AT474854T - Rsv neutralizing antibody with very high affinity - Google Patents

Rsv neutralizing antibody with very high affinity

Info

Publication number
AT474854T
AT474854T AT01903352T AT01903352T AT474854T AT 474854 T AT474854 T AT 474854T AT 01903352 T AT01903352 T AT 01903352T AT 01903352 T AT01903352 T AT 01903352T AT 474854 T AT474854 T AT 474854T
Authority
AT
Austria
Prior art keywords
high affinity
neutralizing antibody
rsv neutralizing
rsv
antibody
Prior art date
Application number
AT01903352T
Other languages
German (de)
Inventor
James Young
Scott Koenig
Leslie Johnson
William Huse
Herren Wu
Jeffry Watkins
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US17842600P priority Critical
Application filed by Medimmune Llc filed Critical Medimmune Llc
Priority to PCT/US2001/002618 priority patent/WO2001055217A1/en
Publication of AT474854T publication Critical patent/AT474854T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses, e.g. hepatitis E virus
    • C07K16/1027Paramyxoviridae, e.g. respiratory syncytial virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
AT01903352T 2000-01-27 2001-01-26 Rsv neutralizing antibody with very high affinity AT474854T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US17842600P true 2000-01-27 2000-01-27
PCT/US2001/002618 WO2001055217A1 (en) 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies

Publications (1)

Publication Number Publication Date
AT474854T true AT474854T (en) 2010-08-15

Family

ID=22652515

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01903352T AT474854T (en) 2000-01-27 2001-01-26 Rsv neutralizing antibody with very high affinity

Country Status (12)

Country Link
US (4) US6656467B2 (en)
EP (2) EP1265928B1 (en)
JP (2) JP4992068B2 (en)
AT (1) AT474854T (en)
AU (2) AU785038B2 (en)
CA (1) CA2398466A1 (en)
CY (1) CY1111542T1 (en)
DE (1) DE60142614D1 (en)
DK (1) DK1265928T3 (en)
ES (1) ES2349348T3 (en)
PT (1) PT1265928E (en)
WO (1) WO2001055217A1 (en)

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WO2018075974A2 (en) 2016-10-21 2018-04-26 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
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Also Published As

Publication number Publication date
EP1265928A1 (en) 2002-12-18
US20120135006A1 (en) 2012-05-31
JP2010180207A (en) 2010-08-19
AU2010201090A1 (en) 2010-04-15
AU2010201090B2 (en) 2012-05-17
AU785038B2 (en) 2006-08-31
JP4992068B2 (en) 2012-08-08
US20020164326A1 (en) 2002-11-07
EP1265928B1 (en) 2010-07-21
AU785038C (en) 2001-08-07
CY1111542T1 (en) 2015-08-05
US6656467B2 (en) 2003-12-02
US7740851B2 (en) 2010-06-22
EP2289550A2 (en) 2011-03-02
DK1265928T3 (en) 2010-11-15
US20040131609A1 (en) 2004-07-08
CA2398466A1 (en) 2001-08-02
AU3118001A (en) 2001-08-07
EP2289550A3 (en) 2012-02-15
US20100266614A1 (en) 2010-10-21
WO2001055217A1 (en) 2001-08-02
PT1265928E (en) 2010-09-30
JP2003528052A (en) 2003-09-24
DE60142614D1 (en) 2010-09-02
ES2349348T3 (en) 2010-12-30

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