AT383875T - Prophylactic or therapeutic agent for inflammatory digestive tract diseases containing antagonistic IL-6 receptor antibody - Google Patents

Prophylactic or therapeutic agent for inflammatory digestive tract diseases containing antagonistic IL-6 receptor antibody

Info

Publication number
AT383875T
AT383875T AT99907951T AT99907951T AT383875T AT 383875 T AT383875 T AT 383875T AT 99907951 T AT99907951 T AT 99907951T AT 99907951 T AT99907951 T AT 99907951T AT 383875 T AT383875 T AT 383875T
Authority
AT
Austria
Prior art keywords
prophylactic
therapeutic agent
digestive tract
receptor antibody
tract diseases
Prior art date
Application number
AT99907951T
Other languages
German (de)
Inventor
Tadamitsu Kishimoto
Hiroaki Ito
Mitsunari Yamamoto
Original Assignee
Chugai Pharmaceutical Co Ltd
Tadamitsu Kishimoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to JP6725098 priority Critical
Application filed by Chugai Pharmaceutical Co Ltd, Tadamitsu Kishimoto filed Critical Chugai Pharmaceutical Co Ltd
Publication of AT383875T publication Critical patent/AT383875T/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13339502&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT383875(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/885Immune response affecting drug
AT99907951T 1998-03-17 1999-03-16 Prophylactic or therapeutic agent for inflammatory digestive tract diseases containing antagonistic IL-6 receptor antibody AT383875T (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6725098 1998-03-17

Publications (1)

Publication Number Publication Date
AT383875T true AT383875T (en) 2008-02-15

Family

ID=13339502

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99907951T AT383875T (en) 1998-03-17 1999-03-16 Prophylactic or therapeutic agent for inflammatory digestive tract diseases containing antagonistic IL-6 receptor antibody

Country Status (19)

Country Link
US (2) US6723319B1 (en)
EP (1) EP1074268B1 (en)
JP (1) JP4124573B2 (en)
KR (1) KR100407811B1 (en)
CN (2) CN101239185A (en)
AT (1) AT383875T (en)
AU (1) AU754006B2 (en)
CA (1) CA2324115C (en)
CZ (1) CZ297083B6 (en)
DE (1) DE69937994T2 (en)
DK (1) DK1074268T3 (en)
ES (1) ES2299241T3 (en)
HK (2) HK1033911A1 (en)
HU (1) HU225539B1 (en)
NO (1) NO327718B1 (en)
PL (1) PL201461B1 (en)
PT (1) PT1074268E (en)
RU (1) RU2195960C2 (en)
WO (1) WO1999047170A1 (en)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017121B2 (en) * 1994-06-30 2011-09-13 Chugai Seiyaku Kabushika Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
CN1306963C (en) * 1994-10-21 2007-03-28 岸本忠三 Remedy for diseases caused by IL-6 production
KR100838862B1 (en) 1997-03-21 2008-06-16 츄가이 세이야꾸 가부시키가이샤 Preventives or remedies for sensitized T cell-related diseases containing IL-6 antagonists as the active ingredient
US20020187150A1 (en) * 1997-08-15 2002-12-12 Chugai Seiyaku Kabushiki Kaisha Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
AT383875T (en) * 1998-03-17 2008-02-15 Chugai Pharmaceutical Co Ltd Prophylactic or therapeutic agent for inflammatory digestive tract diseases containing antagonistic IL-6 receptor antibody
AU775483B2 (en) * 1998-06-10 2004-08-05 Promega Corporation Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease
WO2002036165A1 (en) * 2000-10-27 2002-05-10 Chugai Seiyaku Kabushiki Kaisha Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
BR0208636A (en) 2001-04-02 2004-03-09 Chugai Pharmaceutical Co Ltd therapeutic agent for diseases crÈnicas arthritides diseases related inf ‰ INSTANCE
KR20040085185A (en) * 2002-02-14 2004-10-07 추가이 세이야쿠 가부시키가이샤 Antibody-containing solution pharmaceuticals
CA2496523A1 (en) * 2002-08-30 2004-03-11 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Human antihuman interleukin-6 antibody and fragment of the antibody
GB2401040A (en) * 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
JP4960096B2 (en) * 2003-09-22 2012-06-27 ペントラコール ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of a compound reducing the biological effects of il-6
EP1690550B1 (en) 2003-10-17 2012-08-08 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for mesothelioma
US8617550B2 (en) * 2003-12-19 2013-12-31 Chugai Seiyaku Kabushiki Kaisha Treatment of vasculitis with IL-6 antagonist
EP1728801A4 (en) 2004-03-24 2009-10-21 Chugai Pharmaceutical Co Ltd Subtype of humanized antibody against interleukin-6 receptor
AR048335A1 (en) * 2004-03-24 2006-04-19 Chugai Pharmaceutical Co Ltd therapeutic agents to inner ear disorders comprising an antagonist of IL-6 as an active ingredient
TWI544076B (en) * 2005-03-31 2016-08-01 Chugai Pharmaceutical Co Ltd
KR20080064154A (en) 2005-10-14 2008-07-08 각꼬우호우진 후쿠오카다이가쿠 Inhibitor of transplanted islet dysfunction in islet transplantation
AU2006305119B2 (en) 2005-10-21 2012-12-20 Chugai Seiyaku Kabushiki Kaisha Agents for treating cardiopathy
AR057582A1 (en) 2005-11-15 2007-12-05 Nat Hospital Organization Agents to suppress the induction of cytotoxic T lymphocytes
EP1967209B1 (en) * 2005-11-25 2012-06-06 Keio University Therapeutic agent for prostate cancer
AR059213A1 (en) * 2006-01-27 2008-03-19 Univ Keio therapeutic agents for diseases involving choroidal neovascularization
EP2006381B1 (en) * 2006-03-31 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Method for controlling blood pharmacokinetics of antibodies
JP5144499B2 (en) 2006-03-31 2013-02-13 中外製薬株式会社 Antibodies modified method for the purification of bispecific antibody
EP2025346B1 (en) * 2006-04-07 2016-08-10 Osaka University Muscle regeneration promoter
MX2009012493A (en) * 2007-05-21 2010-01-20 Alder Biopharmaceuticals Inc Novel rabbit antibody humanization methods and humanized rabbit antibodies.
US8080248B2 (en) 2006-06-02 2011-12-20 Regeneron Pharmaceuticals, Inc. Method of treating rheumatoid arthritis with an IL-6R antibody
BRPI0712224A2 (en) 2006-06-02 2012-01-17 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human IL-6 receptor
EA200900037A1 (en) 2006-08-03 2009-10-30 Ваксинекс, Инк. Monoclonal antibodies against interleukin-6 (il-6) and their application
CN101528778A (en) * 2006-08-18 2009-09-09 埃博灵克斯股份有限公司 Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
WO2008065384A2 (en) * 2006-11-30 2008-06-05 Astrazeneca Ab Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor
JP2010095445A (en) * 2006-12-27 2010-04-30 Chugai Pharmaceut Co Ltd Therapeutic agent for inflammatory myopathy containing il-6 antagonist as active ingredient
JP5254807B2 (en) 2007-01-23 2013-08-07 国立大学法人信州大学 Chronic rejection inhibitor
NZ579355A (en) 2007-02-01 2012-03-30 Resverlogix Corp 2-(Aryl)-4-oxo-quinazoline derivatives
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9452227B2 (en) * 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
TWI561530B (en) * 2007-05-21 2016-12-11 Alderbio Holdings Llc Antibodies to il-6 and use thereof
PE07112009A1 (en) 2007-09-26 2009-07-15 Chugai Pharmaceutical Co Ltd constant region antibody mutant
JP5334319B2 (en) 2007-09-26 2013-11-06 中外製薬株式会社 Methods for modifying the isoelectric point of the antibody by amino acid substitutions Cdr
US20110245473A1 (en) * 2007-09-26 2011-10-06 Chugai Seiyaku Kabushiki Kaisha Anti-IL-6 Receptor Antibody
KR101643005B1 (en) * 2007-12-05 2016-07-28 추가이 세이야쿠 가부시키가이샤 Anti-NR10 antibody and use thereof
PE11742009A1 (en) * 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Liquid formulation containing a high concentration of antibody
CN102993304A (en) 2008-04-11 2013-03-27 中外制药株式会社 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US8034344B2 (en) 2008-05-13 2011-10-11 Novimmune S.A. Anti-IL-6/IL-6R antibodies and methods of use thereof
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
US9724410B2 (en) 2009-11-24 2017-08-08 Alderbio Holdings Llc Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity
JP5544290B2 (en) * 2008-06-05 2014-07-09 独立行政法人国立がん研究センター Neural invasion inhibitor
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
TWI440469B (en) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd
US8323649B2 (en) * 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
JP2012516158A (en) * 2009-01-29 2012-07-19 メディミューン,エルエルシー Extended in vivo half-life human anti il-6 antibodies and oncology having, their use in the treatment of autoimmune diseases, and inflammatory diseases
CN105859639A (en) 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 Novel anti-inflammatory agents
EP2409990A4 (en) 2009-03-19 2013-01-23 Chugai Pharmaceutical Co Ltd Antibody constant region variant
JP5717624B2 (en) 2009-03-19 2015-05-13 中外製薬株式会社 Antibody constant region variants
EP2421533B1 (en) 2009-04-22 2018-10-17 Resverlogix Corp. Novel anti-inflammatory agents
RU2011151069A (en) 2009-05-15 2013-06-20 Чугаи Сейяку Кабусики Кайся Anti-axl antibody
JP5837821B2 (en) 2009-09-24 2015-12-24 中外製薬株式会社 Antibody constant region variants
AR079836A1 (en) * 2010-01-08 2012-02-22 Regeneron Pharma Stabilized formulations containing anti-interleukin-6 receptor (IL-6R)
EP2578233B1 (en) 2010-05-28 2017-04-26 National Cancer Center Therapeutic agent for pancreatic cancer
WO2011149051A1 (en) 2010-05-28 2011-12-01 中外製薬株式会社 Antitumor t cell response enhancer
BR112013011305A2 (en) 2010-11-08 2017-07-25 Chugai Pharmaceutical Co Ltd a method of treating a disorder mediated by IL-6, of rheumatoid arthritis treatment method, article of manufacture, inhibiting the progression of structural damage method articular pharmaceutical composition, juvenile idiopathic arthritis treatment method (jewelery), and method of treatment giant cell arteritis (GCA)
WO2012071554A2 (en) 2010-11-23 2012-05-31 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of oral mucositis
EP2520292A1 (en) 2011-05-06 2012-11-07 Helmholtz-Zentrum für Infektionsforschung GmbH Use of spirangiens for the treatment or prevention of IL-8 or IL-6 mediated disorders
MD480Z5 (en) * 2011-07-07 2012-09-30 Эльвира АНДОН Method for treating acute ulcerative nonspecific colitis
NZ627859A (en) 2012-01-23 2015-09-25 Regeneron Pharma Stabilized formulations containing anti-ang2 antibodies
WO2013176471A1 (en) 2012-05-21 2013-11-28 한국생명공학연구원 Pharmaceutical composition for preventing or treating stat3-mediated disease, comprising salvia plebeia r. br. extract or fraction thereof as active ingredient
JP6282591B2 (en) * 2012-09-13 2018-02-21 中外製薬株式会社 Gene knock-in non-human animal
MX363403B (en) 2013-07-04 2019-03-22 Hoffmann La Roche Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples.
DE202014010499U1 (en) 2013-12-17 2015-10-20 Kymab Limited Targeting of human PCSK9 cholesterol treatment
WO2015116852A1 (en) 2014-01-29 2015-08-06 Regeneron Pharmaceuticals, Inc. Methods for treating rheumatoid arthritis by administering an il-6r antibody
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
CN107530356A (en) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 Compositions and therapeutic methods for the treatment of complement-associated diseases

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670373A (en) * 1988-01-22 1997-09-23 Kishimoto; Tadamitsu Antibody to human interleukin-6 receptor
US6428979B1 (en) * 1988-01-22 2002-08-06 Tadamitsu Kishimoto Receptor protein for human B cell stimulatory factor-2
US5171840A (en) * 1988-01-22 1992-12-15 Tadamitsu Kishimoto Receptor protein for human B cell stimulatory factor-2
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2914672B2 (en) 1989-01-17 1999-07-05 中外製薬株式会社 Bsf ▲ under 2 ▼ antagonist
US5210075A (en) * 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
JPH0899996A (en) 1990-03-23 1996-04-16 Yamanouchi Europ Bv Il-6 inhibiting composition
WO1992019759A1 (en) 1991-04-25 1992-11-12 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
US5888511A (en) 1993-02-26 1999-03-30 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS
US5888510A (en) * 1993-07-21 1999-03-30 Chugai Seiyaku Kabushiki Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
AU7967294A (en) 1993-10-06 1995-05-01 Board Of Regents, The University Of Texas System A monoclonal anti-human il-6 receptor antibody
US5420109A (en) 1993-11-12 1995-05-30 Houghten Pharmaceuticals, Inc. Cytokine restraining agents
JPH07324097A (en) * 1994-05-30 1995-12-12 Daicel Chem Ind Ltd Interleukin 6 antagonist, peptides or pharmaceutically permissible salts thereof
WO1995034320A2 (en) 1994-06-07 1995-12-21 Regents Of The University Of Minnesota Methods for inhibiting antigen specific t cell responses
WO1996000081A1 (en) 1994-06-24 1996-01-04 Immunex Corporation Controlled release polypeptide compositions and methods of treating inflammatory bowel disease
JPH0850829A (en) 1994-08-05 1996-02-20 Tokai Rika Co Ltd Lever switch
CN1165539A (en) 1994-09-29 1997-11-19 味之素株式会社 Modification of peptide and protein
AT552012T (en) 1994-10-07 2012-04-15 Chugai Pharmaceutical Co Ltd Inhibiting the abnormal growth of synovial cells il-6 antagonists as drug by
CN1306963C (en) 1994-10-21 2007-03-28 岸本忠三 Remedy for diseases caused by IL-6 production
JPH08245414A (en) 1995-01-27 1996-09-24 Private Biolog Corp Composition and method of treating il-6 associated disease
CA2211578C (en) 1995-02-13 2010-09-21 Chugai Seiyaku Kabushiki Kaisha Muscle protein proteolysis inhibiting agent containing il-6 receptor antibody
US5569680A (en) * 1995-02-13 1996-10-29 Trustees Of The Univ. Of Penna Method of treating inflammatory bowel disease with tributyrin
DE69637481D1 (en) 1995-04-27 2008-05-15 Amgen Fremont Inc Dating from immunized Xenomäusen human antibodies to IL-8
JPH08311098A (en) 1995-05-22 1996-11-26 Daicel Chem Ind Ltd New peptides and interleukin 6 antagonistic agent containing the peptide
US5571513A (en) * 1995-05-31 1996-11-05 The Board Of Regents Of The University Of Oklahoma Anti-gp130 monoclonal antibodies
WO1996040966A1 (en) * 1995-06-07 1996-12-19 Private Biologicals Corporation Compositions and methods of treating il-6 associated diseases
AU1209497A (en) 1995-12-27 1997-07-28 Takeda Chemical Industries Ltd. Oxazole derivatives, their production and use
JPH09235276A (en) * 1995-12-27 1997-09-09 Takeda Chem Ind Ltd Oxazole derivative, production of the same and use of the same
EA000852B1 (en) * 1996-04-09 2000-06-26 Апплайд Резеч Системз Арс Холдинг Н.В. Mutant human il-6 and its internal fragment, the DNA sequences encoding them, methods for their preparation, pharmaceutical compositions containing them, containing the vectors, the host cell line and a method of treating il-6 mediated diseases
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
US20020187150A1 (en) * 1997-08-15 2002-12-12 Chugai Seiyaku Kabushiki Kaisha Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
AT383875T (en) * 1998-03-17 2008-02-15 Chugai Pharmaceutical Co Ltd Prophylactic or therapeutic agent for inflammatory digestive tract diseases containing antagonistic IL-6 receptor antibody
AU775483B2 (en) 1998-06-10 2004-08-05 Promega Corporation Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease
WO2002036165A1 (en) * 2000-10-27 2002-05-10 Chugai Seiyaku Kabushiki Kaisha Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
BR0208636A (en) * 2001-04-02 2004-03-09 Chugai Pharmaceutical Co Ltd therapeutic agent for diseases crÈnicas arthritides diseases related inf ‰ INSTANCE
CN101023946A (en) * 2002-04-12 2007-08-29 美国辉瑞有限公司 Use of EP4 receptor ligands in the treatment of IL-6 involved diseases
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases

Also Published As

Publication number Publication date
CN101239185A (en) 2008-08-13
PL201461B1 (en) 2009-04-30
AU2748199A (en) 1999-10-11
HU225539B1 (en) 2007-02-28
US20040071706A1 (en) 2004-04-15
CN1297357A (en) 2001-05-30
NO20004581L (en) 2000-11-10
CZ297083B6 (en) 2006-09-13
WO1999047170A1 (en) 1999-09-23
CZ20003297A3 (en) 2001-02-14
HU0101694A2 (en) 2002-12-28
RU2195960C2 (en) 2003-01-10
CA2324115C (en) 2008-12-23
DE69937994T2 (en) 2008-12-24
HK1036018A1 (en) 2009-01-30
CN100374159C (en) 2008-03-12
EP1074268A4 (en) 2002-11-20
HU0101694A3 (en) 2003-08-28
PT1074268E (en) 2008-02-28
PL342938A1 (en) 2001-07-16
EP1074268A1 (en) 2001-02-07
NO327718B1 (en) 2009-09-14
ES2299241T3 (en) 2008-05-16
JP4124573B2 (en) 2008-07-23
KR100407811B1 (en) 2003-12-01
CA2324115A1 (en) 1999-09-23
HK1033911A1 (en) 2008-08-29
EP1074268B1 (en) 2008-01-16
DE69937994D1 (en) 2008-03-06
US7824674B2 (en) 2010-11-02
DK1074268T3 (en) 2008-04-28
US6723319B1 (en) 2004-04-20
AU754006B2 (en) 2002-10-31
NO20004581D0 (en) 2000-09-14

Similar Documents

Publication Publication Date Title
DE60238842D1 (en) Radiological treatment device
DK1415053T3 (en) Fastholdelsesvægblok system and multi-channel
DE60043764D1 (en) disposable diaper
DE60016730D1 (en) disposable diaper
DE69933780D1 (en) Controlled drug dosage device
DE60238034D1 (en) Body Fat Monitor
DE60218022D1 (en) medical stent
AT261326T (en) inhaler
DE60204058D1 (en) Network-forming and pectin-containing preparation
AT418920T (en) lung reduction devices and removable systems
DE60038436D1 (en) From the patient portable device for photodynamic therapy
DE60028003D1 (en) Bifidobacterium for treatment of inflammatory diseases
DE60015881D1 (en) Low-voltage electro-surgical device
AT460955T (en) Dry powder inhaler
DK1267866T3 (en) Treatment of respiratory diseases
RU2006120003A (en) The compounds and methods for treatment and diagnosis of chlamydial infections
DE10290911D2 (en) Irradiation device for therapeutic purposes
DK1341542T3 (en) Indanylderivater for the treatment of respiratory diseases
DK1390049T3 (en) Compositions for the treatment of animal diseases and syndromes comprising transfer factor
DE60035911D1 (en) dry powder inhaler
DE69937654D1 (en) Intravaginal set of elements
DE60030862D1 (en) dry powder inhaler
NO320747B1 (en) Sulfonamide and sulfamidsubstituerte Imidazo
DE10191636T1 (en) Endoscope and endoscope system hereby
RU2004103537A (en) Combinations for the treatment of inflammatory diseases

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1074268

Country of ref document: EP