AT408684T - A method for enhancing T-cell receptors - Google Patents

A method for enhancing T-cell receptors

Info

Publication number
AT408684T
AT408684T AT05741949T AT05741949T AT408684T AT 408684 T AT408684 T AT 408684T AT 05741949 T AT05741949 T AT 05741949T AT 05741949 T AT05741949 T AT 05741949T AT 408684 T AT408684 T AT 408684T
Authority
AT
Austria
Prior art keywords
enhancing
method
cell receptors
receptors
cell
Prior art date
Application number
AT05741949T
Other languages
German (de)
Inventor
Steven Mark Dunn
Yi Li
Jonathan BOULTER
Original Assignee
Medigene Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0411125A priority Critical patent/GB0411125D0/en
Priority to GB0419646A priority patent/GB0419646D0/en
Application filed by Medigene Ltd filed Critical Medigene Ltd
Publication of AT408684T publication Critical patent/AT408684T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
AT05741949T 2004-05-19 2005-05-10 A method for enhancing T-cell receptors AT408684T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0411125A GB0411125D0 (en) 2004-05-19 2004-05-19 Method of improving T-cell receptors
GB0419646A GB0419646D0 (en) 2004-09-03 2004-09-03 Method of improving t cell receptors

Publications (1)

Publication Number Publication Date
AT408684T true AT408684T (en) 2008-10-15

Family

ID=35429001

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05741949T AT408684T (en) 2004-05-19 2005-05-10 A method for enhancing T-cell receptors

Country Status (11)

Country Link
US (1) US7608410B2 (en)
EP (1) EP1756278B1 (en)
JP (1) JP4972549B2 (en)
AT (1) AT408684T (en)
AU (1) AU2005246073B2 (en)
CA (1) CA2567349C (en)
DE (1) DE602005009825D1 (en)
HK (1) HK1105995A1 (en)
NZ (1) NZ550815A (en)
WO (1) WO2005114215A2 (en)
ZA (1) ZA200609462B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
BRPI0606399A2 (en) 2005-01-05 2009-06-23 Star Biotechnologische Forschungs U Entw Gmbh Synthetic immunoglobulin domains with binding properties constructed in different regions of the molecule of the complementarity determining regions
CN103059128B (en) * 2005-04-01 2016-01-20 英美偌科有限公司 T cell receptor with high affinity HIV
AU2012211503B2 (en) * 2005-04-01 2014-01-30 Adaptimmune Limited High affinity HIV T cell receptors
GB0511124D0 (en) 2005-06-01 2005-07-06 Avidex Ltd High affinity melan-a t cell receptors
AT503861B1 (en) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw A method for manipulation of T-cell receptors
WO2008039818A2 (en) 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Modified t cell receptors and related materials and methods
EP2158220B1 (en) 2007-06-26 2017-04-19 F-Star Biotechnologische Forschungs- und Entwicklungsges.m.b.H Display of binding agents
AU2008304555A1 (en) * 2007-09-25 2009-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modified T cell receptors and related materials and methods
EP2113255A1 (en) 2008-05-02 2009-11-04 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Cytotoxic immunoglobulin
GB0911566D0 (en) 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
EP2670848B1 (en) 2011-02-06 2016-02-03 Yeda Research and Development Co. Ltd Affinity maturated t cell receptors and use thereof
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
JP6389166B2 (en) 2012-05-07 2018-09-12 トラスティーズ・オブ・ダートマス・カレッジ Anti-B7-H6 antibodies, fusion proteins, and methods of using them
BR112016011567A2 (en) 2013-11-22 2017-10-24 Hutchinson Fred Cancer Res genetically modified high affinity human t cell receptors.
WO2016100977A1 (en) 2014-12-19 2016-06-23 The Broad Institute Inc. Methods for profiling the t-cel- receptor repertoire
CA2993431A1 (en) 2015-07-31 2017-02-09 Regents Of The University Of Minnesota Modified cells and methods of therapy
GB201516275D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516270D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516274D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516269D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516265D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR Libraries
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
US20190255107A1 (en) 2015-10-09 2019-08-22 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
WO2017075478A2 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
US20180355016A1 (en) 2015-11-19 2018-12-13 The Brigham And Women's Hospital, Inc. Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
GB201522592D0 (en) * 2015-12-22 2016-02-03 Immunocore Ltd T cell receptors
WO2017184590A1 (en) 2016-04-18 2017-10-26 The Broad Institute Inc. Improved hla epitope prediction
WO2018035364A1 (en) 2016-08-17 2018-02-22 The Broad Institute Inc. Product and methods useful for modulating and evaluating immune responses
WO2018049025A2 (en) 2016-09-07 2018-03-15 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses
WO2018067991A1 (en) 2016-10-07 2018-04-12 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
CA3053133A1 (en) 2017-02-12 2018-08-16 Neon Therapeutics, Inc. Hla-based methods and compositions and uses thereof
WO2018195019A1 (en) 2017-04-18 2018-10-25 The Broad Institute Inc. Compositions for detecting secretion and methods of use
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9603507D0 (en) * 1996-02-20 1996-04-17 Isis Innovation Antibody variants
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
WO1998039482A1 (en) * 1997-03-07 1998-09-11 Sunol Molecular Corporation Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
EP1118661A1 (en) * 2000-01-13 2001-07-25 Het Nederlands Kanker Instituut T cell receptor libraries
CA2505558C (en) * 2002-11-09 2013-07-02 Avidex Limited T cell receptor display

Also Published As

Publication number Publication date
AU2005246073B2 (en) 2010-10-28
NZ550815A (en) 2009-04-30
ZA200609462B (en) 2008-04-30
US7608410B2 (en) 2009-10-27
HK1105995A1 (en) 2012-08-31
CA2567349C (en) 2012-11-27
AU2005246073A1 (en) 2005-12-01
CA2567349A1 (en) 2005-12-01
JP2007537743A (en) 2007-12-27
WO2005114215A2 (en) 2005-12-01
WO2005114215A9 (en) 2006-07-20
US20090054257A1 (en) 2009-02-26
EP1756278B1 (en) 2008-09-17
DE602005009825D1 (en) 2008-10-30
EP1756278A2 (en) 2007-02-28
JP4972549B2 (en) 2012-07-11
WO2005114215A3 (en) 2006-03-16

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
REN Ceased due to non-payment of the annual fee