AT461282T - Multivalent antigen-binding proteins - Google Patents

Multivalent antigen-binding proteins

Info

Publication number
AT461282T
AT461282T AT98965654T AT98965654T AT461282T AT 461282 T AT461282 T AT 461282T AT 98965654 T AT98965654 T AT 98965654T AT 98965654 T AT98965654 T AT 98965654T AT 461282 T AT461282 T AT 461282T
Authority
AT
Austria
Prior art keywords
binding proteins
multivalent antigen
multivalent
antigen
proteins
Prior art date
Application number
AT98965654T
Other languages
German (de)
Inventor
Leon Gerardus Joseph Frenken
Steven Howell
Adrianus Marinus Ledeboer
Cornelis Van Der Logt
Original Assignee
Bac Ip Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP97308538 priority Critical
Application filed by Bac Ip Bv filed Critical Bac Ip Bv
Priority to PCT/EP1998/006991 priority patent/WO1999023221A2/en
Publication of AT461282T publication Critical patent/AT461282T/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927Diagnostic contrast agent
AT98965654T 1997-10-27 1998-10-27 Multivalent antigen-binding proteins AT461282T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97308538 1997-10-27
PCT/EP1998/006991 WO1999023221A2 (en) 1997-10-27 1998-10-27 Multivalent antigen-binding proteins

Publications (1)

Publication Number Publication Date
AT461282T true AT461282T (en) 2010-04-15

Family

ID=8229570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98965654T AT461282T (en) 1997-10-27 1998-10-27 Multivalent antigen-binding proteins

Country Status (9)

Country Link
US (1) US6670453B2 (en)
EP (1) EP1027439B1 (en)
CN (1) CN1203178C (en)
AT (1) AT461282T (en)
AU (1) AU2152299A (en)
BR (1) BR9813276A (en)
DE (1) DE69841562D1 (en)
DK (1) DK1027439T3 (en)
WO (1) WO1999023221A2 (en)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID30380A (en) 1999-04-22 2001-11-29 Unilever Nv Inhibition of viral infection using a single bivalent antigen-binding protein
EP1196532A1 (en) 1999-07-27 2002-04-17 Unilever N.V. Bleaching detergent compositions
WO2001044301A1 (en) * 1999-11-29 2001-06-21 Unilever Plc Immobilized single domain antigen-binding molecules
ES2218278T3 (en) 1999-12-22 2004-11-16 Unilever N.V. Process for treating tissue and used in the same apparatus.
AT307871T (en) 1999-12-22 2005-11-15 Unilever Nv A process for the treatment of tissue
DE60036959T2 (en) 1999-12-22 2008-08-07 Unilever N.V. Surfactant compositions, improving agents containing
CA2394870A1 (en) 1999-12-22 2001-06-28 Unilever Plc Method of delivering a benefit agent
WO2001048135A1 (en) * 1999-12-23 2001-07-05 Unilever N.V. Bleaching detergent compositions
HU0300369A2 (en) * 2000-04-11 2003-06-28 Genentech, Inc. Multivalent antibodies and uses therefor
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
PT1517921E (en) 2002-06-28 2006-09-29 Domantis Ltd dual specific ligands with increased half-life in serum
JP2005289809A (en) * 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) Mutant heavy-chain antibody
CA2471116A1 (en) * 2001-12-21 2003-07-03 Serge Muyldermans Method for cloning of variable domain sequences
RU2401842C2 (en) 2004-10-08 2010-10-20 Домантис Лимитед Antagonists and method of using said antagonists
CA2492377C (en) 2002-07-18 2015-02-03 Crucell Holland B.V. Recombinant production of mixtures of antibodies
AU2003251238A1 (en) * 2002-08-07 2004-02-25 Umc Utrecht Holding B.V. Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha
AU2004204262B2 (en) 2003-01-10 2010-11-04 Ablynx N.V. Recombinant VHH single domain antibody from camelidae against von willebrand factor (vWF) or against collagen
US20060034845A1 (en) * 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
EP2267027A3 (en) * 2002-11-08 2011-07-20 Ablynx N.V. Method of administering therapeutic polypeptides, and polypeptides therefor
US20070178082A1 (en) * 2002-11-08 2007-08-02 Ablynx N.V. Stabilized single domain antibodies
US20100003253A1 (en) * 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
US9320792B2 (en) 2002-11-08 2016-04-26 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
US20060034833A1 (en) * 2002-11-08 2006-02-16 Els Beirnaert Single domain antibodies directed against interferron-gamma and uses therefor
WO2004041865A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Stabilized single domain antibodies
US6974860B2 (en) * 2002-12-30 2005-12-13 Kimberly-Clark Worldwide, Inc. Target recognizing binding agents
EP2395017A3 (en) 2003-05-30 2012-12-19 Merus B.V. Design and use of paired variable regions of specific binding molecules
US20060228355A1 (en) * 2003-11-07 2006-10-12 Toon Laeremans Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor
WO2005068622A2 (en) 2004-01-20 2005-07-28 Merus B.V. Mixtures of binding proteins
CN102768273B (en) * 2004-03-30 2015-08-26 通用电气医疗集团生物科学公司 Lateral flow format, materials and methods
EP1786827A4 (en) * 2004-05-14 2008-10-29 Kirin Holdings Kk Methods for immunoglobulin purification
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
CN101072794B (en) * 2004-12-02 2012-07-04 贝克知产公司 Method for affinity purification
FR2879605B1 (en) 2004-12-16 2008-10-17 Centre Nat Rech Scient Cnrse antibody formats production and immunological applications of these formats
WO2006074947A2 (en) * 2005-01-14 2006-07-20 Ablynx N.V. METHODS AND ASSAYS FOR DISTINGUISHING BETWEEN DIFFERENT FORMS OF DISEASES AND DISORDERS CHARACTERIZED BY THROMBOCYTOPENIA AND/OR BY SPONTANEOUS INTERACTION BETWEEN VON WILLEBRAND FACTOR (vWF) AND PLATELETS
AT537188T (en) 2005-05-18 2011-12-15 Ablynx Nv Serum albumin-binding proteins
US20070269422A1 (en) * 2006-05-17 2007-11-22 Ablynx N.V. Serum albumin binding proteins with long half-lives
EP3415535A1 (en) 2005-05-20 2018-12-19 Ablynx N.V. Improved nanobodies tm for the treatment of aggregation-mediated disorders
DE102005023617A1 (en) * 2005-05-21 2006-11-23 Aspre Ag A method of mixing colors in a display
CA2622968A1 (en) * 2005-09-23 2007-03-29 Academisch Ziekenhuis Leiden Vhh for the diagnosis, prevention and treatment of diseases associated with protein aggregates
GB0621513D0 (en) 2006-10-30 2006-12-06 Domantis Ltd Novel polypeptides and uses thereof
EP2557090A3 (en) 2006-12-19 2013-05-29 Ablynx N.V. Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
WO2008074840A2 (en) 2006-12-19 2008-06-26 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
EP2535351A3 (en) 2007-09-26 2013-04-03 UCB Pharma S.A. Dual specificity antibody fusions
CA2718081A1 (en) * 2008-03-21 2009-09-24 Ablynx Nv Von willebrand factor specific binders and methods of use therefor
CN102056945A (en) 2008-04-07 2011-05-11 埃博灵克斯股份有限公司 Amino acid sequences directed against the Notch pathways and uses thereof
KR20110014607A (en) 2008-04-29 2011-02-11 아보트 러보러터리즈 Dual variable domain immunoglobulins and uses thereof
EP2297209A4 (en) 2008-06-03 2012-08-01 Abbott Lab Dual variable domain immunoglobulins and uses thereof
NZ589436A (en) 2008-06-03 2012-12-21 Abbott Lab Dual variable domain immunoglobulins and uses thereof
SG192489A1 (en) 2008-07-08 2013-08-30 Abbott Lab Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
US20100136584A1 (en) * 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
CN102164965B (en) * 2008-09-26 2016-03-30 Ucb医药有限公司 Biological Products
RU2481824C2 (en) 2008-10-29 2013-05-20 Аблинкс Н.В Preparations of single domain antigen-binding molecules
MX2011004558A (en) 2008-10-29 2011-06-01 Wyeth Llc Methods for purification of single domain antigen binding molecules.
JP2012512646A (en) 2008-12-19 2012-06-07 アブリンクス エン.ヴェー. Method for generating immunoglobulin sequences
EP2387583B1 (en) 2009-01-14 2018-09-19 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
EP2403873A1 (en) 2009-03-05 2012-01-11 Ablynx N.V. Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof
GB0905023D0 (en) 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
EP2982690A1 (en) 2009-04-30 2016-02-10 Ablynx N.V. Method for the production of domain antibodies
WO2011003622A1 (en) 2009-07-10 2011-01-13 Ablynx N.V. Method for the production of variable domains
BR112012004710A2 (en) 2009-09-01 2016-08-16 Abbott Lab Dual variable domain immunoglobulins and use thereof
WO2011026948A1 (en) 2009-09-03 2011-03-10 Ablynx N.V. Stable formulations of polypeptides and uses thereof
WO2011045079A1 (en) 2009-10-15 2011-04-21 Intercell Ag Hepatitis b virus specific human antibodies
JP2013507928A (en) 2009-10-15 2013-03-07 アボット・ラボラトリーズAbbott Laboratories Dual variable domain immunoglobulin and uses thereof
WO2011046218A1 (en) * 2009-10-16 2011-04-21 株式会社カネカ Hansenula polymorpha capable of producing antibody, process for production of antibody utilizing same, and antibody produced from same
UY32979A (en) 2009-10-28 2011-02-28 Abbott Lab Immunoglobulins Dual variable domain and uses thereof
EP2513145B1 (en) 2009-12-14 2018-01-24 Ablynx N.V. Single variable domain antibodies against ox40l, constructs and therapeutic use
WO2011083141A2 (en) 2010-01-08 2011-07-14 Ablynx Nv Method for generation of immunoglobulin sequences by using lipoprotein particles
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
JP5951508B2 (en) 2010-02-11 2016-07-13 アブリンクス エン.ヴェー. Methods and compositions for the preparation of aerosol
WO2011098518A2 (en) 2010-02-11 2011-08-18 Ablynx Nv Delivery of immunoglobulin variable domains and constructs thereof
BR112012029588A2 (en) 2010-05-20 2017-07-25 Ablynx Nv biological materials related to HER3.
WO2011161263A1 (en) 2010-06-25 2011-12-29 Ablynx Nv Pharmaceutical compositions for cutaneous administration
JP2013537415A (en) 2010-08-03 2013-10-03 アッヴィ・インコーポレイテッド Dual variable domain immunoglobulin and uses thereof
MX2013002270A (en) 2010-08-26 2013-05-14 Abbvie Inc Dual variable domain immunoglobulins and uses thereof.
CN106046161A (en) 2011-09-30 2016-10-26 埃博灵克斯股份有限公司 Biological materials related to c-met
WO2012042026A1 (en) 2010-09-30 2012-04-05 Ablynx Nv Biological materials related to c-met
US20130261288A1 (en) 2010-10-29 2013-10-03 Ablynx N.V. Method for the production of immunoglobulin single variable domains
WO2012062713A1 (en) 2010-11-08 2012-05-18 Novartis Ag Cxcr2 binding polypeptides
BR112014013081A2 (en) 2011-11-30 2017-06-13 Chugai Pharmaceutical Co Ltd vehicle containing drug in the cell to form an immune complex
ES2688591T3 (en) 2011-03-28 2018-11-05 Ablynx N.V. Method for producing individual variables solid formulations comprising immunoglobulin domains
CA2834907A1 (en) 2011-05-05 2012-11-22 Merck Patent Gmbh Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same
WO2012152823A1 (en) 2011-05-09 2012-11-15 Ablynx Nv Method for the production of immunoglobulin single variable domains
EP2723771A1 (en) 2011-06-23 2014-04-30 Ablynx N.V. Serum albumin binding proteins
EP3311837A1 (en) 2011-09-23 2018-04-25 Ablynx NV Prolonged inhibition of interleukin-6 mediated signaling
UY34558A (en) 2011-12-30 2013-07-31 Abbvie Inc Dual specific binding proteins directed against IL-13 and / or IL-17
MX360110B (en) 2012-04-20 2018-10-23 Merus N V Methods and means for the production of ig-like molecules.
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
CN107964042A (en) 2012-05-30 2018-04-27 中外制药株式会社 Target-tissue-specific antigen-binding molecule
PE11792015A1 (en) 2012-11-01 2015-09-12 Abbvie Inc Dual variable domain immunoglobulins anti-vegf / Dll4 and uses thereof
MX2015013166A (en) 2013-03-15 2015-12-11 Abbvie Inc Dual specific binding proteins directed against il-1 beta and il-17.
AU2014250434A1 (en) 2013-04-02 2015-10-15 Chugai Seiyaku Kabushiki Kaisha Fc region variant
NL1040254C2 (en) 2013-05-17 2014-11-24 Ablynx Nv Stable formulations of immunoglobulin single variable domains and uses thereof.
WO2015083764A1 (en) 2013-12-04 2015-06-11 中外製薬株式会社 Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
US20150259420A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
WO2015142675A2 (en) 2014-03-15 2015-09-24 Novartis Ag Treatment of cancer using chimeric antigen receptor
JP2017520575A (en) 2014-07-01 2017-07-27 ファイザー・インク Bispecific heterodimeric diabodies and use thereof
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
US20170211055A1 (en) 2014-07-21 2017-07-27 Novartis Ag Sortase synthesized chimeric antigen receptors
JP2017527271A (en) 2014-07-21 2017-09-21 ノバルティス アーゲー Treatment of cancer using human anti bcma chimeric antigen receptor
WO2016025880A1 (en) 2014-08-14 2016-02-18 Novartis Ag Treatment of cancer using gfr alpha-4 chimeric antigen receptor
AU2015317608A1 (en) 2014-09-17 2017-04-06 Novartis Ag Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
AU2015333687A1 (en) 2014-10-14 2017-04-27 Dana-Farber Cancer Institute, Inc. Antibody molecules to PD-L1 and uses thereof
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
US20180334490A1 (en) 2014-12-03 2018-11-22 Qilong H. Wu Methods for b cell preconditioning in car therapy
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
EP3233910A1 (en) 2014-12-19 2017-10-25 Ablynx N.V. Cysteine linked nanobody dimers
AU2016239948A1 (en) 2015-03-31 2017-09-07 Vhsquared Limited Polypeptides
WO2016156570A1 (en) 2015-04-02 2016-10-06 Ablynx N.V. Bispecific cxcr4-cd-4 polypeptides with potent anti-hiv activity
RU2017134652A (en) 2015-04-08 2019-04-09 Новартис Аг Cd20 therapy, CD22 therapy, and combination therapy with cells expressing the chimeric antigen receptor (car) k cd19
EP3286211A1 (en) 2015-04-23 2018-02-28 Novartis AG Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
CN107847559A (en) 2015-05-13 2018-03-27 埃博灵克斯股份有限公司 T cell recruiting polypeptides based on CD3 reactivity
CA2985698A1 (en) 2015-05-13 2016-11-17 Ablynx N.V. T cell recruiting polypeptides based on tcr alpha/beta reactivity
JP2018517431A (en) * 2015-05-21 2018-07-05 ハープーン セラピューティクス,インク. Using a trispecific binding protein
TW201710286A (en) 2015-06-15 2017-03-16 Abbvie Inc Binding proteins against VEGF, PDGF, and/or their receptors
EP3316902A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to tim-3
EP3317301A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to lag-3
PT3191511T (en) 2015-11-12 2017-11-30 Ablynx Nv Improved tnf binders
US20180312578A1 (en) 2015-11-13 2018-11-01 Ablynx N.V. Improved serum albumin-binding immunoglobulin variable domains
WO2017085172A2 (en) 2015-11-18 2017-05-26 Ablynx Nv Improved serum albumin binders
BR112018009972A2 (en) 2015-11-18 2018-11-13 Merck Sharp & Dohme binders CTLA4
TW201726740A (en) 2015-11-18 2017-08-01 Merck Sharp & Dohme PD1 and/or LAG3 binders
AU2016369623A1 (en) 2015-12-17 2018-06-28 Novartis Ag Combination of c-Met inhibitor with antibody molecule to PD-1 and uses thereof
BR112018012138A2 (en) 2015-12-17 2018-12-04 Novartis Ag antibody molecules for PD-1 and uses thereof
EP3405492A1 (en) 2016-01-21 2018-11-28 Novartis AG Multispecific molecules targeting cll-1
KR20180118175A (en) 2016-03-04 2018-10-30 노파르티스 아게 Multi-chimeric antigen receptor cell and thus the use according to (car) expressing the molecule
WO2017165683A1 (en) 2016-03-23 2017-09-28 Novartis Ag Cell secreted minibodies and uses thereof
SG11201809041TA (en) 2016-04-15 2018-11-29 Novartis Ag Compositions and methods for selective protein expression
AU2017259876A1 (en) 2016-05-02 2018-10-25 Ablynx Nv Treatment of RSV infection
US20170334997A1 (en) 2016-05-20 2017-11-23 Harpoon Therapeutics, Inc. Single chain variable fragment cd3 binding proteins
CN109641047A (en) 2016-05-20 2019-04-16 哈普恩治疗公司 Single domain seralbumin conjugated protein
WO2017210617A2 (en) 2016-06-02 2017-12-07 Porter, David, L. Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
WO2018007442A1 (en) 2016-07-06 2018-01-11 Ablynx N.V. Treatment of il-6r related diseases
CA3030837A1 (en) 2016-07-15 2018-01-18 Novartis Ag Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
SG11201900677SA (en) 2016-07-28 2019-02-27 Novartis Ag Combination therapies of chimeric antigen receptors adn pd-1 inhibitors
WO2018026819A2 (en) 2016-08-01 2018-02-08 Novartis Ag Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
WO2018029182A1 (en) 2016-08-08 2018-02-15 Ablynx N.V. Il-6r single variable domain antibodies for treatment of il-6r related diseases
WO2018050833A1 (en) 2016-09-15 2018-03-22 Ablynx Nv Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
WO2018060453A1 (en) 2016-09-30 2018-04-05 Vhsquared Limited Compositions
US20180125892A1 (en) 2016-10-07 2018-05-10 Barbara Brannetti Treatment of cancer using chimeric antigen receptors
WO2018091606A1 (en) 2016-11-16 2018-05-24 Ablynx Nv T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
WO2018099968A1 (en) 2016-11-29 2018-06-07 Ablynx N.V. Treatment of infection by respiratory syncytial virus (rsv)
WO2018104444A1 (en) 2016-12-07 2018-06-14 Ablynx Nv Improved serum albumin binding immunoglobulin single variable domains
WO2018134234A1 (en) 2017-01-17 2018-07-26 Ablynx Nv Improved serum albumin binders
WO2018134235A1 (en) 2017-01-17 2018-07-26 Ablynx Nv Improved serum albumin binders
WO2019014360A1 (en) 2017-07-11 2019-01-17 Alexion Pharmaceuticals, Inc. Polypeptides that bind complement component c5 or serum albumin and fusion proteins thereof
WO2019016237A1 (en) 2017-07-19 2019-01-24 Vib Vzw Serum albumin binding agents
WO2019018730A1 (en) 2017-07-20 2019-01-24 Novartis Ag Dosage regimens of anti-lag-3 antibodies and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0368684B2 (en) * 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
DE69233528D1 (en) 1991-11-25 2005-07-14 Enzon Inc A process for the production of multivalent antigen-binding proteins
JP3720353B2 (en) * 1992-12-04 2005-11-24 メディカル リサーチ カウンシル Multivalent and multispecific binding proteins, their preparation and use
WO1994013806A1 (en) * 1992-12-11 1994-06-23 The Dow Chemical Company Multivalent single chain antibodies
AT204325T (en) * 1993-04-29 2001-09-15 Unilever Nv Preparation made of antibodies or functional parts thereof derived from heavy chains of immunoglobulins of camelidae
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
EP0894135B1 (en) 1996-04-04 2004-08-11 Unilever N.V. Multivalent and multispecific antigen-binding protein

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EP1027439A2 (en) 2000-08-16
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WO1999023221A3 (en) 1999-10-07
DE69841562D1 (en) 2010-04-29
CN1203178C (en) 2005-05-25
AU2152299A (en) 1999-05-24
WO1999023221A2 (en) 1999-05-14
US20030092892A1 (en) 2003-05-15
US6670453B2 (en) 2003-12-30

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