AT467679T - Oligomeric compounds for the modulation of bcl-2 - Google Patents

Oligomeric compounds for the modulation of bcl-2

Info

Publication number
AT467679T
AT467679T AT04803067T AT04803067T AT467679T AT 467679 T AT467679 T AT 467679T AT 04803067 T AT04803067 T AT 04803067T AT 04803067 T AT04803067 T AT 04803067T AT 467679 T AT467679 T AT 467679T
Authority
AT
Austria
Prior art keywords
bcl
modulation
oligomeric compounds
oligomeric
compounds
Prior art date
Application number
AT04803067T
Other languages
German (de)
Inventor
Miriam Frieden
Jens Hansen
Henrik Yrum
Majken Westergaard
Charlotte Thrue
Original Assignee
Santaris Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US53284403P priority Critical
Priority to DKPA200301929 priority
Priority to US55839204P priority
Priority to DKPA200400517 priority
Priority to DKPA200401069 priority
Priority to US58634004P priority
Priority to US62159404P priority
Priority to DKPA200401629 priority
Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Priority to PCT/DK2004/000917 priority patent/WO2005061710A1/en
Publication of AT467679T publication Critical patent/AT467679T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • C12N2310/3231Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
AT04803067T 2003-12-23 2004-12-23 Oligomeric compounds for the modulation of bcl-2 AT467679T (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US53284403P true 2003-12-23 2003-12-23
DKPA200301929 2003-12-23
US55839204P true 2004-03-31 2004-03-31
DKPA200400517 2004-03-31
US58634004P true 2004-07-07 2004-07-07
DKPA200401069 2004-07-07
US62159404P true 2004-10-22 2004-10-22
DKPA200401629 2004-10-22
PCT/DK2004/000917 WO2005061710A1 (en) 2003-12-23 2004-12-23 Oligomeric compounds for the modulation of bcl-2

Publications (1)

Publication Number Publication Date
AT467679T true AT467679T (en) 2010-05-15

Family

ID=42727309

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04803067T AT467679T (en) 2003-12-23 2004-12-23 Oligomeric compounds for the modulation of bcl-2

Country Status (16)

Country Link
US (1) US7622453B2 (en)
EP (1) EP1706489B9 (en)
JP (1) JP4642775B2 (en)
KR (1) KR20070006709A (en)
CN (1) CN100569945C (en)
AT (1) AT467679T (en)
AU (1) AU2004303464B2 (en)
BR (1) BRPI0418104A (en)
CA (1) CA2550258A1 (en)
DE (1) DE602004027163D1 (en)
DK (1) DK1706489T3 (en)
ES (1) ES2344566T3 (en)
IL (1) IL176320D0 (en)
NZ (1) NZ548254A (en)
RU (1) RU2377301C2 (en)
WO (1) WO2005061710A1 (en)

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Also Published As

Publication number Publication date
RU2377301C2 (en) 2009-12-27
CN100569945C (en) 2009-12-16
CN1918292A (en) 2007-02-21
EP1706489A1 (en) 2006-10-04
KR20070006709A (en) 2007-01-11
US7622453B2 (en) 2009-11-24
JP2007515175A (en) 2007-06-14
RU2006126643A (en) 2008-01-27
AU2004303464B2 (en) 2009-10-01
ES2344566T3 (en) 2010-08-31
EP1706489B1 (en) 2010-05-12
CA2550258A1 (en) 2005-07-07
AU2004303464A1 (en) 2005-07-07
NZ548254A (en) 2008-09-26
DE602004027163D1 (en) 2010-06-24
US20050203042A1 (en) 2005-09-15
BRPI0418104A (en) 2007-04-17
DK1706489T3 (en) 2010-09-13
EP1706489B9 (en) 2011-01-05
IL176320D0 (en) 2006-10-05
JP4642775B2 (en) 2011-03-02
WO2005061710A1 (en) 2005-07-07

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