AT446750T - 3-cyano-chinolin derivatives with antiproliferative effect - Google Patents

3-cyano-chinolin derivatives with antiproliferative effect

Info

Publication number
AT446750T
AT446750T AT04804849T AT04804849T AT446750T AT 446750 T AT446750 T AT 446750T AT 04804849 T AT04804849 T AT 04804849T AT 04804849 T AT04804849 T AT 04804849T AT 446750 T AT446750 T AT 446750T
Authority
AT
Austria
Prior art keywords
chinolin
cyano
derivatives
antiproliferative effect
antiproliferative
Prior art date
Application number
AT04804849T
Other languages
German (de)
Inventor
Eddy Jean Edgard Freyne
Peter Jacobus Johan Buijnsters
Emelen Kristof Van
Werner Constant Johah Embrechts
Timothy Pietro Suren Perera
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to EPPCT/EP03/51059 priority Critical
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to PCT/EP2004/053497 priority patent/WO2005058318A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34684508&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT446750(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of AT446750T publication Critical patent/AT446750T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4748Quinolines; Isoquinolines forming part of bridged ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06Peri-condensed systems
AT04804849T 2003-12-18 2004-12-15 3-cyano-chinolin derivatives with antiproliferative effect AT446750T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EPPCT/EP03/51059 2003-12-18
PCT/EP2004/053497 WO2005058318A1 (en) 2003-12-18 2004-12-15 3-cyano-quinoline derivatives with antiproliferative activity

Publications (1)

Publication Number Publication Date
AT446750T true AT446750T (en) 2009-11-15

Family

ID=34684508

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804849T AT446750T (en) 2003-12-18 2004-12-15 3-cyano-chinolin derivatives with antiproliferative effect

Country Status (23)

Country Link
US (4) US7655642B2 (en)
EP (1) EP1696914B1 (en)
JP (1) JP4892353B2 (en)
KR (1) KR101158440B1 (en)
CN (1) CN1893944B (en)
AR (1) AR047060A1 (en)
AT (1) AT446750T (en)
AU (1) AU2004298784B2 (en)
BR (1) BRPI0417609B1 (en)
CA (1) CA2549728C (en)
DE (1) DE602004023876D1 (en)
EA (1) EA200601176A1 (en)
ES (1) ES2335216T3 (en)
HK (1) HK1095742A1 (en)
IL (1) IL176358A (en)
MX (1) MXPA06007018A (en)
NO (1) NO337622B1 (en)
NZ (1) NZ547795A (en)
SG (1) SG151288A1 (en)
TW (2) TWI389890B (en)
UA (1) UA83880C2 (en)
WO (1) WO2005058318A1 (en)
ZA (1) ZA200604971B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT446750T (en) 2003-12-18 2009-11-15 Janssen Pharmaceutica Nv 3-cyano-chinolin derivatives with antiproliferative effect
UA83881C2 (en) 2003-12-18 2008-08-26 Янссен Фармацевтика Н.В. Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
NI200700147A (en) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Quinazoline derivatives kinase inhibitors targeting multip
JO3088B1 (en) * 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv Macrocyclic Quinazoline derivatives and their use as MTKI
TWI374140B (en) 2004-12-08 2012-10-11 Janssen Pharmaceutica Nv 2,4(4,6)pyrimidine derivatives
TWI407961B (en) * 2005-11-16 2013-09-11 S Bio Pte Ltd Heteroalkyl linked pyrimidine derivatives
JP2009542778A (en) 2006-07-13 2009-12-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap MTKI quinazoline derivative
WO2008087736A1 (en) * 2007-01-19 2008-07-24 Ube Industries, Ltd. Process for producing aromatic amine having aralkyloxy or heteroaralkyloxy group
DK2170827T3 (en) * 2007-06-21 2013-11-18 Janssen Pharmaceutica Nv Indoline-2-ones and aza-indoline-2-ones
DK2185562T3 (en) 2007-07-27 2016-02-22 Janssen Pharmaceutica Nv Pyrrolopyrimidines suitable for treating proliferative diseases
CN102127087B (en) * 2011-01-21 2012-07-04 江苏先声药物研究有限公司 Quinazoline derivatives
US20170022201A1 (en) 2014-04-03 2017-01-26 Janssen Pharmaceutica Nv Macrocylic pyridine derivatives
JP6529513B2 (en) 2014-04-03 2019-06-12 ヤンセン ファーマシューティカ エヌ.ベー. Macrocyclic pyrimidine derivative

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028613A (en) 1990-02-16 1991-07-02 Repligen Corporation Novel pyrroloquinoline alkaloids and methods of use
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
ZA9802771B (en) 1997-04-03 1999-10-01 American Cyanamid Co Substituted 3-Cyano Quinolines.
DK1117659T3 (en) 1998-09-29 2004-03-22 Wyeth Corp Substituted 3-cyanoquinolines as inhibitors of protein tyrosine kinases
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
EA200701302A1 (en) * 2002-03-30 2007-12-28 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг 4- (n-phylenamino) quinazolin / -chinoline as thyrosinkinase inhibitors
JO2785B1 (en) * 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
AT446750T (en) 2003-12-18 2009-11-15 Janssen Pharmaceutica Nv 3-cyano-chinolin derivatives with antiproliferative effect

Also Published As

Publication number Publication date
US20080139601A1 (en) 2008-06-12
MXPA06007018A (en) 2006-08-31
US20100069424A1 (en) 2010-03-18
EP1696914A1 (en) 2006-09-06
TWI374879B (en) 2012-10-21
TW200530187A (en) 2005-09-16
US8778920B2 (en) 2014-07-15
DE602004023876D1 (en) 2009-12-10
CN1893944B (en) 2011-07-06
CA2549728C (en) 2015-07-21
US7655642B2 (en) 2010-02-02
JP2007514711A (en) 2007-06-07
US9365517B2 (en) 2016-06-14
TWI389890B (en) 2013-03-21
US20140256948A1 (en) 2014-09-11
EP1696914B1 (en) 2009-10-28
NO20063324L (en) 2006-07-18
EA200601176A1 (en) 2006-10-27
UA83880C2 (en) 2008-08-26
AU2004298784B2 (en) 2011-06-09
CN1893944A (en) 2007-01-10
AU2004298784A1 (en) 2005-06-30
NO337622B1 (en) 2016-05-09
BRPI0417609A (en) 2007-04-10
ZA200604971B (en) 2009-05-27
US9040511B2 (en) 2015-05-26
JP4892353B2 (en) 2012-03-07
BRPI0417609B1 (en) 2019-02-19
HK1095742A1 (en) 2012-03-02
IL176358A (en) 2010-06-16
SG151288A1 (en) 2009-04-30
AR047060A1 (en) 2006-01-04
KR101158440B1 (en) 2012-07-06
US20130197022A1 (en) 2013-08-01
WO2005058318A1 (en) 2005-06-30
ES2335216T3 (en) 2010-03-23
NZ547795A (en) 2009-07-31
TW201132628A (en) 2011-10-01
CA2549728A1 (en) 2005-06-30
KR20070005560A (en) 2007-01-10
IL176358D0 (en) 2006-10-05

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Legal Events

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