AT393141T - New thiourea derivatives and pharmaceutical compositions containing them - Google Patents

New thiourea derivatives and pharmaceutical compositions containing them

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Publication number
AT393141T
AT393141T AT01958602T AT01958602T AT393141T AT 393141 T AT393141 T AT 393141T AT 01958602 T AT01958602 T AT 01958602T AT 01958602 T AT01958602 T AT 01958602T AT 393141 T AT393141 T AT 393141T
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
compositions containing
thiourea derivatives
new
new thiourea
Prior art date
Application number
AT01958602T
Other languages
German (de)
Inventor
Young Suh
Uh Oh
Hee Kim
Jee Lee
Hyeung Park
Ok Park
Yong Lee
Young Park
Yung Joo
Jin Choi
K M Lim
S Y Kim
Jin Kim
Hyun Koh
Joo Moh
Yeon Jeong
Jung Yi
Young Oh
Original Assignee
Pacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR20000048385 priority Critical
Priority to KR20000048388 priority
Priority to KR20000085126 priority
Application filed by Pacific Corp filed Critical Pacific Corp
Publication of AT393141T publication Critical patent/AT393141T/en

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    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C333/14Dithiocarbamic acids; Derivatives thereof
    • C07C333/18Esters of dithiocarbamic acids
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    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
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    • C07D207/402,5-Pyrrolidine-diones
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    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes unsubstituted on the hetero ring
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Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7378432B2 (en) 2001-09-14 2008-05-27 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
US20030203944A1 (en) * 2000-08-21 2003-10-30 Suh Young Ger Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same
TWI283665B (en) 2001-09-13 2007-07-11 Smithkline Beecham Plc Novel urea compound, pharmaceutical composition containing the same and its use
JP2003192587A (en) * 2001-12-26 2003-07-09 Bayer Ag Urea derivative
JP2005513154A (en) * 2001-12-26 2005-05-12 バイエル・ヘルスケア・アクチェンゲゼルシャフトBayer HealthCare AG Urea derivatives
CN1627944A (en) 2002-01-17 2005-06-15 神经能质公司 Substituted quinazolin-4-ylamine analogues as modulators of capsaicin
PT1472225E (en) 2002-02-01 2010-07-30 Euro Celtique Sa 2-piperazine-pyridines useful for treating pain
WO2003068749A1 (en) 2002-02-15 2003-08-21 Glaxo Group Limited Vanilloid receptor modulators
US6974818B2 (en) 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
US6864261B2 (en) 2002-05-02 2005-03-08 Euro-Celtique S.A. Therapeutic agents useful for treating pain
AU2003241453A1 (en) * 2002-05-17 2003-12-02 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid vr1 receptor
US8569505B2 (en) 2002-05-17 2013-10-29 Janssen Pharmaceutica, Nv Aminotetralin-derived urea modulators of vanilloid VR1 receptor
ES2300613T3 (en) 2002-06-28 2008-06-16 Euro-Celtique S.A. Therapeutic derivatives of piperacina useful to treat the pain.
WO2004007459A2 (en) 2002-07-12 2004-01-22 Janssen Pharmaceutica N.V. Naphthol, quinoline and isoquinoline-derivatives as modulators of vanilloid vr1 receptor
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
WO2004028440A2 (en) * 2002-09-24 2004-04-08 Bayer Healthcare Ag Vr1 antagonists for the treatment of urological disorders
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
KR100556158B1 (en) * 2002-10-17 2006-03-06 (주) 디지탈바이오텍 Novel N-hydroxy thiourea, urea and amide compounds and the pharmaceutical compositions containing the same
EP1578787B1 (en) 2002-12-02 2012-11-14 Xenome Ltd Novel chi-conotoxin peptides (-ii)
CA2509374A1 (en) 2002-12-12 2004-06-24 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
US7423175B2 (en) * 2003-02-12 2008-09-09 Bayer Healthcare Ag Hydroxy-tetrahydro-naphthalenylurea derivatives
CA2554809C (en) * 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
EA013790B1 (en) * 2004-02-05 2010-06-30 Пробиодруг Аг New inhibitors glutaminiltsiklazy
WO2004103281A2 (en) * 2003-05-16 2004-12-02 Georgetown University Vanilloid receptor antagonists, and methods of making and using them
CA2526361C (en) 2003-05-20 2012-05-15 Ajinomoto Co., Inc. Amide derivative
CN1838954B (en) * 2003-06-27 2013-01-16 特拉维夫大学未来科技开发有限公司 Glycogen synthase kinase-3 inhibitors
KR100707123B1 (en) 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 4-methylsulfonylaminophenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical composition containing the same
EP1648892B1 (en) * 2003-07-10 2007-06-20 Neurogen Corporation Aryl-substituted benzo[d]isothiazol-3-ylamine analogues as capsaicin receptor modulators
GB0319150D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
GB0322016D0 (en) * 2003-09-19 2003-10-22 Merck Sharp & Dohme New compounds
PL1670458T3 (en) * 2003-10-08 2007-05-31 Bayer Schering Pharma Aktiengesellschaft 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
DE10347386B4 (en) * 2003-10-08 2006-05-24 Schering Ag Tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
WO2005035471A1 (en) 2003-10-14 2005-04-21 Ajinomoto Co., Inc. Ether derivative
NZ546322A (en) 2003-10-15 2008-11-28 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
KR20050039573A (en) * 2003-10-23 2005-04-29 주식회사 태평양 Thiourea derivative-containing pharmaceutical composition having improved solubility and bioavailability
US20050165004A1 (en) * 2004-01-22 2005-07-28 Staffan Skogvall Bronchorelaxing compounds
DE102004008141A1 (en) * 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidine compounds and their use as binding partners for 5-HT5 receptors
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
ITMI20041231A1 (en) * 2004-06-18 2004-09-18 Pharmeste Srl Vanilloid TRPV1 receptor antagonists
EP1775283A4 (en) * 2004-07-14 2008-12-10 Japan Tobacco Inc 3-aminobenamide compound and vanilloid receptor 1 (vr1) activity inhibitor
CN1984906A (en) 2004-07-15 2007-06-20 日本烟草产业株式会社 Condensed benzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
KR20060017571A (en) * 2004-08-19 2006-02-24 주식회사 태평양 A composition containing a thiourea derivative for preventing or treating pruritic or irritant skin diseases
CA2583015A1 (en) * 2004-10-13 2006-04-20 Bayer Healthcare Ag Substituted 4-benzyloxy-phenylmethylamide derivatives as cold menthol receptor-1 (cmr-1) antagonists for the treatment of urological disorder
ITMI20042042A1 (en) 2004-10-26 2005-01-26 Pharmeste Srl Sulfonamide derivatives vanilloid TRPV1 receptor antagonists
DE602005009017D1 (en) * 2004-11-10 2008-09-25 Pfizer Substituted n-sulfonylaminobenzyl-2-phenoxyacetamide compounds
CN101087771A (en) 2004-11-10 2007-12-12 辉瑞大药厂 Substituted N-sulfonylaminobenzyl-2-phenoxyacetamide compounds
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2006095263A1 (en) 2005-03-10 2006-09-14 Pfizer Japan Inc. Substituted n-sulfonylaminophenylethyl-2-phenoxy acetamide compounds
WO2006097817A1 (en) 2005-03-17 2006-09-21 Pfizer Japan Inc. N- (n-sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain
CN101142174B (en) 2005-03-19 2012-05-09 株式会社Amorepacific Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist, and pharmaceutical compositions containing the same
EP1861357B1 (en) 2005-03-19 2013-04-24 Amorepacific Corporation Novel compounds or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
JP2008534567A (en) * 2005-03-28 2008-08-28 ファイザー株式会社 Substituted aryloxoethylcyclopropanecarboxamide compounds as VR1 receptor antagonists
CA2605073C (en) * 2005-04-13 2017-12-12 Neuraxon, Inc. Substituted indole compounds having nos inhibitory activity
DE102005017286B3 (en) * 2005-04-14 2006-12-28 Schering Ag Tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents
DE102005018191A1 (en) 2005-04-19 2006-10-26 Grünenthal GmbH Substituted cyclic urea derivatives and their use for the preparation of medicaments
DE102005023943A1 (en) 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorosulfanyl-substituted compound and its use for the preparation of medicaments
WO2006129164A1 (en) 2005-05-31 2006-12-07 Pfizer Japan Inc. Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists
EP1910280A2 (en) * 2005-07-20 2008-04-16 Schwarz Pharma Ag Process of sulfonating 4-aminobenzonitriles
WO2007022964A2 (en) * 2005-08-24 2007-03-01 Abbott Gmbh & Co. Kg Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors
AP200804432A0 (en) 2005-10-07 2008-04-30 Glenmark Pharmaceuticals Sa Substituted benzofused derivatives and their use as vanilloid receptor ligands
WO2007047575A2 (en) * 2005-10-14 2007-04-26 The Board Of Trustees Of The University Of Illinois Pharmacological treatments for sleep-related breathing disorders
SI1940821T1 (en) 2005-10-19 2013-07-31 Gruenenthal Gmbh Novel vanilloid receptor ligands and their use for producing medicaments
US7906508B2 (en) 2005-12-28 2011-03-15 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
KR101018819B1 (en) * 2006-02-14 2011-03-04 (주)아모레퍼시픽 Topical preparation composition containing a thiourea derivative for preventing or treating pruritic or irritant skin diseases
EP1834948A1 (en) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiinflammatory drugs
WO2007118314A1 (en) * 2006-04-13 2007-10-25 Neuraxon, Inc. 1,5 and 3,6- substituted indole compounds having nos inhibitory activity
WO2007120012A1 (en) * 2006-04-19 2007-10-25 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
EP1862454A1 (en) * 2006-06-02 2007-12-05 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
US8188048B2 (en) 2006-06-23 2012-05-29 Xenome Limited Combination therapy
JP5254228B2 (en) * 2006-07-27 2013-08-07 株式會社アモーレパシフィックAmorepacific Corporation Novel compounds, isomers or pharmaceutically acceptable salts thereof as vanilloid receptor antagonists; and pharmaceutical compositions containing the same
EP1882687A1 (en) * 2006-07-27 2008-01-30 Amorepacific Corporation Heterocyclic compounds useful as vanilloid receptor antagonists and pharmaceutical compositions containing the same
JP2010510202A (en) 2006-11-17 2010-04-02 ファイザー株式会社 Substituted bicyclocarboxamide compounds
EP1939173A1 (en) 2006-12-21 2008-07-02 Pharmeste S.r.l. O-substituted-dibenzyl urea- or thiourea- derivatives as trpv1 receptor antagonists
ES2372655T3 (en) * 2007-11-13 2012-01-25 Evotec Ag Medical derivatives as ligands of ion channels and pharmaceutical compositions and methods of use of the same.
KR20100103799A (en) * 2007-11-16 2010-09-28 네우렉슨 인코포레이티드 Indole compounds and methods for treating visceral pain
WO2009081222A1 (en) 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
WO2009096701A2 (en) 2008-01-28 2009-08-06 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
JP5438103B2 (en) 2008-07-02 2014-03-12 アモーレパシフィック コーポレイションAmorepacific Corporation Novel compounds as vanilloid receptor antagonists, isomers or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing the same
KR20110137941A (en) * 2010-06-18 2011-12-26 (주) 에빅스젠 Novel thiourea or urea derivative, process for preparing the same and pharmaceutical composition for preventing or treating aids comprising the same
CN106243023A (en) * 2010-09-03 2016-12-21 福马Tm有限责任公司 For suppressing guanidine compound and the compositions of NAMPT
WO2012045729A1 (en) 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
EP2697221A1 (en) 2011-04-11 2014-02-19 Glaxo Group Limited N- cyclobutyl - imidazopyridine - methylamine as trpv1 antagonists
ES2392915B1 (en) * 2011-06-03 2013-09-13 Univ Sevilla Polyphenolic bioactive compounds containing sulfur or selenium and its uses
KR101663864B1 (en) * 2013-04-19 2016-10-07 영남대학교 산학협력단 Pharmaceutical composition for treating or preventing inflammatory bowel disease comprising amidopyridinol derivative or a pharmaceutically acceptable salt
GB201312492D0 (en) * 2013-07-12 2013-08-28 Syngenta Ltd Herbicidal compounds
CN105820087A (en) * 2015-01-05 2016-08-03 齐鲁工业大学 5-[3-(2,5-diethoxy-4-methylsulfonyl-benzyl)-ureido]-2-ethoxy-N-p-methylphenyl-benzamide new compound and preparation method and application thereof
CN105820079A (en) * 2015-01-05 2016-08-03 齐鲁工业大学 5-[3-(2,5-diethoxy-4-methylsulfonyl-benzyl)-ureido]-2-ethoxy-N-methyl-benzamide new compound and preparation method and application thereof
CN105820088A (en) * 2015-01-05 2016-08-03 齐鲁工业大学 N-(4-bromo-phenyl)-5-[3-(2,5-diethoxy-4-methylsulfonyl-benzyl)-ureido]-2-ethoxylbenzamide new compound and preparation method and application thereof
CN105820076A (en) * 2015-01-05 2016-08-03 齐鲁工业大学 N-[2,5-diethoxy-4-(3-p-tolyl-ureidomethyl)-phenyl]-methanesulfonamide new compound and preparation method and application thereof
CN105820073A (en) * 2015-01-05 2016-08-03 齐鲁工业大学 N-{[2,5-diethoxy-4-[(3-phenyl-ureido)-methyl]-phenyl}-methanesulfonamide new compound and preparation method and application thereof
CN105820069A (en) * 2015-01-05 2016-08-03 齐鲁工业大学 N-{4-[3-(3-bromo-phenyl)-ureidomethyl]-2,5-dibutoxy-phenyl}-methanesulfonamide new compound and preparation method and application thereof
CN105820074A (en) * 2015-01-05 2016-08-03 齐鲁工业大学 N-[4-(3-benzyl-ureidomethyl)-2,5-diethoxyphenyl]methanesulfonamide new compound and preparation method and application thereof
CN106344552A (en) * 2015-07-15 2017-01-25 齐鲁工业大学 Novel sulfonamide compound, preparation method, and use of novel sulfonamide compound as protein tyrosine phosphatase 1B inhibitor
CN106397225A (en) * 2016-09-04 2017-02-15 王际菊 Preparation method of chiral compound

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117994A (en) * 1959-12-03 1964-01-14 Monsanto Canada Ltd Nu, nu', nu'-trisubstituted guanidines
GB1031165A (en) 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas
CH490003A (en) 1966-03-08 1970-05-15 Ciba Geigy molluscicidal agents
JPS5390222A (en) * 1977-01-21 1978-08-08 Nippon Tokushu Noyaku Seizo Kk Urea or thioureas, process for their preparation and fungicides for agriculture and horticulture contg. the same as active constituents
US4460602A (en) 1981-06-30 1984-07-17 The Procter & Gamble Company Urea derivatives
JPS6158446B2 (en) * 1981-09-27 1986-12-11 Nitto Electric Ind Co
GB2168975A (en) 1984-12-20 1986-07-02 Procter & Gamble Amides and compositions thereof having anti-inflammatory and analgesic activity
GB8715357D0 (en) * 1987-06-30 1987-08-05 Sandoz Inst For Medical Resear Organic compounds
DE3734083A1 (en) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazoles, process for their production and these compounds containing drug
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
JP2884412B2 (en) * 1988-10-21 1999-04-19 日本バイエルアグロケム株式会社 Insecticidal cyano compound
HU206082B (en) * 1988-12-23 1992-08-28 Sandoz Ag Process for producing capsaicin derivatives and pharmaceutical compositions comprising such compounds
US5403868A (en) * 1988-12-23 1995-04-04 Sandoz Ltd. Capsaicin derivatives
JPH0395153A (en) 1989-06-15 1991-04-19 Mitsubishi Kasei Corp Diphenyl urea derivative
HU210683B (en) 1990-06-18 1995-06-28 Sandoz Ag Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same
JPH0459709A (en) * 1990-06-25 1992-02-26 Nitto Kasei Co Ltd Attaching-inhibiting agent to marine organism
HUT62558A (en) 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
AU8143094A (en) 1993-11-12 1995-05-29 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. (tie-2), a novel receptor tyrosine kinase
JPH07206822A (en) * 1994-01-25 1995-08-08 Nippon Paper Ind Co Ltd New asymmetric thiourea compound and anti-human immunodeficiency virus agent containing the compound as active component
GB9402354D0 (en) 1994-02-08 1994-03-30 Ici Plc Polyhaloalkanoates
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
AU1682897A (en) * 1995-12-29 1997-07-28 Boehringer Ingelheim (Canada) Ltd. Phenyl thiazole derivatives with anti herpes virus properties
US6265564B1 (en) 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
AU5154098A (en) 1996-10-31 1998-05-22 Duke University Soluble tie2 receptor
GB9713484D0 (en) 1997-06-27 1997-09-03 Smithkline Beecham Plc Neuroprotective vanilloid compounds
JPH1135545A (en) 1997-07-22 1999-02-09 Tanabe Seiyaku Co Ltd Urethane derivatives
WO1999037675A1 (en) * 1998-01-22 1999-07-29 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptors
JPH11206378A (en) 1998-01-23 1999-08-03 Fuso Pharmaceutical Industries Ltd Recombinant human mannan binding protein and its production
GB9804121D0 (en) 1998-02-26 1998-04-22 Cancer Res Campaign Tech Anti-angiogenic vaccines: materials and methods relating thereto
CA2331299A1 (en) * 1998-05-11 1999-11-18 Novo Nordisk A/S Substituted guanidines and diaminonitroethenes, their preparation and use
CZ20012067A3 (en) * 1998-12-09 2001-10-17 American Home Products Corporation Thiourea compounds containing alpha methylbenzyl group and phenylene diamine group functioning as inhibitors of herpes viruses
MXPA01008403A (en) 1999-02-22 2003-06-06 Pacific Corp Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof.
CA2367857A1 (en) * 1999-03-19 2000-09-28 Fatih M. Uckun Thiourea and urea liquid-phase combinatorial libraries: synthesis and apoptosis induction
JP2000281659A (en) * 1999-03-30 2000-10-10 Sumitomo Pharmaceut Co Ltd Thiourea derivative
US6207688B1 (en) * 1999-06-23 2001-03-27 Parker Hughes Institute Phenethyl-thiourea compounds and use
KR20010011698A (en) * 1999-07-30 2001-02-15 김선진 Thiourea derivatives or non-toxic salts thereof for inhibiting RAS-transformed cell growth
AU3669801A (en) * 2000-02-07 2001-08-14 Basf Ag 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors
JP4005911B2 (en) * 2000-07-18 2007-11-14 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft New aniline derivatives
KR20030024799A (en) 2000-07-20 2003-03-26 뉴로젠 코포레이션 Capsaicin receptor ligands
US20030203944A1 (en) 2000-08-21 2003-10-30 Suh Young Ger Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same
US7067553B2 (en) 2000-08-21 2006-06-27 Pacific Corporation Thiourea compounds and the pharmaceutical compositions containing the same
GB0105895D0 (en) 2001-03-09 2001-04-25 Smithkline Beecham Plc Novel compounds
HU0303623A2 (en) 2001-03-26 2004-03-01 Novartis Ag. Fused pyridines, processes for their preparation and pharmaceutical compositions containing them vanilloid receptor antagonists for treating pain
GB0110901D0 (en) 2001-05-02 2001-06-27 Smithkline Beecham Plc Novel Compounds
AU2002325381A1 (en) 2001-07-31 2003-02-24 Bayer Healthcare Ag Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists

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CN1418191A (en) 2003-05-14
EP1303483A4 (en) 2004-11-03
DE60133743T2 (en) 2009-07-02
KR100672183B1 (en) 2007-02-28
KR20050090357A (en) 2005-09-13
JP5001505B2 (en) 2012-08-15
WO2002016318A1 (en) 2002-02-28
US8071650B2 (en) 2011-12-06
KR100526897B1 (en) 2005-11-09
KR100564902B1 (en) 2006-03-30
DE60133743D1 (en) 2008-06-05
KR100709014B1 (en) 2007-04-18
NZ523882A (en) 2004-11-26
KR20020039226A (en) 2002-05-25
CA2417507A1 (en) 2002-02-28
KR20050090356A (en) 2005-09-13
AU2001280229B2 (en) 2006-12-07
MXPA03001535A (en) 2004-12-13
AU8022901A (en) 2002-03-04
CN100439332C (en) 2008-12-03
US20080064687A1 (en) 2008-03-13
EP1303483A1 (en) 2003-04-23
KR20040044431A (en) 2004-05-28
EP1303483B1 (en) 2008-04-23

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