AT382681T - stem cells improve heart function through transplantation of mesenchymal - Google Patents

stem cells improve heart function through transplantation of mesenchymal

Info

Publication number
AT382681T
AT382681T AT99941984T AT99941984T AT382681T AT 382681 T AT382681 T AT 382681T AT 99941984 T AT99941984 T AT 99941984T AT 99941984 T AT99941984 T AT 99941984T AT 382681 T AT382681 T AT 382681T
Authority
AT
Austria
Prior art keywords
mesenchymal
transplantation
stem cells
heart function
improve heart
Prior art date
Application number
AT99941984T
Other languages
German (de)
Inventor
Donald Mickle
Ren-Ke Le
Richard Weisel
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US9479498P priority Critical
Priority to US12915299P priority
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of AT382681T publication Critical patent/AT382681T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/06Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1329Cardiomyocytes
AT99941984T 1998-07-31 1999-07-29 stem cells improve heart function through transplantation of mesenchymal AT382681T (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US9479498P true 1998-07-31 1998-07-31
US12915299P true 1999-04-14 1999-04-14

Publications (1)

Publication Number Publication Date
AT382681T true AT382681T (en) 2008-01-15

Family

ID=26789238

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99941984T AT382681T (en) 1998-07-31 1999-07-29 stem cells improve heart function through transplantation of mesenchymal

Country Status (9)

Country Link
US (1) US20050031600A1 (en)
EP (1) EP1100870B1 (en)
JP (1) JP2002521493A (en)
AT (1) AT382681T (en)
AU (1) AU5545499A (en)
BR (1) BR9912662A (en)
CA (1) CA2339182C (en)
DE (1) DE69937888T2 (en)
WO (1) WO2000006701A1 (en)

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AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
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US8764725B2 (en) 2004-02-09 2014-07-01 Covidien Lp Directional anchoring mechanism, method and applications thereof
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
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US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
WO2005097147A1 (en) * 2004-03-30 2005-10-20 Boston Scientific Limited (Incorporated In Ireland) Restenosis therapy using mesenchymal stem cells
US20050277124A1 (en) * 2004-06-10 2005-12-15 White Steven M Cardiac conduction system cells and uses thereof
EP1910518B1 (en) 2005-06-22 2019-05-08 Asterias Biotherapeutics, Inc. Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
US20070231135A1 (en) 2006-03-31 2007-10-04 Orqis Medical Corporation Rotary Blood Pump
WO2007116408A2 (en) * 2006-04-11 2007-10-18 Nanodiagnostics Israel Ltd. Pluripotent stem cells characterized by expression of germline specific genes
WO2008125279A2 (en) * 2007-04-11 2008-10-23 Universitätsklinikum Heidelberg Atrial-radiofrequency catheter ablation mediated targeting of mesenchymal stromal cells
CN101668848B (en) * 2007-04-26 2014-10-22 雷蒙特亚特特拉维夫大学有限公司 Multipotent autologous stem cells from the oral mucosa and methods of use
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WO2014027474A1 (en) * 2012-08-17 2014-02-20 株式会社Clio Pluripotent stem cell that induces repair and regeneration after myocardial infarction
EP2925863A4 (en) 2012-11-30 2016-04-13 Vestion Inc Cardiac stem cells and methods of identifying and using the same
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Also Published As

Publication number Publication date
EP1100870A4 (en) 2004-10-13
DE69937888T2 (en) 2009-01-02
AU5545499A (en) 2000-02-21
CA2339182A1 (en) 2000-02-10
WO2000006701A1 (en) 2000-02-10
US20050031600A1 (en) 2005-02-10
EP1100870A1 (en) 2001-05-23
WO2000006701A9 (en) 2000-06-15
EP1100870B1 (en) 2008-01-02
CA2339182C (en) 2010-04-06
DE69937888D1 (en) 2008-02-14
BR9912662A (en) 2001-06-05
JP2002521493A (en) 2002-07-16

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