AT472526T - New compounds and their use as ppar modulators - Google Patents

New compounds and their use as ppar modulators

Info

Publication number
AT472526T
AT472526T AT03757741T AT03757741T AT472526T AT 472526 T AT472526 T AT 472526T AT 03757741 T AT03757741 T AT 03757741T AT 03757741 T AT03757741 T AT 03757741T AT 472526 T AT472526 T AT 472526T
Authority
AT
Austria
Prior art keywords
use
new compounds
ppar modulators
ppar
modulators
Prior art date
Application number
AT03757741T
Other languages
German (de)
Inventor
Lone Jeppesen
John Mogensen
Ingrid Pettersson
Per Sauerberg
Pavel Pihera
Miroslav Havranek
Original Assignee
High Point Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DKPA200201631 priority Critical
Priority to DKPA200300793 priority
Application filed by High Point Pharmaceuticals Llc filed Critical High Point Pharmaceuticals Llc
Priority to PCT/DK2003/000722 priority patent/WO2004037776A2/en
Publication of AT472526T publication Critical patent/AT472526T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers
    • C07C69/712Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
AT03757741T 2002-10-28 2003-10-27 New compounds and their use as ppar modulators AT472526T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DKPA200201631 2002-10-28
DKPA200300793 2003-05-26
PCT/DK2003/000722 WO2004037776A2 (en) 2002-10-28 2003-10-27 Novel compounds and their use as prar-modulators

Publications (1)

Publication Number Publication Date
AT472526T true AT472526T (en) 2010-07-15

Family

ID=32178576

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03757741T AT472526T (en) 2002-10-28 2003-10-27 New compounds and their use as ppar modulators

Country Status (15)

Country Link
EP (1) EP1558572B1 (en)
JP (1) JP4708184B2 (en)
KR (1) KR20050061562A (en)
AT (1) AT472526T (en)
AU (2) AU2003273783C1 (en)
BR (1) BR0315683A (en)
CA (1) CA2503280A1 (en)
DE (1) DE60333211D1 (en)
ES (1) ES2345882T3 (en)
MX (1) MXPA05004402A (en)
NO (1) NO20052575L (en)
PL (1) PL376718A1 (en)
RU (1) RU2349582C2 (en)
WO (1) WO2004037776A2 (en)
ZA (1) ZA200502814B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129268B2 (en) * 2002-10-28 2006-10-31 Novo Nordisk A/S Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
KR101111475B1 (en) 2003-09-19 2012-03-15 얀센 파마슈티카 엔.브이. 4-phenoxyalkylthio-phenoxyacetic acids and analogs
RU2006112342A (en) * 2003-10-28 2007-12-10 Д-р Редди`с Лабораторис Лтд (IN) New compounds and their use in medicine, the method of producing there and their pharmacetic compositions containing them
AT515494T (en) 2004-05-05 2011-07-15 High Point Pharmaceuticals Llc New compounds, their preparation and use
EP1756062A4 (en) * 2004-05-14 2008-01-02 Irm Llc Compounds and compositions as ppar modulators
JO3006B1 (en) 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv Novel Lysine Salts of 4-((Phenoxy Alkyl)Thio)-Phenoxy Acetic Acid Derivatives
BRPI0620468A2 (en) 2005-12-22 2011-11-08 Transtech Pharma Inc acetic phenoxy acids as activators of delta ppar
UY30288A1 (en) 2006-04-18 2007-08-31 Janssen Pharmaceutica Nv Derivatives of the benzoazepin-oxy-acetic as PPAR-delta acid used to increase HDL-c. reduce LDL-cholesterol and reduce c
WO2007141295A1 (en) * 2006-06-08 2007-12-13 High Point Pharmaceuticals, Llc Process for preparing phenoxy acetic acid derivatives
EP3043789A1 (en) 2013-09-09 2016-07-20 vTv Therapeutics LLC Use of a ppar-delta agonist for treating muscle atrophy

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT262334T (en) 1996-02-02 2004-04-15 Merck & Co Inc Antidiabetic agent
WO1997027847A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Method of treating diabetes and related disease states
DE69723680T9 (en) 1996-02-02 2004-11-04 Merck & Co., Inc. Antidiabetic agents
WO1997028149A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Method for raising hdl cholesterol levels
EP0882029B1 (en) 1996-02-02 2003-04-02 MERCK & CO., INC. Heterocyclic derivatives as antidiabetic and antiobesity agents
US5773469A (en) 1996-06-18 1998-06-30 Ortho Pharmaceutical Corporation Diaryl antimicrobial agents
WO1998027974A1 (en) 1996-12-23 1998-07-02 Merck & Co., Inc. Antidiabetic agents
DE69840510D1 (en) 1997-07-24 2009-03-12 Astellas Pharma Inc Medical compositions with cholesterol effluent effect
CN1348439A (en) 1999-04-20 2002-05-08 诺沃挪第克公司 New compounds, their preparation and use
GB9914977D0 (en) 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
JP2001354671A (en) 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ACTIVATOR FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR δ
JP4790969B2 (en) 2000-08-11 2011-10-12 日本ケミファ株式会社 Activator of peroxisome proliferator-responsive receptor δ
GB0031103D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
IL159547D0 (en) * 2001-07-30 2004-06-01 Novo Nordisk As Novel vinyl carboxylic acid derivatives and their use as antidiabetics

Also Published As

Publication number Publication date
DE60333211D1 (en) 2010-08-12
AU2003273783B2 (en) 2010-03-18
MXPA05004402A (en) 2005-07-26
EP1558572A2 (en) 2005-08-03
EP1558572B1 (en) 2010-06-30
PL376718A1 (en) 2006-01-09
ZA200502814B (en) 2005-12-28
AU2003273783A1 (en) 2004-05-13
JP4708184B2 (en) 2011-06-22
RU2349582C2 (en) 2009-03-20
RU2005116243A (en) 2006-01-20
AU2003273783C1 (en) 2010-08-12
WO2004037776A2 (en) 2004-05-06
AU2010201560A1 (en) 2010-05-06
JP2006503908A (en) 2006-02-02
WO2004037776A3 (en) 2004-06-10
KR20050061562A (en) 2005-06-22
NO20052575L (en) 2005-05-27
BR0315683A (en) 2005-08-30
ES2345882T3 (en) 2010-10-05
CA2503280A1 (en) 2004-05-06

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