AT475652T - quinazoline derivatives - Google Patents

quinazoline derivatives

Info

Publication number
AT475652T
AT475652T AT02700688T AT02700688T AT475652T AT 475652 T AT475652 T AT 475652T AT 02700688 T AT02700688 T AT 02700688T AT 02700688 T AT02700688 T AT 02700688T AT 475652 T AT475652 T AT 475652T
Authority
AT
Austria
Prior art keywords
quinazoline derivatives
quinazoline
derivatives
Prior art date
Application number
AT02700688T
Other languages
German (de)
Inventor
Yasunori Kitano
Eiji Kawahara
Tsuyoshi Suzuki
Daisuke Abe
Masahiro Nakajou
Naoko Ueda
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2001045827 priority Critical
Priority to JP2001353525 priority
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Priority to PCT/JP2002/001575 priority patent/WO2002066445A1/en
Publication of AT475652T publication Critical patent/AT475652T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
AT02700688T 2001-02-21 2002-02-21 quinazoline derivatives AT475652T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001045827 2001-02-21
JP2001353525 2001-11-19
PCT/JP2002/001575 WO2002066445A1 (en) 2001-02-21 2002-02-21 Quinazoline derivatives

Publications (1)

Publication Number Publication Date
AT475652T true AT475652T (en) 2010-08-15

Family

ID=26609852

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02700688T AT475652T (en) 2001-02-21 2002-02-21 quinazoline derivatives

Country Status (10)

Country Link
US (2) US7294629B2 (en)
EP (1) EP1369418B1 (en)
JP (1) JP4285996B2 (en)
KR (1) KR100861486B1 (en)
CN (1) CN1264824C (en)
AT (1) AT475652T (en)
CA (1) CA2442742A1 (en)
DE (1) DE60237145D1 (en)
TW (1) TWI309647B (en)
WO (1) WO2002066445A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813014A (en) 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
GB0309850D0 (en) 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
JP4795952B2 (en) 2003-09-16 2011-10-19 アストラゼネカ アクチボラグ Quinazoline derivatives as tyrosine kinase inhibitors
DK1667992T3 (en) * 2003-09-19 2007-04-30 Astrazeneca Ab quinazoline
CN1882570B (en) * 2003-09-19 2010-12-08 阿斯利康(瑞典)有限公司 Quinazoline derivatives
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
MXPA06003341A (en) * 2003-09-25 2006-06-08 Astrazeneca Ab Quinazoline derivatives.
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
US20050267182A1 (en) * 2003-11-13 2005-12-01 Ambit Biosciences Corporation Urea derivatives as FLT-3 modulators
WO2005051924A1 (en) * 2003-11-28 2005-06-09 Mitsubishi Pharma Corporation Quinazoline derivative and process for producing the same
ES2315834T3 (en) 2004-02-03 2009-04-01 Astrazeneca Ab Quinazoline derivatives.
AP2204A (en) 2004-05-06 2011-02-07 Warner Lambert Co 4-phenylamino-quinazolin-6-yl-amides.
WO2006025490A1 (en) * 2004-09-01 2006-03-09 Mitsubishi Pharma Corporation Molecular chaperone function regulator
JP4881875B2 (en) 2004-12-14 2012-02-22 アストラゼネカ アクチボラグ Pyrazolopyrimidine compounds as antitumor agents
AU2006216266C1 (en) 2005-02-23 2010-08-26 Shionogi & Co., Ltd. Quinazoline derivative having tyrosine kinase inhibitory activity
AT521603T (en) * 2005-02-26 2011-09-15 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
JP4993205B2 (en) * 2005-03-30 2012-08-08 塩野義製薬株式会社 Pyrimidine derivatives having tyrosine kinase inhibitory action
ES2354457T3 (en) 2005-09-20 2011-03-15 Astrazeneca Ab Compounds of 4- (1H-indazol-5-ylamino) quinazoline as inhibitors of erbB receptor tyrosine kinase for treating cancer.
US20100048898A1 (en) * 2006-03-03 2010-02-25 Jacobsen Eric N Process for Synthesizing 7-Alkynyl-4- Aminoquinazolines and a Related Intermediate
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
BRPI0807234A2 (en) 2007-02-06 2014-06-03 Boehringer Ingelheim Int Bicyclic heterocycles, pharmaceutical compositions containing these compounds, use of same and processes for preparing same
MX2010008621A (en) 2008-02-07 2010-09-24 Boehringer Ingelheim Int Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production.
US8088782B2 (en) * 2008-05-13 2012-01-03 Astrazeneca Ab Crystalline 4-(3-chloro-2-fluoroanilino)-7 methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline difumarate form A
EP2313397B1 (en) 2008-08-08 2016-04-20 Boehringer Ingelheim International GmbH Cyclohexyloxy substituted heterocycles, medicine containing these connections, their application and production method
BR112012022868A2 (en) * 2010-03-16 2018-06-05 Merck Patent Gmbh morpholinylquinazolines
KR20140020955A (en) 2011-03-04 2014-02-19 뉴젠 세러퓨틱스 인코포레이티드 Alkyne substituted quinazoline compound and methods of use
WO2012155339A1 (en) 2011-05-17 2012-11-22 江苏康缘药业股份有限公司 4-phenylamino-6-butenamide-7-alkyloxy quinazoline derivatives, preparative method and use thereof
US9034885B2 (en) 2012-01-13 2015-05-19 Acea Biosciences Inc. EGFR modulators and uses thereof
US9586965B2 (en) 2012-01-13 2017-03-07 Acea Biosciences Inc. Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
US9464089B2 (en) 2012-01-13 2016-10-11 Acea Biosciences Inc. Heterocyclic compounds and uses thereof
CN103254143B (en) * 2013-04-26 2015-10-07 浙江工业大学 4- [4- (2-diethylamino-acetylamino) anilino] quinazoline-6-substituted compound and preparation and application
WO2014177038A1 (en) 2013-04-28 2014-11-06 Sunshine Lake Pharma Co., Ltd. Aminoquinazoline derivatives and their salts and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3134236B2 (en) 1992-01-30 2001-02-13 株式会社林原生物化学研究所 Separation system for the production method and the production of α- glycosyl -L- ascorbate-rich product
JP2994165B2 (en) 1992-06-26 1999-12-27 ゼネカ・リミテッド Quinazoline derivatives, pharmaceutical formulations for obtaining anticancer activity containing their production and the quinazoline derivative
AT213730T (en) 1996-04-12 2002-03-15 Warner Lambert Co kinases reversible inhibitors of tyrosine
EP0837063A1 (en) * 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazoline derivatives
ZA9806732B (en) * 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
US6251912B1 (en) * 1997-08-01 2001-06-26 American Cyanamid Company Substituted quinazoline derivatives
WO2005051924A1 (en) * 2003-11-28 2005-06-09 Mitsubishi Pharma Corporation Quinazoline derivative and process for producing the same

Also Published As

Publication number Publication date
US7294629B2 (en) 2007-11-13
JP4285996B2 (en) 2009-06-24
CN1492860A (en) 2004-04-28
CA2442742A1 (en) 2002-08-29
KR20030086269A (en) 2003-11-07
KR100861486B1 (en) 2008-10-02
EP1369418A4 (en) 2005-09-14
JPWO2002066445A1 (en) 2004-06-17
US20070265260A1 (en) 2007-11-15
WO2002066445A1 (en) 2002-08-29
CN1264824C (en) 2006-07-19
DE60237145D1 (en) 2010-09-09
TWI309647B (en) 2009-05-11
US20040116422A1 (en) 2004-06-17
EP1369418A1 (en) 2003-12-10
EP1369418B1 (en) 2010-07-28

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties