AT463578T - Compositions and methods for inducing an immune response based on alphavirus systems vektoren- - Google Patents

Compositions and methods for inducing an immune response based on alphavirus systems vektoren-

Info

Publication number
AT463578T
AT463578T AT00923558T AT00923558T AT463578T AT 463578 T AT463578 T AT 463578T AT 00923558 T AT00923558 T AT 00923558T AT 00923558 T AT00923558 T AT 00923558T AT 463578 T AT463578 T AT 463578T
Authority
AT
Austria
Prior art keywords
vektoren
alphavirus
inducing
compositions
systems
Prior art date
Application number
AT00923558T
Other languages
German (de)
Inventor
John Polo
Thomas Dubensky
Ilya Frolov
Jason Gardner
Gillis Otten
Susan Barnett
David Driver
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12949899P priority Critical
Priority to US14808699P priority
Priority to US19136300P priority
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Priority to PCT/US2000/010722 priority patent/WO2000061772A2/en
Publication of AT463578T publication Critical patent/AT463578T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse Transcribing RNA Viruses
    • C12N2740/00011Reverse Transcribing RNA Viruses
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense
    • C12N2770/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense ssRNA Viruses positive-sense
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
AT00923558T 1999-04-14 2000-04-14 Compositions and methods for inducing an immune response based on alphavirus systems vektoren- AT463578T (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12949899P true 1999-04-14 1999-04-14
US14808699P true 1999-08-09 1999-08-09
US19136300P true 2000-03-22 2000-03-22
PCT/US2000/010722 WO2000061772A2 (en) 1999-04-14 2000-04-14 Compositions and methods for generating an immune response utilizing alphavirus-based vector systems

Publications (1)

Publication Number Publication Date
AT463578T true AT463578T (en) 2010-04-15

Family

ID=27383889

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00923558T AT463578T (en) 1999-04-14 2000-04-14 Compositions and methods for inducing an immune response based on alphavirus systems vektoren-

Country Status (9)

Country Link
US (1) US7771979B2 (en)
EP (2) EP2196472A3 (en)
JP (1) JP4637368B2 (en)
AT (1) AT463578T (en)
AU (1) AU4366000A (en)
CA (2) CA2760534A1 (en)
DE (1) DE60044125D1 (en)
DK (1) DK1175497T3 (en)
WO (1) WO2000061772A2 (en)

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JP4790984B2 (en) 2001-09-06 2011-10-12 アルファヴァックス,インコーポレイテッド Alphavirus replicon vector system
CN1708320A (en) * 2002-11-07 2005-12-14 郎基·常 Modified dendritic cells
ES2630222T3 (en) 2002-12-13 2017-08-18 Alphavax, Inc. alphaviral particles and methods of preparation
WO2004055166A2 (en) 2002-12-13 2004-07-01 Alphavax, Inc. Multi-antigenic alphavirus replicon particles and methods
BRPI0408424A (en) 2003-03-20 2006-03-21 Alphavax Inc nucleic acid population of infectious particles and defective alphavirus, pharmaceutical composition, alpha-virus particle, method for producing the infectious particles and defective alphavirus cell and method for eliciting an immune response in an individual
WO2005007689A1 (en) 2003-07-11 2005-01-27 Alphavax, Inc. Alphavirus-based cytomegalovirus vaccines
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CA2567446C (en) 2004-05-21 2018-01-02 Chiron Corporation Alphavirus vectors for respiratory pathogen vaccines
WO2006130855A2 (en) 2005-06-01 2006-12-07 California Institute Of Technology Method of targeted gene delivery using viral vectors
CN101355960A (en) 2005-10-18 2009-01-28 诺华疫苗和诊断公司 Mucosal and systemic immunizations with alphavirus replicon particles
JP5215865B2 (en) 2005-11-22 2013-06-19 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド Norovirus antigen and support viral antigens
KR20140035537A (en) 2006-07-21 2014-03-21 캘리포니아 인스티튜트 오브 테크놀로지 Targeted gene delivery for dendritic cell vaccination
JP5602624B2 (en) 2007-06-21 2014-10-08 アルファバックス, インコーポレイテッド Promoter-less cassette for the expression of α viral structural protein
JP2011500036A (en) 2007-10-15 2011-01-06 ザ ユニバーシティー オブ クイーンズランド Construct system and their use
EP2456786B2 (en) * 2009-07-24 2017-04-19 Immune Design Corp Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein
US9795658B2 (en) 2010-04-20 2017-10-24 Admedus Vaccines Pty Ltd Expression system for modulating an immune response
US9422529B2 (en) * 2010-12-22 2016-08-23 The Board Of Regents Of The University Of Texas System Alphavirus compositions and methods of use
WO2012088473A1 (en) * 2010-12-22 2012-06-28 The Board Of Regents Of The University Of Texas System Alphavirus compositions and methods of use
US9487563B2 (en) 2011-01-31 2016-11-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Virus-like particles and methods of use
RU2014104090A (en) 2011-07-06 2015-08-20 Новартис Аг Liposomes with an effective ratio of n: p to deliver molecules phk
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
US8323662B1 (en) 2012-03-30 2012-12-04 Immune Design Corp. Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein
JP2015522580A (en) * 2012-07-06 2015-08-06 ノバルティス アーゲー Immunological compositions and the use thereof
US20150224181A1 (en) 2012-09-14 2015-08-13 The United States Of America As Represented By The Secretary Department Of Health And Human Se Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use
CN109535228A (en) * 2012-12-05 2019-03-29 生控基因疫苗股份有限公司 Fusion protein as the immunogenicity reinforcing agent for inducing T cells with antigenic specificity reaction
EP3068783A4 (en) 2013-11-15 2017-08-09 The Board of Trustees of The Leland Stanford Junior University Methods of treating heart failure with agonists of hypocretin receptor 2
CA3010974A1 (en) 2016-01-11 2017-07-20 Verndari, Inc. Microneedle compositions and methods of using same

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Also Published As

Publication number Publication date
EP2196472A2 (en) 2010-06-16
US7771979B2 (en) 2010-08-10
CA2373300A1 (en) 2000-10-19
WO2000061772A2 (en) 2000-10-19
WO2000061772A3 (en) 2001-02-08
DK1175497T3 (en) 2010-05-31
AU4366000A (en) 2000-11-14
JP2002541814A (en) 2002-12-10
EP1175497A2 (en) 2002-01-30
JP4637368B2 (en) 2011-02-23
DE60044125D1 (en) 2010-05-20
US20080226598A1 (en) 2008-09-18
EP1175497B1 (en) 2010-04-07
CA2760534A1 (en) 2000-10-19
CA2373300C (en) 2012-02-21
EP2196472A3 (en) 2011-04-13

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