Other languages
German (de)
Inventor
Mathai Mammen
Sarah Dunham
Adam Hughes
Tae Weon Lee
Craig Husfeld
Eric Stangeland
Yan Chen
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US44784303P priority Critical
Priority to US46703503P priority
Application filed by Theravance Inc filed Critical Theravance Inc
Priority to PCT/US2004/004449 priority patent/WO2004074246A2/en
Publication of AT482934T publication Critical patent/AT482934T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/452Piperidinium derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/48Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406Neurotransmitters
    • G01N33/9433(Nor)adrenaline
AT04711253T 2003-02-14 2004-02-13 Biphenyl derivatives with beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity AT482934T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US44784303P true 2003-02-14 2003-02-14
US46703503P true 2003-05-01 2003-05-01
PCT/US2004/004449 WO2004074246A2 (en) 2003-02-14 2004-02-13 Biphenyl derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity

Publications (1)

Publication Number Publication Date
AT482934T true AT482934T (en) 2010-10-15

Family

ID=32912274

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04711253T AT482934T (en) 2003-02-14 2004-02-13 Biphenyl derivatives with beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity

Country Status (28)

Country Link
US (15) US7141671B2 (en)
EP (5) EP2246345B1 (en)
JP (6) JP2006517971A (en)
KR (3) KR20110132634A (en)
AR (1) AR043176A1 (en)
AT (1) AT482934T (en)
AU (2) AU2004213411B2 (en)
BR (1) BRPI0407508B1 (en)
CA (1) CA2515777C (en)
CY (2) CY1111276T1 (en)
DE (1) DE602004029347D1 (en)
DK (2) DK2246345T3 (en)
ES (2) ES2566155T3 (en)
HK (3) HK1086266A1 (en)
HU (1) HUE027380T2 (en)
IL (1) IL169922A (en)
IS (1) IS2847B (en)
MX (1) MXPA05008528A (en)
MY (1) MY148487A (en)
NO (2) NO331947B1 (en)
NZ (1) NZ541579A (en)
PE (1) PE09502004A1 (en)
PL (1) PL216397B1 (en)
PT (1) PT1615889E (en)
RU (1) RU2330841C2 (en)
SI (2) SI1615889T1 (en)
TW (1) TWI331995B (en)
WO (3) WO2004074246A2 (en)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa New quinuclidine derivatives and pharmaceutical compositions containing them.
AR040962A1 (en) * 2002-08-09 2005-04-27 Novartis Ag Thiazole derivatives compounds 1.3-2-one, pharmaceutical composition and process of preparing the compound
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
PE09502004A1 (en) * 2003-02-14 2005-01-01 Theravance Inc Biphenyl derivatives as agonists beta2 adrenoceptor antagonists RECEIVERS AND muscarinic receptor
US7317102B2 (en) 2003-04-01 2008-01-08 Theravance, Inc. Diarylmethyl and related compounds
JP4616264B2 (en) * 2003-05-28 2011-01-19 セラヴァンス, インコーポレーテッド Azabicycloalkanes compounds as muscarinic receptor antagonists
DE602004025803D1 (en) * 2003-06-06 2010-04-15 Arexis Ab Use of condensed heterocyclic compounds as SCCE inhibitors for the treatment of skin conditions
US20050026948A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
WO2005051946A2 (en) 2003-11-21 2005-06-09 Theravance, Inc. Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
TW200531692A (en) * 2004-01-12 2005-10-01 Theravance Inc Aryl aniline derivatives as β2 adrenergic receptor agonists
WO2005080375A1 (en) * 2004-02-13 2005-09-01 Theravance, Inc. Crystalline form of a biphenyl compound
TWI341836B (en) 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
WO2005087735A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP1723108A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
WO2005087734A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP1723113A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP1723112A1 (en) 2004-03-11 2006-11-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7560469B2 (en) 2004-03-11 2009-07-14 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
TW200538095A (en) * 2004-03-11 2005-12-01 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
ES2257152B1 (en) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Antimuscarinics and combinations comprising beta-adrenergic agents agonists.
ES2317245T3 (en) * 2004-05-31 2009-04-16 Laboratorios Almirall, S.A. Antimuscarinics and combinations comprising beta-adrenergic agents agonists.
WO2006023457A1 (en) * 2004-08-16 2006-03-02 Theravance, Inc. COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound
US7569586B2 (en) 2004-08-16 2009-08-04 Theravance, Inc. Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
GT200500281A (en) 2004-10-22 2006-04-24 Novartis Ag organic compounds.
EP1824483A4 (en) * 2004-10-29 2009-11-04 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
DE102004054054A1 (en) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg A process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
US7629336B2 (en) * 2005-03-10 2009-12-08 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
TW200714587A (en) * 2005-03-10 2007-04-16 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
US7659403B2 (en) 2005-03-10 2010-02-09 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7642355B2 (en) 2005-03-10 2010-01-05 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP1856049A1 (en) * 2005-03-10 2007-11-21 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
ES2265276B1 (en) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivatives of 4- (2-amino-1-hydroxyethyl) phenol as beta2 adrenergic receptor agonists.
JP2008546695A (en) * 2005-06-13 2008-12-25 セラヴァンス, インコーポレーテッド Useful biphenyl compounds as muscarinic receptor antagonists
US8429052B2 (en) * 2005-07-19 2013-04-23 Lincoln National Life Insurance Company Method and system for providing employer-sponsored retirement plan
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
EP1924553A1 (en) 2005-08-08 2008-05-28 Argenta Discovery Limited Bicyclo[2.2.]hept-7-ylamine derivatives and their uses
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
KR101461263B1 (en) 2005-10-21 2014-11-17 노파르티스 아게 Human antibodies against IL-13 and therapeutic uses
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
GB0602778D0 (en) * 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
US7973055B2 (en) * 2006-03-09 2011-07-05 Theravance, Inc. Crystalline forms of a biphenyl compound
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
KR101064787B1 (en) 2006-03-20 2011-09-14 화이자 리미티드 Amine derivatives
AT549337T (en) 2006-04-21 2012-03-15 Novartis Ag Purine derivatives for use as adenosine A2a receptor agonist
TW200811105A (en) 2006-04-25 2008-03-01 Theravance Inc Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
TW200811104A (en) * 2006-04-25 2008-03-01 Theravance Inc Crystalline forms of a dimethylphenyl compound
ES2296516B1 (en) * 2006-04-27 2009-04-01 Laboratorios Almirall S.A. Derivatives of 4- (2-amino-1-hydroxyethyl) phenol as beta2 adrenergic receptor agonists.
CA2873524C (en) 2006-05-04 2018-02-20 Boehringer Ingelheim International Gmbh A polymeric form of 1-((4-methyl-quinazolin-2-yl)methyl)-3-7-(2-butyn-1-yl)-8-(3-(r)-aminopiperidin-1-yl)xanthine
PE02352011A1 (en) 2006-05-04 2011-04-14 Boehringer Ingelheim Int pharmaceutical combinations comprising metformin and linagliptin
GB0613154D0 (en) * 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
KR20090050104A (en) * 2006-10-04 2009-05-19 화이자 리미티드 Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists
ES2302447B1 (en) * 2006-10-20 2009-06-12 Laboratorios Almirall S.A. Derivatives of 4- (2-amino-1-hydroxyethyl) phenol as beta2 adrenergic receptor agonists.
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
EP2104535B9 (en) 2007-01-10 2011-06-15 Irm Llc Compounds and compositions as channel activating protease inhibitors
CN101595088B (en) 2007-01-31 2013-06-19 东丽株式会社 Benzylamine derivative or pharmaceutically acceptable acid addition salt thereof, and use thereof for medical purposes
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
ES2306595B1 (en) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Napadisylate salt of 5- (2 - ((6- (2,2-difluoro-2-phenylethoxy) hexyl) amino) -1-hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one as beta2 adrenergic receptor agonist .
US8682466B2 (en) * 2007-05-04 2014-03-25 Taiwan Semiconductor Manufacturing Company, Ltd. Automatic virtual metrology for semiconductor wafer result prediction
CA2685546A1 (en) 2007-05-07 2008-11-13 Novartis Ag Organic compounds
ES2320961B1 (en) * 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivatives of 4- (2-amino-1-hydroxyethyl) phenol as beta2 adrenergic receptor agonists.
JP5455922B2 (en) 2007-12-10 2014-03-26 ノバルティス アーゲー Organic compounds
MX2010007604A (en) 2008-01-11 2010-08-02 Novartis Ag Pyrimidines as kinase inhibitors.
EA018711B1 (en) * 2008-02-06 2013-10-30 Астразенека Аб Derivatives diazaspiro [5.5] undecane as muscarinic receptor antagonists and agonists, beta-adrenergic receptors for use in treating pulmonary disorders
EP2096105A1 (en) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
AR071175A1 (en) 2008-04-03 2010-06-02 Boehringer Ingelheim Int pharmaceutical composition comprising an inhibitor of dipeptidyl peptidase-4 (DPP4) and a companion drug
WO2009150137A2 (en) 2008-06-10 2009-12-17 Novartis Ag Organic compounds
AU2009260899B2 (en) 2008-06-18 2012-02-23 Astrazeneca Ab Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders
US8263623B2 (en) * 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
KR20110017452A (en) * 2008-07-15 2011-02-21 화이자 리미티드 Novel compounds active as muscarinic receptor antagonists
WO2010007561A1 (en) * 2008-07-15 2010-01-21 Pfizer Limited Novel compounds active as muscarinic receptor antagonists
KR20190016601A (en) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 Treatment for diabetes in patients inappropriate for metformin therapy
UY32297A (en) 2008-12-22 2010-05-31 Almirall Sa mesylate salt of 5- (2 - {[6- (2,2-difluoro-2-fenilitoxi) hexyl] amino} -1-hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one as b receptor agonist (beta ) 2 acrenérgico
TWI508965B (en) 2008-12-23 2015-11-21 Boehringer Ingelheim Int Salt forms of organic compound
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
MX2011009700A (en) 2009-03-17 2011-12-08 Daiichi Sankyo Co Ltd Amide derivative.
US8519138B2 (en) * 2009-04-14 2013-08-27 Glaxo Group Limited Process for the preparation of a biphenyl-2-yl carbamic acid ester
AU2015234331B2 (en) * 2009-04-23 2017-08-03 Theravance Respiratory Company, Llc Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
SI3210981T1 (en) 2009-04-23 2019-05-31 Theravance Respiratory Company, Llc Diamide compounds having muscarinic receptor antagonist and beta 2 adrenergic receptor agonist activity
MX2011011446A (en) * 2009-04-30 2011-11-18 Teijin Pharma Ltd Quaternary ammonium salt compound.
EP2813227A1 (en) 2009-10-22 2014-12-17 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
KR20120107080A (en) 2009-11-27 2012-09-28 베링거 인겔하임 인터내셔날 게엠베하 Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
WO2011138421A1 (en) 2010-05-05 2011-11-10 Boehringer Ingelheim International Gmbh Combination therapy
ITRM20110083U1 (en) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Plate for the construction of trucks for airplanes
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
CA2801101C (en) * 2010-07-13 2018-01-16 Theravance, Inc. Process for preparing a biphenyl-2-ylcarbamic acid
NZ605528A (en) 2010-07-14 2015-02-27 Novartis Ag Ip receptor agonist heterocyclic compounds
WO2012032546A2 (en) * 2010-09-08 2012-03-15 Cadila Healthcare Limited Process for the preparation of salmeterol and its intermediates
UY33597A (en) 2010-09-09 2012-04-30 Irm Llc Compounds and compositions as inhibitors of trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
AR083115A1 (en) * 2010-09-30 2013-01-30 Theravance Inc Crystalline oxalate salts of a diamide compound
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
AR083878A1 (en) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Vasoprotectives and cardioprotective anti-diabetic therapy, linagliptin, treatment method
GEP20156285B (en) 2011-02-25 2015-05-11 Aierem Elelsi Compounds and compositions as trk inhibitors
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
KR101906630B1 (en) 2011-06-10 2018-10-10 키에시 파르마슈티시 엣스. 피. 에이. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
WO2012168359A1 (en) 2011-06-10 2012-12-13 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
MX2014000354A (en) 2011-07-15 2014-05-01 Boehringer Ingelheim Int Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions.
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
US9056867B2 (en) 2011-09-16 2015-06-16 Novartis Ag N-substituted heterocyclyl carboxamides
EP2755967B1 (en) 2011-09-16 2015-10-21 Novartis AG Heterocyclic compounds for the treatment of cystic fibrosis
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
TW201335160A (en) 2012-01-13 2013-09-01 Novartis Ag IP receptor agonist heterocyclic compounds
EP2802581A1 (en) 2012-01-13 2014-11-19 Novartis AG 7,8- dihydropyrido [3, 4 - b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
EP2802582A1 (en) 2012-01-13 2014-11-19 Novartis AG Fused dihydropyrido [2,3 -b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
EP2802583A1 (en) 2012-01-13 2014-11-19 Novartis AG Fused piperidines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
US9115129B2 (en) 2012-01-13 2015-08-25 Novartis Ag Substituted pyrido[2,3-B]pyrazines as IP receptor agonists
WO2013105066A1 (en) 2012-01-13 2013-07-18 Novartis Ag Salts of an ip receptor agonist
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2014044288A1 (en) 2012-09-21 2014-03-27 Crystal Pharma Sa Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
CN104854105B (en) 2012-12-06 2017-05-17 奇斯药制品公司 Having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity of the compound
AU2013354043C1 (en) 2012-12-06 2017-08-31 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
BR112015013628A2 (en) 2012-12-18 2017-07-11 Almirall Sa cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
ES2637719T3 (en) 2013-02-13 2017-10-16 Novartis Ag IP receptor agonist heterocyclic compounds
TWI643853B (en) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
CZ306252B6 (en) * 2013-03-15 2016-10-26 Zentiva, K.S. Process for preparing 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-quinolin-2-one (indacaterol)
SG11201600241RA (en) 2013-07-18 2016-02-26 Novartis Ag Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core
US20160168119A1 (en) 2013-07-18 2016-06-16 Novartis Ag Autotaxin inhibitors
TWI641373B (en) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES
WO2015128453A1 (en) 2014-02-28 2015-09-03 Boehringer Ingelheim International Gmbh Medical use of a dpp-4 inhibitor
US10004732B2 (en) 2014-04-24 2018-06-26 Novartis Ag Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
MX2016013981A (en) 2014-04-24 2016-11-15 Novartis Ag Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors.
BR112016023967A2 (en) 2014-04-24 2017-08-15 Novartis Ag pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
TW201617343A (en) 2014-09-26 2016-05-16 Almirall Sa Agonists and M3 antagonist activity of the novel mushroom poisoning bicyclic derivatives having adrenergic β2
TW201636338A (en) 2015-02-12 2016-10-16 Chiesi Farma Spa Compound muscarinic receptor antagonists and agonists of β2 adrenergic receptor activity having mushroom
AR104828A1 (en) 2015-06-01 2017-08-16 Chiesi Farm Spa COMPOUNDS antagonist activity and muscarinic receptor agonist activity b2 ADRENERGIC
WO2017001907A1 (en) * 2015-06-29 2017-01-05 Teva Pharmaceuticals International Gmbh Biocatalytic processes for the preparation of vilanterol
WO2017093208A1 (en) 2015-12-03 2017-06-08 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
JP2019504069A (en) * 2016-01-22 2019-02-14 スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド Nitrogen-containing heterocyclic amide derivative, method for producing the same, and pharmaceutical use
BR112018072401A2 (en) 2016-06-10 2019-02-19 Boehringer Ingelheim Int linagliptin and metformin combination
WO2018011090A1 (en) 2016-07-13 2018-01-18 Chiesi Farmaceutici S.P.A. Hydroxyquinolinone compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
CN106706868B (en) * 2016-11-15 2018-12-04 河南省农业科学院 Application of the artificial expression HSP27 albumen in terms of detecting beta-2-adrenoreceptor agonists class medicament residue
WO2018108089A1 (en) 2016-12-14 2018-06-21 北京硕佰医药科技有限责任公司 Class of bifunctional compounds with quaternary ammonium salt structure
CN106632257B (en) * 2016-12-15 2019-02-12 上海市奉贤区中心医院 The synthetic method of GSK961081 and its intermediate

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026897A (en) * 1974-01-31 1977-05-31 Otsuka Pharmaceutical Company 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
BR8007911A (en) 1979-12-06 1981-06-16 Glaxo Group Ltd inhaler perfected
DE3274065D1 (en) 1981-07-08 1986-12-11 Draco Ab Powder inhalator
DE3134590A1 (en) 1981-09-01 1983-03-10 Boehringer Ingelheim Kg New benzo-heterocycles
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
ES2000781A6 (en) 1985-07-30 1988-03-16 Glaxo Group Ltd Device for delivering drugs to patients in finely divided solid form
US4894219A (en) * 1988-03-29 1990-01-16 University Of Florida Beta-agonist carbostyril derivatives, assay method and pharmacological composition
US5225183A (en) 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
DK443489D0 (en) 1989-09-08 1989-09-08 Ferrosan As Substituted urea compounds, their preparation and use
SK280967B6 (en) 1990-03-02 2000-10-09 Glaxo Group Limited Inhalation device
US6006745A (en) 1990-12-21 1999-12-28 Minnesota Mining And Manufacturing Company Device for delivering an aerosol
US5874063A (en) 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
AU2178392A (en) 1991-06-12 1993-01-12 Minnesota Mining And Manufacturing Company Albuterol sulfate suspension aerosol formulations
US5337740A (en) 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
EP0717987B1 (en) 1991-12-18 2001-08-29 Minnesota Mining And Manufacturing Company Suspension aerosol formulations
DE69327583T2 (en) 1992-03-31 2000-05-31 Glaxo Group Ltd Substituted phenyl carbamates and phenylureas, their production and their use as 5-HT4 antagonists
US5239993A (en) 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
CA2123728A1 (en) * 1993-05-21 1994-11-22 Noriyoshi Sueda Urea derivatives and their use as acat inhibitors
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
AU7545894A (en) 1993-09-02 1995-03-22 Yamanouchi Pharmaceutical Co., Ltd. Carbamate derivative and medicine containing the same
US5983956A (en) 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
US5415162A (en) 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
WO1995021820A1 (en) 1994-02-10 1995-08-17 Yamanouchi Pharmaceutical Co., Ltd. Novel carbamate derivative and medicinal composition containing the same
US5495054A (en) 1994-05-31 1996-02-27 Sepracor, Inc. Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts
SE9501384D0 (en) 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
DK0820323T3 (en) 1995-04-14 2003-11-24 Smithkline Beecham Corp A metered dose inhaler of salmeterol
DE19536902A1 (en) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Apparatus for generating high pressure in a fluid in miniature version
DE69615214T2 (en) 1995-10-13 2002-06-27 Banyu Pharma Co Ltd Substituted heteroaromatic derivatives
PE92198A1 (en) 1996-08-01 1999-01-09 Banyu Pharma Co Ltd Derivatives of 1,4-disubstituted piperidine containing fluorine
US6040344A (en) 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
AU9281298A (en) 1997-10-01 1999-04-23 Kyowa Hakko Kogyo Co. Ltd. Benzodioxole derivatives
CA2313125A1 (en) 1997-12-12 1999-06-24 Laramie Mary Gaster Quinolinepiperazine and quinolinepiperidine derivatives, their preparation and their use as combined 5-ht1a, 5-ht1b and 5-ht1d receptor antagonists
WO1999047505A1 (en) 1998-03-14 1999-09-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone pde iii/iv inhibitors
MA26621A1 (en) 1998-04-18 2004-12-20 Glaxo Group Ltd Composition for pharmaceutical aerosols
GB9808802D0 (en) 1998-04-24 1998-06-24 Glaxo Group Ltd Pharmaceutical formulations
GB9812088D0 (en) 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
US6713651B1 (en) * 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
SG80041A1 (en) 1998-06-08 2001-04-17 Advanced Medicine Inc Muscarinic receptor antagonists
US6541669B1 (en) * 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
SE9804000D0 (en) 1998-11-23 1998-11-23 Astra Ab New composition of matter
EP1140834A1 (en) * 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Heterocyclic piperidines as modulators of chemokine receptor activity
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
JP2002541183A (en) 1999-04-14 2002-12-03 グラクソ グループ リミテッド Medicinal aerosol formulations
DE19921693A1 (en) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Pharmaceutical composition for treating respiratory disorders, e.g. asthma, comprises combination of anticholinergic and beta-mimetic agents having synergistic bronchospasmolytic activity and reduced side-effects
US6593497B1 (en) * 1999-06-02 2003-07-15 Theravance, Inc. β2-adrenergic receptor agonists
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
AU783095B2 (en) * 1999-12-07 2005-09-22 Theravance Biopharma R&D Ip, Llc Carbamate derivatives having muscarinic receptor antagonist activity
IL149289D0 (en) * 1999-12-07 2002-11-10 Theravance Inc Urea compounds having muscarinic receptor antagonist activity
US6576793B1 (en) * 1999-12-08 2003-06-10 Theravance, Inc. β2-adrenergic receptor agonists
BR0111440A (en) 2000-06-05 2003-06-03 Altana Pharma Ag Compounds effective as agonists (beta) 2-adrenoceptor well as PDE4 inhibitors
UA76131C2 (en) 2000-12-22 2003-09-15 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and medicinal compositions containing said derivatives
GB0103630D0 (en) 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
AT365720T (en) 2001-03-08 2007-07-15 Glaxo Group Ltd Agonists of beta-adrenergic receptors
ES2296923T3 (en) 2001-03-22 2008-05-01 Glaxo Group Limited You formanilides derivatives as beta2 adrenoreceptor agonists.
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
PT1425001E (en) 2001-09-14 2009-02-18 Glaxo Group Ltd Phenethanolamine derivatives for treatment of respiratory diseases
US6653323B2 (en) * 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
AU2003232201B2 (en) 2002-04-12 2009-06-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments containing betamimetic drugs and a novel anticholinesterase drug
EP1507754A1 (en) * 2002-05-28 2005-02-23 Theravance, Inc. Alkoxy aryl beta-2 adrenergic receptor agonists
US6711451B2 (en) * 2002-07-02 2004-03-23 3D Systems, Inc. Power management in selective deposition modeling
GB0217225D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
UY27927A1 (en) 2002-08-06 2003-12-31 Glaxo Group Ltd M3 muscarinic receptor antagonists of acetylcholine
PE09502004A1 (en) * 2003-02-14 2005-01-01 Theravance Inc Biphenyl derivatives as agonists beta2 adrenoceptor antagonists RECEIVERS AND muscarinic receptor
US7317102B2 (en) * 2003-04-01 2008-01-08 Theravance, Inc. Diarylmethyl and related compounds
JP4616264B2 (en) 2003-05-28 2011-01-19 セラヴァンス, インコーポレーテッド Azabicycloalkanes compounds as muscarinic receptor antagonists
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
WO2005007645A1 (en) * 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
WO2005051946A2 (en) 2003-11-21 2005-06-09 Theravance, Inc. Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
WO2005080375A1 (en) * 2004-02-13 2005-09-01 Theravance, Inc. Crystalline form of a biphenyl compound
EP1725525A1 (en) * 2004-03-11 2006-11-29 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1723113A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP1723112A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP1723108A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
WO2005087735A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
WO2005087734A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
TW200538095A (en) * 2004-03-11 2005-12-01 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
WO2006023457A1 (en) * 2004-08-16 2006-03-02 Theravance, Inc. COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
US7569586B2 (en) * 2004-08-16 2009-08-04 Theravance, Inc. Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound
TW200811104A (en) * 2006-04-25 2008-03-01 Theravance Inc Crystalline forms of a dimethylphenyl compound
TW200811105A (en) * 2006-04-25 2008-03-01 Theravance Inc Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity

Also Published As

Publication number Publication date
US7345175B2 (en) 2008-03-18
JP2007119496A (en) 2007-05-17
HK1216892A1 (en) 2016-12-09
US20060223859A1 (en) 2006-10-05
BRPI0407508A (en) 2006-02-14
IL169922A (en) 2013-08-29
US7524959B2 (en) 2009-04-28
US20130150404A1 (en) 2013-06-13
CY1117459T1 (en) 2017-04-26
DE602004029347D1 (en) 2010-11-11
US20040167167A1 (en) 2004-08-26
EP3012254B1 (en) 2017-05-17
JP2011225617A (en) 2011-11-10
MY148487A (en) 2013-04-30
US8242135B2 (en) 2012-08-14
MXPA05008528A (en) 2005-10-20
EP2246345B1 (en) 2016-02-10
NZ541579A (en) 2008-08-29
WO2004074246A2 (en) 2004-09-02
US7141671B2 (en) 2006-11-28
US20140235864A1 (en) 2014-08-21
NO333394B1 (en) 2013-05-27
JP5436503B2 (en) 2014-03-05
EP1592685A1 (en) 2005-11-09
WO2004074812A2 (en) 2004-09-02
US7507751B2 (en) 2009-03-24
RU2330841C2 (en) 2008-08-10
EP2246345A1 (en) 2010-11-03
NO20054206L (en) 2005-10-19
NO20054206D0 (en) 2005-09-09
IS2847B (en) 2013-09-15
JP2010159291A (en) 2010-07-22
CY1111276T1 (en) 2015-08-05
TW200424173A (en) 2004-11-16
IS7964A (en) 2005-07-28
JP4555283B2 (en) 2010-09-29
CA2515777A1 (en) 2004-09-02
ES2636480T3 (en) 2017-10-05
PL216397B1 (en) 2014-03-31
AU2010219338B2 (en) 2012-07-12
US7521561B2 (en) 2009-04-21
KR20110132634A (en) 2011-12-08
KR101224497B1 (en) 2013-01-23
CA2515777C (en) 2013-01-22
AR043176A1 (en) 2005-07-20
US20070276003A1 (en) 2007-11-29
ES2566155T3 (en) 2016-04-11
EP3012254A1 (en) 2016-04-27
PL378025A1 (en) 2006-02-20
US20110312994A1 (en) 2011-12-22
KR101223991B1 (en) 2013-01-21
US7355046B2 (en) 2008-04-08
JP2006517978A (en) 2006-08-03
US20060229334A1 (en) 2006-10-12
JP5247757B2 (en) 2013-07-24
EP1615889B1 (en) 2010-09-29
US8618131B2 (en) 2013-12-31
EP1594860A2 (en) 2005-11-16
HK1086266A1 (en) 2010-12-31
US7829583B2 (en) 2010-11-09
EP1615889A2 (en) 2006-01-18
US8969571B2 (en) 2015-03-03
HUE027380T2 (en) 2016-09-28
AU2010219338A1 (en) 2010-09-30
US20060223858A1 (en) 2006-10-05
US20060223860A1 (en) 2006-10-05
US20070208176A1 (en) 2007-09-06
TWI331995B (en) 2010-10-21
DK2246345T3 (en) 2016-05-02
JP2006517971A (en) 2006-08-03
KR20050102114A (en) 2005-10-25
US7879879B2 (en) 2011-02-01
HK1149548A1 (en) 2016-08-12
WO2004074276B1 (en) 2004-10-07
WO2004074246A3 (en) 2004-11-18
US20040209860A1 (en) 2004-10-21
US20080015220A1 (en) 2008-01-17
AU2004213411B2 (en) 2010-06-24
SI1615889T1 (en) 2011-01-31
BRPI0407508B1 (en) 2015-12-01
NO20120150L (en) 2005-10-19
US20040209915A1 (en) 2004-10-21
US20070037984A1 (en) 2007-02-15
KR20110053393A (en) 2011-05-20
NO331947B1 (en) 2012-05-07
SI2246345T1 (en) 2016-06-30
PE09502004A1 (en) 2005-01-01
RU2005128557A (en) 2006-03-20
US7514558B2 (en) 2009-04-07
JP2006518739A (en) 2006-08-17
AU2004213411A1 (en) 2004-09-02
WO2004074276A1 (en) 2004-09-02
PT1615889E (en) 2010-12-09
US20070088054A1 (en) 2007-04-19
DK1615889T3 (en) 2010-12-20
WO2004074812A3 (en) 2004-11-04

Similar Documents

Publication Publication Date Title
DE60004066D1 (en) Benzofurylpiperazine: 5-HT2C agonist serotonin receptor
DE60239485D1 (en) Benzamide and heteroarylamid as P2X7 receptor antagonists
AT470396T (en) With locking device provided surgical instrument
DE602004004811D1 (en) quinazoline derivatives
DE602005008489D1 (en) Occupant protection device
DE602004005033D1 (en) Benzamidinhibitoren the P2X7 receptor
DE602004024963D1 (en) Oxycodone conjugate lower missbrauch- potential and extensive activities permanently
DE602004022029D1 (en) St) distributed command interpretation and generalized command protocol
DE602005023149D1 (en) Wirbelsäulenfixierelement with adjustable angle
DE60221901D1 (en) Benzimidazole derivatives and their use as GnRH antagonists
DE602005007060D1 (en) Connector lead with lock and connector for
AT516911T (en) Pulse welding device and its use
DK1583763T3 (en) Benzoazolylpiperazinderivater with VR1 antagonist
DE602005018568D1 (en) Monitor support device
AT344261T (en) Cyclic n-aroylamine as orexin receptor antagonists
AT474600T (en) Combinations with antimuscarinic agents and PDE4 inhibitors
IS6775A (en) EP4 receptor selective agonist for the treatment ábeinþynningu
DE502004006697D1 (en) Spirocyclic cyclohexane derivatives with affinity for the ORL1 receptor
AT510252T (en) Improved device interface
DE60335891D1 (en) derivatives Sulphonylaminoessigsaeure and their use as orexin receptor antagoniste
DE60332842D1 (en) Antagonists of the nogo receptor
AT545427T (en) Against abuse protected amphetamine compounds
IS8190A (en) New P2X7 receptor antagonists and their use
DE60317516D1 (en) A soap bar with simultaneous hautabschilfernden and moisturizing properties
AT250577T (en) Indole derivatives and antagonists its use as mcp-1 receptor

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1615889

Country of ref document: EP