AT468336T - Azolylaminoazine as protein kinase inhibitors - Google Patents

Azolylaminoazine as protein kinase inhibitors

Info

Publication number
AT468336T
AT468336T AT03714208T AT03714208T AT468336T AT 468336 T AT468336 T AT 468336T AT 03714208 T AT03714208 T AT 03714208T AT 03714208 T AT03714208 T AT 03714208T AT 468336 T AT468336 T AT 468336T
Authority
AT
Austria
Prior art keywords
azolylaminoazine
protein kinase
kinase inhibitors
inhibitors
protein
Prior art date
Application number
AT03714208T
Other languages
German (de)
Inventor
David Bebbington
Hayley Binch
Jean-Damien Charrier
Simon Everitt
Julian M C Golec
David Kay
Ronald Knegtel
Andrew Miller
Francoise Pierard
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US36486402P priority Critical
Application filed by Vertex Pharma filed Critical Vertex Pharma
Priority to PCT/US2003/008125 priority patent/WO2003078427A1/en
Publication of AT468336T publication Critical patent/AT468336T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
AT03714208T 2002-03-15 2003-03-14 Azolylaminoazine as protein kinase inhibitors AT468336T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US36486402P true 2002-03-15 2002-03-15
PCT/US2003/008125 WO2003078427A1 (en) 2002-03-15 2003-03-14 Azolylaminoazines as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
AT468336T true AT468336T (en) 2010-06-15

Family

ID=28041974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03714208T AT468336T (en) 2002-03-15 2003-03-14 Azolylaminoazine as protein kinase inhibitors

Country Status (6)

Country Link
US (2) US20040009981A1 (en)
EP (1) EP1485380B1 (en)
AT (1) AT468336T (en)
AU (1) AU2003218215A1 (en)
DE (1) DE60332604D1 (en)
WO (1) WO2003078427A1 (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
DE60120194T2 (en) * 2000-09-15 2007-03-29 Vertex Pharmaceuticals Inc., Cambridge Pyrazole compounds as protein kinase inhibitors-
MXPA03005609A (en) * 2000-12-21 2003-10-06 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors.
AU2003215087B2 (en) * 2002-02-06 2009-07-16 Vertex Pharmaceuticals Incorporated Heteroaryl compounds useful as inhibitors of GSK-3
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
KR101212025B1 (en) 2002-06-21 2013-01-09 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Stabilised solid compositions of factor ⅶ polypeptides
NZ550883A (en) 2002-08-02 2008-06-30 Vertex Pharma Pyrazole compositions useful as inhibitors of glycogen synthase kinase-3 (GSK-3)
KR101052482B1 (en) * 2002-11-21 2011-07-28 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Force Fourteen dill inositol (pi) use thereof in the treatment of cancer and Dean hwanpi limiter 3-kinase inhibitor, 2,4,6 mackerel
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
JP2006521398A (en) 2003-03-28 2006-09-21 サイオス・インコーポレーテツド TGFβ of the two - bicyclic pyrimidine inhibitor
WO2005000404A2 (en) * 2003-05-29 2005-01-06 Synta Pharmaceuticals, Corp. Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss
CA2554566A1 (en) * 2003-08-05 2005-02-17 Vertex Pharmaceuticals Incorporated Condensed pyramidine compounds as inhibitors of voltage-gated ion channels
US7592340B2 (en) * 2003-12-04 2009-09-22 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
WO2005061519A1 (en) * 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
US20050250829A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Kinase inhibitors
EP1778669A2 (en) 2004-08-18 2007-05-02 Takeda San Diego, Inc. Kinase inhibitors
US7285569B2 (en) 2004-09-24 2007-10-23 Hoff Hoffmann-La Roche Inc. Tricycles, their manufacture and use as pharmaceutical agents
TW200624431A (en) 2004-09-24 2006-07-16 Hoffmann La Roche Phthalazinone derivatives, their manufacture and use as pharmaceutical agents
AR052771A1 (en) 2004-09-30 2007-04-04 Tibotec Pharm Ltd Pyrimidines bicyclic inhibitory vhc
DE602005023333D1 (en) 2004-10-15 2010-10-14 Takeda Pharmaceutical kinase inhibitors
US7491720B2 (en) 2004-10-29 2009-02-17 Banyu Pharmaceutical Co., Ltd. Aminopyridine derivatives having Aurora A selective inhibitory action
CA2587427A1 (en) 2004-11-17 2006-05-26 Miikana Therapeutics, Inc. Kinase inhibitors
WO2006065590A2 (en) * 2004-12-16 2006-06-22 Xtl Biopharmaceuticals Inc. Pyridine and pyrimidine antiviral compositions
ES2336243T3 (en) 2005-01-26 2010-04-09 Schering Corporation The 3- (indazol-5-yl) - (1,2,4) triazine and similar compositions as protein kinase inhibitors for cancer treatment.
KR20070122194A (en) 2005-03-25 2007-12-28 티보텍 파마슈티칼즈 리미티드 Heterobicyclic inhibitors of hcv
WO2006108489A1 (en) 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
AR056347A1 (en) 2005-05-12 2007-10-03 Tibotec Pharm Ltd Use of pteridine compounds for producing medicaments and pharmaceutical compositions
EP1891082A4 (en) * 2005-05-27 2009-02-18 Leyland Jones Brian Novel inhibitors of pyruvate kinase as therapeutic agents for cancer
EP1928456B1 (en) 2005-09-30 2015-04-22 Miikana Therapeutics, Inc. Substituted pyrazole compounds
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2010505961A (en) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド Kinase inhibitors
BRPI0719883A2 (en) 2006-10-09 2015-05-05 Takeda Pharmaceutical Kinase Inhibitors
RU2427578C2 (en) * 2005-11-03 2011-08-27 Вертекс Фармасьютикалз Инкорпорейтед Aminopyrimidines as kinase inhibitors
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي PI-3 Kinase inhibitors and methods of their use
WO2008051547A1 (en) 2006-10-23 2008-05-02 Cephalon, Inc. Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors
JP2010509231A (en) * 2006-11-02 2010-03-25 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Useful aminopyridine and aminopyrimidine as inhibitors of protein kinases
ES2347721T3 (en) * 2006-12-19 2010-11-03 Vertex Pharmaceuticals, Inc. Aminopyrimidines useful as inhibitors of protein kinases.
KR20090108124A (en) * 2007-02-06 2009-10-14 노파르티스 아게 Pi 3-kinase inhibitors and methods of their use
NZ579483A (en) * 2007-03-09 2012-07-27 Vertex Pharma Aminopyridines useful as inhibitors of protein kinases
AU2008226466B2 (en) * 2007-03-09 2013-06-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
WO2008112642A1 (en) * 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
US20080221103A1 (en) * 2007-03-09 2008-09-11 Orchid Research Laboratories Ltd. New heterocyclic compounds
WO2008117050A1 (en) * 2007-03-27 2008-10-02 Astrazeneca Ab Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer
JP2010523700A (en) 2007-04-13 2010-07-15 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Useful aminopyrimidine as kinase inhibitors
CN101801959A (en) * 2007-05-02 2010-08-11 沃泰克斯药物股份有限公司 Aminopyrimidines useful as kinase inhibitors
CN101679387A (en) * 2007-05-02 2010-03-24 沃泰克斯药物股份有限公司 Aminopyrimidines useful as kinase inhibitors
MX2009011810A (en) 2007-05-02 2010-01-14 Vertex Pharma Thiazoles and pyrazoles useful as kinase inhibitors.
WO2008147626A2 (en) * 2007-05-24 2008-12-04 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
US20090029992A1 (en) * 2007-06-11 2009-01-29 Agoston Gregory E Substituted pyrazole compounds
ES2400104T3 (en) * 2007-07-31 2013-04-05 Vertex Pharmaceuticals Incorporated Process for preparation of 5-fluoro-1H-pyrazolo [3,4-b] pyridin-3-amine and derivatives thereof
NZ583538A (en) 2007-09-21 2012-06-29 Array Biopharma Inc Pyridin-2-yl-amino-1,2,4 -thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
MX2011002312A (en) * 2008-09-03 2011-04-26 Vertex Pharma Co-crystals and pharmaceutical formulations comprising the same.
US7989463B2 (en) 2008-09-03 2011-08-02 Dr. Reddy's Laboratories Limited Biccyclic compounds as GATA modulators
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
PT2401267E (en) * 2009-02-27 2014-04-10 Ambit Biosciences Corp Jak kinase modulating quinazoline derivatives and their use in methods
BRPI1010887A2 (en) * 2009-06-08 2016-12-27 California Capital Equity Llc triazine derivatives and their therapeutic applications.
AU2010259002B2 (en) * 2009-06-08 2014-03-20 Nantbio, Inc. Triazine derivatives and their therapeutical applications
AU2010258993B2 (en) * 2009-06-09 2014-07-31 Nantbio, Inc. Styryl-triazine derivatives and their therapeutical applications
ES2438509T3 (en) 2009-12-14 2014-01-17 Merck Patent Gmbh Sphingosine kinase inhibitors
WO2012030910A1 (en) * 2010-09-01 2012-03-08 Ambit Biosciences Corporation 2-cycloquinazoline derivatives and methods of use thereof
CN103298805A (en) * 2010-09-01 2013-09-11 埃姆比特生物科学公司 Quinazoline compounds and methods of use thereof
RU2608742C2 (en) 2011-03-28 2017-01-23 ЭмИАй ФАРМА, ИНК. (alpha-substituted aralkylamino- and heteroarylalkylamino)pyrimidinyl- and 1,3,5-triazinylbenzimidazoles, pharmaceutical compositions thereof and use thereof in treating proliferative diseases
JP6026544B2 (en) 2011-09-27 2016-11-16 ノバルティス アーゲー As inhibitors of mutant idh 3- pyrimidin-4-yl - oxazolidin-2-ones
EP2836486B1 (en) 2012-02-17 2017-10-04 AbbVie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
UY34632A (en) 2012-02-24 2013-05-31 Novartis Ag Oxazolidin-2-one compounds and uses thereof
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
MX355945B (en) 2013-03-14 2018-05-07 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh.
HUE034906T2 (en) 2013-03-15 2018-03-28 Quanticel Pharmaceuticals Inc Histone demethylase inhibitors
WO2015155738A2 (en) 2014-04-09 2015-10-15 Christopher Rudd Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
WO2016044429A1 (en) * 2014-09-17 2016-03-24 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
US10030017B2 (en) 2014-09-17 2018-07-24 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
CN105541823B (en) * 2016-02-03 2018-03-06 三峡大学 Triazine compounds, a process for preparing an oxazoline ring containing in its application anticancer drugs

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133081A (en) * 1964-05-12 J-aminoindazole derivatives
US3935183A (en) * 1970-01-26 1976-01-27 Imperial Chemical Industries Limited Indazole-azo phenyl compounds
BE754242A (en) * 1970-07-15 1971-02-01 Geigy Ag J R Diamino-s-triazines and dinitro-s-triazines
US3998951A (en) * 1974-03-13 1976-12-21 Fmc Corporation Substituted 2-arylquinazolines as fungicides
DE2458965C3 (en) * 1974-12-13 1979-10-11 Bayer Ag, 5090 Leverkusen
MA18829A1 (en) 1979-05-18 1980-12-31 Ciba Geigy Ag Derivatives of pyrimidine, processes for their preparation, pharmaceutical compositions containing such compounds and their therapeutic use
DOP1981004033A (en) * 1980-12-23 1990-12-29 Ciba Geigy Ag Method for protecting crop plants from the phytotoxic action of herbicides.
SE8102193L (en) * 1981-04-06 1982-10-07 Pharmacia Ab Therapeutically active organic compound, and its priority over
SE8102194L (en) * 1981-04-06 1982-10-07 Pharmacia Ab Therapeutically active organic compound and pharmaceutical preparation CONTAINING this
JPH0378383B2 (en) * 1982-01-20 1991-12-13 Mitsui Toatsu Chemicals
EP0136976A3 (en) 1983-08-23 1985-05-15 Ciba-Geigy Ag Use of phenyl pyrimidines as plant regulators
DE3725638A1 (en) 1987-08-03 1989-02-16 Bayer Ag New aryloxy (or thio) aminopyrimidine
JPH0532662A (en) 1990-11-09 1993-02-09 Nissan Chem Ind Ltd Substituted pyrazole derivative and agricultural and horticultural fungicide
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5597920A (en) 1992-04-30 1997-01-28 Neurogen Corporation Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes
JPH0665237A (en) 1992-05-07 1994-03-08 Nissan Chem Ind Ltd Substituted pyrazole derivative and germicide for agriculture and horticulture
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
WO1996014843A2 (en) * 1994-11-10 1996-05-23 Cor Therapeutics, Inc. Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
IL117659A (en) * 1995-04-13 2000-12-06 Dainippon Pharmaceutical Co Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6716575B2 (en) * 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
JPH10130150A (en) 1996-09-05 1998-05-19 Dainippon Pharmaceut Co Ltd Medicine comprising acetic acid amide derivative
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
US6267952B1 (en) * 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
JP2000026421A (en) 1998-01-29 2000-01-25 Ihara Chem Ind Co Ltd Diaryl sulfide derivative and pest controlling agent
KR20010041015A (en) * 1998-02-17 2001-05-15 윌리엄 제이. 리플린 Anti-viral pyrimidine derivatives
CA2339188A1 (en) * 1998-08-21 2000-03-02 Dupont Pharmaceuticals Company Isoxazolo¬4,5-d|pyrimidines as crf antagonists
US6184226B1 (en) * 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
US20020065270A1 (en) * 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
JP4783532B2 (en) * 2000-02-05 2011-09-28 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Useful pyrazole compositions as inhibitors of Erk
AU2001237041B9 (en) * 2000-02-17 2005-07-28 Amgen Inc. Kinase inhibitors
GB0004887D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
CN1267431C (en) * 2000-06-28 2006-08-02 阿斯特拉曾尼卡有限公司 Substituted quinazoline derivatives and their use as inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
DE60120194T2 (en) * 2000-09-15 2007-03-29 Vertex Pharmaceuticals Inc., Cambridge Pyrazole compounds as protein kinase inhibitors-
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6610677B2 (en) * 2000-09-15 2003-08-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6613776B2 (en) * 2000-09-15 2003-09-02 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
EP1317453B1 (en) * 2000-09-15 2006-08-09 Vertex Pharmaceuticals Incorporated Isoxazoles and their use as inhibitors of erk
DE10061863A1 (en) * 2000-12-12 2002-06-13 Basf Ag Preparation of triethylenediamine, useful for making pharmaceuticals and polymers, by reacting ethylenediamine over specific zeolite catalyst
US6716851B2 (en) * 2000-12-12 2004-04-06 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
MXPA03005609A (en) * 2000-12-21 2003-10-06 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors.
PL364565A1 (en) * 2001-02-09 2004-12-13 Vertex Pharmaceuticals Incorporated Heterocyclic inhibitors of erk2 and uses thereof
JP4160401B2 (en) * 2001-03-29 2008-10-01 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated C-Jun N-terminal kinase (jnk) and inhibitors of other protein kinases
US6642227B2 (en) * 2001-04-13 2003-11-04 Vertex Pharmaceuticals Incorporated Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
WO2002085909A1 (en) * 2001-04-20 2002-10-31 Vertex Pharmaceuticals Incorporated 9-deazaguanine derivatives as inhibitors of gsk-3
US6884804B2 (en) * 2001-05-16 2005-04-26 Vertex Pharmaceuticals Incorporated Inhibitors of Src and other protein kinases
DE60232510D1 (en) * 2001-06-15 2009-07-16 Vertex Pharma 5- (2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors
EP1417205B1 (en) * 2001-07-03 2006-08-23 Vertex Pharmaceuticals Incorporated Isoxazolyl-pyrimidines as inhibitors of src and lck protein kinases
EP2198867A1 (en) * 2001-12-07 2010-06-23 Vertex Pharmaceuticals, Inc. Pyrimidine-based compounds useful as GSK-3 inhibitors
WO2003077921A1 (en) * 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azinylaminoazoles as inhibitors of protein kinases
DE60327999D1 (en) * 2002-03-15 2009-07-30 Vertex Pharma Azolylaminoazine as inhibitors of protein kinases
WO2003078423A1 (en) * 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Compositions useful as inhibitors of protein kinases
US20030207873A1 (en) * 2002-04-10 2003-11-06 Edmund Harrington Inhibitors of Src and other protein kinases
EP1506189A1 (en) * 2002-04-26 2005-02-16 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
CA2491895C (en) * 2002-07-09 2011-01-18 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
NZ550883A (en) 2002-08-02 2008-06-30 Vertex Pharma Pyrazole compositions useful as inhibitors of glycogen synthase kinase-3 (GSK-3)

Also Published As

Publication number Publication date
DE60332604D1 (en) 2010-07-01
EP1485380A1 (en) 2004-12-15
US20070190634A1 (en) 2007-08-16
WO2003078427A1 (en) 2003-09-25
EP1485380B1 (en) 2010-05-19
US8669081B2 (en) 2014-03-11
AU2003218215A1 (en) 2003-09-29
US20040009981A1 (en) 2004-01-15

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