AT481401T - Tetrahydro-4h-pyridoe1,2-atpyrimidines and related compounds use as hiv integrase hemmer - Google Patents

Tetrahydro-4h-pyridoe1,2-atpyrimidines and related compounds use as hiv integrase hemmer

Info

Publication number
AT481401T
AT481401T AT03768014T AT03768014T AT481401T AT 481401 T AT481401 T AT 481401T AT 03768014 T AT03768014 T AT 03768014T AT 03768014 T AT03768014 T AT 03768014T AT 481401 T AT481401 T AT 481401T
Authority
AT
Austria
Prior art keywords
atpyrimidines
pyridoe1
hemmer
tetrahydro
4h
Prior art date
Application number
AT03768014T
Other languages
German (de)
Inventor
Benedetta Crescenzi
Olaf Kinzel
Ester Muraglia
Federica Orvieto
Giovanna Pescatore
Michael Rowley
Vincenzo Summa
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US43683002P priority Critical
Priority to US52877603P priority
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Priority to PCT/GB2003/005536 priority patent/WO2004058756A1/en
Publication of AT481401T publication Critical patent/AT481401T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
AT03768014T 2002-12-27 2003-12-18 Tetrahydro-4h-pyridoe1,2-atpyrimidines and related compounds use as hiv integrase hemmer AT481401T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US43683002P true 2002-12-27 2002-12-27
US52877603P true 2003-12-12 2003-12-12
PCT/GB2003/005536 WO2004058756A1 (en) 2002-12-27 2003-12-18 Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
AT481401T true AT481401T (en) 2010-10-15

Family

ID=32685467

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03768014T AT481401T (en) 2002-12-27 2003-12-18 Tetrahydro-4h-pyridoe1,2-atpyrimidines and related compounds use as hiv integrase hemmer

Country Status (20)

Country Link
US (2) US7414045B2 (en)
EP (1) EP1578748B1 (en)
JP (1) JP4733986B2 (en)
KR (1) KR20050087865A (en)
CN (1) CN100343253C (en)
AT (1) AT481401T (en)
AU (2) AU2003292437A1 (en)
BR (1) BR0317749A (en)
CA (1) CA2509554C (en)
DE (1) DE60334248D1 (en)
EC (1) ECSP055890A (en)
HR (1) HRP20050593A2 (en)
IS (1) IS7892A (en)
MA (1) MA27583A1 (en)
MX (1) MXPA05007010A (en)
NO (1) NO20053624L (en)
NZ (1) NZ540729A (en)
PL (1) PL377354A1 (en)
RU (1) RU2329265C2 (en)
WO (2) WO2004058756A1 (en)

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AR046938A1 (en) * 2003-12-12 2006-01-04 Merck & Co Inc Process for preparing hexahydropyrimido [1,2-a] azepin-2-carboxylates and similar compuetos
TW200526635A (en) * 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
US7273859B2 (en) 2004-05-12 2007-09-25 Bristol-Myers Squibb Company HIV integrase inhibitors: cyclic pyrimidinone compounds
US7115601B2 (en) 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
US7176196B2 (en) 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7173022B2 (en) 2004-05-28 2007-02-06 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7192948B2 (en) * 2004-05-28 2007-03-20 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7157447B2 (en) 2004-05-28 2007-01-02 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
WO2006060225A2 (en) * 2004-11-23 2006-06-08 Merck & Co., Inc. Process for asymmetric synthesis of hexahydropyrimido[1,2-a] azepine-2-carboxamides and related compounds
AR052034A1 (en) * 2004-12-03 2007-02-28 Merck & Co Inc Potassium salt of an inhibitor of HIV integrase
ES2727577T3 (en) 2004-12-03 2019-10-17 Merck Sharp & Dohme Pharmaceutical composition containing an antinucleating agent
NZ555120A (en) 2004-12-03 2009-11-27 Merck & Co Inc Pharmaceutical formulation of carboxamide HIV integrase inhibitors containing a release rate controlling composition
CA2588466A1 (en) * 2004-12-03 2006-06-08 Merck & Co., Inc. Use of atazanavir for improving the pharmacokinetics of drugs metabolized by ugt1a1
EP1852434B1 (en) * 2005-02-21 2011-07-13 Shionogi Co., Ltd. Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity
US7981879B2 (en) * 2005-03-31 2011-07-19 Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. HIV integrase inhibitors
DK2465580T3 (en) * 2005-04-28 2014-03-10 Viiv Healthcare Co Polycyclic carbamoyl pyridone derivatives with hiv integrase inhibitive activity
MX2008000212A (en) 2005-06-30 2008-03-24 Wyeth Corp Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation.
US7494984B2 (en) * 2005-08-31 2009-02-24 Bristol-Myers Squibb Company Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
AU2006299042B8 (en) * 2005-10-04 2011-09-15 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa HIV integrase inhibitors
WO2007050510A2 (en) * 2005-10-27 2007-05-03 Merck & Co., Inc. Hiv integrase inhibitors
MX2008005137A (en) 2005-10-27 2008-09-29 Shionogi & Co Polycyclic carbamoylpyridone derivative having inhibitory activity on hiv integrase.
WO2007058646A1 (en) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors: cyclic pyrimidinone compounds
WO2007059125A2 (en) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
US8039458B2 (en) * 2005-11-17 2011-10-18 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064316A1 (en) * 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Bicyclic heterocycles as hiv integrase inhibitors
US20070129379A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Hiv integrase inhibitors
WO2007087188A2 (en) * 2006-01-20 2007-08-02 Merck & Co., Inc. Taste-masked tablets and granules
US7897593B2 (en) 2006-05-30 2011-03-01 Bristol-Myers Squibb Company HIV integrase inhibitors
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2010042391A2 (en) * 2008-10-06 2010-04-15 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
ES2641765T3 (en) * 2008-12-11 2017-11-13 Shionogi & Co., Ltd. Synthesis of HIV integrase inhibitors carbamoylpyridone and intermediates
US8143244B2 (en) * 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
WO2011001113A2 (en) * 2009-07-02 2011-01-06 Sanofi-Aventis Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
EP2488521B1 (en) 2009-10-13 2013-12-18 Elanco Animal Health Ireland Limited Macrocyclic integrase inhibitors
US8383639B2 (en) 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
CA2777937C (en) 2009-10-26 2017-08-29 Merck Sharp & Dohme Corp. Solid pharmaceutical compositions containing an integrase inhibitor
RU2567385C2 (en) 2010-04-02 2015-11-10 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Macrocyclic integrase inhibitors
US8653092B2 (en) 2010-07-06 2014-02-18 Novartis Ag Tetrahydro-pyrido-pyrimidine derivatives
CA2857302A1 (en) 2011-12-15 2013-06-20 Novartis Ag Use of inhibitors of the activity or function of pi3k
WO2014099586A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
EP2986291B1 (en) 2013-04-16 2020-05-27 Merck Sharp & Dohme Corp. 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
LT2997033T (en) 2013-05-17 2018-02-12 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
US9951079B2 (en) 2013-06-13 2018-04-24 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
EP3049081B1 (en) 2013-09-27 2019-11-27 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
PE20190968A1 (en) 2016-12-02 2019-07-08 Merck Sharp & Dohme Heterocycle tetracyclic compounds useful as inhibitors of HIV integrase

Family Cites Families (19)

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US6262055B1 (en) * 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) * 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) * 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
AU5880600A (en) 1999-06-25 2001-01-31 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
DE60131160T2 (en) * 2000-06-07 2008-08-07 Vertex Pharmaceuticals Inc., Cambridge Caspase inhibitors and its uses
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
CA2321348A1 (en) * 2000-09-27 2002-03-27 Blaise Magloire N'zemba Aromatic derivatives with hiv integrase inhibitory properties
US20050010048A1 (en) 2000-10-12 2005-01-13 Linghang Zhuang Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors
KR20030036922A (en) * 2000-10-12 2003-05-09 머크 앤드 캄파니 인코포레이티드 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
US6919351B2 (en) 2000-10-12 2005-07-19 Merck & Co., Inc. Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors
ES2274913T3 (en) 2000-10-12 2007-06-01 MERCK & CO., INC. Aza and poliaza-naftalenil carboxamids useful as integrated hiv inhibitors.
PT2266958T (en) 2001-08-10 2017-05-10 Shionogi & Co Antiviral agent
EP1441734B1 (en) * 2001-10-26 2007-02-28 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
CN102219750B (en) * 2001-10-26 2013-05-29 P.安杰莱蒂分子生物学研究所 N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase
EP1467970B1 (en) 2002-01-17 2007-08-22 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
WO2004004657A2 (en) * 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Hiv integrase inhibitors
US7135467B2 (en) * 2003-01-13 2006-11-14 Bristol-Myers Squibb Company HIV integrase inhibitors
US7037908B2 (en) * 2003-04-24 2006-05-02 Bristol-Myers Squibb Company HIV integrase inhibitors
AR046938A1 (en) * 2003-12-12 2006-01-04 Merck & Co Inc Process for preparing hexahydropyrimido [1,2-a] azepin-2-carboxylates and similar compuetos

Also Published As

Publication number Publication date
JP2006513200A (en) 2006-04-20
HRP20050593A2 (en) 2006-03-31
CN100343253C (en) 2007-10-17
BR0317749A (en) 2005-11-22
NO20053624D0 (en) 2005-07-26
PL377354A1 (en) 2006-01-23
RU2005123807A (en) 2006-01-20
NZ540729A (en) 2008-03-28
CA2509554C (en) 2011-02-01
WO2004058756A1 (en) 2004-07-15
JP4733986B2 (en) 2011-07-27
MA27583A1 (en) 2005-10-03
NO20053624L (en) 2005-09-26
MXPA05007010A (en) 2005-08-18
WO2004058757A1 (en) 2004-07-15
RU2329265C2 (en) 2008-07-20
AU2003292436A1 (en) 2004-07-22
CN1753892A (en) 2006-03-29
AU2003292436B2 (en) 2009-07-30
US7968553B2 (en) 2011-06-28
US20060046985A1 (en) 2006-03-02
EP1578748A1 (en) 2005-09-28
US7414045B2 (en) 2008-08-19
US20080176869A1 (en) 2008-07-24
KR20050087865A (en) 2005-08-31
DE60334248D1 (en) 2010-10-28
CA2509554A1 (en) 2004-07-15
IS7892A (en) 2005-06-13
EP1578748B1 (en) 2010-09-15
ECSP055890A (en) 2005-09-20
AU2003292437A1 (en) 2004-07-22

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties