AT435661T - Adjuvant qs-21 containing compositions with polysorbate or cyclodextrin as aid - Google Patents

Adjuvant qs-21 containing compositions with polysorbate or cyclodextrin as aid

Info

Publication number
AT435661T
AT435661T AT98944600T AT98944600T AT435661T AT 435661 T AT435661 T AT 435661T AT 98944600 T AT98944600 T AT 98944600T AT 98944600 T AT98944600 T AT 98944600T AT 435661 T AT435661 T AT 435661T
Authority
AT
Austria
Prior art keywords
cyclodextrin
polysorbate
aid
containing compositions
adjuvant qs
Prior art date
Application number
AT98944600T
Other languages
German (de)
Inventor
Charlotte Kensil
Gerald Beltz
Original Assignee
Antigenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US5725597P priority Critical
Application filed by Antigenics Inc filed Critical Antigenics Inc
Priority to PCT/US1998/017940 priority patent/WO1999010008A1/en
Publication of AT435661T publication Critical patent/AT435661T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
AT98944600T 1997-08-29 1998-08-28 Adjuvant qs-21 containing compositions with polysorbate or cyclodextrin as aid AT435661T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US5725597P true 1997-08-29 1997-08-29
PCT/US1998/017940 WO1999010008A1 (en) 1997-08-29 1998-08-28 Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient

Publications (1)

Publication Number Publication Date
AT435661T true AT435661T (en) 2009-07-15

Family

ID=22009474

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98944600T AT435661T (en) 1997-08-29 1998-08-28 Adjuvant qs-21 containing compositions with polysorbate or cyclodextrin as aid

Country Status (10)

Country Link
US (2) US6645495B1 (en)
EP (2) EP1009429B1 (en)
JP (3) JP5220248B2 (en)
AT (1) AT435661T (en)
AU (1) AU734180B2 (en)
CA (2) CA2654522C (en)
DE (1) DE69840962D1 (en)
ES (2) ES2500490T3 (en)
HK (1) HK1129846A1 (en)
WO (1) WO1999010008A1 (en)

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Also Published As

Publication number Publication date
CA2302522A1 (en) 1999-03-04
US20050191310A1 (en) 2005-09-01
AU9210798A (en) 1999-03-16
CA2302522C (en) 2010-08-17
JP5220248B2 (en) 2013-06-26
ES2500490T3 (en) 2014-09-30
EP1009429B1 (en) 2009-07-08
EP1009429A1 (en) 2000-06-21
DE69840962D1 (en) 2009-08-20
CA2654522A1 (en) 1999-03-04
JP2009197014A (en) 2009-09-03
EP2050465A2 (en) 2009-04-22
JP2011162559A (en) 2011-08-25
JP2001513575A (en) 2001-09-04
CA2654522C (en) 2014-01-28
AU734180B2 (en) 2001-06-07
EP2050465B1 (en) 2014-06-11
US6645495B1 (en) 2003-11-11
HK1129846A1 (en) 2015-04-24
EP2050465A3 (en) 2009-09-02
WO1999010008A1 (en) 1999-03-04
ES2327693T3 (en) 2009-11-02

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