AT445642T - Separation of polypeptides having a racemized amino acid - Google Patents

Separation of polypeptides having a racemized amino acid

Info

Publication number
AT445642T
AT445642T AT04739039T AT04739039T AT445642T AT 445642 T AT445642 T AT 445642T AT 04739039 T AT04739039 T AT 04739039T AT 04739039 T AT04739039 T AT 04739039T AT 445642 T AT445642 T AT 445642T
Authority
AT
Austria
Prior art keywords
polypeptides
separation
amino acid
racemized amino
racemized
Prior art date
Application number
AT04739039T
Other languages
German (de)
Inventor
Thomas Budde Hansen
Steffen Kidal
Camilla Kornbeck
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DKPA200301196 priority Critical
Priority to US49825003P priority
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to PCT/DK2004/000542 priority patent/WO2005019261A1/en
Publication of AT445642T publication Critical patent/AT445642T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
AT04739039T 2003-08-21 2004-08-18 Separation of polypeptides having a racemized amino acid AT445642T (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DKPA200301196 2003-08-21
US49825003P true 2003-08-27 2003-08-27
PCT/DK2004/000542 WO2005019261A1 (en) 2003-08-21 2004-08-18 Separation of polypeptides comprising a racemized amino acid

Publications (1)

Publication Number Publication Date
AT445642T true AT445642T (en) 2009-10-15

Family

ID=34219529

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04739039T AT445642T (en) 2003-08-21 2004-08-18 Separation of polypeptides having a racemized amino acid

Country Status (13)

Country Link
US (1) US7749955B2 (en)
EP (1) EP1664108B1 (en)
JP (2) JP5622998B2 (en)
KR (1) KR20060106812A (en)
AT (1) AT445642T (en)
AU (1) AU2004266757A1 (en)
BR (1) BRPI0413644A (en)
CA (1) CA2532340A1 (en)
DE (1) DE602004023626D1 (en)
ES (1) ES2335211T3 (en)
MX (1) MXPA06001814A (en)
RU (1) RU2006103860A (en)
WO (1) WO2005019261A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
GB0300571D0 (en) * 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
GB0511986D0 (en) * 2005-06-13 2005-07-20 Imp College Innovations Ltd Novel compounds and their effects on feeding behaviour
WO2008023050A1 (en) * 2006-08-25 2008-02-28 Novo Nordisk A/S Acylated exendin-4 compounds
EP2280993A1 (en) * 2008-05-15 2011-02-09 Novo Nordisk A/S Purification of peptides prepared by solid phase synthesis
EP2373391A1 (en) 2008-12-08 2011-10-12 Novo Nordisk A/S Counter current purification of polypeptides
MY150536A (en) 2009-03-20 2014-01-30 Hanmi Science Co Ltd Method for preparing a site-specific physiologically active polypeptide conjugate
CA2828147A1 (en) * 2011-03-08 2012-09-13 Sanwa Kagaku Kenkyusho Co., Ltd. Analysis method
MX2015008077A (en) 2012-12-21 2015-10-30 Sanofi Sa Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists.
TW201609796A (en) 2013-12-13 2016-03-16 Sanofi Sa Non-acylated EXENDIN-4 peptide analogues
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
EP3080150B1 (en) 2013-12-13 2018-08-01 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201625670A (en) 2014-04-07 2016-07-16 Sanofi Sa Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4
TW201625669A (en) 2014-04-07 2016-07-16 Sanofi Sa Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4
TW201625668A (en) 2014-04-07 2016-07-16 Sanofi Sa Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
AR105284A1 (en) 2015-07-10 2017-09-20 Sanofi Sa Exendin-4 derivatives as dual specific peptide agonists receptor glp-1 / glucagon
CN109311960A (en) 2016-03-23 2019-02-05 巴切姆股份公司 The purification process of glucagon-like peptide 1 analog

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US3907676A (en) * 1970-07-28 1975-09-23 Novo Terapeutisk Labor As Process for purifying insulin
DE2629568C3 (en) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt, De
DK155887C (en) * 1979-04-13 1989-10-16 Shionogi & Co A process for preparing oeb30-Thr (R 1) (R 2) aa - insulin
US4361510A (en) * 1980-05-27 1982-11-30 Cutter Laboratories, Inc. Blood coagulation promoting product
CA1284000C (en) 1985-07-01 1991-05-07 David Gregory Maskalick Process for recovering glucagon from pancreas glands
CA1341320C (en) 1986-05-05 2001-11-20 Joel Habener Insulinotropic hormone
DE3726655A1 (en) * 1987-08-11 1989-02-23 Hoechst Ag A process for the isolation of basic proteins from protein mixtures containing such basic proteins
BR8803345A (en) 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S An improved process for large-scale production of purified human insulin crystals
BR8803346A (en) 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S An improved process for producing purified on a large scale insulin crystals
EP0464022B1 (en) 1989-03-20 2000-05-31 The General Hospital Corporation Insulinotropic hormone
DE69129226D1 (en) 1990-01-24 1998-05-14 Douglas I Buckley GLP-1 analogs useful in the treatment of diabetes
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
JP3138513B2 (en) * 1991-10-17 2001-02-26 信和化工株式会社 The separating agent for optical isomers
FR2684999B1 (en) * 1991-12-16 1995-05-05 Aquitaine Dev Transf Sanguine
JPH05246898A (en) * 1992-03-03 1993-09-24 Shinwa Kako Kk Separating agent for optical isomer
FR2718452B1 (en) * 1994-04-06 1996-06-28 Pf Medicament Element immunogen, immunogenic agent, pharmaceutical composition and method of preparation.
US5574008A (en) 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5990077A (en) 1995-04-14 1999-11-23 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
JPH08337600A (en) 1995-06-13 1996-12-24 Ito Ham Kk Production of glucagon
JP4046377B2 (en) 1996-08-19 2008-02-13 財団法人化学及血清療法研究所 Method for producing activated blood coagulation vii factor based on activation method and the method of the blood coagulation vii factor
JPH1059866A (en) 1996-08-19 1998-03-03 Chemo Sero Therapeut Res Inst Production of blood coagulation factor vii and/or activated blood coagulation factor vii
US6268343B1 (en) * 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
DE122009000079I2 (en) 1996-08-30 2011-06-16 Novo Nordisk As Novo Alle GLP-1 derivatives
EP0929576A1 (en) 1996-08-30 1999-07-21 Novo Nordisk A/S Glp-2 derivatives
DE19652713C2 (en) 1996-12-18 2001-11-22 Aventis Pharma Gmbh A process for the purification of insulin and insulin derivatives by chromatography on a strongly acidic cation exchanger
RU2122549C1 (en) * 1997-12-29 1998-11-27 Закрытое акционерное общество "Фосфосорб" Chromatography method of isolation and purification of proteins, peptides and their complexes
US7108986B2 (en) * 1998-10-16 2006-09-19 The Regents Of The University Of California Glypican-1 in human breast cancer
US6444788B1 (en) * 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
EP1163268B1 (en) * 1999-03-15 2011-05-11 Novo Nordisk A/S Ion exchange chromatographic separation of glp-1 and related peptides

Also Published As

Publication number Publication date
ES2335211T3 (en) 2010-03-23
JP5622998B2 (en) 2014-11-12
EP1664108A1 (en) 2006-06-07
US7749955B2 (en) 2010-07-06
WO2005019261A1 (en) 2005-03-03
EP1664108B1 (en) 2009-10-14
MXPA06001814A (en) 2006-05-04
RU2006103860A (en) 2006-07-27
US20060183669A1 (en) 2006-08-17
AU2004266757A1 (en) 2005-03-03
JP2012102104A (en) 2012-05-31
KR20060106812A (en) 2006-10-12
CA2532340A1 (en) 2005-03-03
BRPI0413644A (en) 2006-10-17
DE602004023626D1 (en) 2009-11-26
JP2007526234A (en) 2007-09-13

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