AT431426T - Method for identifying lrrk2-interactive molecules and cleaning lrrk2 - Google Patents

Method for identifying lrrk2-interactive molecules and cleaning lrrk2

Info

Publication number
AT431426T
AT431426T AT07717962T AT07717962T AT431426T AT 431426 T AT431426 T AT 431426T AT 07717962 T AT07717962 T AT 07717962T AT 07717962 T AT07717962 T AT 07717962T AT 431426 T AT431426 T AT 431426T
Authority
AT
Austria
Prior art keywords
lrrk2
identifying
cleaning
interactive molecules
interactive
Prior art date
Application number
AT07717962T
Other languages
German (de)
Inventor
Gerard Drewes
Carsten Hopf
Valerie Reader
Original Assignee
Cellzome Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US78211906P priority Critical
Application filed by Cellzome Ag filed Critical Cellzome Ag
Priority to PCT/EP2007/052357 priority patent/WO2007104763A1/en
Publication of AT431426T publication Critical patent/AT431426T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette
AT07717962T 2006-03-14 2007-03-13 Method for identifying lrrk2-interactive molecules and cleaning lrrk2 AT431426T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US78211906P true 2006-03-14 2006-03-14
PCT/EP2007/052357 WO2007104763A1 (en) 2006-03-14 2007-03-13 Methods for the identification of lrrk2 interacting molecules and for the purification of lrrk2

Publications (1)

Publication Number Publication Date
AT431426T true AT431426T (en) 2009-05-15

Family

ID=38093568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07717962T AT431426T (en) 2006-03-14 2007-03-13 Method for identifying lrrk2-interactive molecules and cleaning lrrk2

Country Status (11)

Country Link
US (1) US8163511B2 (en)
EP (1) EP1866433B1 (en)
JP (1) JP2009529860A (en)
CN (1) CN101426927B (en)
AT (1) AT431426T (en)
AU (1) AU2007224411B2 (en)
CA (1) CA2645214A1 (en)
DE (1) DE602007001103D1 (en)
DK (1) DK1866433T3 (en)
ES (1) ES2325797T3 (en)
WO (1) WO2007104763A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206942B2 (en) 2007-04-05 2012-06-26 Medical Research Council Methods of identifying LRRK2 inhibitors
GB0706709D0 (en) 2007-04-05 2007-05-16 Medical Res Council Methods
DE602007007624D1 (en) 2007-10-05 2010-08-19 Max Planck Gesellschaft Proteome-wide quantification of small molecules bound to target cellular proteins
ES2375541T3 (en) * 2008-02-04 2012-03-01 Cellzome Ag Obtaining the profile of selection of molecules of interaction with pi3k against multiple targets.
GB2463656B (en) * 2008-09-18 2010-10-13 Medical Res Council Substrate of LRRK2 and methods of assessing LRRK2 activity
US8367349B2 (en) * 2010-04-19 2013-02-05 Medical Research Council Methods for identifying modulators of LRRK2
US9187567B2 (en) * 2011-05-18 2015-11-17 Parkinson's Institute Assay to determine LRRK2 activity in parkinson's disease
ES2637245T3 (en) 2012-06-29 2017-10-11 Pfizer Inc. New 4- (substituted amino) -7H-pyrrolo [2,3-d] pyrimidines as LRRK2 inhibitors
EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
EP3350178A1 (en) 2015-09-14 2018-07-25 Pfizer Inc Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797725B2 (en) * 2001-04-09 2004-09-28 Sugen, Inc. Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
AU2003253880A1 (en) 2002-07-15 2004-02-02 Sugen, Inc. Novel kinases
CA2611365C (en) * 2005-06-14 2014-02-11 Cellzome Ag Process for the identification of novel enzyme interacting compounds

Also Published As

Publication number Publication date
US8163511B2 (en) 2012-04-24
WO2007104763A9 (en) 2007-11-15
EP1866433B1 (en) 2009-05-13
CA2645214A1 (en) 2007-09-20
CN101426927B (en) 2012-05-23
US20090220992A1 (en) 2009-09-03
ES2325797T3 (en) 2009-09-17
AU2007224411A1 (en) 2007-09-20
DE602007001103D1 (en) 2009-06-25
AU2007224411B2 (en) 2012-11-01
CN101426927A (en) 2009-05-06
DK1866433T3 (en) 2009-08-17
WO2007104763A1 (en) 2007-09-20
EP1866433A1 (en) 2007-12-19
JP2009529860A (en) 2009-08-27

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