AT428466T - Transdermal arzneistoffverabreichungssytem with coated micro-projections - Google Patents

Transdermal arzneistoffverabreichungssytem with coated micro-projections

Info

Publication number
AT428466T
AT428466T AT01273947T AT01273947T AT428466T AT 428466 T AT428466 T AT 428466T AT 01273947 T AT01273947 T AT 01273947T AT 01273947 T AT01273947 T AT 01273947T AT 428466 T AT428466 T AT 428466T
Authority
AT
Austria
Prior art keywords
arzneistoffverabreichungssytem
transdermal
projections
coated micro
micro
Prior art date
Application number
AT01273947T
Other languages
German (de)
Inventor
Michel Cormier
Wendy Young
Kofi Nyam
Peter Daddona
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US24403800P priority Critical
Application filed by Alza Corp filed Critical Alza Corp
Priority to PCT/US2001/051496 priority patent/WO2002094368A1/en
Publication of AT428466T publication Critical patent/AT428466T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles
AT01273947T 2000-10-26 2001-10-26 Transdermal arzneistoffverabreichungssytem with coated micro-projections AT428466T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US24403800P true 2000-10-26 2000-10-26
PCT/US2001/051496 WO2002094368A1 (en) 2000-10-26 2001-10-26 Transdermal drug delivery devices having coated microprotrusions

Publications (1)

Publication Number Publication Date
AT428466T true AT428466T (en) 2009-05-15

Family

ID=22921144

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01273947T AT428466T (en) 2000-10-26 2001-10-26 Transdermal arzneistoffverabreichungssytem with coated micro-projections

Country Status (24)

Country Link
US (2) US7537795B2 (en)
EP (2) EP2085109A3 (en)
JP (2) JP4659336B2 (en)
KR (1) KR100812097B1 (en)
CN (1) CN1239212C (en)
AT (1) AT428466T (en)
AU (1) AU2001297823B2 (en)
BR (1) BR0114909A (en)
CA (1) CA2427381A1 (en)
CZ (1) CZ20031164A3 (en)
DE (1) DE60138407D1 (en)
DK (1) DK1333880T3 (en)
ES (1) ES2322023T3 (en)
HU (1) HU0302924A2 (en)
IL (1) IL155583D0 (en)
MA (1) MA26061A1 (en)
MX (1) MXPA03003815A (en)
NO (1) NO20031875L (en)
NZ (1) NZ525551A (en)
PL (1) PL365677A1 (en)
PT (1) PT1333880E (en)
RU (1) RU2282468C2 (en)
WO (1) WO2002094368A1 (en)
ZA (1) ZA200303988B (en)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
WO2002019985A2 (en) * 2000-09-08 2002-03-14 Alza Corporation Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
PL360998A1 (en) * 2000-10-13 2004-09-20 Alza Corporation Apparatus and method for piercing skin with microprotrusions
PL360977A1 (en) * 2000-10-13 2004-09-20 Alza Corporation Microprotrusion member retainer for impact applicator
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
JP2004528900A (en) * 2001-04-20 2004-09-24 アルザ・コーポレーシヨン Microprojection array having a coating containing a beneficial agent
US20030199810A1 (en) * 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
DK1465535T3 (en) * 2001-12-20 2008-04-07 Alza Corp Micro-Projections for piercing the skin with penetration depth control
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
AR040819A1 (en) * 2002-08-08 2005-04-20 Alza Corp Transdermal delivery device having coated vaccine microprojections
CA2516547A1 (en) * 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
AR042815A1 (en) * 2002-12-26 2005-07-06 Alza Corp Delivery device active agent having composite members
MXPA06000283A (en) * 2003-06-30 2006-07-03 Johnson & Johnson Method for coating skin piercing microprojections.
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
JP5456234B2 (en) * 2003-06-30 2014-03-26 アルザ・コーポレーシヨン Formulations for coated microprojections containing non-volatile counterions
JP2007521092A (en) * 2003-07-02 2007-08-02 アルザ・コーポレーシヨン Immunization patches and methods small projection array
KR20060115717A (en) * 2003-08-04 2006-11-09 알자 코포레이션 Method and device for enhancing transdermal agent flux
CA2536249A1 (en) 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
AU2004266161A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
CN101415443A (en) * 2003-10-23 2009-04-22 阿尔扎公司 Compositions of stabilized DNA for coating microprojctions
CN1897898A (en) 2003-10-24 2007-01-17 阿尔扎公司 Pretreatment method and system for enhancing transdermal drug delivery
JP2007508914A (en) * 2003-10-24 2007-04-12 アルザ・コーポレーシヨン Apparatus and method for facilitating transdermal drug delivery
WO2005044139A2 (en) 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
ES2377647T3 (en) * 2003-10-31 2012-03-29 Alza Corporation Self-acting applicator for microprojection ordering
US20050106209A1 (en) * 2003-11-13 2005-05-19 Mahmoud Ameri Composition and apparatus for transdermal delivery
DE10353629A1 (en) * 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Device for the transdermal administration of active substances
CA2547382A1 (en) * 2003-11-28 2005-06-09 Acrux Dds Pty Ltd. Method and system for rapid transdermal administration
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
JP4832082B2 (en) * 2004-02-03 2011-12-07 久光製薬株式会社 Interface for transdermal drug delivery device
US8158728B2 (en) 2004-02-13 2012-04-17 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
KR20060135931A (en) * 2004-04-01 2006-12-29 알자 코포레이션 Apparatus and method for transdermal delivery of influenza vaccine
WO2005103303A2 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of multiple vaccines
CN100566669C (en) * 2004-05-13 2009-12-09 阿尔扎公司 Apparatus for transdermal delivery of parathyroid hormone agents
WO2005112984A2 (en) * 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2005112463A2 (en) * 2004-05-19 2005-11-24 Alza Corporation Method and formulation for transdermal delivery of immunologically active agents
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060100584A1 (en) * 2004-08-10 2006-05-11 Orest Olejnik Needleless microprotrusion elastoplast system
AR050608A1 (en) * 2004-08-19 2006-11-08 Alza Corp Apparatus and method for transdermal administration of vascular endothelial growth factors
WO2006029279A1 (en) * 2004-09-08 2006-03-16 Alza Corporation Microprojection array with improved skin adhesion and compliance
US20060093658A1 (en) * 2004-10-26 2006-05-04 Gayatri Sathyan Apparatus and method for transdermal delivery of desmopressin
WO2006047198A2 (en) * 2004-10-26 2006-05-04 Caritas St. Elizabeth Medical Center Of Boston, Inc. Composition and method for using a cytokine to treat restenosis
US8057842B2 (en) * 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
AU2005306426B2 (en) * 2004-11-18 2011-04-28 3M Innovative Properties Company Masking method for coating a microneedle array
US8900180B2 (en) * 2005-11-18 2014-12-02 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
KR20070102669A (en) * 2004-11-18 2007-10-19 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Low-profile microneedle array applicator
AU2005306372B2 (en) * 2004-11-18 2011-01-06 3M Innovative Properties Company Method of contact coating a microneedle array
CA2594291C (en) * 2004-12-28 2012-03-06 Nabtesco Corporation Skin needle manufacturing apparatus and skin needle manufacturing method
US20060188555A1 (en) * 2005-01-21 2006-08-24 Micheal Cormier Therapeutic peptide formulations with improved stability
TW200640519A (en) * 2005-02-16 2006-12-01 Alza Corp Microprojection arrays with improved biocompatibility
JP2008530230A (en) * 2005-02-16 2008-08-07 アルザ・コーポレーシヨン Apparatus and method for transdermal delivery of agents based on erythropoietin
CA2602814A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
EP1888126A1 (en) * 2005-06-02 2008-02-20 Alza Corporation Method for terminal sterilization of transdermal delivery devices
WO2006130869A1 (en) * 2005-06-02 2006-12-07 Alza Corporation Method for terminal sterilization of transdermal delivery devices
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
CN101242869B (en) * 2005-09-02 2010-05-26 Iomai公司 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
US20070293814A1 (en) * 2005-09-12 2007-12-20 Trautman Joseph C Coatable transdermal delivery microprojection assembly
EP1957145A4 (en) * 2005-11-30 2011-03-23 3M Innovative Properties Co Microneedle arrays and methods of use thereof
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
CA2635251A1 (en) * 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations
WO2007081876A2 (en) 2006-01-04 2007-07-19 Liquidia Technologies, Inc. Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
CA2680690A1 (en) * 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
US20070224252A1 (en) * 2006-03-27 2007-09-27 Trautman Joseph C Microprojections with capillary control features and method
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
WO2007127811A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with grouped microprojections for high drug loading
JP4821993B2 (en) * 2006-07-21 2011-11-24 芳一 飛永 Micro-implement and manufacturing method thereof
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
EP2153863A4 (en) 2007-05-15 2014-01-08 Hisamitsu Pharmaceutical Co Method of coating microneedle
CA2690945C (en) * 2007-06-21 2015-07-21 Fujimoto Co., Ltd. Transdermal or transmucosal pharmaceutical composition comprising 1-(benzofuran-2-yl)-2-propylaminopentane
AU2008283929B2 (en) * 2007-08-06 2013-10-10 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
ES2612061T3 (en) * 2007-09-28 2017-05-11 The Queen's University Of Belfast Device and delivery method
US7806878B2 (en) * 2007-10-17 2010-10-05 Cascio Gregory R Medicament applicator
US20090105673A1 (en) * 2007-10-17 2009-04-23 Cascio Gregory R Medicament applicator
JP5538897B2 (en) * 2007-11-21 2014-07-02 株式会社バイオセレンタック Preparation for body surface application, and preparation holding sheet for body surface application
WO2009079712A1 (en) 2007-12-24 2009-07-02 The University Of Queensland Coating method
CN102007066B (en) 2008-02-07 2013-06-26 昆士兰大学 Patch production
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
SI2712622T1 (en) 2008-05-21 2016-10-28 Ferring B.V. Orodispersible desmopressin for increasing initial period of sleep undisturbed by nocturia
AU2009250341A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
US8834446B2 (en) * 2008-06-12 2014-09-16 DePuy Synthes Products, LLC Pulsatile flux drug delivery
EP2379160B1 (en) 2008-12-22 2014-09-10 The University Of Queensland Patch production
US20110006458A1 (en) * 2009-04-24 2011-01-13 Corium International, Inc. Methods for manufacturing microprojection arrays
US20100286600A1 (en) * 2009-05-08 2010-11-11 Bommannan D Bommi Transdermal patch device
DE102009056746A1 (en) * 2009-12-04 2011-06-09 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the administration of peptides
DE102009056745A1 (en) 2009-12-04 2011-06-09 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the administration of peptides
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
WO2011105496A1 (en) * 2010-02-24 2011-09-01 久光製薬株式会社 Micro-needle device
CA2801247C (en) * 2010-05-04 2018-09-04 Corium International, Inc. Applicators for microneedles
LT2568806T (en) 2010-05-12 2016-09-26 Radius Health, Inc. Therapeutic regimens
EP2575845B1 (en) 2010-05-28 2017-02-15 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
UA112769C2 (en) 2011-02-18 2016-10-25 Ендо Фармасьютікалз Інк. Aminoindanovi compounds and their use in treating pain
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
US8301238B2 (en) * 2011-03-31 2012-10-30 Incline Therapeutics, Inc. Two-part electrotransport device
JP2013043034A (en) * 2011-08-26 2013-03-04 Dainippon Printing Co Ltd Method for manufacturing microneedle device
JP5870551B2 (en) * 2011-08-26 2016-03-01 大日本印刷株式会社 Manufacturing method of microneedle device
ES2596215T3 (en) 2011-10-24 2017-01-05 Asana Biosciences, Llc Cyclohexylamines
KR101392947B1 (en) * 2011-12-13 2014-05-12 주식회사 스몰랩 Micro-needle massage patch containing fiber and method of preparing the same
US20130296824A1 (en) * 2012-05-03 2013-11-07 Uc Biodevices Corporation Microneedle based transdermal drug delivery device and method
US20150305739A1 (en) * 2012-06-15 2015-10-29 University Of Washington Through Its Center For Commercialization Microstructure-based wound closure devices
JP2016514133A (en) 2013-03-15 2016-05-19 コリウム インターナショナル, インコーポレイテッド Microarray containing fine structure containing no polymer, manufacturing method and use method
MX2015012933A (en) 2013-03-15 2016-09-19 Corium Int Inc Microarray for delivery of therapeutic agent and methods of use.
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
WO2015027173A1 (en) 2013-08-22 2015-02-26 Zp Opco, Inc. Stable glucagon peptide formulations
US9782344B2 (en) 2013-08-22 2017-10-10 Zp Opco, Inc. Stable glucagon peptide formulations
EP3083619A1 (en) 2013-12-16 2016-10-26 Asana BioSciences, LLC P2x3 and/or p2x2/3 compounds and methods
US10232160B2 (en) * 2014-04-30 2019-03-19 Sorrento Therapeutics, Inc. Transdermal drug delivery apparatus and methods
GB201410270D0 (en) 2014-06-10 2014-07-23 Univ Belfast Cell delivery system and method
JP2016093325A (en) 2014-11-14 2016-05-26 ロレアル Microneedle sheet for reducing wrinkles
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
EP3416618A1 (en) 2016-02-19 2018-12-26 ZP Opco, Inc. Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
CA3047411A1 (en) 2017-01-05 2018-07-12 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
WO2019040063A1 (en) 2017-08-23 2019-02-28 Zp Opco, Inc. Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
USRE25637E (en) 1964-09-08 Means for vaccinating
US25637A (en) * 1859-10-04 Cooking-stove
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3470011A (en) * 1967-02-07 1969-09-30 American Cyanamid Co Process for applying liquid biologicals to applicators for intracutaneous injection
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
CH580961A5 (en) 1972-01-13 1976-10-29 Alza Corp Dispenser - functioning by osmotic pressure using active agents in solid or semi solid form
BE795384A (en) 1972-02-14 1973-08-13 Ici Ltd dressings
OA5448A (en) 1975-10-16 1981-03-31 Manufrance Manufacture Francai Multipenetrating vaccinating device
FR2474856B1 (en) * 1980-01-31 1983-10-07 Merieux Inst
SE8501990D0 (en) * 1985-04-24 1985-04-24 Pharmacia Ab Beleggningsforfarande
US4878892A (en) 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5321008A (en) * 1991-01-10 1994-06-14 Amylin Pharmaceuticals, Inc. Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions
US5298256A (en) * 1992-04-28 1994-03-29 Corint, Ltd. Desmopressin buccal patch composition
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
EE03593B1 (en) 1994-08-04 2002-02-15 Quadrant Holdings Cambridge Limited Solid controlled-release delivery of molecules and the methods for their preparation
AU3758595A (en) 1994-09-30 1996-04-26 Rutgers, The State University Direct introduction of foreign materials into cells
DE59505328D1 (en) 1994-12-09 1999-04-15 Novartis Ag The transdermal system
US5985316A (en) * 1995-04-28 1999-11-16 Alza Corporation Composition and method of enhancing electrotransport agent delivery
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (en) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug release system
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
EP0921840B1 (en) 1996-07-03 2003-05-28 Altea Therapeutics Corporation Multiple mechanical microporation of skin or mucosa
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
GB9623634D0 (en) 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
WO1998028037A1 (en) 1996-12-20 1998-07-02 Alza Corporation Device and method for enhancing transdermal agent flux
DE19654391A1 (en) 1996-12-27 1998-07-02 Basf Ag Catalyst for the selective production of propylene from propane
ID21673A (en) 1996-12-31 1999-07-08 Shell Internationale Res Maatc Rig mast with vertical grooves
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CN1161164C (en) * 1997-12-11 2004-08-11 阿尔扎有限公司 Device for enhaning transdermal agent flux
PT1037687E (en) 1997-12-11 2008-12-17 Alza Corp Device for enhancing transdermal agent flux
CA2313698C (en) 1997-12-11 2008-04-15 Alza Corporation Device for enhancing transdermal agent flux
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
JP2002517300A (en) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション Microneedle device and a manufacturing method and use thereof
AT280615T (en) 1998-08-31 2004-11-15 Johnson & Johnson Consumer Electrotransport device with sound
EP1140275A1 (en) 1998-12-18 2001-10-10 Minimed Inc. Insertion sets with micro-piercing members for use with medical devices and methods of using the same
JP4072268B2 (en) 1998-12-24 2008-04-09 キヤノン株式会社 Skin absorption type drug solution administration device
DE60007290T2 (en) 1999-01-28 2004-09-23 Cyto Pulse Sciences, Inc. Introducing macromolecules into cells
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
WO2002019985A2 (en) * 2000-09-08 2002-03-14 Alza Corporation Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
CZ20031035A3 (en) 2000-10-13 2004-02-18 Alza Corporation Impact applicator fitted with a plurality of micro blades
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
PL360998A1 (en) 2000-10-13 2004-09-20 Alza Corporation Apparatus and method for piercing skin with microprotrusions
PL360977A1 (en) 2000-10-13 2004-09-20 Alza Corporation Microprotrusion member retainer for impact applicator
US6855372B2 (en) 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
JP2004528900A (en) 2001-04-20 2004-09-24 アルザ・コーポレーシヨン Microprojection array having a coating containing a beneficial agent
US20030199810A1 (en) 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
DK1465535T3 (en) 2001-12-20 2008-04-07 Alza Corp Micro-Projections for piercing the skin with penetration depth control
US7015262B2 (en) 2002-05-01 2006-03-21 Lifescan, Inc. Hydrophilic coatings for medical implements
MXPA05000205A (en) 2002-06-28 2005-09-30 Johnson & Johnson Transdermal drug delivery devices having coated microprotrusions.
AR042815A1 (en) 2002-12-26 2005-07-06 Alza Corp Delivery device active agent having composite members
US20050123507A1 (en) 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
JP5456234B2 (en) 2003-06-30 2014-03-26 アルザ・コーポレーシヨン Formulations for coated microprojections containing non-volatile counterions
AU2004287059A1 (en) 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
ES2377647T3 (en) 2003-10-31 2012-03-29 Alza Corporation Self-acting applicator for microprojection ordering
US20050106209A1 (en) 2003-11-13 2005-05-19 Mahmoud Ameri Composition and apparatus for transdermal delivery
WO2005112984A2 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US20060188555A1 (en) 2005-01-21 2006-08-24 Micheal Cormier Therapeutic peptide formulations with improved stability
JP5277456B2 (en) 2005-01-31 2013-08-28 アルザ コーポレイション Coated microprojection with low variability and method for producing the same

Also Published As

Publication number Publication date
MXPA03003815A (en) 2004-08-12
ES2322023T3 (en) 2009-06-16
NZ525551A (en) 2005-09-30
AU2001297823B2 (en) 2005-05-12
PL365677A1 (en) 2005-01-10
MA26061A1 (en) 2004-04-01
JP4659336B2 (en) 2011-03-30
CN1239212C (en) 2006-02-01
NO20031875L (en) 2003-06-23
BR0114909A (en) 2004-02-03
DK1333880T3 (en) 2009-07-20
DE60138407D1 (en) 2009-05-28
NO20031875D0 (en) 2003-04-25
US7537795B2 (en) 2009-05-26
EP2085109A2 (en) 2009-08-05
JP2007075629A (en) 2007-03-29
EP1333880B1 (en) 2009-04-15
JP2004520152A (en) 2004-07-08
PT1333880E (en) 2009-05-11
CZ20031164A3 (en) 2004-04-14
KR20030060922A (en) 2003-07-16
IL155583D0 (en) 2003-11-23
US20060200069A1 (en) 2006-09-07
EP2085109A3 (en) 2009-09-02
EP1333880A1 (en) 2003-08-13
RU2282468C2 (en) 2006-08-27
CA2427381A1 (en) 2002-11-28
US20020128599A1 (en) 2002-09-12
CN1501826A (en) 2004-06-02
JP4875457B2 (en) 2012-02-15
US8663155B2 (en) 2014-03-04
ZA200303988B (en) 2004-05-21
HU0302924A2 (en) 2003-12-29
WO2002094368A1 (en) 2002-11-28
KR100812097B1 (en) 2008-03-12

Similar Documents

Publication Publication Date Title
DE60044873D1 (en) oriented biopolymermembrane
DE60120224D1 (en) autoinjector
DE60137995D1 (en) Light-emitting devices
DE60114765D1 (en) Garments with audio devices
DE60044722D1 (en) Che
AT298528T (en) Mikroklingeanordungsaufprallapplikator
AT274321T (en) Perkolationsvorrichtung
AT302569T (en) Schädelkalottenfixiereinrichtung
AT294053T (en) Strukturverbaupanele
AT272996T (en) Kieselsäureester-mixtures
AT252099T (en) Biarylcarboxamide
AT304876T (en) Anti-kickback-catheter
AT314248T (en) Fahrradantriebsnabe
DE60142573D1 (en) En-ethylene copolymers
DE60042859D1 (en) polymerization
AT285299T (en) Flüssigkeitssprühgeräte
DE60127497D1 (en) luminescent
DE60236090D1 (en) Iedriger specific surface
DE60031248D1 (en) Electroactive pore
DE60101939D1 (en) With nitrogen heterocycles substituted electron-poor-fluorescein
DE60116093D1 (en) washer
DE60012884D1 (en) Antitachykardiales walked make
AR027956A1 (en) New drug combinations
DE60105957D1 (en) Disc-shaped maskaraapplikator
DE60108726D1 (en) Luminescent polymer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties