AT471311T - Inhibitors of11-beta-hydroxysteroid dehydrogenase 1 - Google Patents

Inhibitors of11-beta-hydroxysteroid dehydrogenase 1

Info

Publication number
AT471311T
AT471311T AT07782529T AT07782529T AT471311T AT 471311 T AT471311 T AT 471311T AT 07782529 T AT07782529 T AT 07782529T AT 07782529 T AT07782529 T AT 07782529T AT 471311 T AT471311 T AT 471311T
Authority
AT
Austria
Prior art keywords
of11
inhibitors
beta
hydroxysteroid dehydrogenase
hydroxysteroid
Prior art date
Application number
AT07782529T
Other languages
German (de)
Inventor
Larry Leonard Winneroski
Thomas Edward Mabry
Nancy June Snyder
Owen Brendan Wallace
Yanping Xu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US74557406P priority Critical
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to PCT/US2007/067350 priority patent/WO2007127763A2/en
Publication of AT471311T publication Critical patent/AT471311T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
AT07782529T 2006-04-25 2007-04-25 Inhibitors of11-beta-hydroxysteroid dehydrogenase 1 AT471311T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US74557406P true 2006-04-25 2006-04-25
PCT/US2007/067350 WO2007127763A2 (en) 2006-04-25 2007-04-25 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
AT471311T true AT471311T (en) 2010-07-15

Family

ID=38541939

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07782529T AT471311T (en) 2006-04-25 2007-04-25 Inhibitors of11-beta-hydroxysteroid dehydrogenase 1

Country Status (14)

Country Link
US (1) US7968585B2 (en)
JP (1) JP5324427B2 (en)
CN (1) CN101432265B (en)
AT (1) AT471311T (en)
AU (1) AU2007244861B2 (en)
BR (1) BRPI0710231A2 (en)
CA (1) CA2648019C (en)
DE (1) DE602007007211D1 (en)
DK (1) DK2035379T3 (en)
EA (1) EA015499B1 (en)
ES (1) ES2344616T3 (en)
MX (1) MX2008013650A (en)
PT (1) PT2035379E (en)
WO (1) WO2007127763A2 (en)

Families Citing this family (60)

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ES2422165T3 (en) 2006-04-21 2013-09-09 Lilly Co Eli Ciclohexilimidazol lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
UA95798C2 (en) * 2006-04-21 2011-09-12 Эли Лилли Энд Компани Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AU2007240458B2 (en) 2006-04-21 2012-03-15 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
PT2029529E (en) 2006-04-24 2010-09-02 Lilly Co Eli Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US8153807B2 (en) * 2006-04-24 2012-04-10 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2007127704A1 (en) 2006-04-24 2007-11-08 Eli Lilly And Company Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PT2021337E (en) 2006-04-25 2010-02-22 Lilly Co Eli Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EP2016071B1 (en) * 2006-04-25 2013-07-24 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
DK2049513T3 (en) * 2006-04-28 2012-02-27 Lilly Co Eli Piperidinyl-substituted pyrrolidinones as inhibitors of 11-beta hydroxysteroid dehydrogenase 1
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8329897B2 (en) 2007-07-26 2012-12-11 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
WO2009134400A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5696037B2 (en) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β- hydroxy cyclic inhibitors of steroid dehydrogenase 1
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
AR069207A1 (en) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Cyclic ureas as inhibitors of 11 beta - hydroxy steroid dehydrogenase-1
EP2220048B1 (en) 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
EP2229368A1 (en) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2715290A1 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200950780A (en) 2008-05-13 2009-12-16 Boehringer Ingelheim Int Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
CA2729993A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
EP2324017B1 (en) 2008-07-25 2014-12-31 Boehringer Ingelheim International GmbH INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
EP2243479A3 (en) 2009-04-20 2011-01-19 Abbott Laboratories Novel amide and amidine derivates and uses thereof
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
US8440710B2 (en) 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
TW201118069A (en) * 2009-10-28 2011-06-01 Lundbeck & Co As H Spirolactam derivatives and uses of same
WO2011056737A1 (en) 2009-11-05 2011-05-12 Boehringer Ingelheim International Gmbh Novel chiral phosphorus ligands
AR078887A1 (en) 2009-11-06 2011-12-07 Boehringer Ingelheim Int And aryl derivatives and heteroarylcarbonyl hexahydroindenopyridine octahidrobenzoquinolina and pharmaceutical compositions containing them.
TWI537258B (en) 2010-11-05 2016-06-11 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US8871208B2 (en) * 2009-12-04 2014-10-28 Abbvie Inc. 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
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WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011157827A1 (en) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
JP2013540801A (en) 2010-11-02 2013-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング The pharmaceutical combination for metabolic abnormalities treatment
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683705B1 (en) 2011-03-08 2015-04-22 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120053A1 (en) 2011-03-08 2012-09-13 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8722721B2 (en) * 2011-03-16 2014-05-13 Hoffmann-La Roche Inc. SEC-hydroxycyclohexyl derivatives
US8703807B2 (en) * 2011-03-17 2014-04-22 Hoffmann-La Roche Inc. Azaspirodecanone compounds
US8809384B2 (en) * 2011-03-25 2014-08-19 Hoffmann-La Roche Inc. Azaspirodecanone compounds
US8501768B2 (en) * 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
EP2554539B1 (en) 2011-08-02 2014-12-10 Universität Potsdam Method for producing gamma-spirolactams from cyclic unsaturated carboxylic acids
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
LT3169666T (en) 2014-07-15 2018-08-10 GrĆ¼nenthal GmbH Substituted azaspiro(4.5)decane derivatives
TW201607923A (en) 2014-07-15 2016-03-01 Gruenenthal Gmbh Substituted azaspiro (4.5) decane derivatives
WO2019099760A1 (en) 2017-11-16 2019-05-23 University Of Houston System Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures

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WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
ES2307175T3 (en) 2004-05-07 2008-11-16 Janssen Pharmaceutica Nv Derivatives adamantyl pyrrolidin-2-one derivatives as inhibitors dela 11-beta-hydroxysteroid dehydrogenase.
ES2525319T3 (en) * 2004-05-07 2014-12-22 Janssen Pharmaceutica Nv Derivatives pyrrolidin-2-one and piperidin-2-one derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase
US8138342B2 (en) 2004-10-12 2012-03-20 High Point Pharmacueticals, LLC 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
EP1807072B1 (en) 2004-10-29 2009-01-07 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN102731499B (en) 2004-11-10 2016-01-13 因塞特控股公司 Lactam compounds and their use as medicaments
ES2308602T3 (en) 2004-12-20 2008-12-01 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1.
ES2308601T3 (en) 2004-12-21 2008-12-01 Eli Lilly And Company Lactam derivatives as inhibitors cycloalkyl-11-beta-hydroxysteroid dehydrogenase 1 '.
WO2006104280A1 (en) 2005-03-31 2006-10-05 Takeda Pharmaceutical Company Limited Prophylactic/therapeutic agent for diabetes
WO2007084314A2 (en) 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
ES2422165T3 (en) 2006-04-21 2013-09-09 Lilly Co Eli Ciclohexilimidazol lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AU2007240458B2 (en) 2006-04-21 2012-03-15 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
UA95798C2 (en) 2006-04-21 2011-09-12 Эли Лилли Энд Компани Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US8153807B2 (en) 2006-04-24 2012-04-10 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2007127704A1 (en) 2006-04-24 2007-11-08 Eli Lilly And Company Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PT2029529E (en) 2006-04-24 2010-09-02 Lilly Co Eli Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PT2021337E (en) 2006-04-25 2010-02-22 Lilly Co Eli Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EP2016071B1 (en) 2006-04-25 2013-07-24 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
DK2049513T3 (en) 2006-04-28 2012-02-27 Lilly Co Eli Piperidinyl-substituted pyrrolidinones as inhibitors of 11-beta hydroxysteroid dehydrogenase 1
KR101554471B1 (en) 2007-06-21 2015-09-30 인사이트 홀딩스 코포레이션 Spirocycles as inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1

Also Published As

Publication number Publication date
CN101432265B (en) 2011-12-14
WO2007127763A2 (en) 2007-11-08
CA2648019C (en) 2014-04-01
PT2035379E (en) 2010-07-13
EA200870475A1 (en) 2009-06-30
AU2007244861A1 (en) 2007-11-08
MX2008013650A (en) 2008-11-04
JP2009535357A (en) 2009-10-01
AU2007244861B2 (en) 2012-03-15
US7968585B2 (en) 2011-06-28
US20090099180A1 (en) 2009-04-16
DE602007007211D1 (en) 2010-07-29
WO2007127763A3 (en) 2007-12-13
CA2648019A1 (en) 2007-11-08
ES2344616T3 (en) 2010-09-01
CN101432265A (en) 2009-05-13
BRPI0710231A2 (en) 2011-08-02
EA015499B1 (en) 2011-08-30
DK2035379T3 (en) 2010-09-06
JP5324427B2 (en) 2013-10-23

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