AT404210T - Compositions of polyacids, nonionic polymer of alkylene oxide monomers and multivalent cations, and their use to reduce tissue adhesion - Google Patents

Compositions of polyacids, nonionic polymer of alkylene oxide monomers and multivalent cations, and their use to reduce tissue adhesion

Info

Publication number
AT404210T
AT404210T AT00921450T AT00921450T AT404210T AT 404210 T AT404210 T AT 404210T AT 00921450 T AT00921450 T AT 00921450T AT 00921450 T AT00921450 T AT 00921450T AT 404210 T AT404210 T AT 404210T
Authority
AT
Austria
Prior art keywords
polyacids
compositions
use
alkylene oxide
nonionic polymer
Prior art date
Application number
AT00921450T
Other languages
German (de)
Inventor
Herbert Schwartz
John Blackmore
Stephanie Cortese
William Oppelt
Original Assignee
Fziomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12757199P priority Critical
Priority to US09/472,110 priority patent/US6869938B1/en
Application filed by Fziomed Inc filed Critical Fziomed Inc
Publication of AT404210T publication Critical patent/AT404210T/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/041Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06Use of macromolecular materials
    • A61L33/062Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
AT00921450T 1997-06-17 2000-03-23 Compositions of polyacids, nonionic polymer of alkylene oxide monomers and multivalent cations, and their use to reduce tissue adhesion AT404210T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12757199P true 1999-04-02 1999-04-02
US09/472,110 US6869938B1 (en) 1997-06-17 1999-12-27 Compositions of polyacids and polyethers and methods for their use in reducing adhesions

Publications (1)

Publication Number Publication Date
AT404210T true AT404210T (en) 2008-08-15

Family

ID=26825748

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00921450T AT404210T (en) 1997-06-17 2000-03-23 Compositions of polyacids, nonionic polymer of alkylene oxide monomers and multivalent cations, and their use to reduce tissue adhesion

Country Status (8)

Country Link
EP (1) EP1181023B1 (en)
JP (1) JP2003530136A (en)
AT (1) AT404210T (en)
AU (1) AU778853B2 (en)
CA (1) CA2366880C (en)
DE (1) DE60039868D1 (en)
ES (1) ES2311455T3 (en)
WO (1) WO2000059516A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
AT425776T (en) * 2000-04-28 2009-04-15 Fziomed Inc Hemostatic compilation of polyacid and polyalkylene oxides and their use methods
JP4794057B2 (en) * 2001-02-28 2011-10-12 京セラ株式会社 Bone repair material manufacturing method and bone repair material
FR2823119B1 (en) * 2001-04-05 2004-02-20 Seppic Sa Immunity adjuvant containing a complex metal cation and the vaccine containing
WO2005000374A1 (en) * 2003-06-30 2005-01-06 Denki Kagaku Kogyo Kabushiki Kaisha Adhesion inhibiting material for vertebral/spinal operation
US7914805B2 (en) 2003-07-31 2011-03-29 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent
CN1220528C (en) * 2003-08-19 2005-09-28 大连永兴医用材料有限公司 Carboxymethyl chitosan / carboxymethyl cellulose operative antiblocking film and method for making the same
DE10350481A1 (en) * 2003-10-29 2005-06-16 Henkel Kgaa Optimized strength polymers with mixed oxyalkylene units
SE0401182D0 (en) * 2004-05-05 2004-05-05 Q Med Ab Novel use of a viscoelastic composition
AU2005244059A1 (en) * 2004-05-07 2005-11-24 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
KR101125934B1 (en) * 2008-11-19 2012-03-21 주식회사 제네웰 Temperature Sensitive Tissue Adhesion Prevention Composition And Method For Preparing Thereof
CA2731187A1 (en) * 2010-03-16 2011-09-16 Confluent Surgical, Inc. Mitigating thrombus formation on medical devices by influencing ph microenvironment near the surface
US9445795B2 (en) 2009-10-16 2016-09-20 Confluent Surgical, Inc. Prevention of premature gelling of delivery devices for pH dependent forming materials
CA2730598C (en) * 2010-03-16 2018-03-13 Confluent Surgical, Inc. Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
KR101142234B1 (en) * 2009-12-28 2012-07-09 한남대학교 산학협력단 Injectable Porous Microparticle Filler System
US20130052236A1 (en) * 2011-08-30 2013-02-28 Mast Biosurgery Composite polylactic acid/alginate surgical barrier
DE102012222365A1 (en) * 2012-12-05 2014-06-05 Aesculap Ag Composition for use in the prophylaxis of post-surgical adhesions
EP2774953B1 (en) * 2013-03-08 2018-06-27 Fluoron Gmbh Gelatable compositions
US10105387B2 (en) * 2014-07-24 2018-10-23 Medytox Inc. Temperature sensitive adhesion prevention composition and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
US4618491A (en) * 1984-06-05 1986-10-21 Daicel Chemical Industries Ltd. Stable gel composition containing a carboxymethyl cellulose salt and a process for the preparation of them
JPS6325008B2 (en) * 1984-11-30 1988-05-24 Mitsui Du Pont Polychemical
US5156839A (en) * 1987-05-04 1992-10-20 Mdr Group, Inc. Viscoelastic fluid for use in spine and general surgery and other surgery and therapies and method of using same
BR9007807A (en) * 1989-10-31 1992-09-29 Columbia Lab Inc Composition and method for tissue moistening
US5066709A (en) * 1990-09-20 1991-11-19 Gaf Chemicals Corporation Bioadhesive composition
GR920100122A (en) * 1991-04-05 1993-03-16 Ethicon Inc Ionically crosslinked carboxyl-containing polysaccharides for adhension prevention.
US5192802A (en) * 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
GR1002418B (en) * 1992-07-29 1996-08-21 Johnson & Johnson Consumer Products Inc. Bioactive treatment compositions and methods of use.
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions

Also Published As

Publication number Publication date
EP1181023B1 (en) 2008-08-13
ES2311455T3 (en) 2009-02-16
CA2366880C (en) 2013-02-12
AU4177000A (en) 2000-10-23
DE60039868D1 (en) 2008-09-25
JP2003530136A (en) 2003-10-14
CA2366880A1 (en) 2000-10-12
EP1181023A4 (en) 2004-03-31
EP1181023A1 (en) 2002-02-27
WO2000059516A1 (en) 2000-10-12
AU778853B2 (en) 2004-12-23

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