AT437946T - Ribozyme with wide trna-aminoacylation effect - Google Patents

Ribozyme with wide trna-aminoacylation effect

Info

Publication number
AT437946T
AT437946T AT03709182T AT03709182T AT437946T AT 437946 T AT437946 T AT 437946T AT 03709182 T AT03709182 T AT 03709182T AT 03709182 T AT03709182 T AT 03709182T AT 437946 T AT437946 T AT 437946T
Authority
AT
Austria
Prior art keywords
aminoacylation
trna
ribozyme
wide
effect
Prior art date
Application number
AT03709182T
Other languages
German (de)
Inventor
Hiroaki Suga
Hiroshi Murakami
Hirohide Saito
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US35742402P priority Critical
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Priority to PCT/US2003/005007 priority patent/WO2003070740A1/en
Publication of AT437946T publication Critical patent/AT437946T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/12Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
AT03709182T 2002-02-15 2003-02-18 Ribozyme with wide trna-aminoacylation effect AT437946T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US35742402P true 2002-02-15 2002-02-15
PCT/US2003/005007 WO2003070740A1 (en) 2002-02-15 2003-02-18 RIBOZYMES WITH BROAD tRNA AMINOACYLATION ACTIVITY

Publications (1)

Publication Number Publication Date
AT437946T true AT437946T (en) 2009-08-15

Family

ID=27757615

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03709182T AT437946T (en) 2002-02-15 2003-02-18 Ribozyme with wide trna-aminoacylation effect

Country Status (8)

Country Link
US (1) US7622248B2 (en)
EP (1) EP1483282B1 (en)
JP (1) JP4464684B2 (en)
AT (1) AT437946T (en)
AU (1) AU2003213136A1 (en)
CA (1) CA2476425C (en)
DE (1) DE60328587D1 (en)
WO (1) WO2003070740A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069220A2 (en) 2004-12-22 2006-06-29 Ambrx, Inc. Modified human growth hormone
CN106443006A (en) 2005-11-16 2017-02-22 Ambrx公司 Methods and compositions comprising non-natural amino acids
WO2007066627A1 (en) * 2005-12-06 2007-06-14 The University Of Tokyo Multi-purpose acylation catalayst and use thereof
WO2008030558A2 (en) 2006-09-08 2008-03-13 Ambrx, Inc. Modified human plasma polypeptide or fc scaffolds and their uses
JP5200241B2 (en) * 2006-11-17 2013-06-05 国立大学法人 東京大学 Translational synthesis of polypeptides with non-natural backbone at the N-terminus and their applications
EP3012265B1 (en) 2007-03-26 2017-06-28 The University of Tokyo Process for synthesizing cyclic peptide compound
AU2008232937B2 (en) 2007-03-30 2012-09-27 Ambrx, Inc. Modified FGF-21 polypeptides and their uses
US8114630B2 (en) 2007-05-02 2012-02-14 Ambrx, Inc. Modified interferon beta polypeptides and their uses
KR101656107B1 (en) 2007-11-20 2016-09-08 암브룩스, 인코포레이티드 Modified insulin polypeptides and their uses
BRPI0916515A2 (en) 2008-07-23 2018-03-13 Ambrx Inc modified bovine g-csf polypeptide and uses thereof
JP5709754B2 (en) 2008-09-26 2015-04-30 アンブルックス,インコーポレイテッドAmbrx,Inc. Microorganisms and vaccines that rely on replication with unnatural amino acids
WO2010081111A1 (en) * 2009-01-12 2010-07-15 Sutro Biopharma, Inc. Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system
EP2805965A1 (en) 2009-12-21 2014-11-26 Ambrx, Inc. Modified porcine somatotropin polypeptides and their uses
EP2805964A1 (en) 2009-12-21 2014-11-26 Ambrx, Inc. Modified bovine somatotropin polypeptides and their uses
KR101963460B1 (en) 2010-08-17 2019-03-28 암브룩스, 인코포레이티드 Modified relaxin polypeptides and their uses
JP5818237B2 (en) * 2010-09-09 2015-11-18 国立大学法人 東京大学 Translational construction and search for active species of special peptide compound library containing N-methylamino acid and other special amino acids
WO2012074130A1 (en) 2010-12-03 2012-06-07 国立大学法人東京大学 Peptide library production method, peptide library, and screening method
EP3209316A2 (en) 2014-10-24 2017-08-30 Bristol-Myers Squibb Company Modified fgf-21 polypeptides and uses thereof
WO2020056066A1 (en) 2018-09-11 2020-03-19 Ambrx, Inc. Interleukin-2 polypeptide conjugates and their uses
WO2020082057A1 (en) 2018-10-19 2020-04-23 Ambrx, Inc. Interleukin-10 polypeptide conjugates, dimers thereof, and their uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5475096A (en) * 1990-06-11 1995-12-12 University Research Corporation Nucleic acid ligands
US5998142A (en) * 1993-09-08 1999-12-07 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US6063566A (en) * 1994-05-13 2000-05-16 The Scripps Research Institute Catalytic RNA molecules
ES2127106B1 (en) * 1996-03-21 1999-11-16 Menarini Lab Benzopyranic derivatives with antagonistic action of the leucotrenees, procedure for their preparation and use of the same.
US5871924A (en) * 1997-01-27 1999-02-16 Nexstar Pharmaceuticals, Inc. Method for the production of ligands capable of facilitating aminoacyl-RNA synthesis
US6280936B1 (en) * 1997-06-09 2001-08-28 Ribozyme Pharmaceuticals, Inc. Method for screening nucleic acid catalysts
DE19801153A1 (en) * 1998-01-14 1999-07-15 Jenne Andreas Selection of a ribozymes useful for, e.g. inhibiting gene expression and improving nuclease resistance
WO2001038582A1 (en) * 1999-11-24 2001-05-31 The Research Foundation Of State University Of New York CATALYTIC RNAs WITH AMINOACYLATION ACTIVITY

Also Published As

Publication number Publication date
EP1483282A1 (en) 2004-12-08
WO2003070740A1 (en) 2003-08-28
CA2476425A1 (en) 2003-08-28
EP1483282B1 (en) 2009-07-29
JP2005528090A (en) 2005-09-22
JP4464684B2 (en) 2010-05-19
US20030228593A1 (en) 2003-12-11
DE60328587D1 (en) 2009-09-10
CA2476425C (en) 2012-04-17
US7622248B2 (en) 2009-11-24
AU2003213136A1 (en) 2003-09-09
EP1483282A4 (en) 2007-06-06

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